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Aliases for TMEM63C Gene

Aliases for TMEM63C Gene

  • Transmembrane Protein 63C 2 3 4
  • C14orf171 3 4
  • CSC1 3 4
  • Calcium Permeable Stress-Gated Cation Channel 1 Homolog (Arabidopsis) 2
  • Calcium Permeable Stress-Gated Cation Channel 1 Homolog 3
  • Calcium Permeable Stress-Gated Cation Channel 1 3
  • Chromosome 14 Open Reading Frame 171 2
  • HsCSC1 3

External Ids for TMEM63C Gene

Previous Symbols for TMEM63C Gene

  • C14orf171

Summaries for TMEM63C Gene

GeneCards Summary for TMEM63C Gene

TMEM63C is a Protein Coding gene. An important paralog of this gene is TMEM63B.

UniProtKB/Swiss-Prot for TMEM63C Gene

  • Acts as an osmosensitive calcium-permeable cation channel.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM63C Gene

Genomics for TMEM63C Gene

Genomic Location for TMEM63C Gene

Start:
77,116,568 bp from pter
End:
77,259,495 bp from pter
Size:
142,928 bases
Orientation:
Plus strand

Genomic View for TMEM63C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM63C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM63C Gene

Regulatory Elements for TMEM63C Gene

Proteins for TMEM63C Gene

  • Protein details for TMEM63C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1W3-CSC1_HUMAN
    Recommended name:
    Calcium permeable stress-gated cation channel 1
    Protein Accession:
    Q9P1W3
    Secondary Accessions:
    • B2RN22
    • B3KWJ5
    • Q86TS3
    • Q86TS4
    • Q9NSQ4
    • Q9P1W1

    Protein attributes for TMEM63C Gene

    Size:
    806 amino acids
    Molecular mass:
    93317 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF62556.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for TMEM63C Gene

Proteomics data for TMEM63C Gene at MOPED

Post-translational modifications for TMEM63C Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn16 and Asn75

Other Protein References for TMEM63C Gene

No data available for DME Specific Peptides for TMEM63C Gene

Domains for TMEM63C Gene

Protein Domains for TMEM63C Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CSC1_HUMAN
Family:
  • Belongs to the CSC1 (TC 1.A.17) family.:
    • Q9P1W3
genes like me logo Genes that share domains with TMEM63C: view

No data available for Gene Families for TMEM63C Gene

Function for TMEM63C Gene

Molecular function for TMEM63C Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Activated by hyperosmotic shock after mannitol treatment.
UniProtKB/Swiss-Prot Function: Acts as an osmosensitive calcium-permeable cation channel.

Gene Ontology (GO) - Molecular Function for TMEM63C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005227 calcium activated cation channel activity IDA 24503647
genes like me logo Genes that share ontologies with TMEM63C: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM63C Gene

Localization for TMEM63C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM63C Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM63C Gene COMPARTMENTS Subcellular localization image for TMEM63C gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TMEM63C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM63C: view

Pathways for TMEM63C Gene

SuperPathways for TMEM63C Gene

No Data Available

Interacting Proteins for TMEM63C Gene

Gene Ontology (GO) - Biological Process for TMEM63C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport IDA 24503647
GO:0098655 cation transmembrane transport IDA 24503647
genes like me logo Genes that share ontologies with TMEM63C: view

No data available for Pathways by source for TMEM63C Gene

Transcripts for TMEM63C Gene

mRNA/cDNA for TMEM63C Gene

Unigene Clusters for TMEM63C Gene

Transmembrane protein 63C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM63C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - -
SP2: - -
SP3: - -
SP4: -
SP5:
SP6: -

ExUns: 23 ^ 24a · 24b ^ 25 ^ 26a · 26b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for TMEM63C Gene

GeneLoc Exon Structure for
TMEM63C
ECgene alternative splicing isoforms for
TMEM63C

