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Aliases for TMEM62 Gene

Aliases for TMEM62 Gene

  • Transmembrane Protein 62 2 3

External Ids for TMEM62 Gene

Previous GeneCards Identifiers for TMEM62 Gene

  • GC15P041214
  • GC15P043425
  • GC15P020273
  • GC15P043415

Summaries for TMEM62 Gene

GeneCards Summary for TMEM62 Gene

TMEM62 (Transmembrane Protein 62) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM62 Gene

Genomics for TMEM62 Gene

Regulatory Elements for TMEM62 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM62 Gene

43,123,279 bp from pter
43,185,147 bp from pter
61,869 bases
Plus strand

Genomic View for TMEM62 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM62 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM62 Gene

Proteins for TMEM62 Gene

  • Protein details for TMEM62 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 62
    Protein Accession:
    Secondary Accessions:
    • Q6I9Y5
    • Q9H5J6

    Protein attributes for TMEM62 Gene

    643 amino acids
    Molecular mass:
    73133 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15630.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMEM62 Gene

Proteomics data for TMEM62 Gene at MOPED

Post-translational modifications for TMEM62 Gene

  • Glycosylation at Asn 180, Asn 467, and Asn 626
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM62 Gene

Domains & Families for TMEM62 Gene

Protein Domains for TMEM62 Gene

Suggested Antigen Peptide Sequences for TMEM62 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM62: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM62 Gene

Function for TMEM62 Gene

Gene Ontology (GO) - Molecular Function for TMEM62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TMEM62: view

Animal Model Products

miRNA for TMEM62 Gene

miRTarBase miRNAs that target TMEM62

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM62 Gene

Localization for TMEM62 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM62 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM62: view

No data available for Subcellular locations from COMPARTMENTS for TMEM62 Gene

Pathways & Interactions for TMEM62 Gene

SuperPathways for TMEM62 Gene

No Data Available

Interacting Proteins for TMEM62 Gene

Selected Interacting proteins: Q0P6H9-TMM62_HUMAN for TMEM62 Gene via I2D

Gene Ontology (GO) - Biological Process for TMEM62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with TMEM62: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM62 Gene

Drugs & Compounds for TMEM62 Gene

No Compound Related Data Available

Transcripts for TMEM62 Gene

Unigene Clusters for TMEM62 Gene

Transmembrane protein 62:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM62 Gene

No ASD Table

Relevant External Links for TMEM62 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM62 Gene

mRNA expression in normal human tissues for TMEM62 Gene

Protein differential expression in normal tissues from HIPED for TMEM62 Gene

This gene is overexpressed in Islet of Langerhans (47.5) and Retina (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TMEM62 Gene

SOURCE GeneReport for Unigene cluster for TMEM62 Gene Hs.511175

genes like me logo Genes that share expression patterns with TMEM62: view

Protein tissue co-expression partners for TMEM62 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM62 Gene

Orthologs for TMEM62 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM62 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM62 35
  • 88.7 (n)
  • 83.83 (a)
TMEM62 36
  • 84 (a)
(Canis familiaris)
Mammalia TMEM62 35
  • 89.99 (n)
  • 88.18 (a)
TMEM62 36
  • 83 (a)
(Mus musculus)
Mammalia Tmem62 35
  • 85.43 (n)
  • 83.2 (a)
Tmem62 16
Tmem62 36
  • 83 (a)
(Pan troglodytes)
Mammalia TMEM62 35
  • 99.74 (n)
  • 99.84 (a)
TMEM62 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tmem62 35
  • 84.55 (n)
  • 82.74 (a)
(Monodelphis domestica)
Mammalia TMEM62 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM62 36
  • 61 (a)
(Gallus gallus)
Aves TMEM62 35
  • 69.34 (n)
  • 65.59 (a)
TMEM62 36
  • 63 (a)
(Anolis carolinensis)
Reptilia TMEM62 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem62 35
  • 62.67 (n)
  • 60.1 (a)
(Danio rerio)
Actinopterygii Dr.26190 35
tmem62 35
  • 61.51 (n)
  • 60.17 (a)
tmem62 36
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010204 35
  • 47.85 (n)
  • 41.94 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G03305 35
  • 43.94 (n)
  • 30.39 (a)
(Oryza sativa)
Liliopsida Os01g0894000 35
  • 46.73 (n)
  • 35.19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for TMEM62:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM62 Gene

Gene Tree for TMEM62 (if available)
Gene Tree for TMEM62 (if available)

Paralogs for TMEM62 Gene

No data available for Paralogs for TMEM62 Gene

Variants for TMEM62 Gene

Sequence variations from dbSNP and Humsavar for TMEM62 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs476342 -- 43,181,709(-) GCCTG(C/G)CCAAC intron-variant
rs486177 -- 43,177,822(-) tgttc(C/T)ccttc intron-variant
rs574856 -- 43,168,636(+) tccac(A/G)agagg intron-variant
rs1464344 -- 43,135,383(-) GCTCA(C/T)GAGAC intron-variant
rs1464345 -- 43,134,961(-) TGCTT(C/T)AATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM62 Gene

Variant ID Type Subtype PubMed ID
nsv525461 CNV Loss 19592680
nsv515876 CNV Gain+Loss 19592680
dgv2368n71 CNV Loss 21882294
nsv94791 CNV Loss 16902084
esv2678276 CNV Deletion 23128226

Variation tolerance for TMEM62 Gene

Residual Variation Intolerance Score: 55.38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM62 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM62 Gene

Disorders for TMEM62 Gene

Relevant External Links for TMEM62

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMEM62: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM62 Gene

Publications for TMEM62 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PMID: 19159218) Chen R. … Zou H. (J. Proteome Res. 2009) 67
  3. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for TMEM62 Gene

Sources for TMEM62 Gene

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