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Aliases for TMEM64 Gene

Aliases for TMEM64 Gene

  • Transmembrane Protein 64 2 3 5

External Ids for TMEM64 Gene

Previous GeneCards Identifiers for TMEM64 Gene

  • GC08M091705
  • GC08M086845
  • GC08M091634

Summaries for TMEM64 Gene

GeneCards Summary for TMEM64 Gene

TMEM64 (Transmembrane Protein 64) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM64 Gene

  • Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM64 Gene

Genomics for TMEM64 Gene

Regulatory Elements for TMEM64 Gene

Enhancers for TMEM64 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM64 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM64 Gene

Chromosome:
8
Start:
90,621,995 bp from pter
End:
90,791,632 bp from pter
Size:
169,638 bases
Orientation:
Minus strand

Genomic View for TMEM64 Gene

Genes around TMEM64 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM64 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM64 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM64 Gene

Proteins for TMEM64 Gene

  • Protein details for TMEM64 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6YI46-TMM64_HUMAN
    Recommended name:
    Transmembrane protein 64
    Protein Accession:
    Q6YI46
    Secondary Accessions:
    • B4DUC0
    • F5GXM4
    • Q2HIZ7
    • Q8N3G6

    Protein attributes for TMEM64 Gene

    Size:
    380 amino acids
    Molecular mass:
    39665 Da
    Quaternary structure:
    • Interacts with ATP2A2.
    SequenceCaution:
    • Sequence=AAN05737.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD39028.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM64 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM64 Gene

Proteomics data for TMEM64 Gene at MOPED

Post-translational modifications for TMEM64 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM64 Gene

No data available for DME Specific Peptides for TMEM64 Gene

Domains & Families for TMEM64 Gene

Protein Domains for TMEM64 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6YI46

UniProtKB/Swiss-Prot:

TMM64_HUMAN :
  • Belongs to the TVP38/TMEM64 family.
Family:
  • Belongs to the TVP38/TMEM64 family.
genes like me logo Genes that share domains with TMEM64: view

No data available for Gene Families for TMEM64 Gene

Function for TMEM64 Gene

Molecular function for TMEM64 Gene

UniProtKB/Swiss-Prot Function:
Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1.
genes like me logo Genes that share phenotypes with TMEM64: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM64

miRNA for TMEM64 Gene

miRTarBase miRNAs that target TMEM64

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM64 Gene

Localization for TMEM64 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM64 Gene

Membrane; Multi-pass membrane protein. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM64 Gene COMPARTMENTS Subcellular localization image for TMEM64 gene
Compartment Confidence
plasma membrane 3
cytosol 2
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for TMEM64 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with TMEM64: view

Pathways & Interactions for TMEM64 Gene

SuperPathways for TMEM64 Gene

No Data Available

Interacting Proteins for TMEM64 Gene

Gene Ontology (GO) - Biological Process for TMEM64 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation ISS --
GO:0045668 negative regulation of osteoblast differentiation ISS --
GO:0045780 positive regulation of bone resorption IEA --
GO:0051480 regulation of cytosolic calcium ion concentration IEA --
GO:0090090 negative regulation of canonical Wnt signaling pathway ISS --
genes like me logo Genes that share ontologies with TMEM64: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM64 Gene

Drugs & Compounds for TMEM64 Gene

No Compound Related Data Available

Transcripts for TMEM64 Gene

Unigene Clusters for TMEM64 Gene

Transmembrane protein 64:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM64 Gene

No ASD Table

Relevant External Links for TMEM64 Gene

GeneLoc Exon Structure for
TMEM64
ECgene alternative splicing isoforms for
TMEM64

Expression for TMEM64 Gene

mRNA expression in normal human tissues for TMEM64 Gene

Protein differential expression in normal tissues from HIPED for TMEM64 Gene

This gene is overexpressed in Adipocyte (39.5) and Pancreas (29.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM64 Gene



SOURCE GeneReport for Unigene cluster for TMEM64 Gene Hs.567759

genes like me logo Genes that share expression patterns with TMEM64: view

Protein tissue co-expression partners for TMEM64 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM64 Gene

Orthologs for TMEM64 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM64 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM64 35
  • 90.46 (n)
  • 92.14 (a)
TMEM64 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem64 35
  • 88.04 (n)
  • 87.34 (a)
Tmem64 16
Tmem64 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM64 35
  • 99.47 (n)
  • 98.95 (a)
TMEM64 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem64 35
  • 89.89 (n)
  • 91.29 (a)
dog
(Canis familiaris)
Mammalia TMEM64 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM64 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM64 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM64 35
  • 78.59 (n)
  • 82.48 (a)
TMEM64 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM64 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem64 35
  • 75.42 (n)
  • 79.92 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem64 35
  • 71.29 (n)
  • 80.15 (a)
tmem64 36
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012406 35
  • 49.24 (n)
  • 38.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11367 35
  • 50.43 (n)
  • 36.09 (a)
CG11367 36
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for TMEM64:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM64 Gene

ENSEMBL:
Gene Tree for TMEM64 (if available)
TreeFam:
Gene Tree for TMEM64 (if available)

Paralogs for TMEM64 Gene

No data available for Paralogs for TMEM64 Gene

Variants for TMEM64 Gene

Sequence variations from dbSNP and Humsavar for TMEM64 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs7829606 -- 90,628,386(+) aaaga(C/T)ggaaa intron-variant
rs7836315 -- 90,627,098(+) AAAGT(C/G)ATACG intron-variant
rs7837109 -- 90,626,950(+) TACAG(C/T)TCCTC intron-variant
rs7839542 -- 90,633,031(+) tggta(C/G)gcaac intron-variant
rs7840321 -- 90,632,865(+) TTATG(C/G)AATTA intron-variant

Variation tolerance for TMEM64 Gene

Gene Damage Index Score: 2.13; 38.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM64 Gene

HapMap Linkage Disequilibrium report
TMEM64

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM64 Gene

Disorders for TMEM64 Gene

Relevant External Links for TMEM64

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM64

No disorders were found for TMEM64 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM64 Gene

Publications for TMEM64 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PMID: 19167051) Weinmann L. … Meister G. (Cell 2009) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM64 Gene

Sources for TMEM64 Gene

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