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Aliases for TMEM63B Gene

Aliases for TMEM63B Gene

  • Transmembrane Protein 63B 2 3 4 5
  • C6orf110 3 4
  • Chromosome 6 Open Reading Frame 110 2

External Ids for TMEM63B Gene

Previous HGNC Symbols for TMEM63B Gene

  • C6orf110

Previous GeneCards Identifiers for TMEM63B Gene

  • GC06P044203
  • GC06P043823

Summaries for TMEM63B Gene

GeneCards Summary for TMEM63B Gene

TMEM63B (Transmembrane Protein 63B) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding. An important paralog of this gene is TMEM63C.

UniProtKB/Swiss-Prot for TMEM63B Gene

  • Acts as an osmosensitive calcium-permeable cation channel.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM63B Gene

Genomics for TMEM63B Gene

Regulatory Elements for TMEM63B Gene

Enhancers for TMEM63B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM63B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM63B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM63B on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM63B Gene

Chromosome:
6
Start:
44,126,757 bp from pter
End:
44,155,519 bp from pter
Size:
28,763 bases
Orientation:
Plus strand

Genomic View for TMEM63B Gene

Genes around TMEM63B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM63B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM63B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM63B Gene

Proteins for TMEM63B Gene

  • Protein details for TMEM63B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T3F8-CSCL2_HUMAN
    Recommended name:
    CSC1-like protein 2
    Protein Accession:
    Q5T3F8
    Secondary Accessions:
    • B9EGU3
    • Q5T3F9
    • Q6AHX4
    • Q6P5A0
    • Q8N219
    • Q8NDE1
    • Q9NSG5

    Protein attributes for TMEM63B Gene

    Size:
    832 amino acids
    Molecular mass:
    94958 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH10540.1; Type=Frameshift; Positions=647; Evidence={ECO:0000305}; Sequence=CAI20530.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM63B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM63B Gene

Proteomics data for TMEM63B Gene at MOPED

Post-translational modifications for TMEM63B Gene

  • Ubiquitination at Lys 258
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM63B Gene

No data available for DME Specific Peptides for TMEM63B Gene

Domains & Families for TMEM63B Gene

Protein Domains for TMEM63B Gene

Suggested Antigen Peptide Sequences for TMEM63B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T3F8

UniProtKB/Swiss-Prot:

CSCL2_HUMAN :
  • Belongs to the CSC1 (TC 1.A.17) family.
Family:
  • Belongs to the CSC1 (TC 1.A.17) family.
genes like me logo Genes that share domains with TMEM63B: view

No data available for Gene Families for TMEM63B Gene

Function for TMEM63B Gene

Molecular function for TMEM63B Gene

UniProtKB/Swiss-Prot Function:
Acts as an osmosensitive calcium-permeable cation channel.
genes like me logo Genes that share phenotypes with TMEM63B: view

Animal Models for TMEM63B Gene

MGI Knock Outs for TMEM63B:

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM63B

CRISPR Products

miRNA for TMEM63B Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM63B Gene

Localization for TMEM63B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM63B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM63B Gene COMPARTMENTS Subcellular localization image for TMEM63B gene
Compartment Confidence
plasma membrane 5
cytoskeleton 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM63B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with TMEM63B: view

Pathways & Interactions for TMEM63B Gene

SuperPathways for TMEM63B Gene

No Data Available

Interacting Proteins for TMEM63B Gene

Gene Ontology (GO) - Biological Process for TMEM63B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM63B Gene

Drugs & Compounds for TMEM63B Gene

No Compound Related Data Available

Transcripts for TMEM63B Gene

Unigene Clusters for TMEM63B Gene

Transmembrane protein 63B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM63B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^
SP1: - - -
SP2: - -
SP3: - - - - - - - - - - - - -
SP4: -
SP5: - - - -
SP6: - -
SP7:
SP8:

ExUns: 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for TMEM63B Gene

GeneLoc Exon Structure for
TMEM63B
ECgene alternative splicing isoforms for
TMEM63B

Expression for TMEM63B Gene

mRNA expression in normal human tissues for TMEM63B Gene

Protein differential expression in normal tissues from HIPED for TMEM63B Gene

This gene is overexpressed in Monocytes (30.6), NK cells (15.1), and Kidney (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM63B Gene



SOURCE GeneReport for Unigene cluster for TMEM63B Gene Hs.414473

genes like me logo Genes that share expression patterns with TMEM63B: view

Protein tissue co-expression partners for TMEM63B Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM63B Gene

Orthologs for TMEM63B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM63B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM63B 35
  • 94.02 (n)
  • 97.95 (a)
TMEM63B 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM63B 35
  • 94.71 (n)
  • 98.32 (a)
TMEM63B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem63b 35
  • 92.95 (n)
  • 98.2 (a)
Tmem63b 16
Tmem63b 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM63B 35
  • 99.48 (n)
  • 99.64 (a)
TMEM63B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem63b 35
  • 92.51 (n)
  • 97.96 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM63B 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM63B 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM63B 35
  • 81.98 (n)
  • 91.13 (a)
TMEM63B 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM63B 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15155 35
zebrafish
(Danio rerio)
Actinopterygii tmem63ba 35
  • 75.04 (n)
  • 80.85 (a)
wufk59g12 35
tmem63bb 36
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11210 36
  • 32 (a)
OneToMany
Species with no ortholog for TMEM63B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM63B Gene

ENSEMBL:
Gene Tree for TMEM63B (if available)
TreeFam:
Gene Tree for TMEM63B (if available)

Paralogs for TMEM63B Gene

Paralogs for TMEM63B Gene

(2) SIMAP similar genes for TMEM63B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMEM63B: view

Variants for TMEM63B Gene

Sequence variations from dbSNP and Humsavar for TMEM63B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs4714759 - 44,147,432(+) AGAAC(A/G)TGCCT reference, missense
rs1041523 -- 44,153,533(-) GCCCC(A/G)TGCCC intron-variant
rs6458370 -- 44,140,829(+) CTGTT(A/G)GAAAC intron-variant
rs1539378 -- 44,135,358(-) TCCTG(C/T)TCCAC intron-variant, reference, synonymous-codon
rs1539379 -- 44,148,127(-) TTTTT(C/T)TTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM63B Gene

Variant ID Type Subtype PubMed ID
nsv462935 CNV Loss 19166990
nsv509132 CNV Insertion 20534489

Variation tolerance for TMEM63B Gene

Residual Variation Intolerance Score: 4.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.25; 76.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM63B Gene

Disorders for TMEM63B Gene

Relevant External Links for TMEM63B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM63B

No disorders were found for TMEM63B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM63B Gene

Publications for TMEM63B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3

Products for TMEM63B Gene

Sources for TMEM63B Gene

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