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Aliases for TMEM71 Gene

Aliases for TMEM71 Gene

  • Transmembrane Protein 71 2 3 5

External Ids for TMEM71 Gene

Previous GeneCards Identifiers for TMEM71 Gene

  • GC08M133792
  • GC08M129040
  • GC08M133697

Summaries for TMEM71 Gene

GeneCards Summary for TMEM71 Gene

TMEM71 (Transmembrane Protein 71) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM71 Gene

Genomics for TMEM71 Gene

Regulatory Elements for TMEM71 Gene

Enhancers for TMEM71 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F132758 1.4 FANTOM5 ENCODE 43.6 +0.6 584 4.2 CTCF PKNOX1 RNF2 JUN BHLHE40 HNF1A POLR2A FOXP2 TMEM71 PHF20L1 LRRC6
GH08F133080 1.6 FANTOM5 Ensembl ENCODE 42.2 -321.7 -321689 4.4 CTCF ZFP64 ZBTB11 ZNF140 CEBPB ZBTB8A REST ZNF623 RAD21 ZNF518A TMEM71 PHF20L1 WISP1 SLA ST3GAL1 TG GC08P133070
GH08F133077 1.3 FANTOM5 ENCODE 41.7 -317.5 -317456 0.7 MAX TMEM71 PHF20L1 WISP1 SLA ST3GAL1 GC08P133070
GH08F133142 1.5 FANTOM5 Ensembl ENCODE 37.5 -384.6 -384589 6.2 ATF3 CREM SPI1 ZNF7 TMEM71 PHF20L1 WISP1 ST3GAL1 SLA TG NDRG1 LOC105375769 GC08M133177
GH08F133149 1.3 FANTOM5 Ensembl ENCODE 26 -390.9 -390922 4.1 ZNF133 EBF1 YY1 FOS MAFK NFE2L2 MTA2 BHLHE40 JUNB MNT PHF20L1 TMEM71 WISP1 SLA TG ENSG00000223697 ST3GAL1 LOC105375769 GC08M133177
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM71 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM71 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001402470 1212 2201 CTCF PKNOX1 HNF1A RNF2 FOS FOXP2

Genomic Location for TMEM71 Gene

Chromosome:
8
Start:
132,685,007 bp from pter
End:
132,760,712 bp from pter
Size:
75,706 bases
Orientation:
Minus strand

Genomic View for TMEM71 Gene

Genes around TMEM71 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM71 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM71 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM71 Gene

Proteins for TMEM71 Gene

  • Protein details for TMEM71 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P5X7-TMM71_HUMAN
    Recommended name:
    Transmembrane protein 71
    Protein Accession:
    Q6P5X7
    Secondary Accessions:
    • Q3KRC2
    • Q8WVZ4
    • Q96LX9

    Protein attributes for TMEM71 Gene

    Size:
    295 amino acids
    Molecular mass:
    32983 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM71 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM71 Gene

Post-translational modifications for TMEM71 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM71 Gene

Domains & Families for TMEM71 Gene

Protein Domains for TMEM71 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM71 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P5X7

UniProtKB/Swiss-Prot:

TMM71_HUMAN :
  • Belongs to the TMEM71 family.
Family:
  • Belongs to the TMEM71 family.
genes like me logo Genes that share domains with TMEM71: view

No data available for Gene Families for TMEM71 Gene

Function for TMEM71 Gene

genes like me logo Genes that share phenotypes with TMEM71: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM71 Gene

Localization for TMEM71 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM71 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM71 Gene COMPARTMENTS Subcellular localization image for TMEM71 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM71 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM71: view

Pathways & Interactions for TMEM71 Gene

SuperPathways for TMEM71 Gene

No Data Available

Interacting Proteins for TMEM71 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000349296%0d%0a9606.ENSP00000353622%0d%0a9606.ENSP00000307183%0d%0a
Selected Interacting proteins: ENSP00000349296 Q6P5X7-TMM71_HUMAN for TMEM71 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM71 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM71 Gene

Transcripts for TMEM71 Gene

Unigene Clusters for TMEM71 Gene

Transmembrane protein 71:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM71 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4:
SP5: - -
SP6: -
SP7: - - - -
SP8: - - - -
SP9: - -

Relevant External Links for TMEM71 Gene

GeneLoc Exon Structure for
TMEM71
ECgene alternative splicing isoforms for
TMEM71

Expression for TMEM71 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM71 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM71 Gene

This gene is overexpressed in Whole Blood (x30.2) and Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for TMEM71 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM71 Gene



Protein tissue co-expression partners for TMEM71 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM71 Gene:

TMEM71

SOURCE GeneReport for Unigene cluster for TMEM71 Gene:

Hs.293842
genes like me logo Genes that share expression patterns with TMEM71: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM71 Gene

Orthologs for TMEM71 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM71 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM71 34 35
  • 99.03 (n)
cow
(Bos Taurus)
Mammalia TMEM71 34 35
  • 80 (n)
dog
(Canis familiaris)
Mammalia TMEM71 34 35
  • 80 (n)
mouse
(Mus musculus)
Mammalia Tmem71 34 16 35
  • 77.78 (n)
rat
(Rattus norvegicus)
Mammalia Tmem71 34
  • 76.73 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM71 35
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM71 35
  • 35 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM71 34 35
  • 51.46 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM71 35
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TMEM71 35
  • 28 (a)
OneToOne
Species where no ortholog for TMEM71 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM71 Gene

ENSEMBL:
Gene Tree for TMEM71 (if available)
TreeFam:
Gene Tree for TMEM71 (if available)

Paralogs for TMEM71 Gene

No data available for Paralogs for TMEM71 Gene

Variants for TMEM71 Gene

Sequence variations from dbSNP and Humsavar for TMEM71 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10086748 -- 132,761,624(+) ATTTC(A/G)AAGTt upstream-variant-2KB
rs10089392 -- 132,720,424(+) CTAGA(C/T)GTGTT intron-variant
rs10089874 -- 132,714,888(+) acttg(A/C)aaaaa intron-variant
rs10094650 -- 132,746,488(+) ATATA(C/T)ATATA intron-variant
rs10096655 -- 132,712,652(+) CACCC(A/T)GGTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM71 Gene

Variant ID Type Subtype PubMed ID
dgv256n6 CNV deletion 16902084
esv1274548 CNV deletion 17803354
esv2267942 CNV deletion 18987734
esv2494945 CNV insertion 19546169
esv2673001 CNV deletion 23128226
esv2737600 CNV deletion 23290073
esv2737601 CNV deletion 23290073
esv2737602 CNV deletion 23290073
esv3618878 CNV loss 21293372
esv3618882 CNV loss 21293372
nsv1121691 CNV deletion 24896259
nsv1128453 CNV deletion 24896259
nsv1130883 CNV deletion 24896259
nsv831463 CNV gain 17160897
nsv958464 CNV deletion 24416366

Variation tolerance for TMEM71 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM71 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM71

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM71 Gene

Disorders for TMEM71 Gene

Relevant External Links for TMEM71

Genetic Association Database (GAD)
TMEM71
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM71

No disorders were found for TMEM71 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM71 Gene

Publications for TMEM71 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan R.S. … Benjamin E.J. (BMC Med. Genet. 2007) 46 64

Products for TMEM71 Gene

Sources for TMEM71 Gene

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