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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM62 Gene

protein-coding   GIFtS: 42
GCID: GC15P043415

Transmembrane Protein 62

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 621 2

External Ids:    HGNC: 262691   Entrez Gene: 800212   Ensembl: ENSG000001378427   UniProtKB: Q0P6H93   

Export aliases for TMEM62 gene to outside databases

Previous GC identifers: GC15P041214 GC15P043425 GC15P020273


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM62 Gene: 
TMEM62 (transmembrane protein 62) is a protein-coding gene. Diseases associated with TMEM62 include congenital dyserythropoietic anemia type i, and congenital dyserythropoietic anemia.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM62 gene promoter:
         AP-1   Lmo2   POU2F1   Ik-2   FOXJ2 (long isoform)   POU2F1a   STAT3   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM62 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM62

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM62


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.2   Ensembl cytogenetic band:  15q15.2   HGNC cytogenetic band: 15q15.2

TMEM62 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM62 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P043415:  view genomic region     (about GC identifiers)

Start:
43,415,477 bp from pter      End:
43,477,344 bp from pter
Size:
61,868 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TMM62_HUMAN, Q0P6H9 (See protein sequence)
Recommended Name: Transmembrane protein 62  
Size: 643 amino acids; 73133 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAB15630.1; Type=Erroneous initiation;
Secondary accessions: Q6I9Y5 Q9H5J6

Explore the universe of human proteins at neXtProt for TMEM62: NX_Q0P6H9

Explore proteomics data for TMEM62 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q0P6H9

  • TMEM62 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMEM62 Protein Expression
    REFSEQ proteins: NP_079232.3  
    ENSEMBL proteins: 
     ENSP00000455482   ENSP00000454683   ENSP00000457314   ENSP00000260403   ENSP00000455413  
     ENSP00000456003   ENSP00000457503   ENSP00000456151   ENSP00000458098  

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    Cloud-Clone Corp. Proteins for TMEM62 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    TMEM62 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q0P6H9


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding ----
         
    TMEM62 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM62 
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    SwitchGear 3'UTR luciferase reporter plasmidTMEM62 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM62

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/8 Interacting proteins for TMEM62 (Q0P6H93 ENSP000002604034) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA5P110213, ENSP000003241734I2D: score=3 STRING: ENSP00000324173
    CSE1LP550603, ENSP000002629824I2D: score=4 STRING: ENSP00000262982
    LTA4HP099603I2D: score=4 
    APEHP137983I2D: score=3 
    PTPN6P293503I2D: score=3 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM62 (TMM62)

    Search CenterWatch for drugs/clinical trials and news about TMEM62 / TMM62

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM62 gene: 
    NM_024956.3  

    Unigene Cluster for TMEM62:

    Transmembrane protein 62
    Hs.511175  [show with all ESTs]
    Unigene Representative Sequence: NM_024956
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000564698 ENST00000569535 ENST00000565291 ENST00000260403(uc001zqr.3 uc010bda.3)
    ENST00000569926 ENST00000570109 ENST00000568182 ENST00000567441 ENST00000568197
    ENST00000564494 ENST00000569897 ENST00000566308 ENST00000563859 ENST00000569369
    ENST00000566122
    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM62 (see all 11):
    hsa-miR-579 hsa-miR-222* hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-551b* hsa-miR-664 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidTMEM62 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TMEM62
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM62
    Clone
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    OriGene clones in human, mouse for TMEM62 (see all 7)
    OriGene ORF clones in mouse, rat for TMEM62
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMEM62 (NM_024956)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM62
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM62
    Sirion Biotech Customized lentivirus for stable overexpression of TMEM62 
                         Customized lentivirus expression plasmids for stable overexpression of TMEM62 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMEM62
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM62
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM62

    Additional mRNA sequence: 

    AK027028.1 AK225353.1 AK309679.1 BC009981.2 CR457370.1 

    13 DOTS entries:

    DT.95168952  DT.116591  DT.121051476  DT.121051408  DT.91697311  DT.116594  DT.40106984  DT.95168955 
    DT.91697309  DT.95131978  DT.95211127  DT.99984077  DT.75165850 

