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Aliases for TMEM65 Gene

Aliases for TMEM65 Gene

  • Transmembrane Protein 65 2 3 5

External Ids for TMEM65 Gene

Previous GeneCards Identifiers for TMEM65 Gene

  • GC08M125394
  • GC08M120650

Summaries for TMEM65 Gene

GeneCards Summary for TMEM65 Gene

TMEM65 (Transmembrane Protein 65) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM65 Gene

  • Plays an important role in cardiac development and function. Regulates cardiac conduction and the function of the gap junction protein GJA1. Contributes to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM65 Gene

Genomics for TMEM65 Gene

Regulatory Elements for TMEM65 Gene

Enhancers for TMEM65 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F124179 1.5 FANTOM5 Ensembl ENCODE 61.4 +190.8 190815 4.0 ATF1 PKNOX1 SIN3A FEZF1 ZNF766 GATA2 CBX5 FOS JUNB TBX21 TMEM65 FER1L6-AS2 LOC101927588
GH08F124175 1.2 Ensembl ENCODE 45.4 +197.4 197385 0.6 JUND GATA3 RFX1 ZMYM3 FOS MAFK TMEM65 FER1L6-AS2 LOC101927588
GH08F124147 1.1 Ensembl ENCODE 42.9 +224.8 224752 0.7 SIX4 CTCF JUN RAD21 JUND GATA3 IKZF1 PRDM10 FOSL2 FOS TMEM65 FER1L6-AS2 ENSG00000254249 FER1L6-AS1 ARF1P3 LOC392268
GH08F124138 0.8 Ensembl ENCODE 42.8 +234.2 234174 1.0 PKNOX1 KLF17 FEZF1 RAD21 ZBTB40 RCOR1 ZNF391 ZNF362 HCFC1 OVOL3 TMEM65 FER1L6-AS2 ENSG00000254249 FER1L6-AS1 LOC392268 GC08M124076
GH08F124140 0.9 Ensembl ENCODE 40.2 +231.4 231399 1.4 TBP ZNF362 SMAD5 ZNF121 POLR2A IKZF1 KDM1A FOS SPI1 TMEM65 FER1L6-AS2 ENSG00000254249 FER1L6-AS1 LOC392268 GC08M124076
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM65 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM65 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001400812 999 3800 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF766 CBX5 ZNF143

Genomic Location for TMEM65 Gene

Chromosome:
8
Start:
124,306,189 bp from pter
End:
124,372,699 bp from pter
Size:
66,511 bases
Orientation:
Minus strand

Genomic View for TMEM65 Gene

Genes around TMEM65 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM65 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM65 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM65 Gene

Proteins for TMEM65 Gene

  • Protein details for TMEM65 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PI78-TMM65_HUMAN
    Recommended name:
    Transmembrane protein 65
    Protein Accession:
    Q6PI78
    Secondary Accessions:
    • Q8N5G8
    • Q8WVK5

    Protein attributes for TMEM65 Gene

    Size:
    240 amino acids
    Molecular mass:
    25498 Da
    Quaternary structure:
    • Monomer (By similarity). Homodimer (PubMed:26403541). Interacts with GJA1 (By similarity). Interacts weakly with DSP (By similarity).
    SequenceCaution:
    • Sequence=AAH32396.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TMEM65 Gene

Post-translational modifications for TMEM65 Gene

No Post-translational modifications

Other Protein References for TMEM65 Gene

No data available for DME Specific Peptides for TMEM65 Gene

Domains & Families for TMEM65 Gene

Protein Domains for TMEM65 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM65 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM65: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM65 Gene

Function for TMEM65 Gene

Molecular function for TMEM65 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in cardiac development and function. Regulates cardiac conduction and the function of the gap junction protein GJA1. Contributes to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication.
genes like me logo Genes that share phenotypes with TMEM65: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM65 Gene

Localization for TMEM65 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM65 Gene

Cell membrane; Multi-pass membrane protein. Note=Localizes at the intercalated disk in the ventricular tissue. {ECO:0000269 PubMed:26403541}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM65 Gene COMPARTMENTS Subcellular localization image for TMEM65 gene
Compartment Confidence
plasma membrane 5
mitochondrion 3
nucleus 2

Gene Ontology (GO) - Cellular Components for TMEM65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005886 plasma membrane IEA,IDA 26403541
GO:0014704 intercalated disc IDA 26403541
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM65: view

