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Aliases for TMEM68 Gene

Aliases for TMEM68 Gene

  • Transmembrane Protein 68 2 3 5

External Ids for TMEM68 Gene

Previous GeneCards Identifiers for TMEM68 Gene

  • GC08M056814
  • GC08M056651
  • GC08M052119

Summaries for TMEM68 Gene

GeneCards Summary for TMEM68 Gene

TMEM68 (Transmembrane Protein 68) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring acyl groups.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM68 Gene

Genomics for TMEM68 Gene

Regulatory Elements for TMEM68 Gene

Enhancers for TMEM68 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F055771 1.1 ENCODE 18.5 +0.0 38 4.0 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 TGS1 TMEM68 RPS20 LYN
GH08F055760 0.8 ENCODE 16.6 +12.0 12034 0.9 PKNOX1 ZNF501 ZNF843 HIC1 OSR2 CTBP1 ZNF366 ZNF610 PATZ1 GLIS1 TMEM68 TGS1 RNA5SP265
GH08F055842 1.4 FANTOM5 Ensembl ENCODE 16.1 -71.2 -71157 4.2 PKNOX1 WRNIP1 SIN3A FEZF1 YY1 CBX5 ZNF143 JUNB TBX21 CREB3 LYN TMEM68 TGS1 GC08P055855
GH08F055839 1.5 FANTOM5 Ensembl ENCODE 14.9 -67.3 -67279 2.0 TGS1 TMEM68 LYN GC08P055855
GH08F055987 1 FANTOM5 Ensembl ENCODE 10.9 -217.9 -217937 7.1 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 BMI1 RAD21 EGR1 ZNF207 RCOR1 LYN TGS1 TMEM68 RPS20 PSMC6P1 GC08P056003 RN7SL798P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM68 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM68 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001392191 7 4001 PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for TMEM68 Gene

Chromosome:
8
Start:
55,696,424 bp from pter
End:
55,773,407 bp from pter
Size:
76,984 bases
Orientation:
Minus strand

Genomic View for TMEM68 Gene

Genes around TMEM68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM68 Gene

Proteins for TMEM68 Gene

  • Protein details for TMEM68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MH6-TMM68_HUMAN
    Recommended name:
    Transmembrane protein 68
    Protein Accession:
    Q96MH6
    Secondary Accessions:
    • Q658X6
    • Q8WUD2

    Protein attributes for TMEM68 Gene

    Size:
    324 amino acids
    Molecular mass:
    37425 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM68 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM68 Gene

Post-translational modifications for TMEM68 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM68 Gene

Domains & Families for TMEM68 Gene

Protein Domains for TMEM68 Gene

Suggested Antigen Peptide Sequences for TMEM68 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM68: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM68 Gene

Function for TMEM68 Gene

Gene Ontology (GO) - Molecular Function for TMEM68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with TMEM68: view

Phenotypes for TMEM68 Gene

genes like me logo Genes that share phenotypes with TMEM68: view

Animal Models for TMEM68 Gene

MGI Knock Outs for TMEM68:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM68 Gene

Localization for TMEM68 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM68 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM68 Gene COMPARTMENTS Subcellular localization image for TMEM68 gene
Compartment Confidence
mitochondrion 2
nucleus 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM68: view

Pathways & Interactions for TMEM68 Gene

SuperPathways for TMEM68 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with TMEM68: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM68 Gene

Transcripts for TMEM68 Gene

Unigene Clusters for TMEM68 Gene

Transmembrane protein 68:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM68 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d
SP1: -
SP2: - - -
SP3:
SP4: - - - - - - - -
SP5: -
SP6: - - - - - -
SP7: - - - - - - - - - -
SP8: - -
SP9:
SP10: - - -

Relevant External Links for TMEM68 Gene

GeneLoc Exon Structure for
TMEM68
ECgene alternative splicing isoforms for
TMEM68

Expression for TMEM68 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM68 Gene

Protein differential expression in normal tissues from HIPED for TMEM68 Gene

This gene is overexpressed in Nasal epithelium (58.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM68 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM68 Gene:

TMEM68

SOURCE GeneReport for Unigene cluster for TMEM68 Gene:

Hs.420076
genes like me logo Genes that share expression patterns with TMEM68: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TMEM68 Gene

