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Aliases for TMEM64 Gene

Aliases for TMEM64 Gene

  • Transmembrane Protein 64 2 3

External Ids for TMEM64 Gene

Summaries for TMEM64 Gene

GeneCards Summary for TMEM64 Gene

TMEM64 is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM64 Gene

Genomics for TMEM64 Gene

Genomic Location for TMEM64 Gene

Start:
90,621,995 bp from pter
End:
90,791,632 bp from pter
Size:
169,638 bases
Orientation:
Minus strand

Genomic View for TMEM64 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM64 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM64 Gene

Regulatory Elements for TMEM64 Gene

Proteins for TMEM64 Gene

  • Protein details for TMEM64 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6YI46-TMM64_HUMAN
    Recommended name:
    Transmembrane protein 64
    Protein Accession:
    Q6YI46
    Secondary Accessions:
    • B4DUC0
    • F5GXM4
    • Q2HIZ7
    • Q8N3G6

    Protein attributes for TMEM64 Gene

    Size:
    380 amino acids
    Molecular mass:
    39665 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAN05737.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD39028.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM64 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM64 Gene

Proteomics data for TMEM64 Gene at MOPED

Post-translational modifications for TMEM64 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM64 Gene

No data available for DME Specific Peptides for TMEM64 Gene

Domains for TMEM64 Gene

Protein Domains for TMEM64 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TMM64_HUMAN
Family:
  • Belongs to the TVP38/TMEM64 family.:
    • Q6YI46
genes like me logo Genes that share domains with TMEM64: view

No data available for Gene Families for TMEM64 Gene

Function for TMEM64 Gene

Gene Ontology (GO) - Molecular Function for TMEM64 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TMEM64: view
genes like me logo Genes that share phenotypes with TMEM64: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM64 Gene

Localization for TMEM64 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM64 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM64 Gene COMPARTMENTS Subcellular localization image for TMEM64 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM64 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM64: view

Pathways for TMEM64 Gene

SuperPathways for TMEM64 Gene

No Data Available

Interacting Proteins for TMEM64 Gene

Gene Ontology (GO) - Biological Process for TMEM64 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043462 regulation of ATPase activity IEA --
GO:0045672 positive regulation of osteoclast differentiation IEA --
GO:0045780 positive regulation of bone resorption IEA --
GO:0051480 cytosolic calcium ion homeostasis IEA --
genes like me logo Genes that share ontologies with TMEM64: view

No data available for Pathways by source for TMEM64 Gene

Transcripts for TMEM64 Gene

Unigene Clusters for TMEM64 Gene

Transmembrane protein 64:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM64 Gene

No ASD Table

Relevant External Links for TMEM64 Gene

GeneLoc Exon Structure for
TMEM64
ECgene alternative splicing isoforms for
TMEM64

Expression for TMEM64 Gene

mRNA expression in normal human tissues for TMEM64 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMEM64 Gene

SOURCE GeneReport for Unigene cluster for TMEM64 Gene Hs.567759

genes like me logo Genes that share expressions with TMEM64: view

Orthologs for TMEM64 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM64 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM64 36
  • 99.47 (n)
  • 98.95 (a)
TMEM64 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM64 36
  • 90.46 (n)
  • 92.14 (a)
TMEM64 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM64 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem64 36
  • 88.04 (n)
  • 87.34 (a)
Tmem64 16
Tmem64 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM64 37
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM64 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem64 36
  • 89.89 (n)
  • 91.29 (a)
chicken
(Gallus gallus)
Aves TMEM64 36
  • 78.59 (n)
  • 82.48 (a)
TMEM64 37
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM64 37
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem64 36
  • 75.42 (n)
  • 79.92 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem64 36
  • 71.29 (n)
  • 80.15 (a)
tmem64 37
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012406 36
  • 49.24 (n)
  • 38.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11367 36
  • 50.43 (n)
  • 36.09 (a)
CG11367 37
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 37 (a)
OneToOne
Species with no ortholog for TMEM64:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM64 Gene

ENSEMBL:
Gene Tree for TMEM64 (if available)
TreeFam:
Gene Tree for TMEM64 (if available)

Paralogs for TMEM64 Gene

No data available for Paralogs for TMEM64 Gene

Variants for TMEM64 Gene

Sequence variations from dbSNP and Humsavar for TMEM64 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs4324886 -- 90,639,715(+) AATAC(A/G)TATCA intron-variant
rs4339599 -- 90,643,980(+) GTTAG(A/T)ATTAT intron-variant
rs4446695 -- 90,639,358(+) CTGGT(G/T)TAACC intron-variant
rs4495387 -- 90,638,769(+) TTAAT(C/T)GGATT intron-variant
rs4500048 -- 90,644,193(+) AATCA(C/T)TGAAT intron-variant

Relevant External Links for TMEM64 Gene

HapMap Linkage Disequilibrium report
TMEM64

No data available for Structural Variations from Database of Genomic Variants (DGV) for TMEM64 Gene

Disorders for TMEM64 Gene

No disorders were found for TMEM64 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM64 Gene

Publications for TMEM64 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PMID: 19167051) Weinmann L. … Meister G. (Cell 2009) 3
  3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  4. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for TMEM64 Gene

Sources for TMEM64 Gene

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