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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM70 Gene

protein-coding   GIFtS: 49
GCID: GC08P074888

transmembrane protein 70
 Explore 8 diseases affiliated with
TMEM70 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TMEM70    

Aliases
for TMEM70 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transmembrane Protein 701 2
FLJ205331
MC5DN22
Transmembrane Protein 70, Mitochondrial2

External Ids:    HGNC: 260501   Entrez Gene: 549682   Ensembl: ENSG000001756067   OMIM: 6124185   UniProtKB: Q9BUB73   
ORGUL members:         
NONCODE:n409175    

Export aliases for TMEM70 gene to outside databases

Previous GC identifers: GC08P075051 GC08P070379


Summaries
for TMEM70 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TMEM70:
This gene likely encodes a mitochondrial membrane protein. The encoded protein may play a role in biogenesis of
mitochondrial ATP synthase. Mutations in this gene have been associated with neonatal mitochondrial
encephalocardiomyopathy due to ATP synthase deficiency. Alternatively spliced transcript variants have been described.
(provided by RefSeq, Feb 2010)

UniProtKB/Swiss-Prot: TMM70_HUMAN, Q9BUB7
Function: Involved in biogenesis of mitochondrial ATP synthase




Genomic Views
for TMEM70 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM70 gene promoter:
         TBP   AML1a   AP-1   ATF-2   IRF-1   GATA-1   MZF-1   c-Jun   Msx-1   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMEM70 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM70

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM70


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.11   Ensembl cytogenetic band:  8q21.11   HGNC cytogenetic band: 8q21.11

TMEM70 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM70 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P074888:  view genomic region     (about GC identifiers)

Start:
 74,884,672 bp from pter      End:
 74,895,018 bp from pter
Size:
 10,347 bases      Orientation:
 plus strand

Proteins
for TMEM70 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TMM70_HUMAN, Q9BUB7 (See protein sequence)
Recommended Name: Transmembrane protein 70, mitochondrial precursor  
Size: 260 amino acids; 28969 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Secondary accessions: Q9NWY5
Alternative splicing: 2 isoforms:  Q9BUB7-1   Q9BUB7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM70: NX_Q9BUB7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BUB7

    • TMEM70 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001035703.1  NP_060336.3  

    ENSEMBL proteins: 
     ENSP00000407695   ENSP00000429467   ENSP00000312599  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: TMEM70
    OriGene Protein Over-expression Lysate (see all 2): TMEM70
    OriGene Custom Protein Services for TMEM70 
    GenScript Custom Purified and Recombinant Proteins Services for TMEM70
    Novus Biologicals TMEM70 Protein
    Novus Biologicals TMEM70 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TMEM70

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IEA--
    GO:0032592integral to mitochondrial membrane IDA18953340


    TMEM70 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TMEM70

    Protein Domains /
    Families
    for TMEM70 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TMEM70 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009724 DUF1301_TMEM70

    Graphical View of Domain Structure for InterPro Entry Q9BUB7

    ProtoNet protein and cluster: Q9BUB7

    UniProtKB/Swiss-Prot: TMM70_HUMAN, Q9BUB7
    Similarity: Belongs to the TMEM70 family


    Function
    for TMEM70 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TMM70_HUMAN, Q9BUB7
    Function: Involved in biogenesis of mitochondrial ATP synthase

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM70
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM70:
    hsa-miR-875-3p hsa-miR-607 hsa-miR-578 hsa-miR-551b* hsa-miR-1305 hsa-miR-590-3p hsa-miR-378* hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmid: TMEM70 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM70 (see all 7)
    OriGene shRNA RFP: TMEM70
    OriGene siRNA: TMEM70
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM70

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TMEM70

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM70 (see all 5)
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    GenScript: all cDNA clones in your preferred vector (see all 2): TMEM70 (NM_017866)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM70
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM70 

    Cell Line
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    Search LifeMap BioReagents cell lines for TMEM70

