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Aliases for TMEM63B Gene

Aliases for TMEM63B Gene

  • Transmembrane Protein 63B 2 3 4
  • C6orf110 3 4
  • Chromosome 6 Open Reading Frame 110 2
  • CSC1-Like Protein 2 3

External Ids for TMEM63B Gene

Previous Symbols for TMEM63B Gene

  • C6orf110

Summaries for TMEM63B Gene

GeneCards Summary for TMEM63B Gene

TMEM63B is a Protein Coding gene. GO annotations related to this gene include nucleotide binding. An important paralog of this gene is TMEM63C.

UniProtKB/Swiss-Prot for TMEM63B Gene

  • Acts as an osmosensitive calcium-permeable cation channel.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM63B Gene

Genomics for TMEM63B Gene

Genomic Location for TMEM63B Gene

44,126,889 bp from pter
44,155,519 bp from pter
28,631 bases
Plus strand

Genomic View for TMEM63B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM63B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM63B Gene

Regulatory Elements for TMEM63B Gene

Proteins for TMEM63B Gene

  • Protein details for TMEM63B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CSC1-like protein 2
    Protein Accession:
    Secondary Accessions:
    • B9EGU3
    • Q5T3F9
    • Q6AHX4
    • Q6P5A0
    • Q8N219
    • Q8NDE1
    • Q9NSG5

    Protein attributes for TMEM63B Gene

    832 amino acids
    Molecular mass:
    94958 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAH10540.1; Type=Frameshift; Positions=647; Evidence={ECO:0000305}; Sequence=CAI20530.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM63B Gene


neXtProt entry for TMEM63B Gene

Proteomics data for TMEM63B Gene at MOPED

Post-translational modifications for TMEM63B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys258
  • Glycosylation at Asn15, Asn266, and Asn462

Other Protein References for TMEM63B Gene

No data available for DME Specific Peptides for TMEM63B Gene

Domains for TMEM63B Gene

Protein Domains for TMEM63B Gene


  • Belongs to the CSC1 (TC 1.A.17) family.:
    • Q5T3F8
genes like me logo Genes that share domains with TMEM63B: view

No data available for Gene Families for TMEM63B Gene

Function for TMEM63B Gene

Molecular function for TMEM63B Gene

UniProtKB/Swiss-Prot Function: Acts as an osmosensitive calcium-permeable cation channel.

Gene Ontology (GO) - Molecular Function for TMEM63B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
genes like me logo Genes that share ontologies with TMEM63B: view
genes like me logo Genes that share phenotypes with TMEM63B: view

miRNA for TMEM63B Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM63B Gene

Localization for TMEM63B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM63B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM63B Gene COMPARTMENTS Subcellular localization image for TMEM63B gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM63B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM63B: view

Pathways for TMEM63B Gene

SuperPathways for TMEM63B Gene

No Data Available

Interacting Proteins for TMEM63B Gene

Gene Ontology (GO) - Biological Process for TMEM63B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
genes like me logo Genes that share ontologies with TMEM63B: view

No data available for Pathways by source for TMEM63B Gene

Transcripts for TMEM63B Gene

Unigene Clusters for TMEM63B Gene

Transmembrane protein 63B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM63B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^
SP1: - - -
SP2: - -
SP3: - - - - - - - - - - - - -
SP4: -
SP5: - - - -
SP6: - -

ExUns: 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26
SP1: -

Relevant External Links for TMEM63B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM63B Gene

mRNA expression in normal human tissues for TMEM63B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM63B Gene

SOURCE GeneReport for Unigene cluster for TMEM63B Gene Hs.414473

genes like me logo Genes that share expressions with TMEM63B: view

Orthologs for TMEM63B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM63B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM63B 36
  • 99.48 (n)
  • 99.64 (a)
TMEM63B 37
  • 100 (a)
(Bos Taurus)
Mammalia TMEM63B 36
  • 94.02 (n)
  • 97.95 (a)
TMEM63B 37
  • 98 (a)
(Canis familiaris)
Mammalia TMEM63B 36
  • 94.71 (n)
  • 98.32 (a)
TMEM63B 37
  • 99 (a)
(Mus musculus)
Mammalia Tmem63b 36
  • 92.95 (n)
  • 98.2 (a)
Tmem63b 16
Tmem63b 37
  • 98 (a)
(Monodelphis domestica)
Mammalia TMEM63B 37
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM63B 37
  • 78 (a)
(Rattus norvegicus)
Mammalia Tmem63b 36
  • 92.51 (n)
  • 97.96 (a)
(Gallus gallus)
Aves TMEM63B 36
  • 81.98 (n)
  • 91.13 (a)
TMEM63B 37
  • 90 (a)
(Anolis carolinensis)
Reptilia TMEM63B 37
  • 89 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15155 36
(Danio rerio)
Actinopterygii tmem63ba 36
  • 75.04 (n)
  • 80.85 (a)
tmem63bb 37
  • 44 (a)
wufk59g12 36
fruit fly
(Drosophila melanogaster)
Insecta CG11210 37
  • 32 (a)
Species with no ortholog for TMEM63B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM63B Gene

Gene Tree for TMEM63B (if available)
Gene Tree for TMEM63B (if available)

Paralogs for TMEM63B Gene

Paralogs for TMEM63B Gene

Selected SIMAP similar genes for TMEM63B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMEM63B: view

Variants for TMEM63B Gene

Sequence variations from dbSNP and Humsavar for TMEM63B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1041523 -- 44,153,533(-) GCCCC(A/G)TGCCC intron-variant
rs1539378 -- 44,135,358(-) TCCTG(C/T)TCCAC reference, synonymous-codon, intron-variant
rs1539379 -- 44,148,127(-) TTTTT(C/T)TTTGG intron-variant
rs2096200 -- 44,142,358(-) GAGAC(A/G)AGGTT intron-variant
rs2277127 -- 44,154,210(+) GCAGG(C/T)GGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM63B Gene

Variant ID Type Subtype PubMed ID
nsv462935 CNV Loss 19166990
nsv509132 CNV Insertion 20534489

Relevant External Links for TMEM63B Gene

HapMap Linkage Disequilibrium report

Disorders for TMEM63B Gene

No disorders were found for TMEM63B Gene.

No data available for UniProtKB/Swiss-Prot for TMEM63B Gene

Publications for TMEM63B Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3

Products for TMEM63B Gene

  • antibodies-online peptides for TMEM63B
  • antibodies-online antibodies for TMEM63B
  • antibodies-online kits for TMEM63B

Sources for TMEM63B Gene

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