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Aliases for TMEM71 Gene

Aliases for TMEM71 Gene

  • Transmembrane Protein 71 2 3 5

External Ids for TMEM71 Gene

Previous GeneCards Identifiers for TMEM71 Gene

  • GC08M133792
  • GC08M129040
  • GC08M133697

Summaries for TMEM71 Gene

GeneCards Summary for TMEM71 Gene

TMEM71 (Transmembrane Protein 71) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM71 Gene

Genomics for TMEM71 Gene

Regulatory Elements for TMEM71 Gene

Promoters for TMEM71 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM71 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM71 Gene

Chromosome:
8
Start:
132,685,007 bp from pter
End:
132,760,712 bp from pter
Size:
75,706 bases
Orientation:
Minus strand

Genomic View for TMEM71 Gene

Genes around TMEM71 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM71 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM71 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM71 Gene

Proteins for TMEM71 Gene

  • Protein details for TMEM71 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P5X7-TMM71_HUMAN
    Recommended name:
    Transmembrane protein 71
    Protein Accession:
    Q6P5X7
    Secondary Accessions:
    • Q3KRC2
    • Q8WVZ4
    • Q96LX9

    Protein attributes for TMEM71 Gene

    Size:
    295 amino acids
    Molecular mass:
    32983 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM71 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM71 Gene

Proteomics data for TMEM71 Gene at MOPED

Post-translational modifications for TMEM71 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM71 Gene

Domains & Families for TMEM71 Gene

Protein Domains for TMEM71 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM71 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P5X7

UniProtKB/Swiss-Prot:

TMM71_HUMAN :
  • Belongs to the TMEM71 family.
Family:
  • Belongs to the TMEM71 family.
genes like me logo Genes that share domains with TMEM71: view

No data available for Gene Families for TMEM71 Gene

Function for TMEM71 Gene

genes like me logo Genes that share phenotypes with TMEM71: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM71 Gene

Localization for TMEM71 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM71 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM71 Gene COMPARTMENTS Subcellular localization image for TMEM71 gene
Compartment Confidence
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for TMEM71 Gene

Pathways & Interactions for TMEM71 Gene

SuperPathways for TMEM71 Gene

No Data Available

Interacting Proteins for TMEM71 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000349296%0d%0a9606.ENSP00000353622%0d%0a9606.ENSP00000307183%0d%0a
Selected Interacting proteins: ENSP00000349296 Q6P5X7-TMM71_HUMAN for TMEM71 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TMEM71 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM71 Gene

Drugs & Compounds for TMEM71 Gene

No Compound Related Data Available

Transcripts for TMEM71 Gene

Unigene Clusters for TMEM71 Gene

Transmembrane protein 71:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM71 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4:
SP5: - -
SP6: -
SP7: - - - -
SP8: - - - -
SP9: - -

Relevant External Links for TMEM71 Gene

GeneLoc Exon Structure for
TMEM71
ECgene alternative splicing isoforms for
TMEM71

Expression for TMEM71 Gene

mRNA expression in normal human tissues for TMEM71 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM71 Gene

This gene is overexpressed in Whole Blood (x30.2) and Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for TMEM71 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM71 Gene



SOURCE GeneReport for Unigene cluster for TMEM71 Gene Hs.293842

genes like me logo Genes that share expression patterns with TMEM71: view

Protein tissue co-expression partners for TMEM71 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM71 Gene

Orthologs for TMEM71 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM71 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM71 35
  • 99.03 (n)
  • 98.91 (a)
TMEM71 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM71 36
  • 64 (a)
OneToOne
TMEM71 35
  • 80 (n)
  • 69.82 (a)
dog
(Canis familiaris)
Mammalia TMEM71 35
  • 80 (n)
  • 66.67 (a)
TMEM71 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem71 16
Tmem71 36
  • 63 (a)
OneToOne
Tmem71 35
  • 77.78 (n)
  • 68.56 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM71 36
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM71 36
  • 35 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem71 35
  • 76.73 (n)
  • 67.55 (a)
chicken
(Gallus gallus)
Aves TMEM71 35
  • 51.46 (n)
  • 37.64 (a)
TMEM71 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM71 36
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TMEM71 36
  • 28 (a)
OneToOne
Species with no ortholog for TMEM71:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM71 Gene

ENSEMBL:
Gene Tree for TMEM71 (if available)
TreeFam:
Gene Tree for TMEM71 (if available)

Paralogs for TMEM71 Gene

No data available for Paralogs for TMEM71 Gene

Variants for TMEM71 Gene

Sequence variations from dbSNP and Humsavar for TMEM71 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs890210 -- 132,761,822(-) CACAT(A/G)GGCTT upstream-variant-2KB
rs1048490 -- 132,710,035(+) CATTA(C/T)CATTT utr-variant-3-prime
rs1593398 -- 132,714,382(+) AAGAG(A/G)GTAGA intron-variant
rs1834437 -- 132,742,769(-) TCAAC(A/C)AATGG intron-variant
rs1425705 -- 132,716,219(+) gctcc(C/T)gttgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM71 Gene

Variant ID Type Subtype PubMed ID
esv2494945 CNV Insertion 19546169
nsv831463 CNV Gain 17160897
esv2737600 CNV Deletion 23290073
esv2267942 CNV Deletion 18987734
esv2737601 CNV Deletion 23290073
esv1274548 CNV Deletion 17803354
dgv256n6 CNV Loss 16902084
esv2737602 CNV Deletion 23290073
esv2673001 CNV Deletion 23128226

Variation tolerance for TMEM71 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM71 Gene

HapMap Linkage Disequilibrium report
TMEM71

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM71 Gene

Disorders for TMEM71 Gene

Relevant External Links for TMEM71

Genetic Association Database (GAD)
TMEM71
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM71

No disorders were found for TMEM71 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM71 Gene

Publications for TMEM71 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for TMEM71 Gene

Sources for TMEM71 Gene

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