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Aliases for TMEM68 Gene

Aliases for TMEM68 Gene

  • Transmembrane Protein 68 2 3 5

External Ids for TMEM68 Gene

Previous GeneCards Identifiers for TMEM68 Gene

  • GC08M056814
  • GC08M056651
  • GC08M052119

Summaries for TMEM68 Gene

GeneCards Summary for TMEM68 Gene

TMEM68 (Transmembrane Protein 68) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups.

Additional gene information for TMEM68 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM68 Gene

Genomics for TMEM68 Gene

GeneHancer (GH) Regulatory Elements for TMEM68 Gene

Promoters and enhancers for TMEM68 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I055771 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 568.5 +0.0 38 4 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 TGS1 TMEM68 RPS20 LYN
GH08I055763 Promoter 0.5 EPDnew 566.7 +9.4 9429 0.1 TMEM68 RPS20 TGS1 RNA5SP265
GH08I055842 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 16.1 -71.2 -71156 4.2 PKNOX1 ATF1 SIN3A FEZF1 IRF4 ZNF766 ZNF143 ATF7 RUNX3 CAVIN1 LYN TMEM68 TGS1 GC08P055855
GH08I055987 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -217.9 -217937 7.1 HDGF PKNOX1 FOXA2 SMAD1 SIN3A IRF4 ZNF207 ATF7 FOS RUNX3 LYN TGS1 TMEM68 RPS20 PSMC6P1 GC08P056003 RN7SL798P
GH08I056004 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -232.8 -232826 3 HDGF CTCF EBF1 NFXL1 NFATC1 BCLAF1 IKZF2 RUNX3 RXRA REST LYN TGS1 TMEM68 RPS20 GC08P056003 RN7SL323P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM68 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM68 gene promoter:

Genomic Locations for TMEM68 Gene

Genomic Locations for TMEM68 Gene
chr8:55,696,424-55,773,407
(GRCh38/hg38)
Size:
76,984 bases
Orientation:
Minus strand
chr8:56,608,983-56,685,966
(GRCh37/hg19)

Genomic View for TMEM68 Gene

Genes around TMEM68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM68 Gene

Proteins for TMEM68 Gene

  • Protein details for TMEM68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MH6-TMM68_HUMAN
    Recommended name:
    Transmembrane protein 68
    Protein Accession:
    Q96MH6
    Secondary Accessions:
    • Q658X6
    • Q8WUD2

    Protein attributes for TMEM68 Gene

    Size:
    324 amino acids
    Molecular mass:
    37425 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM68 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM68 Gene

Post-translational modifications for TMEM68 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM68 Gene

Domains & Families for TMEM68 Gene

Gene Families for TMEM68 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM68 Gene

Suggested Antigen Peptide Sequences for TMEM68 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM68: view

No data available for UniProtKB/Swiss-Prot for TMEM68 Gene

Function for TMEM68 Gene

Phenotypes From GWAS Catalog for TMEM68 Gene

Gene Ontology (GO) - Molecular Function for TMEM68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with TMEM68: view

Phenotypes for TMEM68 Gene

genes like me logo Genes that share phenotypes with TMEM68: view

Animal Models for TMEM68 Gene

MGI Knock Outs for TMEM68:

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM68 Gene

Localization for TMEM68 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM68 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM68 gene
Compartment Confidence
plasma membrane 2
mitochondrion 2
nucleus 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM68: view

Pathways & Interactions for TMEM68 Gene

SuperPathways for TMEM68 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with TMEM68: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM68 Gene

Drugs & Compounds for TMEM68 Gene

No Compound Related Data Available

Transcripts for TMEM68 Gene

Unigene Clusters for TMEM68 Gene

Transmembrane protein 68:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM68 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d
SP1: -
SP2: - - -
SP3:
SP4: - - - - - - - -
SP5: -
SP6: - - - - - -
SP7: - - - - - - - - - -
SP8: - -
SP9:
SP10: - - -

Relevant External Links for TMEM68 Gene

GeneLoc Exon Structure for
TMEM68
ECgene alternative splicing isoforms for
TMEM68

Expression for TMEM68 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM68 Gene

Protein differential expression in normal tissues from HIPED for TMEM68 Gene

This gene is overexpressed in Nasal epithelium (58.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM68 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM68 Gene:

TMEM68

SOURCE GeneReport for Unigene cluster for TMEM68 Gene:

Hs.420076

Evidence on tissue expression from TISSUES for TMEM68 Gene

  • Nervous system(4.4)
  • Stomach(4.3)
genes like me logo Genes that share expression patterns with TMEM68: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM68 Gene

Orthologs for TMEM68 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM68 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM68 33 34
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia TMEM68 33 34
  • 94.86 (n)
mouse
(Mus musculus)
Mammalia Tmem68 33 16 34
  • 90.09 (n)
rat
(Rattus norvegicus)
Mammalia Tmem68 33
  • 88.54 (n)
cow
(Bos Taurus)
Mammalia TMEM68 33 34
  • 87.72 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM68 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM68 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM68 33 34
  • 69.66 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 39 (a)
OneToMany
-- 34
  • 37 (a)
OneToMany
-- 34
  • 33 (a)
OneToMany
-- 34
  • 32 (a)
OneToMany
-- 34
  • 32 (a)
OneToMany
-- 34
  • 31 (a)
OneToMany
-- 34
  • 28 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem68 33
  • 69.57 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem68 33 34 34
  • 65.43 (n)
zgc63809 33
fruit fly
(Drosophila melanogaster)
Insecta CG34348 33 34
  • 54.21 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001441 33
  • 53.5 (n)
worm
(Caenorhabditis elegans)
Secernentea Y38C1AA.1 33 34
  • 55.71 (n)
Species where no ortholog for TMEM68 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM68 Gene

ENSEMBL:
Gene Tree for TMEM68 (if available)
TreeFam:
Gene Tree for TMEM68 (if available)

Paralogs for TMEM68 Gene

Pseudogenes.org Pseudogenes for TMEM68 Gene

genes like me logo Genes that share paralogs with TMEM68: view

No data available for Paralogs for TMEM68 Gene

Variants for TMEM68 Gene

Sequence variations from dbSNP and Humsavar for TMEM68 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000108739 -- 55,743,947(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000156856 -- 55,774,536(-) T/A upstream_transcript_variant
rs1000233448 -- 55,755,701(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000282849 -- 55,756,979(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000608617 -- 55,753,801(-) T/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM68 Gene

Variant ID Type Subtype PubMed ID
dgv245n6 CNV deletion 16902084
dgv459n21 CNV gain 19592680
esv1134681 CNV deletion 17803354
esv1187136 CNV deletion 17803354
esv1413049 CNV insertion 17803354
esv1781494 CNV deletion 17803354
esv2112192 CNV deletion 18987734
esv2177489 CNV deletion 18987734
esv2239294 CNV deletion 18987734
esv2422388 CNV duplication 17116639
esv2466341 CNV deletion 19546169
esv2536220 CNV insertion 19546169
esv2571467 CNV deletion 19546169
esv2662132 CNV deletion 23128226
esv2668724 CNV deletion 23128226
esv2737016 CNV deletion 23290073
esv2737018 CNV deletion 23290073
esv2737019 CNV deletion 23290073
esv2737020 CNV deletion 23290073
esv2737021 CNV deletion 23290073
esv3114605 CNV deletion 24192839
esv3395747 CNV duplication 20981092
esv3543525 CNV deletion 23714750
esv3543526 CNV deletion 23714750
esv4861 CNV loss 18987735
esv996855 CNV deletion 20482838
nsv1075137 CNV deletion 25765185
nsv1076085 CNV deletion 25765185
nsv1137368 CNV deletion 24896259
nsv1137369 CNV deletion 24896259
nsv1142530 CNV tandem duplication 24896259
nsv1147762 CNV deletion 26484159
nsv512956 CNV insertion 21212237
nsv527341 CNV gain 19592680
nsv611392 CNV gain 21841781
nsv611393 CNV gain 21841781
nsv956076 CNV deletion 24416366
nsv956080 CNV deletion 24416366
nsv956090 CNV deletion 24416366

Variation tolerance for TMEM68 Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM68 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM68

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM68 Gene

Disorders for TMEM68 Gene

Additional Disease Information for TMEM68

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM68 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM68 Gene

Publications for TMEM68 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TMEM68 Gene

Sources for TMEM68 Gene

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