TMEM68 Gene
protein-coding GIFtS: 41
GCID: GC08M056651
|
|
transmembrane protein 68
| |
Aliases
for TMEM68 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 681 2 | | FLJ323701 |
Export aliases for TMEM68 gene to outside databasesPrevious GC identifers: GC08M056814 GC08M052119 |
Summaries
for TMEM68 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM68 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM68 gene promoter:
COUP-TF1 TBP POU3F1 COUP HNF-4alpha2 HNF-4alpha1 PPAR-gamma1 COUP-TF TFIID PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM68
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM68 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q12.1 Ensembl cytogenetic band: 8q12.1 HGNC cytogenetic band: 8q12.1TMEM68 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M056651: view genomic region
(about GC identifiers)
Start:
|
56,608,983 bp from pter |
End:
|
56,685,966 bp from pter |
Size:
|
76,984 bases |
Orientation:
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minus strand |
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Proteins
for TMEM68 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TMM68_HUMAN, Q96MH6 (See
protein sequence)Recommended Name: Transmembrane protein 68 Size: 324 amino acids; 37425 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q658X6 Q8WUD2Alternative splicing: 3 isoforms: Q96MH6-1 Q96MH6-2 Q96MH6-3 Explore the universe of human proteins at neXtProt for TMEM68: NX_Q96MH6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96MH6
TMEM68 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689630.1
ENSEMBL proteins: ENSP00000428318 ENSP00000395204 ENSP00000335416 ENSP00000428688 ENSP00000431018 ENSP00000429026 ENSP00000429667 ENSP00000430542 ENSP00000428236 ENSP00000430838 ENSP00000429175 ENSP00000429758 ENSP00000429210 ENSP00000431047 ENSP00000427939
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
-- | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TMEM68 for ontologies About GeneDecksing
TMEM68 Antibody Products:
Assay Products for TMEM68: |
Protein
Domains /
Families
for TMEM68 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM68 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96MH6ProtoNet protein and cluster: Q96MH6 1 Blocks protein family: IPB002123 Phospholipid/glycerol acyltransferase
|
Function
for TMEM68 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM68 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM68
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM68 (NM_152417) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM68 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM68 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM68 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004629 | phospholipase C activity |
-- | -- | | GO:0016746 | transferase activity, transferring acyl groups |
IEA | -- |
TMEM68 for ontologies About GeneDecksing
Animal Models:
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tmem68):
TMEM68 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TMEM68 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM68
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for TMEM68 (ENSP000003354164) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006629 | lipid metabolic process |
-- | -- | | GO:0035556 | intracellular signal transduction |
-- | -- |
TMEM68 for ontologies About GeneDecksing
|
Drugs & Compounds
for TMEM68 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM68
Search CenterWatch for drugs/clinical trials and news about TMEM68 / TMM68
|
Transcripts
for TMEM68 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM68 gene: NM_152417.1 Unigene Cluster for TMEM68: Transmembrane protein 68 Hs.420076 [show with all ESTs]Unigene Representative Sequence: BC04341717 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000522470 ENST00000519460 ENST00000434581(uc003xsg.1) ENST00000334667(uc003xsh.1)
ENST00000519784 ENST00000517576 ENST00000523073 ENST00000519780 ENST00000522090
ENST00000520061 ENST00000524121 ENST00000522030 ENST00000523423 ENST00000520414
ENST00000521229(uc003xsi.1) ENST00000522576 ENST00000523180
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM68 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM68
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM68 (NM_152417) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM68 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM68 |
Additional cDNA sequence: AF147306.1 AK056932.1 AK308247.1 AL832935.1 BC020835.1 BC043417.1 BC071636.1 13 DOTS entries: DT.100752485 DT.99986828 DT.411888 DT.95103538 DT.91637959 DT.100678057 DT.100752487 DT.102842628 DT.91755634 DT.95213199 DT.97852970 DT.100674770 DT.91968165 24/126 AceView cDNA sequences (see all 126): BQ876519 BM725986 AK056932 NM_152417 AI357541 AI352501 CN480731 AA506442 BE502417 BF445835 AI310529 AI292331 AA426017 AF147306 CB306526 AI364800 AA846147 AI056009 BU581422 BM471639 BI913136 AA042829 AL832935 BU620499
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM68 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM68
|
Expression
for TMEM68 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM68 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TMEM68 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM68
SOURCE GeneReport for Unigene cluster: Hs.420076
SABiosciences Custom PCR Arrays for TMEM68
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM68
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM68 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM68 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM68 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM68 |
Orthologs
for TMEM68 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM68 gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for TMEM68 (if available)
TreeFam Gene Tree for TMEM68 (if available) |
Paralogs
for TMEM68 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM68 gene
TMEM68 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for TMEM68
PGOHUM00000257177 PGOHUM00000262538
|
Genomic Variants
for TMEM68 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM68 (56608983 - 56685966 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 15 variations for TMEM68
2 CNVs: 5256 52585
13 Indels: 13059 100353 28947 100354 28948 41089 41088 47557 47558 28946 13060 41827 47556 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM68 |
|
Disorders
/ Diseases
for TMEM68 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TMEM68 for disorders About MalaCards
TMEM68 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: TMEM68 (1 document)
Export disorders for TMEM68 gene to outside databases
|
Publications
for TMEM68 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM68 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM68) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
|
External Searches for TMEM68 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM68 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM68 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM68 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM68 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM68 gene:
Search GeneIP for patents involving TMEM68
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM68 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM68 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM68 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM68 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM68 | | OriGene 3'-UTR Clone for TMEM68 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM68 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM68 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM68 | | OriGene Custom Protein Services for TMEM68 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM68 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM68 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM68 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM68 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM68 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM68 |
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 |  |  |  | |
| | | | Search Tocris compounds for TMEM68 |
| |  |  |  |  | | | | |
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 | | | TMEM68 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM68 |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM68 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM68 |
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