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Aliases for TMEM63A Gene

Aliases for TMEM63A Gene

  • Transmembrane Protein 63A 2 3 4
  • KIAA0792 2 3 4
  • CSC1-Like Protein 1 3
  • KIAA0489 4

External Ids for TMEM63A Gene

Previous Symbols for TMEM63A Gene

  • KIAA0792

Summaries for TMEM63A Gene

GeneCards Summary for TMEM63A Gene

TMEM63A is a Protein Coding gene. GO annotations related to this gene include nucleotide binding. An important paralog of this gene is TMEM63C.

UniProtKB/Swiss-Prot for TMEM63A Gene

  • Acts as an osmosensitive calcium-permeable cation channel.

Gene Wiki entry for TMEM63A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM63A Gene

Genomics for TMEM63A Gene

Genomic Location for TMEM63A Gene

Start:
225,845,532 bp from pter
End:
225,882,720 bp from pter
Size:
37,189 bases
Orientation:
Minus strand

Genomic View for TMEM63A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM63A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM63A Gene

Regulatory Elements for TMEM63A Gene

Proteins for TMEM63A Gene

  • Protein details for TMEM63A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94886-CSCL1_HUMAN
    Recommended name:
    CSC1-like protein 1
    Protein Accession:
    O94886
    Secondary Accessions:
    • Q53GI7
    • Q5TE96
    • Q8N2U2

    Protein attributes for TMEM63A Gene

    Size:
    807 amino acids
    Molecular mass:
    92126 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA34512.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD96654.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD96664.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TMEM63A Gene

Proteomics data for TMEM63A Gene at MOPED

Post-translational modifications for TMEM63A Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn38 and Asn450

Other Protein References for TMEM63A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM63A Gene

Domains for TMEM63A Gene

Protein Domains for TMEM63A Gene

UniProtKB/Swiss-Prot:

CSCL1_HUMAN
Family:
  • Belongs to the CSC1 (TC 1.A.17) family.:
    • O94886
genes like me logo Genes that share domains with TMEM63A: view

No data available for Gene Families for TMEM63A Gene

Function for TMEM63A Gene

Molecular function for TMEM63A Gene

UniProtKB/Swiss-Prot Function: Acts as an osmosensitive calcium-permeable cation channel.

Gene Ontology (GO) - Molecular Function for TMEM63A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
genes like me logo Genes that share ontologies with TMEM63A: view

Phenotypes for TMEM63A Gene

GenomeRNAi human phenotypes for TMEM63A:
genes like me logo Genes that share phenotypes with TMEM63A: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM63A Gene

Localization for TMEM63A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM63A Gene

Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM63A Gene COMPARTMENTS Subcellular localization image for TMEM63A gene
Compartment Confidence
lysosome 5
vacuole 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM63A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TMEM63A: view

Pathways for TMEM63A Gene

SuperPathways for TMEM63A Gene

No Data Available

Interacting Proteins for TMEM63A Gene

Gene Ontology (GO) - Biological Process for TMEM63A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
genes like me logo Genes that share ontologies with TMEM63A: view

No data available for Pathways by source for TMEM63A Gene

Transcripts for TMEM63A Gene

Unigene Clusters for TMEM63A Gene

Transmembrane protein 63A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM63A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a ·
SP1:
SP2:
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: -
SP7: - - - - - - - - -
SP8:
SP9: - - - - -
SP10: - - - - - - - -
SP11: -
SP12: - - -
SP13:
SP14: - -
SP15: - -
SP16: -
SP17:
SP18:

ExUns: 14b ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for TMEM63A Gene

GeneLoc Exon Structure for
TMEM63A
ECgene alternative splicing isoforms for
TMEM63A

Expression for TMEM63A Gene

mRNA expression in normal human tissues for TMEM63A Gene

mRNA differential expression in normal tissues according to GTEx for TMEM63A Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM63A Gene

SOURCE GeneReport for Unigene cluster for TMEM63A Gene Hs.119387

genes like me logo Genes that share expressions with TMEM63A: view

Orthologs for TMEM63A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMEM63A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM63A 36
  • 99.34 (n)
  • 99.75 (a)
TMEM63A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM63A 36
  • 88.81 (n)
  • 89.39 (a)
TMEM63A 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM63A 36
  • 88.72 (n)
  • 89.43 (a)
TMEM63A 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem63a 36
  • 87.27 (n)
  • 90.05 (a)
Tmem63a 16
Tmem63a 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM63A 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM63A 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem63a 36
  • 85.66 (n)
  • 88.31 (a)
chicken
(Gallus gallus)
Aves TMEM63A 36
  • 68.01 (n)
  • 69.32 (a)
TMEM63A 37
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM63A 37
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem63a 36
  • 67.27 (n)
  • 66.88 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem63a 36
  • 62.48 (n)
  • 58.07 (a)
tmem63a 37
  • 52 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004584 36
  • 49.27 (n)
  • 39.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11210 36
  • 47.75 (n)
  • 35.85 (a)
CG11210 37
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 39
Species with no ortholog for TMEM63A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM63A Gene

ENSEMBL:
Gene Tree for TMEM63A (if available)
TreeFam:
Gene Tree for TMEM63A (if available)

Paralogs for TMEM63A Gene

Paralogs for TMEM63A Gene

Selected SIMAP similar genes for TMEM63A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMEM63A: view

Variants for TMEM63A Gene

Sequence variations from dbSNP and Humsavar for TMEM63A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs111990 -- 225,852,986(-) AGCAC(G/T)AGCAA intron-variant
rs168618 -- 225,870,116(+) aggcc(A/G)aggca intron-variant
rs168619 -- 225,870,284(+) gaggc(A/G)gaggc intron-variant
rs184852 -- 225,849,143(-) GCCTT(A/G)CCTTT intron-variant
rs184853 -- 225,873,366(+) GGGAA(A/G)GATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM63A Gene

Variant ID Type Subtype PubMed ID
nsv524126 CNV Gain 19592680
nsv873231 CNV Loss 21882294
nsv520628 CNV Loss 19592680
nsv160017 CNV Loss 16902084

Relevant External Links for TMEM63A Gene

HapMap Linkage Disequilibrium report
TMEM63A
Human Gene Mutation Database (HGMD)
TMEM63A

Disorders for TMEM63A Gene

Relevant External Links for TMEM63A

Genetic Association Database (GAD)
TMEM63A
Human Genome Epidemiology (HuGE) Navigator
TMEM63A
genes like me logo Genes that share disorders with TMEM63A: view

No data available for UniProtKB/Swiss-Prot for TMEM63A Gene

Publications for TMEM63A Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 2 3
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TMEM63A Gene

Sources for TMEM63A Gene

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