Pathways & Interactions for TMEM65 Gene

SuperPathways for TMEM65 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003231 cardiac ventricle development ISS --
GO:1903779 regulation of cardiac conduction IEA,ISS --
genes like me logo Genes that share ontologies with TMEM65: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM65 Gene

Transcripts for TMEM65 Gene

mRNA/cDNA for TMEM65 Gene

Unigene Clusters for TMEM65 Gene

Transmembrane protein 65:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM65 Gene

No ASD Table

Relevant External Links for TMEM65 Gene

GeneLoc Exon Structure for
TMEM65
ECgene alternative splicing isoforms for
TMEM65

Expression for TMEM65 Gene

mRNA expression in normal human tissues for TMEM65 Gene

Protein differential expression in normal tissues from HIPED for TMEM65 Gene

This gene is overexpressed in Nasal epithelium (23.7) and Brain (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM65 Gene



Protein tissue co-expression partners for TMEM65 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM65 Gene:

TMEM65

SOURCE GeneReport for Unigene cluster for TMEM65 Gene:

Hs.187646

mRNA Expression by UniProt/SwissProt for TMEM65 Gene:

Q6PI78-TMM65_HUMAN
Tissue specificity: Predominantly expressed the ventricular tissue (at protein level).
genes like me logo Genes that share expression patterns with TMEM65: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TMEM65 Gene

Orthologs for TMEM65 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM65 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM65 34 35
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia TMEM65 34 35
  • 96.05 (n)
cow
(Bos Taurus)
Mammalia TMEM65 34 35
  • 94.63 (n)
rat
(Rattus norvegicus)
Mammalia Tmem65 34
  • 89.74 (n)
mouse
(Mus musculus)
Mammalia Tmem65 34 16 35
  • 89.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM65 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM65 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM65 34 35
  • 84.66 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM65 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem65 34
  • 74.82 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13983 34
zebrafish
(Danio rerio)
Actinopterygii tmem65 34 35
  • 64.29 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6265 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009021 34
  • 48.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17715 35
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tag-321 35
  • 38 (a)
OneToOne
Species where no ortholog for TMEM65 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM65 Gene

ENSEMBL:
Gene Tree for TMEM65 (if available)
TreeFam:
Gene Tree for TMEM65 (if available)

Paralogs for TMEM65 Gene

No data available for Paralogs for TMEM65 Gene

Variants for TMEM65 Gene

Sequence variations from dbSNP and Humsavar for TMEM65 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10090414 -- 124,331,372(+) tatat(A/T)atatt intron-variant, upstream-variant-2KB
rs10090489 -- 124,331,331(+) TATAA(C/T)TGAAT intron-variant, upstream-variant-2KB
rs10093809 -- 124,331,749(+) TCACT(C/G)TAAAG intron-variant, upstream-variant-2KB
rs10093812 -- 124,331,794(+) TACAA(A/G)CTAGA intron-variant, upstream-variant-2KB
rs10096657 -- 124,344,800(+) ctaga(A/G)tatta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM65 Gene

Variant ID Type Subtype PubMed ID
esv2669472 CNV deletion 23128226
esv2762769 CNV gain 21179565
esv3618688 CNV loss 21293372
nsv1034768 CNV gain 25217958
nsv1075168 CNV deletion 25765185
nsv1112965 CNV deletion 24896259
nsv1144234 CNV deletion 24896259
nsv516190 CNV loss 19592680
nsv521356 CNV loss 19592680
nsv527751 CNV loss 19592680

Variation tolerance for TMEM65 Gene

Residual Variation Intolerance Score: 46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM65 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM65

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM65 Gene

Disorders for TMEM65 Gene

Relevant External Links for TMEM65

Genetic Association Database (GAD)
TMEM65
Human Genome Epidemiology (HuGE) Navigator
TMEM65
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM65

No disorders were found for TMEM65 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM65 Gene

Publications for TMEM65 Gene

  1. Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. (PMID: 26403541) Sharma P. … Gramolini A.O. (Nat. Commun. 2015) 3 4 64
  2. TMEM65 is a mitochondrial inner-membrane protein. (PMID: 24765583) Nishimura N. … Yano M. (PeerJ 2014) 2 3 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 64

Products for TMEM65 Gene

Sources for TMEM65 Gene

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