    24/149 AceView cDNA sequences (see all 149):

    CF126574 AI284949 AL542417 AW050924 CK429279 AW294863 AI380053 AI379988 
    AI277128 AW058518 AI380564 BF513439 AA134264 AI695754 AI393993 AI479920 
    AI347435 AI970865 AI281173 BF594527 AI818808 BC009981 AI738483 BU616786 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM62 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAGCACTT
    TMEM62 Expression
    About this image


    See TMEM62 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM62

    SOURCE GeneReport for Unigene cluster: Hs.511175
        SABiosciences Custom PCR Arrays for TMEM62
    Primer
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    OriGene qPCR primer pairs and template standards for TMEM62
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM62
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM62
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM62

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TMEM62 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem621 , 5 transmembrane protein 621, 5 85.43(n)1
    83.2(a)1
      2 (60.37 cM)5
    969571  NM_175285.31  NP_780494.11 
     1209770175 
    chicken
    (Gallus gallus)
    Aves TMEM621 transmembrane protein 62 69.48(n)
    66.03(a)
      423243  XM_430033.2  XP_430033.2 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM626
    Uncharacterized protein
    63(a)
    1 ↔ 1
    1(39417156-39445131)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.261902 Transcribed sequences 72.28(n)    CD590032.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0102041 AGAP010204-PA 47.85(n)
    41.94(a)
      1279625  XM_319387.4  XP_319387.4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G033051 calcineurin-like metallo-phosphoesterase-like protein 44.55(n)
    31.36(a)
      821291  NM_111201.4  NP_566200.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g08940001 hypothetical protein 44.67(n)
    32.43(a)
      4324960  NM_001051601.1  NP_001045066.1 


    ENSEMBL Gene Tree for TMEM62 (if available)
    TreeFam Gene Tree for TMEM62 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/756 SNPs in TMEM62 are shown (see all 756)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1419610811,2
    --43423893(+) GGGTGC/TGGTAG 1 -- us2k10--------
    rs64930781,2
    C,A--43424122(+) GATCGC/TGCCAC 1 -- us2k14Minor allele frequency- T:0.12NA WA 8
    rs1869527641,2
    --43424181(+) AAAAAA/GAAAAA 1 -- us2k10--------
    rs71730051,2
    C,F,H--43424193(+) aaaaaT/GaaaaT 1 -- us2k1 tfbs34Minor allele frequency- G:0.01NS EA 406
    rs1427303011,2
    --43424335(+) TTTAGA/TCTGTT 1 -- us2k10--------
    rs1917479511,2
    --43424355(+) TAGGAC/TTTTCT 1 -- us2k10--------
    rs604356961,2
    C--43424365(+) TGAGAG/CAGATA 1 -- us2k12Minor allele frequency- C:0.24CSA WA 120
    rs1473537451,2
    C--43424408(+) TCTCCC/TGGGTC 1 -- us2k10--------
    rs1998360431,2
    C--43424693(+) AAAAA-/ACACAT 1 -- us2k10--------
    rs1830881351,2
    --43424965(+) TAAGGG/TAGGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMEM62 (43415477 - 43477344 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TMEM62:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2678276CNV Deletion23128226
    dgv2368n71CNV Loss21882294
    nsv525461CNV Loss19592680
    nsv94791CNV Loss16902084
    nsv515876CNV Gain+Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for TMEM62:    About MalaCards
    congenital dyserythropoietic anemia type i    congenital dyserythropoietic anemia    anemia


    TMEM62 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMEM62

    Export disorders for TMEM62 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM62 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMEM62)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
    4. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    5. Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. (PubMed id 12434312)1 Dgany O.... Tamary H. (2002)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80021 HGNC: 26269 AceView: FLJ23375 Ensembl:ENSG00000137842 euGenes: HUgn80021
    ECgene: TMEM62 H-InvDB: TMEM62

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM62 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM62 gene:
    Search GeneIP for patents involving TMEM62

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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