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Aliases for TMEM69 Gene

Aliases for TMEM69 Gene

  • Transmembrane Protein 69 2 3 5
  • C1orf154 3 4
  • Chromosome 1 Open Reading Frame 154 2

External Ids for TMEM69 Gene

Previous HGNC Symbols for TMEM69 Gene

  • C1orf154

Previous GeneCards Identifiers for TMEM69 Gene

  • GC01P045822
  • GC01P045925
  • GC01P046152
  • GC01P044264

Summaries for TMEM69 Gene

GeneCards Summary for TMEM69 Gene

TMEM69 (Transmembrane Protein 69) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM69 Gene

Genomics for TMEM69 Gene

Regulatory Elements for TMEM69 Gene

Enhancers for TMEM69 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G046130 1.2 ENCODE 21.1 +446.1 446088 5.6 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 TOE1 GPBP1L1 RPL7AP16 CCDC163 MAST2 EFCAB14-AS1 RPS15AP10 TMEM69 ZSWIM5 TSPAN1
GH01G045302 1.2 ENCODE 20.6 -383.0 -383027 2.7 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MEF2D ZNF610 TOE1 RPL7AP16 RPS15AP10 GPBP1L1 TMEM69 RPS8 ZSWIM5 CCDC163 PTCH2 POMGNT1
GH01G044720 1.7 Ensembl ENCODE dbSUPER 12 -964.4 -964411 4.8 MLX CREB3L1 AGO1 ZFP64 FEZF1 YBX1 YY1 ZNF143 SP3 NFYC GPBP1L1 TOE1 RPS8 RPL7AP16 RPS15AP10 DMAP1 TMEM69 RPS15AP11 SNORD38B UROD
GH01G044739 1.4 ENCODE dbSUPER 12 -947.1 -947132 2.1 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC ZNF610 GLIS1 TOE1 DMAP1 GPBP1L1 RPL7AP16 RPS15AP10 TMEM69 UROD DPH2 ZSWIM5 BEST4
GH01G046246 1.4 FANTOM5 ENCODE 10.9 +560.8 560796 3.1 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 TOE1 GPBP1L1 EFCAB14-AS1 RPL7AP16 IPP RPS15AP10 TMEM69 NSUN4 RAD54L GC01M046227
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM69 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM69 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000005881 -414 4801 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for TMEM69 Gene

Chromosome:
1
Start:
45,687,214 bp from pter
End:
45,694,443 bp from pter
Size:
7,230 bases
Orientation:
Plus strand

Genomic View for TMEM69 Gene

Genes around TMEM69 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM69 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM69 Gene

Proteins for TMEM69 Gene

  • Protein details for TMEM69 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SWH9-TMM69_HUMAN
    Recommended name:
    Transmembrane protein 69
    Protein Accession:
    Q5SWH9
    Secondary Accessions:
    • Q3SWW5
    • Q7Z2G0
    • Q9P0P9

    Protein attributes for TMEM69 Gene

    Size:
    247 amino acids
    Molecular mass:
    27551 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF36149.1; Type=Frameshift; Positions=53; Evidence={ECO:0000305};

neXtProt entry for TMEM69 Gene

Post-translational modifications for TMEM69 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM69 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM69 Gene

Domains & Families for TMEM69 Gene

Protein Domains for TMEM69 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM69 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM69: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM69 Gene

Function for TMEM69 Gene

genes like me logo Genes that share phenotypes with TMEM69: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM69 Gene

Localization for TMEM69 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM69 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM69 gene
Compartment Confidence
plasma membrane 3
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TMEM69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM69: view

Pathways & Interactions for TMEM69 Gene

SuperPathways for TMEM69 Gene

No Data Available

Interacting Proteins for TMEM69 Gene

Selected Interacting proteins: Q5SWH9-TMM69_HUMAN for TMEM69 Gene via IID

Symbol External ID(s) Details
PRSS22

Gene Ontology (GO) - Biological Process for TMEM69 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM69 Gene

Drugs & Compounds for TMEM69 Gene

No Compound Related Data Available

Transcripts for TMEM69 Gene

mRNA/cDNA for TMEM69 Gene

(1) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(176) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM69 Gene

Transmembrane protein 69:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM69 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d · 3e
SP1: -
SP2: - -
SP3:
SP4: -
SP5: - -

Relevant External Links for TMEM69 Gene

GeneLoc Exon Structure for
TMEM69
ECgene alternative splicing isoforms for
TMEM69

Expression for TMEM69 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM69 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM69 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM69 Gene:

TMEM69

SOURCE GeneReport for Unigene cluster for TMEM69 Gene:

Hs.699548

Evidence on tissue expression from TISSUES for TMEM69 Gene

  • Lung(4.7)
  • Nervous system(4.5)
  • Skin(4.4)
  • Blood(4.3)
  • Intestine(3.1)
  • Pancreas(3.1)
  • Eye(2.6)
  • Liver(2.4)
  • Kidney(2)
genes like me logo Genes that share expression patterns with TMEM69: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM69 Gene

Orthologs for TMEM69 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM69 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM69 34 35
  • 99.19 (n)
dog
(Canis familiaris)
Mammalia TMEM69 34 35
  • 86.23 (n)
mouse
(Mus musculus)
Mammalia Tmem69 34 16 35
  • 80.19 (n)
rat
(Rattus norvegicus)
Mammalia Tmem69 34
  • 79.15 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM69 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM69 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM69 34 35
  • 54.48 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM69 35
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem69 34
  • 52.95 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem69 34 35
  • 55.87 (n)
Species where no ortholog for TMEM69 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM69 Gene

ENSEMBL:
Gene Tree for TMEM69 (if available)
TreeFam:
Gene Tree for TMEM69 (if available)

Paralogs for TMEM69 Gene

Pseudogenes.org Pseudogenes for TMEM69 Gene

genes like me logo Genes that share paralogs with TMEM69: view

No data available for Paralogs for TMEM69 Gene

Variants for TMEM69 Gene

Sequence variations from dbSNP and Humsavar for TMEM69 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000154561 -- 45,687,547(+) GCCTG(G/T)TGCCA upstream-variant-2KB
rs1000540441 -- 45,692,377(+) TTCAA(-/T)TTTTT intron-variant
rs1000574232 -- 45,691,411(+) GGGGT(C/T)ACACG intron-variant
rs1000658036 -- 45,692,115(+) GCACT(A/C)CAGCC intron-variant
rs1001023908 -- 45,686,704(+) TGCCA(A/G)CGTTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM69 Gene

Variant ID Type Subtype PubMed ID
esv3577360 CNV gain 25503493
esv3577471 CNV gain 25503493
esv3893512 CNV gain 25118596
nsv1014128 CNV gain 25217958
nsv945922 CNV duplication 23825009

Variation tolerance for TMEM69 Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM69 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM69

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM69 Gene

Disorders for TMEM69 Gene

Relevant External Links for TMEM69

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM69

No disorders were found for TMEM69 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM69 Gene

Publications for TMEM69 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TMEM69 Gene

Sources for TMEM69 Gene

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