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Aliases for TMEM62 Gene

Aliases for TMEM62 Gene

  • Transmembrane Protein 62 2 3 5

External Ids for TMEM62 Gene

Previous GeneCards Identifiers for TMEM62 Gene

  • GC15P041214
  • GC15P043425
  • GC15P020273
  • GC15P043415

Summaries for TMEM62 Gene

GeneCards Summary for TMEM62 Gene

TMEM62 (Transmembrane Protein 62) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding.

Additional gene information for TMEM62 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM62 Gene

Genomics for TMEM62 Gene

Regulatory Elements for TMEM62 Gene

Enhancers for TMEM62 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H043122 1 ENCODE 0.7 -0.2 -214 1.7 PKNOX1 ATF1 BRCA1 YY1 GLIS2 ELK1 ATF7 SP3 MCM3 GTF2B LRRC57 RPS3AP47 GANC WDR76 LOC105370795 TMEM87A CDAN1 VPS39 SNAP23 MFAP1
GH15H043124 0.8 ENCODE 0.7 +3.7 3727 4.3 ELF3 SOX13 DRAP1 ZNF146 FOXA2 SAP130 CEBPG THRB RARA GATA3 CCNDBP1 ZSCAN29 CDAN1 TGM7 KRT8P50 ADAL TMEM62 SPCS2P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM62 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM62 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000075810 -179 1001 PKNOX1 ATF1 BRCA1 GLIS2 ELK1 ZNF143 ATF7 SP3 MCM3 GTF2B

Genomic Locations for TMEM62 Gene

Genomic Locations for TMEM62 Gene
chr15:43,123,279-43,185,147
(GRCh38/hg38)
Size:
61,869 bases
Orientation:
Plus strand
chr15:43,415,477-43,477,344
(GRCh37/hg19)

Genomic View for TMEM62 Gene

Genes around TMEM62 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM62 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM62 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM62 Gene

Proteins for TMEM62 Gene

  • Protein details for TMEM62 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0P6H9-TMM62_HUMAN
    Recommended name:
    Transmembrane protein 62
    Protein Accession:
    Q0P6H9
    Secondary Accessions:
    • Q6I9Y5
    • Q9H5J6

    Protein attributes for TMEM62 Gene

    Size:
    643 amino acids
    Molecular mass:
    73133 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15630.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMEM62 Gene

Post-translational modifications for TMEM62 Gene

  • Glycosylation at posLast=180180, Asn467, and Asn626
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM62 Gene

Domains & Families for TMEM62 Gene

Gene Families for TMEM62 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM62 Gene

Suggested Antigen Peptide Sequences for TMEM62 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM62: view

No data available for UniProtKB/Swiss-Prot for TMEM62 Gene

Function for TMEM62 Gene

Gene Ontology (GO) - Molecular Function for TMEM62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TMEM62: view

miRNA for TMEM62 Gene

miRTarBase miRNAs that target TMEM62

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM62 Gene

Localization for TMEM62 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM62 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM62 gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (2)
  • Nuclear bodies (2)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM62: view

Pathways & Interactions for TMEM62 Gene

SuperPathways for TMEM62 Gene

No Data Available

Interacting Proteins for TMEM62 Gene

Gene Ontology (GO) - Biological Process for TMEM62 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM62 Gene

Drugs & Compounds for TMEM62 Gene

No Compound Related Data Available

Transcripts for TMEM62 Gene

Unigene Clusters for TMEM62 Gene

Transmembrane protein 62:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM62 Gene

No ASD Table

Relevant External Links for TMEM62 Gene

GeneLoc Exon Structure for
TMEM62
ECgene alternative splicing isoforms for
TMEM62

Expression for TMEM62 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM62 Gene

Protein differential expression in normal tissues from HIPED for TMEM62 Gene

This gene is overexpressed in Islet of Langerhans (47.5) and Retina (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM62 Gene



Protein tissue co-expression partners for TMEM62 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM62 Gene:

TMEM62

SOURCE GeneReport for Unigene cluster for TMEM62 Gene:

Hs.511175

Evidence on tissue expression from TISSUES for TMEM62 Gene

  • Liver(4.1)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with TMEM62: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM62 Gene

Orthologs for TMEM62 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM62 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM62 33 34
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia TMEM62 33 34
  • 89.99 (n)
cow
(Bos Taurus)
Mammalia TMEM62 33 34
  • 88.7 (n)
mouse
(Mus musculus)
Mammalia Tmem62 33 16 34
  • 85.43 (n)
rat
(Rattus norvegicus)
Mammalia Tmem62 33
  • 84.55 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM62 34
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM62 34
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM62 33 34
  • 69.34 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM62 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem62 33
  • 62.67 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem62 33 34
  • 61.51 (n)
Dr.26190 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010204 33
  • 47.85 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G03305 33
  • 43.94 (n)
rice
(Oryza sativa)
Liliopsida Os01g0894000 33
  • 46.73 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToOne
Species where no ortholog for TMEM62 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM62 Gene

ENSEMBL:
Gene Tree for TMEM62 (if available)
TreeFam:
Gene Tree for TMEM62 (if available)

Paralogs for TMEM62 Gene

No data available for Paralogs for TMEM62 Gene

Variants for TMEM62 Gene

Sequence variations from dbSNP and Humsavar for TMEM62 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000020246 -- 43,137,202(+) ATAAA(G/T)GTTGA intron-variant, upstream-variant-2KB
rs1000164823 -- 43,172,238(+) ATAAT(A/G)TAACT intron-variant
rs1000176170 -- 43,168,173(+) GGAGA(C/G)GGAGA intron-variant
rs1000289051 -- 43,168,197(+) GGAGA(A/G)GGAGA intron-variant
rs1000395794 -- 43,185,269(+) GGAGG(A/C)GGCGG intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM62 Gene

Variant ID Type Subtype PubMed ID
nsv984062 CNV duplication 23825009
nsv974566 CNV duplication 23825009
nsv952616 CNV deletion 24416366
nsv94791 CNV deletion 16902084
nsv569241 CNV loss 21841781
nsv525461 CNV loss 19592680
nsv515876 CNV gain+loss 19592680
esv3636288 CNV loss 21293372
esv2678276 CNV deletion 23128226
dgv4500n54 CNV loss 21841781

Variation tolerance for TMEM62 Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM62 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM62

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM62 Gene

Disorders for TMEM62 Gene

Relevant External Links for TMEM62

Genetic Association Database (GAD)
TMEM62
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM62

No disorders were found for TMEM62 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM62 Gene

Publications for TMEM62 Gene

  1. Arachidonic acid metabolism in the human placenta: identification of a putative lipoxygenase. (PMID: 24767823) Jadoon A … McDermott LC (Placenta 2014) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for TMEM62 Gene

Sources for TMEM62 Gene

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