Expression for TMEM63C Gene

mRNA expression in normal human tissues for TMEM63C Gene

mRNA differential expression in normal tissues according to GTEx for TMEM63C Gene

This gene is overexpressed in Pituitary (7.9), Brain - Cerebellum (7.9), and Brain - Cerebellar Hemisphere (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMEM63C Gene

SOURCE GeneReport for Unigene cluster for TMEM63C Gene Hs.22452

genes like me logo Genes that share expressions with TMEM63C: view

Orthologs for TMEM63C Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM63C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM63C 36
  • 98.05 (n)
  • 97.96 (a)
TMEM63C 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM63C 36
  • 85.36 (n)
  • 82.34 (a)
TMEM63C 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM63C 36
  • 86.77 (n)
  • 85.2 (a)
TMEM63C 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem63c 36
  • 83.79 (n)
  • 83.92 (a)
Tmem63c 16
Tmem63c 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM63C 37
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM63C 37
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem63c 36
  • 83.37 (n)
  • 83.17 (a)
chicken
(Gallus gallus)
Aves TMEM63C 36
  • 67.41 (n)
  • 58.66 (a)
TMEM63C 37
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM63C 37
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem63c 36
  • 59.89 (n)
  • 55.35 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100000800 36
  • 62.39 (n)
  • 56.22 (a)
TMEM63C 37
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11210 37
  • 27 (a)
OneToMany
Species with no ortholog for TMEM63C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM63C Gene

ENSEMBL:
Gene Tree for TMEM63C (if available)
TreeFam:
Gene Tree for TMEM63C (if available)

Paralogs for TMEM63C Gene

Paralogs for TMEM63C Gene

Selected SIMAP similar genes for TMEM63C Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TMEM63C: view

Variants for TMEM63C Gene

Sequence variations from dbSNP and Humsavar for TMEM63C Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs70165 -- 77,208,441(-) GACAG(A/G)AAGGG intron-variant
rs207801 -- 77,210,106(+) TTTGG(A/G)TCATC intron-variant
rs207802 -- 77,209,404(+) TTATT(C/T)TTTCC intron-variant
rs207803 -- 77,209,012(+) ACTGC(A/G)GCGGA intron-variant
rs207804 -- 77,207,472(+) TACCC(C/G)AGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM63C Gene

Variant ID Type Subtype PubMed ID
nsv832834 CNV Gain+Loss 17160897
dgv404e199 CNV Deletion 23128226
esv2748895 CNV Deletion 23290073
esv2741938 CNV Deletion 23290073
esv2748897 CNV Deletion 23290073
esv2237407 CNV Deletion 18987734
esv2748898 CNV Deletion 23290073
esv1001977 CNV Deletion 20482838
esv1173459 CNV Deletion 17803354
esv1308109 CNV Deletion 17803354
esv2748899 CNV Deletion 23290073
esv2748900 CNV Deletion 23290073
nsv1361 CNV Loss 18451855
nsv902104 CNV Loss 21882294

Relevant External Links for TMEM63C Gene

HapMap Linkage Disequilibrium report
TMEM63C

Disorders for TMEM63C Gene

Relevant External Links for TMEM63C

Genetic Association Database (GAD)
TMEM63C
Human Genome Epidemiology (HuGE) Navigator
TMEM63C
genes like me logo Genes that share disorders with TMEM63C: view

No data available for UniProtKB/Swiss-Prot for TMEM63C Gene

Publications for TMEM63C Gene

  1. DUF221 proteins are a family of osmosensitive calcium-permeable cation channels conserved across eukaryotes. (PMID: 24503647) Hou C. … Li L. (Cell Res. 2014) 2 3 4
  2. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder. (PMID: 22925353) Lee H.J. … Kelsoe J.R. (J Affect Disord 2013) 3

Products for TMEM63C Gene

  • antibodies-online peptides for TMEM63C
  • antibodies-online antibodies for TMEM63C
  • antibodies-online kits for TMEM63C

Sources for TMEM63C Gene

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