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Aliases for TMEM69 Gene

Aliases for TMEM69 Gene

  • Transmembrane Protein 69 2 3
  • C1orf154 3 4
  • Chromosome 1 Open Reading Frame 154 2

External Ids for TMEM69 Gene

Previous HGNC Symbols for TMEM69 Gene

  • C1orf154

Previous GeneCards Identifiers for TMEM69 Gene

  • GC01P045822
  • GC01P045925
  • GC01P046152
  • GC01P044264

Summaries for TMEM69 Gene

GeneCards Summary for TMEM69 Gene

TMEM69 is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM69 Gene

Genomics for TMEM69 Gene

Regulatory Elements for TMEM69 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM69 Gene

Start:
45,687,214 bp from pter
End:
45,694,443 bp from pter
Size:
7,230 bases
Orientation:
Plus strand

Genomic View for TMEM69 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM69 Gene

Proteins for TMEM69 Gene

  • Protein details for TMEM69 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SWH9-TMM69_HUMAN
    Recommended name:
    Transmembrane protein 69
    Protein Accession:
    Q5SWH9
    Secondary Accessions:
    • Q3SWW5
    • Q7Z2G0
    • Q9P0P9

    Protein attributes for TMEM69 Gene

    Size:
    247 amino acids
    Molecular mass:
    27551 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF36149.1; Type=Frameshift; Positions=53; Evidence={ECO:0000305};

neXtProt entry for TMEM69 Gene

Proteomics data for TMEM69 Gene at MOPED

Post-translational modifications for TMEM69 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM69 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM69 Gene

Domains for TMEM69 Gene

Protein Domains for TMEM69 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM69 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM69: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM69 Gene

Function for TMEM69 Gene

Animal Model Products

CRISPR Products

miRNA for TMEM69 Gene

miRTarBase miRNAs that target TMEM69

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM69

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM69 Gene

Localization for TMEM69 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM69 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM69 Gene COMPARTMENTS Subcellular localization image for TMEM69 gene
Compartment Confidence
plasma membrane 3
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TMEM69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM69: view

Pathways for TMEM69 Gene

SuperPathways for TMEM69 Gene

No Data Available

Interacting Proteins for TMEM69 Gene

Gene Ontology (GO) - Biological Process for TMEM69 Gene

None

No data available for Pathways by source for TMEM69 Gene

Transcripts for TMEM69 Gene

mRNA/cDNA for TMEM69 Gene

(176) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM69 Gene

Transmembrane protein 69:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM69

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM69 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d · 3e
SP1: -
SP2: - -
SP3:
SP4: -
SP5: - -

Relevant External Links for TMEM69 Gene

GeneLoc Exon Structure for
TMEM69
ECgene alternative splicing isoforms for
TMEM69

Expression for TMEM69 Gene

mRNA expression in normal human tissues for TMEM69 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TMEM69 Gene

SOURCE GeneReport for Unigene cluster for TMEM69 Gene Hs.699548

genes like me logo Genes that share expressions with TMEM69: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM69 Gene

Orthologs for TMEM69 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM69 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM69 35
  • 99.19 (n)
  • 98.79 (a)
TMEM69 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM69 35
  • 86.23 (n)
  • 76.92 (a)
TMEM69 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem69 35
  • 80.19 (n)
  • 69.26 (a)
Tmem69 16
Tmem69 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM69 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM69 36
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem69 35
  • 79.15 (n)
  • 69.14 (a)
chicken
(Gallus gallus)
Aves TMEM69 35
  • 54.48 (n)
  • 45.83 (a)
TMEM69 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM69 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem69 35
  • 52.95 (n)
  • 51.04 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem69 35
  • 55.87 (n)
  • 50.84 (a)
tmem69 36
  • 40 (a)
OneToOne
Species with no ortholog for TMEM69:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM69 Gene

ENSEMBL:
Gene Tree for TMEM69 (if available)
TreeFam:
Gene Tree for TMEM69 (if available)

Paralogs for TMEM69 Gene

Pseudogenes.org Pseudogenes for TMEM69 Gene

genes like me logo Genes that share paralogs with TMEM69: view

No data available for Paralogs for TMEM69 Gene

Variants for TMEM69 Gene

Sequence variations from dbSNP and Humsavar for TMEM69 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3013596 -- 45,690,416(+) agaat(C/T)gcttg intron-variant
rs6686944 -- 45,690,636(+) TTTTG(G/T)TTTTT intron-variant
rs10789470 -- 45,692,659(+) TGAAT(G/T)TTGAA intron-variant
rs10890342 -- 45,691,415(+) TCACA(C/T)GCCTA intron-variant
rs10890343 -- 45,692,250(+) ACTTA(C/T)AAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM69 Gene

Variant ID Type Subtype PubMed ID
nsv871928 CNV Gain 21882294
nsv870511 CNV Gain 21882294
nsv871233 CNV Gain 21882294

Relevant External Links for TMEM69 Gene

HapMap Linkage Disequilibrium report
TMEM69

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM69 Gene

Disorders for TMEM69 Gene

No disorders were found for TMEM69 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM69 Gene

Publications for TMEM69 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM69 Gene

  • antibodies-online peptides for TMEM69
  • antibodies-online antibodies for TMEM69
  • antibodies-online kits for TMEM69

Sources for TMEM69 Gene

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