Orthologs for TMEM68 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM68 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM68 34 35
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia TMEM68 34 35
  • 94.86 (n)
mouse
(Mus musculus)
Mammalia Tmem68 34 16 35
  • 90.09 (n)
rat
(Rattus norvegicus)
Mammalia Tmem68 34
  • 88.54 (n)
cow
(Bos Taurus)
Mammalia TMEM68 34 35
  • 87.72 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM68 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM68 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM68 34 35
  • 69.66 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 39 (a)
OneToMany
-- 35
  • 37 (a)
OneToMany
-- 35
  • 33 (a)
OneToMany
-- 35
  • 32 (a)
OneToMany
-- 35
  • 32 (a)
OneToMany
-- 35
  • 31 (a)
OneToMany
-- 35
  • 28 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem68 34
  • 69.57 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem68 34 35 35
  • 65.43 (n)
zgc63809 34
fruit fly
(Drosophila melanogaster)
Insecta CG34348 34 35
  • 54.21 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001441 34
  • 53.5 (n)
worm
(Caenorhabditis elegans)
Secernentea Y38C1AA.1 34 35
  • 55.71 (n)
Species where no ortholog for TMEM68 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM68 Gene

ENSEMBL:
Gene Tree for TMEM68 (if available)
TreeFam:
Gene Tree for TMEM68 (if available)

Paralogs for TMEM68 Gene

Pseudogenes.org Pseudogenes for TMEM68 Gene

genes like me logo Genes that share paralogs with TMEM68: view

No data available for Paralogs for TMEM68 Gene

Variants for TMEM68 Gene

Sequence variations from dbSNP and Humsavar for TMEM68 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10105744 -- 55,744,000(+) AAAAG(A/G)CAAAC intron-variant
rs10106127 -- 55,740,849(+) TCATC(A/T)TGAAC intron-variant
rs10110862 -- 55,764,279(+) AAGAT(A/G)TATAA intron-variant, upstream-variant-2KB
rs10448023 -- 55,760,944(+) GAGCA(A/T)TAAAG intron-variant, utr-variant-3-prime
rs10537043 -- 55,755,592(+) ATGAC(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM68 Gene

Variant ID Type Subtype PubMed ID
dgv245n6 CNV deletion 16902084
dgv459n21 CNV gain 19592680
esv1134681 CNV deletion 17803354
esv1187136 CNV deletion 17803354
esv1413049 CNV insertion 17803354
esv1781494 CNV deletion 17803354
esv2112192 CNV deletion 18987734
esv2177489 CNV deletion 18987734
esv2239294 CNV deletion 18987734
esv2422388 CNV duplication 17116639
esv2466341 CNV deletion 19546169
esv2536220 CNV insertion 19546169
esv2571467 CNV deletion 19546169
esv2662132 CNV deletion 23128226
esv2668724 CNV deletion 23128226
esv2737016 CNV deletion 23290073
esv2737018 CNV deletion 23290073
esv2737019 CNV deletion 23290073
esv2737020 CNV deletion 23290073
esv2737021 CNV deletion 23290073
esv3114605 CNV deletion 24192839
esv3395747 CNV duplication 20981092
esv3543525 CNV deletion 23714750
esv3543526 CNV deletion 23714750
esv4861 CNV loss 18987735
esv996855 CNV deletion 20482838
nsv1075137 CNV deletion 25765185
nsv1076085 CNV deletion 25765185
nsv1137368 CNV deletion 24896259
nsv1137369 CNV deletion 24896259
nsv1142530 CNV tandem duplication 24896259
nsv1147762 CNV deletion 26484159
nsv512956 CNV insertion 21212237
nsv527341 CNV gain 19592680
nsv611392 CNV gain 21841781
nsv611393 CNV gain 21841781
nsv956076 CNV deletion 24416366
nsv956080 CNV deletion 24416366
nsv956090 CNV deletion 24416366

Variation tolerance for TMEM68 Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM68 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM68

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM68 Gene

Disorders for TMEM68 Gene

Relevant External Links for TMEM68

Genetic Association Database (GAD)
TMEM68
Human Genome Epidemiology (HuGE) Navigator
TMEM68
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM68

No disorders were found for TMEM68 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM68 Gene

Publications for TMEM68 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for TMEM68 Gene

Sources for TMEM68 Gene

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