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Aliases for TMEM72 Gene

Aliases for TMEM72 Gene

  • Transmembrane Protein 72 2 3
  • Kidney-Specific Secretory Protein Of 37 KDa 3 4
  • C10orf127 3 4
  • KSP37 3 4
  • Chromosome 10 Open Reading Frame 127 2

External Ids for TMEM72 Gene

Previous HGNC Symbols for TMEM72 Gene

  • C10orf127

Previous GeneCards Identifiers for TMEM72 Gene

  • GC10P044731
  • GC10P045406
  • GC10P041931

Summaries for TMEM72 Gene

GeneCards Summary for TMEM72 Gene

TMEM72 (Transmembrane Protein 72) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM72 Gene

Genomics for TMEM72 Gene

Regulatory Elements for TMEM72 Gene

Genomic Location for TMEM72 Gene

Chromosome:
10
Start:
44,911,200 bp from pter
End:
44,937,010 bp from pter
Size:
25,811 bases
Orientation:
Plus strand

Genomic View for TMEM72 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM72 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM72 Gene

Proteins for TMEM72 Gene

  • Protein details for TMEM72 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0PK05-TMM72_HUMAN
    Recommended name:
    Transmembrane protein 72
    Protein Accession:
    A0PK05
    Secondary Accessions:
    • A1L181
    • Q5T740

    Protein attributes for TMEM72 Gene

    Size:
    275 amino acids
    Molecular mass:
    29891 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM72 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM72 Gene

Proteomics data for TMEM72 Gene at MOPED

Post-translational modifications for TMEM72 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM72 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM72 Gene

Domains & Families for TMEM72 Gene

Protein Domains for TMEM72 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM72 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM72: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM72 Gene

Function for TMEM72 Gene

Phenotypes for TMEM72 Gene

GenomeRNAi human phenotypes for TMEM72:
genes like me logo Genes that share phenotypes with TMEM72: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM72

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM72 Gene

Localization for TMEM72 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM72 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM72: view

No data available for Subcellular locations from COMPARTMENTS for TMEM72 Gene

Pathways & Interactions for TMEM72 Gene

SuperPathways for TMEM72 Gene

No Data Available

Interacting Proteins for TMEM72 Gene

Gene Ontology (GO) - Biological Process for TMEM72 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM72 Gene

Drugs & Compounds for TMEM72 Gene

No Compound Related Data Available

Transcripts for TMEM72 Gene

mRNA/cDNA for TMEM72 Gene

(5) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM72 Gene

Transmembrane protein 72:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM72

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM72 Gene

No ASD Table

Relevant External Links for TMEM72 Gene

GeneLoc Exon Structure for
TMEM72
ECgene alternative splicing isoforms for
TMEM72

Expression for TMEM72 Gene

mRNA expression in normal human tissues for TMEM72 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM72 Gene

This gene is overexpressed in Kidney - Cortex (x33.0) and Colon - Transverse (x8.4).

Protein differential expression in normal tissues from HIPED for TMEM72 Gene

This gene is overexpressed in Ovary (63.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM72 Gene



SOURCE GeneReport for Unigene cluster for TMEM72 Gene Hs.292788

genes like me logo Genes that share expression patterns with TMEM72: view

Protein tissue co-expression partners for TMEM72 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM72 Gene

Orthologs for TMEM72 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM72 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM72 35
  • 86.37 (n)
  • 86.13 (a)
TMEM72 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM72 35
  • 86.79 (n)
  • 87.27 (a)
TMEM72 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem72 35
  • 84.48 (n)
  • 84.36 (a)
Tmem72 16
Tmem72 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM72 35
  • 99.15 (n)
  • 99.27 (a)
TMEM72 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem72 35
  • 84.73 (n)
  • 84.73 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM72 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM72 35
  • 65.55 (n)
  • 60.59 (a)
TMEM72 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM72 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem72 35
  • 56.45 (n)
  • 52.15 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem72 35
  • 50.89 (n)
  • 41.15 (a)
tmem72 36
  • 40 (a)
OneToOne
Species with no ortholog for TMEM72:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM72 Gene

ENSEMBL:
Gene Tree for TMEM72 (if available)
TreeFam:
Gene Tree for TMEM72 (if available)

Paralogs for TMEM72 Gene

No data available for Paralogs for TMEM72 Gene

Variants for TMEM72 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM72 Gene

Variant ID Type Subtype PubMed ID
nsv517161 CNV Gain+Loss 19592680
nsv831844 CNV Gain 17160897
nsv831845 CNV Gain 17160897
nsv831846 CNV Loss 17160897
nsv466909 CNV Gain 19166990
esv2678805 CNV Deletion 23128226
nsv818757 CNV Loss 17921354
esv2736094 CNV Deletion 23290073

Variation tolerance for TMEM72 Gene

Residual Variation Intolerance Score: 77.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM72 Gene

HapMap Linkage Disequilibrium report
TMEM72

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TMEM72 Gene

Disorders for TMEM72 Gene

Relevant External Links for TMEM72

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM72
genes like me logo Genes that share disorders with TMEM72: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM72 Gene

Publications for TMEM72 Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 67
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for TMEM72 Gene

Sources for TMEM72 Gene

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