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM70

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--


    TMEM70 for ontologies           About GeneDecksing



    Pathways & Interactions
    for TMEM70 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM70

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TMEM70 (Q9BUB72, 3 ENSP000003125994) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PHC2Q8IXK02, 3, ENSP000002571184MINT-65031 I2D: score=4 STRING: ENSP00000257118
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0033615mitochondrial proton-transporting ATP synthase complex assembly IMP18953340


    TMEM70 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TMEM70 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM70
    Search CenterWatch for drugs/clinical trials and news about TMEM70 / TMM70 

    Transcripts
    for TMEM70 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TMEM70 gene (2 alternative transcripts): 
    NM_001040613.2  NM_017866.5  

    Unigene Cluster for TMEM70:

    Transmembrane protein 70
    Hs.106650  [show with all ESTs]
    Unigene Representative Sequence: NR_033334
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520167 ENST00000523794 ENST00000416961 ENST00000517439 ENST00000312184(uc022awa.1 uc003yac.3 uc003yab.3)
    ENST00000517614 ENST00000519551

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): TMEM70
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM70
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM70:
    hsa-miR-875-3p hsa-miR-607 hsa-miR-578 hsa-miR-551b* hsa-miR-1305 hsa-miR-590-3p hsa-miR-378* hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmid: TMEM70 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM70 (see all 7)
    OriGene shRNA RFP: TMEM70
    OriGene siRNA: TMEM70
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM70
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM70 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM70 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): TMEM70 (NM_017866)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM70
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM70 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM70
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM70

    Additional cDNA sequence: 

    AK000540.1 AK225531.1 AK225536.1 BC002748.2 NR_033334.1 

    7 DOTS entries:

    DT.456197  DT.99942340  DT.100035879  DT.91840410  DT.92057247  DT.95269396  DT.100819704 

    24/105 AceView cDNA sequences (see all 105):

    AI276098 BU542365 BC002748 CD369236 BX283954 AA290639 AA570688 NM_017866 
    AI209029 AI082789 BM762854 CD370329 AA975695 CD369312 CD678202 CD677114 
    BQ061477 AA258745 BV176854 BE702650 BM710393 BX400191 AA436029 AI929238 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM70    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
    SP1:                    -                           
    SP2:                    -     -                     
    SP3:                          -                     


    ECgene alternative splicing isoforms for TMEM70

    Expression
    for TMEM70 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM70 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATTTACCAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See TMEM70 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM70

    SOURCE GeneReport for Unigene cluster: Hs.106650
        SABiosciences Custom PCR Arrays for TMEM70
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM70
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM70

    Orthologs
    for TMEM70 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TMEM70 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tmem701 , 5 transmembrane protein 701, 5 73.91(n)1
    61.66(a)1    		   1 (5.10 cM)5
    703971  NM_027415.21  NP_081691.21 
     166652075 
    chicken
    (Gallus gallus)    		 Aves TMEM701 transmembrane protein 70 63.07(n)
    58.52(a)    		   420188  NM_001012848.1  NP_001012866.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TMEM706
    		 --
    		 57(a)
    		 1 ↔ 1
    		 4(33820208-33821477)
    zebrafish
    (Danio rerio)    		 Actinopterygii tmem706
    		 transmembrane protein 70
    		 41(a)
    		 1 ↔ 1
    		 2(29964809-29967179)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG75066
    		 --
    		 29(a)
    		 1 ↔ 1
    		 3L(7633898-7634748)


    ENSEMBL Gene Tree for TMEM70 (if available)
    TreeFam Gene Tree for TMEM70 (if available) 

