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Aliases for TMEM68 Gene

Aliases for TMEM68 Gene

  • Transmembrane Protein 68 2 3

External Ids for TMEM68 Gene

Previous GeneCards Identifiers for TMEM68 Gene

  • GC08M056814
  • GC08M056651
  • GC08M052119

Summaries for TMEM68 Gene

GeneCards Summary for TMEM68 Gene

TMEM68 is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring acyl groups.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM68 Gene

Genomics for TMEM68 Gene

Regulatory Elements for TMEM68 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM68 Gene

Start:
55,696,424 bp from pter
End:
55,773,407 bp from pter
Size:
76,984 bases
Orientation:
Minus strand

Genomic View for TMEM68 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM68 Gene

Proteins for TMEM68 Gene

  • Protein details for TMEM68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MH6-TMM68_HUMAN
    Recommended name:
    Transmembrane protein 68
    Protein Accession:
    Q96MH6
    Secondary Accessions:
    • Q658X6
    • Q8WUD2

    Protein attributes for TMEM68 Gene

    Size:
    324 amino acids
    Molecular mass:
    37425 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM68 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM68 Gene

Proteomics data for TMEM68 Gene at MOPED

Post-translational modifications for TMEM68 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM68 Gene

Domains for TMEM68 Gene

Protein Domains for TMEM68 Gene

Suggested Antigen Peptide Sequences for TMEM68 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM68: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM68 Gene

Function for TMEM68 Gene

Gene Ontology (GO) - Molecular Function for TMEM68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with TMEM68: view
genes like me logo Genes that share phenotypes with TMEM68: view

Animal Model Products

CRISPR Products

miRNA for TMEM68 Gene

miRTarBase miRNAs that target TMEM68

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM68 Gene

Localization for TMEM68 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM68 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM68 Gene COMPARTMENTS Subcellular localization image for TMEM68 gene
Compartment Confidence
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM68: view

Pathways for TMEM68 Gene

SuperPathways for TMEM68 Gene

No Data Available

Interacting Proteins for TMEM68 Gene

Gene Ontology (GO) - Biological Process for TMEM68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with TMEM68: view

No data available for Pathways by source for TMEM68 Gene

Transcripts for TMEM68 Gene

Unigene Clusters for TMEM68 Gene

Transmembrane protein 68:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM68

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM68 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d
SP1: -
SP2: - - -
SP3:
SP4: - - - - - - - -
SP5: -
SP6: - - - - - -
SP7: - - - - - - - - - -
SP8: - -
SP9:
SP10: - - -

Relevant External Links for TMEM68 Gene

GeneLoc Exon Structure for
TMEM68
ECgene alternative splicing isoforms for
TMEM68

Expression for TMEM68 Gene

mRNA expression in normal human tissues for TMEM68 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM68 Gene

SOURCE GeneReport for Unigene cluster for TMEM68 Gene Hs.420076

genes like me logo Genes that share expressions with TMEM68: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM68 Gene

Orthologs for TMEM68 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM68 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM68 35
  • 99.49 (n)
  • 99.69 (a)
TMEM68 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM68 35
  • 87.72 (n)
  • 93.5 (a)
TMEM68 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM68 35
  • 94.86 (n)
  • 97.53 (a)
TMEM68 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem68 35
  • 90.09 (n)
  • 93.19 (a)
Tmem68 16
Tmem68 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM68 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM68 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem68 35
  • 88.54 (n)
  • 93.5 (a)
chicken
(Gallus gallus)
Aves TMEM68 35
  • 69.66 (n)
  • 60.37 (a)
TMEM68 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
OneToMany
-- 36
  • 32 (a)
OneToMany
-- 36
  • 32 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem68 35
  • 69.57 (n)
  • 68.01 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem68 35
  • 65.43 (n)
  • 68.83 (a)
tmem68 36
  • 63 (a)
OneToMany
tmem68 36
  • 41 (a)
OneToMany
zgc63809 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001441 35
  • 53.5 (n)
  • 52.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34348 35
  • 54.21 (n)
  • 49.83 (a)
CG34348 36
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y38C1AA.1 35
  • 55.71 (n)
  • 48.25 (a)
Y38C1AA.1 36
  • 27 (a)
OneToOne
Species with no ortholog for TMEM68:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM68 Gene

ENSEMBL:
Gene Tree for TMEM68 (if available)
TreeFam:
Gene Tree for TMEM68 (if available)

Paralogs for TMEM68 Gene

Pseudogenes.org Pseudogenes for TMEM68 Gene

genes like me logo Genes that share paralogs with TMEM68: view

No data available for Paralogs for TMEM68 Gene

Variants for TMEM68 Gene

Sequence variations from dbSNP and Humsavar for TMEM68 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs16738 -- 55,739,490(+) ATGAC(-/AT)AATTT utr-variant-3-prime
rs765158 -- 55,747,998(+) TACCT(C/T)TCTAG intron-variant
rs765159 -- 55,748,232(+) atgat(A/C/G)taggc intron-variant
rs1823504 -- 55,748,329(+) caccc(A/G)actaa intron-variant
rs2044814 -- 55,763,950(-) AGATA(C/T)TTATC utr-variant-5-prime, intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM68 Gene

Variant ID Type Subtype PubMed ID
dgv459n21 CNV Gain 19592680
nsv527341 CNV Gain 19592680
esv2422388 CNV Duplication 17116639
nsv890930 CNV Gain 21882294
nsv512956 CNV Insertion 21212237
esv2536220 CNV Insertion 19546169
esv2737016 CNV Deletion 23290073
esv2239294 CNV Deletion 18987734
esv2737018 CNV Deletion 23290073
esv2668724 CNV Deletion 23128226
esv1187136 CNV Deletion 17803354
esv1413049 CNV Insertion 17803354
esv2466341 CNV Deletion 19546169
esv2737019 CNV Deletion 23290073
esv2112192 CNV Deletion 18987734
esv996855 CNV Deletion 20482838
esv2662132 CNV Deletion 23128226
dgv245n6 CNV Loss 16902084
esv1134681 CNV Deletion 17803354
esv2571467 CNV Deletion 19546169
esv2737020 CNV Deletion 23290073
esv2737021 CNV Deletion 23290073
esv2177489 CNV Deletion 18987734
esv4861 CNV Deletion 18987735
esv1781494 CNV Deletion 17803354

Relevant External Links for TMEM68 Gene

HapMap Linkage Disequilibrium report
TMEM68

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM68 Gene

Disorders for TMEM68 Gene

Relevant External Links for TMEM68

Genetic Association Database (GAD)
TMEM68
Human Genome Epidemiology (HuGE) Navigator
TMEM68
genes like me logo Genes that share disorders with TMEM68: view

No data available for UniProtKB/Swiss-Prot for TMEM68 Gene

Publications for TMEM68 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for TMEM68 Gene

Sources for TMEM68 Gene

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