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Aliases for TMEM64 Gene

Aliases for TMEM64 Gene

  • Transmembrane Protein 64 2 3 5

External Ids for TMEM64 Gene

Previous GeneCards Identifiers for TMEM64 Gene

  • GC08M091705
  • GC08M086845
  • GC08M091634

Summaries for TMEM64 Gene

GeneCards Summary for TMEM64 Gene

TMEM64 (Transmembrane Protein 64) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM64 Gene

  • Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1.

Additional gene information for TMEM64 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM64 Gene

Genomics for TMEM64 Gene

Regulatory Elements for TMEM64 Gene

Enhancers for TMEM64 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H090640 1.4 Ensembl ENCODE 15.8 +147.8 147845 7 HDGF PKNOX1 ARNT SIN3A DMAP1 ZNF2 ZBTB7B YY1 CBX5 ZNF143 TMEM64 LOC102724670 NECAB1 LINC01030 ENSG00000254180
GH08H090692 1 ENCODE dbSUPER 21.9 +98.1 98083 2 HDGF ESRRA JUN SIN3A NFXL1 CTBP1 GATA3 FOSL2 FOS TCF7L2 TMEM64 NECAB1 ENSG00000254182 LOC102724670
GH08H090698 1 ENCODE dbSUPER 11.6 +91.2 91155 2 NFIB JUN CEBPG ZNF316 NFE2 FOS MAFK NFE2L2 TCF7L2 CEBPB NECAB1 TMEM64 ENSG00000254182 LOC102724670
GH08H090669 1.3 Ensembl ENCODE dbSUPER 7.8 +120.7 120679 2 GTF2F1 TBP NFIB JUN ZBTB40 RFX5 CTBP1 GATA3 ZBTB48 POLR2A TMEM64 LOC102724670 ENSG00000254182
GH08H090675 1.1 Ensembl ENCODE dbSUPER 7.6 +115.3 115322 1 ZNF217 CTCF CTBP1 NFIB POLR2A RCOR1 FOXA1 OTUD6B-AS1 OTUD6B TMEM64 LRRC69 ENSG00000254182 LOC102724670
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM64 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM64 Gene

Chromosome:
8
Start:
90,621,995 bp from pter
End:
90,791,632 bp from pter
Size:
169,638 bases
Orientation:
Minus strand

Genomic View for TMEM64 Gene

Genes around TMEM64 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM64 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM64 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM64 Gene

Proteins for TMEM64 Gene

  • Protein details for TMEM64 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6YI46-TMM64_HUMAN
    Recommended name:
    Transmembrane protein 64
    Protein Accession:
    Q6YI46
    Secondary Accessions:
    • B4DUC0
    • F5GXM4
    • Q2HIZ7
    • Q8N3G6

    Protein attributes for TMEM64 Gene

    Size:
    380 amino acids
    Molecular mass:
    39665 Da
    Quaternary structure:
    • Interacts with ATP2A2.
    SequenceCaution:
    • Sequence=AAN05737.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD39028.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM64 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM64 Gene

Post-translational modifications for TMEM64 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM64 Gene

No data available for DME Specific Peptides for TMEM64 Gene

Domains & Families for TMEM64 Gene

Gene Families for TMEM64 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM64 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6YI46

UniProtKB/Swiss-Prot:

TMM64_HUMAN :
  • Belongs to the TVP38/TMEM64 family.
Family:
  • Belongs to the TVP38/TMEM64 family.
genes like me logo Genes that share domains with TMEM64: view

Function for TMEM64 Gene

Molecular function for TMEM64 Gene

UniProtKB/Swiss-Prot Function:
Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1.

Phenotypes From GWAS Catalog for TMEM64 Gene

genes like me logo Genes that share phenotypes with TMEM64: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM64

CRISPR Products

miRNA for TMEM64 Gene

miRTarBase miRNAs that target TMEM64

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM64
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM64 Gene

Localization for TMEM64 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM64 Gene

Membrane; Multi-pass membrane protein. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM64 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for TMEM64 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM64: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM64 Gene

Pathways & Interactions for TMEM64 Gene

SuperPathways for TMEM64 Gene

No Data Available

Interacting Proteins for TMEM64 Gene

Gene Ontology (GO) - Biological Process for TMEM64 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043462 regulation of ATPase activity IEA --
GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation ISS --
GO:0045600 positive regulation of fat cell differentiation ISS --
GO:0045668 negative regulation of osteoblast differentiation ISS --
GO:0045672 positive regulation of osteoclast differentiation IEA --
genes like me logo Genes that share ontologies with TMEM64: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM64 Gene

Drugs & Compounds for TMEM64 Gene

No Compound Related Data Available

Transcripts for TMEM64 Gene

Unigene Clusters for TMEM64 Gene

Transmembrane protein 64:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM64
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM64 Gene

No ASD Table

Relevant External Links for TMEM64 Gene

GeneLoc Exon Structure for
TMEM64
ECgene alternative splicing isoforms for
TMEM64

Expression for TMEM64 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM64 Gene

Protein differential expression in normal tissues from HIPED for TMEM64 Gene

This gene is overexpressed in Adipocyte (39.5) and Pancreas (29.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM64 Gene



Protein tissue co-expression partners for TMEM64 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM64 Gene:

TMEM64

SOURCE GeneReport for Unigene cluster for TMEM64 Gene:

Hs.567759

Evidence on tissue expression from TISSUES for TMEM64 Gene

  • Skin(3.9)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with TMEM64: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM64 Gene

Orthologs for TMEM64 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM64 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM64 33 34
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia TMEM64 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM64 33 34
  • 90.46 (n)
rat
(Rattus norvegicus)
Mammalia Tmem64 33
  • 89.89 (n)
mouse
(Mus musculus)
Mammalia Tmem64 33 16 34
  • 88.04 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM64 34
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM64 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM64 33 34
  • 78.59 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM64 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem64 33
  • 75.42 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem64 33 34
  • 71.29 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11367 33 34
  • 50.43 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012406 33
  • 49.24 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
OneToOne
Species where no ortholog for TMEM64 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM64 Gene

ENSEMBL:
Gene Tree for TMEM64 (if available)
TreeFam:
Gene Tree for TMEM64 (if available)

Paralogs for TMEM64 Gene

No data available for Paralogs for TMEM64 Gene

Variants for TMEM64 Gene

Sequence variations from dbSNP and Humsavar for TMEM64 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000012190 -- 90,633,977(+) AAATG(C/T)TTTTA intron-variant
rs1000071107 -- 90,646,231(+) CGGGG(C/G)TCGCG upstream-variant-2KB
rs1000084579 -- 90,646,532(+) GCTCA(C/T)ATCCG upstream-variant-2KB
rs1000295521 -- 90,627,383(+) AAAAG(A/C)AACAA intron-variant
rs1000536483 -- 90,633,657(+) ATGAA(C/G/T)GTGTC intron-variant

Variation tolerance for TMEM64 Gene

Gene Damage Index Score: 2.13; 38.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM64 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM64

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM64 Gene

Disorders for TMEM64 Gene

Relevant External Links for TMEM64

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM64

No disorders were found for TMEM64 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM64 Gene

Publications for TMEM64 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PMID: 19167051) Weinmann L … Meister G (Cell 2009) 3 60
  3. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 60
  4. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for TMEM64 Gene

Sources for TMEM64 Gene

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