Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM72 Gene

Aliases for TMEM72 Gene

  • Transmembrane Protein 72 2 3 5
  • Kidney-Specific Secretory Protein Of 37 KDa 3 4
  • C10orf127 3 4
  • KSP37 3 4
  • Chromosome 10 Open Reading Frame 127 2

External Ids for TMEM72 Gene

Previous HGNC Symbols for TMEM72 Gene

  • C10orf127

Previous GeneCards Identifiers for TMEM72 Gene

  • GC10P044731
  • GC10P045406
  • GC10P041931

Summaries for TMEM72 Gene

Entrez Gene Summary for TMEM72 Gene

  • This gene encodes a transmembrane protein which may be expressed specifically in the kidney. [provided by RefSeq, Sep 2016]

GeneCards Summary for TMEM72 Gene

TMEM72 (Transmembrane Protein 72) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM72 Gene

Genomics for TMEM72 Gene

Regulatory Elements for TMEM72 Gene

Enhancers for TMEM72 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F044878 1.5 FANTOM5 Ensembl ENCODE 19.8 -32.1 -32068 1.7 SREBF2 ZNF335 ZNF121 GLIS2 ZNF366 ZNF143 KLF7 FOS KLF13 EGR2 TMEM72 ENSG00000234504 ENSG00000223462 AGAP10P CXCL12 AGAP4 EIF2AP4
GH10F044945 1.4 FANTOM5 Ensembl ENCODE 20.2 +37.2 37154 5.3 CTCF PKNOX1 ZNF133 EBF1 ZIC2 RAD21 RARA TEAD3 RELA ZNF316 TMEM72 C10orf25 ZNF22 RASSF4 ENSG00000227683 TMEM72-AS1 RSU1P2 ALOX5 ENSG00000223462
GH10F044971 1.8 FANTOM5 Ensembl ENCODE 10.3 +68.6 68643 16.9 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC AGAP4 C10orf25 ZNF22 TMEM72-AS1 RASSF4 FAM21FP ENSG00000223462 ENSG00000234504 TMEM72 CEP164P1
GH10F044957 1.4 FANTOM5 ENCODE 10.3 +52.6 52617 12.3 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 ZNF22 TMEM72-AS1 AGAP4 C10orf25 ENSG00000223462 ENSG00000234504 TMEM72 RASSF4 CEP164P1 ALOX5
GH10F044910 1.3 Ensembl ENCODE 10.2 +1.6 1606 4.4 PKNOX1 ATF1 ARNT ZNF133 ZNF48 ZNF766 CBX5 ELK1 GATA2 KDM4B ENSG00000223462 TMEM72 TMEM72-AS1 ENSG00000234504
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM72 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM72 Gene

Chromosome:
10
Start:
44,911,200 bp from pter
End:
44,937,010 bp from pter
Size:
25,811 bases
Orientation:
Plus strand

Genomic View for TMEM72 Gene

Genes around TMEM72 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM72 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM72 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM72 Gene

Proteins for TMEM72 Gene

  • Protein details for TMEM72 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0PK05-TMM72_HUMAN
    Recommended name:
    Transmembrane protein 72
    Protein Accession:
    A0PK05
    Secondary Accessions:
    • A1L181
    • Q5T740

    Protein attributes for TMEM72 Gene

    Size:
    275 amino acids
    Molecular mass:
    29891 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM72 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM72 Gene

Post-translational modifications for TMEM72 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM72 Gene

No data available for DME Specific Peptides for TMEM72 Gene

Domains & Families for TMEM72 Gene

Protein Domains for TMEM72 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM72 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM72: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM72 Gene

Function for TMEM72 Gene

Phenotypes for TMEM72 Gene

GenomeRNAi human phenotypes for TMEM72:
genes like me logo Genes that share phenotypes with TMEM72: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM72 Gene

Localization for TMEM72 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM72 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM72 gene
Compartment Confidence
plasma membrane 3
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM72: view

