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Aliases for TMEM71 Gene

Aliases for TMEM71 Gene

  • Transmembrane Protein 71 2 3 5

External Ids for TMEM71 Gene

Previous GeneCards Identifiers for TMEM71 Gene

  • GC08M133792
  • GC08M129040
  • GC08M133697

Summaries for TMEM71 Gene

GeneCards Summary for TMEM71 Gene

TMEM71 (Transmembrane Protein 71) is a Protein Coding gene.

Additional gene information for TMEM71 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM71 Gene

Genomics for TMEM71 Gene

Regulatory Elements for TMEM71 Gene

Enhancers for TMEM71 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H133080 1.5 FANTOM5 Ensembl ENCODE dbSUPER 42.2 -321.4 -321442 3 CTCF POLR2A CEBPG RAD21 NR2F2 GABPA TMEM71 PHF20L1 WISP1 SLA ST3GAL1 TG GC08P133070
GH08H133147 1.4 FANTOM5 Ensembl ENCODE dbSUPER 37.6 -386.5 -386530 1 ZBTB21 ATF7 RUNX3 ATF2 CREM TMEM71 PHF20L1 WISP1 SLA TG ST3GAL1 LOC105375769 GC08M133177
GH08H132758 1.2 FANTOM5 ENCODE dbSUPER 43.6 +0.6 584 4 CTCF PKNOX1 JUND RNF2 POLR2A JUN FOXP2 TMEM71 PHF20L1 LRRC6
GH08H133077 1 FANTOM5 ENCODE dbSUPER 41.7 -317.5 -317456 0 MAX TMEM71 PHF20L1 WISP1 SLA ST3GAL1 GC08P133070
GH08H133149 1.4 FANTOM5 Ensembl ENCODE dbSUPER 26 -390.0 -389989 2 POLR2A ATF2 GABPA YY1 TMEM71 PHF20L1 WISP1 SLA ST3GAL1 LOC105375769 GC08M133177
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM71 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM71 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000231183 312 401 CTCF JUND FOS FOXP2

Genomic Location for TMEM71 Gene

Chromosome:
8
Start:
132,685,007 bp from pter
End:
132,760,712 bp from pter
Size:
75,706 bases
Orientation:
Minus strand

Genomic View for TMEM71 Gene

Genes around TMEM71 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM71 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM71 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM71 Gene

Proteins for TMEM71 Gene

  • Protein details for TMEM71 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P5X7-TMM71_HUMAN
    Recommended name:
    Transmembrane protein 71
    Protein Accession:
    Q6P5X7
    Secondary Accessions:
    • Q3KRC2
    • Q8WVZ4
    • Q96LX9

    Protein attributes for TMEM71 Gene

    Size:
    295 amino acids
    Molecular mass:
    32983 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM71 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM71 Gene

Post-translational modifications for TMEM71 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM71 Gene

Domains & Families for TMEM71 Gene

Gene Families for TMEM71 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM71 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM71 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P5X7

UniProtKB/Swiss-Prot:

TMM71_HUMAN :
  • Belongs to the TMEM71 family.
Family:
  • Belongs to the TMEM71 family.
genes like me logo Genes that share domains with TMEM71: view

Function for TMEM71 Gene

Phenotypes From GWAS Catalog for TMEM71 Gene

genes like me logo Genes that share phenotypes with TMEM71: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM71
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM71 Gene

Localization for TMEM71 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM71 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM71 gene
Compartment Confidence
mitochondrion 4
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM71 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM71: view

Pathways & Interactions for TMEM71 Gene

SuperPathways for TMEM71 Gene

No Data Available

Interacting Proteins for TMEM71 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000349296%0d%0a9606.ENSP00000307183%0d%0a9606.ENSP00000353622%0d%0a
Selected Interacting proteins: ENSP00000349296 Q6P5X7-TMM71_HUMAN for TMEM71 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM71 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM71 Gene

Drugs & Compounds for TMEM71 Gene

No Compound Related Data Available

Transcripts for TMEM71 Gene

Unigene Clusters for TMEM71 Gene

Transmembrane protein 71:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM71
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM71 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4:
SP5: - -
SP6: -
SP7: - - - -
SP8: - - - -
SP9: - -

Relevant External Links for TMEM71 Gene

GeneLoc Exon Structure for
TMEM71
ECgene alternative splicing isoforms for
TMEM71

Expression for TMEM71 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM71 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM71 Gene

This gene is overexpressed in Whole Blood (x30.2) and Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for TMEM71 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM71 Gene



Protein tissue co-expression partners for TMEM71 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM71 Gene:

TMEM71

SOURCE GeneReport for Unigene cluster for TMEM71 Gene:

Hs.293842

Evidence on tissue expression from TISSUES for TMEM71 Gene

  • Lung(4.1)
  • Blood(2.8)
genes like me logo Genes that share expression patterns with TMEM71: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM71 Gene

Orthologs for TMEM71 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM71 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM71 33 34
  • 99.03 (n)
cow
(Bos Taurus)
Mammalia TMEM71 33 34
  • 80 (n)
dog
(Canis familiaris)
Mammalia TMEM71 33 34
  • 80 (n)
mouse
(Mus musculus)
Mammalia Tmem71 33 16 34
  • 77.78 (n)
rat
(Rattus norvegicus)
Mammalia Tmem71 33
  • 76.73 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM71 34
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM71 34
  • 35 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM71 33 34
  • 51.46 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM71 34
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TMEM71 34
  • 28 (a)
OneToOne
Species where no ortholog for TMEM71 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM71 Gene

ENSEMBL:
Gene Tree for TMEM71 (if available)
TreeFam:
Gene Tree for TMEM71 (if available)

Paralogs for TMEM71 Gene

No data available for Paralogs for TMEM71 Gene

Variants for TMEM71 Gene

Sequence variations from dbSNP and Humsavar for TMEM71 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000064989 -- 132,737,594(+) CCTCA(C/T)ATATA intron-variant
rs1000077506 -- 132,709,689(+) CACTG(C/G)AAGCT downstream-variant-500B
rs1000083696 -- 132,747,734(+) CTGCA(G/T)CAGAT intron-variant
rs1000123809 -- 132,726,270(+) AAAAC(-/A)AAAAA intron-variant
rs1000234543 -- 132,725,585(+) CTATA(C/T)CTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM71 Gene

Variant ID Type Subtype PubMed ID
dgv256n6 CNV deletion 16902084
esv1274548 CNV deletion 17803354
esv2267942 CNV deletion 18987734
esv2494945 CNV insertion 19546169
esv2673001 CNV deletion 23128226
esv2737600 CNV deletion 23290073
esv2737601 CNV deletion 23290073
esv2737602 CNV deletion 23290073
esv3618878 CNV loss 21293372
esv3618882 CNV loss 21293372
nsv1121691 CNV deletion 24896259
nsv1128453 CNV deletion 24896259
nsv1130883 CNV deletion 24896259
nsv831463 CNV gain 17160897
nsv958464 CNV deletion 24416366

Variation tolerance for TMEM71 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM71 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM71

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM71 Gene

Disorders for TMEM71 Gene

Relevant External Links for TMEM71

Genetic Association Database (GAD)
TMEM71
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM71

No disorders were found for TMEM71 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM71 Gene

Publications for TMEM71 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan RS … Benjamin EJ (BMC medical genetics 2007) 45 60

Products for TMEM71 Gene

Sources for TMEM71 Gene

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