    Paralogs
    for TMEM70 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for TMEM70 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/182 NCBI SNPs in TMEM70 are shown (see all 182)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1836271791,2
    		--74886687(+) GTGGGC/TGGATA 3 -- us2k10--------
    rs44346141,2
    		C,--74886732(+) TATATG/AGTGAA 3 -- us2k16Minor allele frequency- A:0.20WA CSA NA EA 363
    rs101137911,2
    		C,A,H,--74887093(+) gtagaG/Cacagg 3 -- us2k14Minor allele frequency- C:0.17WA NA CSA 125
    rs1148021141,2
    		F,--74887173(+) GTAGTA/GTTGGA 3 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1378917741,2
    		--74887204(+) CCCCTA/GGCCAC 3 -- us2k10--------
    rs1884122841,2
    		--74887242(+) CTCTCC/TGGTGC 3 -- us2k10--------
    rs789315191,2
    		F,--74887408(+) CTGTGG/ACATTT 3 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1434608331,2
    		--74887632(+) TCCCTC/GTATTG 3 -- us2k10--------
    rs736871161,2
    		C,--74887742(+) TTGTAT/CATTGC 3 -- us2k15Minor allele frequency- C:0.25WA CSA NA EA 361
    rs726618591,2
    		C,F,--74887760(+) CAATTG/ATATTA 3 -- us2k17Minor allele frequency- A:0.45WA NA CSA EA 365

    HapMap Linkage Disequilibrium report for TMEM70 (74884672 - 74895018 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TMEM70: --
    Human Gene Mutation Database (HGMD): TMEM70

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM70
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM70

    Disorders / Diseases
    for TMEM70 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TMEM70 for disorders           About GeneDecksing

    OMIM gene information: 612418   
    OMIM disorders: 604273  
    UniProtKB/Swiss-Prot: TMM70_HUMAN, Q9BUB7
  • Defects in TMEM70 are a cause of mitochondrial complex V deficiency nuclear type 2 (MC5DN2) [MIM:614052]. A
    • mitochondrial disorder with heterogeneous clinical manifestations including dysmorphic features, psychomotor
    retardation, hypotonia, growth retardation, cardiomyopathy, enlarged liver, hypoplastic kidneys and elevated lactate
    levels in urine, plasma and cerebrospinal fluid

    8 diseases for TMEM70:    About MalaCards
    mitochondrial complex v deficiency    complex v    lactic acidosis    hypotonia
    hepatitis b    osteoporosis    myopathy    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for TMEM70:
    Lactic acidosis     Hypertrophic cardiomyopathy
    Human Genome Epidemiology (HuGE) Navigator: TMEM70 (6 documents)

    Export disorders for TMEM70 gene to outside databases

    Publications
    for TMEM70 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM70 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with TMEM70)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Restoration of complex V deficiency caused by a novel deletion in the human TMEM70 gene normalizes mitochondrial morphology. (PubMed id 21945727)1, 3 Jonckheere A.I....Rodenburg R.J. (2011)
    2. Expression and processing of the TMEM70 protein. (PubMed id 20937241)1, 2 Hejzlarova K.... Houstek J. (2011)
    3. TMEM70 mutations cause isolated ATP synthase deficiency and neonatal mitochondrial encephalocardiomyopathy. (PubMed id 18953340)1, 2 Cizkova A....Kmoch S. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. TMEM70: a mutational hot spot in nuclear ATP synthase deficiency with a pivotal role in complex V biogenesis. (PubMed id 22986587)2 Torraco A.... Carrozzo R. (2012)
    7. TMEM70 mutations are a common cause of nuclear encode d ATP synthase assembly defect: further delineation of a new syndrome. (PubMed id 21147908)1 Spiegel R....Yatsiv I. (2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    External Searches for TMEM70 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing TMEM70 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54968 HGNC: 26050 AceView: FLJ20533 Ensembl:ENSG00000175606 euGenes: HUgn54968
    ECgene: TMEM70 H-InvDB: TMEM70

    Other Databases showing TMEM70 gene

    (According to HUGE)
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    Specialized Databases showing TMEM70 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM70 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TMEM70 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TMEM70 gene:
    Search GeneIP for patents involving TMEM70

    GeneCards and IP:
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