Pathways & Interactions for TMEM72 Gene

SuperPathways for TMEM72 Gene

No Data Available

Interacting Proteins for TMEM72 Gene

Gene Ontology (GO) - Biological Process for TMEM72 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM72 Gene

Transcripts for TMEM72 Gene

mRNA/cDNA for TMEM72 Gene

(5) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM72 Gene

Transmembrane protein 72:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM72 Gene

No ASD Table

Relevant External Links for TMEM72 Gene

GeneLoc Exon Structure for
TMEM72
ECgene alternative splicing isoforms for
TMEM72

Expression for TMEM72 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM72 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM72 Gene

This gene is overexpressed in Kidney - Cortex (x33.0) and Colon - Transverse (x8.4).

Protein differential expression in normal tissues from HIPED for TMEM72 Gene

This gene is overexpressed in Ovary (63.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM72 Gene



Protein tissue co-expression partners for TMEM72 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM72 Gene:

TMEM72

SOURCE GeneReport for Unigene cluster for TMEM72 Gene:

Hs.292788
genes like me logo Genes that share expression patterns with TMEM72: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM72 Gene

Orthologs for TMEM72 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM72 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM72 34 35
  • 99.15 (n)
dog
(Canis familiaris)
Mammalia TMEM72 34 35
  • 86.79 (n)
cow
(Bos Taurus)
Mammalia TMEM72 34 35
  • 86.37 (n)
rat
(Rattus norvegicus)
Mammalia Tmem72 34
  • 84.73 (n)
mouse
(Mus musculus)
Mammalia Tmem72 34 16 35
  • 84.48 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM72 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM72 34 35
  • 65.55 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM72 35
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem72 34
  • 56.45 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem72 34 35
  • 50.89 (n)
Species where no ortholog for TMEM72 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM72 Gene

ENSEMBL:
Gene Tree for TMEM72 (if available)
TreeFam:
Gene Tree for TMEM72 (if available)

Paralogs for TMEM72 Gene

No data available for Paralogs for TMEM72 Gene

Variants for TMEM72 Gene

Sequence variations from dbSNP and Humsavar for TMEM72 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs587777896 untested 44,934,719(+) GAAAG(A/C)TGCCC intron-variant, reference, missense
rs10751362 -- 44,935,873(+) CTGAA(A/C)GCAGT intron-variant, utr-variant-3-prime
rs10793566 -- 44,915,717(+) GTACA(C/G)TGAAG intron-variant
rs10793567 -- 44,919,759(+) CCAAC(C/T)GAATG intron-variant, utr-variant-5-prime
rs10793568 -- 44,919,761(+) AACTG(A/G)ATGTC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM72 Gene

Variant ID Type Subtype PubMed ID
dgv438n106 CNV deletion 24896259
esv2678805 CNV deletion 23128226
esv2736094 CNV deletion 23290073
esv2762860 CNV loss 21179565
esv3546235 CNV deletion 23714750
esv3576560 CNV gain 25503493
esv3623075 CNV loss 21293372
esv3623076 CNV gain 21293372
nsv1068307 CNV deletion 25765185
nsv1120219 CNV tandem duplication 24896259
nsv1153452 CNV deletion 26484159
nsv466909 CNV gain 19166990
nsv517161 CNV gain+loss 19592680
nsv550714 CNV gain 21841781
nsv818757 CNV loss 17921354
nsv831844 CNV gain 17160897
nsv831845 CNV gain 17160897
nsv831846 CNV loss 17160897

Variation tolerance for TMEM72 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM72 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM72

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM72 Gene

Disorders for TMEM72 Gene

Relevant External Links for TMEM72

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM72

No disorders were found for TMEM72 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM72 Gene

Publications for TMEM72 Gene

  1. Expression of pre-selected TMEMs with predicted ER localization as potential classifiers of ccRCC tumors. (PMID: 26169495) WrzesiA8ski T. … Wesoly J. (BMC Cancer 2015) 3 64
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TMEM72 Gene

Sources for TMEM72 Gene

Content
Loading form....