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TMEM61 Gene

protein-coding   GIFtS: 37
GCID: GC01P055446

Transmembrane Protein 61

  Search for TMEM61
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 611 2

External Ids:    HGNC: 272961   Entrez Gene: 1999642   Ensembl: ENSG000001430017   UniProtKB: Q8N0U23   

Export aliases for TMEM61 gene to outside databases

Previous GC identifers: GC01P055159 GC01P053560


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM61 Gene:
TMEM61 (transmembrane protein 61) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM61 gene promoter:
         Max1   Tal-1   Pax-2   Pax-2a   HNF-4alpha2   LCR-F1   E47   HNF-4alpha1   COMP1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM61 promoter sequence
   Search Chromatin IP Primers for TMEM61

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM61


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

TMEM61 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM61 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P055446:  view genomic region     (about GC identifiers)

Start:
55,446,465 bp from pter      End:
55,457,966 bp from pter
Size:
11,502 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TMM61_HUMAN, Q8N0U2 (See protein sequence)
Recommended Name: Transmembrane protein 61  
Size: 210 amino acids; 22170 Da

Explore the universe of human proteins at neXtProt for TMEM61: NX_Q8N0U2

Explore proteomics data for TMEM61 at MOPED


See TMEM61 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_872338.1  
ENSEMBL proteins: 
 ENSP00000360315  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR028164 TMEM61

Graphical View of Domain Structure for InterPro Entry Q8N0U2

ProtoNet protein and cluster: Q8N0U2


TMEM61 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     3 GenomeRNAi human phenotypes for TMEM61:
 Decreased cell number and incr  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TMM61_HUMAN, Q8N0U2: Membrane; Multi-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane3
extracellular2
cytosol1
nucleus1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

TMEM61 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM61
Interactions:

    Search GeneGlobe Interaction Network for TMEM61

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for TMEM61 (TMM61)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TMEM61 gene: 
NM_182532.1  

Unigene Cluster for TMEM61:

Transmembrane protein 61
Hs.663950  [show with all ESTs]
Unigene Representative Sequence: NM_182532
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000371268(uc001cyd.3)
miRNA
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Inhib. RNA
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Additional mRNA sequence: BC029775.1 

7 DOTS entries:

DT.208874  DT.91928422  DT.40207495  DT.121394983  DT.91971408  DT.95344396  DT.100885762 

Selected AceView cDNA sequences (see all 32):

BU689881 CB177450 BG430102 NM_182532 CB177824 CA776923 BU078780 BC029775 
AW169033 BI764342 AA918832 CK902389 CD250870 CA777206 BU074698 AA999716 
BU074413 CA952563 AI284406 BM129334 AA953219 BU070568 CA952779 AA873561 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TMEM61 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACAGTCAGCG
TMEM61 Expression
About this image

TMEM61 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TMEM61 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.663950
    Custom PCR Arrays for TMEM61
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for TMEM61 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmem611 transmembrane protein 61 66.67(n)
50.53(a)
  329909  XM_006503496.1  XP_006503559.1 
chicken
(Gallus gallus)
Aves TMEM611 transmembrane protein 61 63.33(n)
50.59(a)
  424662  XM_004936835.1  XP_004936892.1 


ENSEMBL Gene Tree for TMEM61 (if available)
TreeFam Gene Tree for TMEM61 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TMEM61 gene

TMEM61 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for TMEM61
PGOHUM00000234605


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TMEM61 (see all 319)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1996928721,2
Cuntested1110023396(+) TGGTCC/TGTCAA 2 S syn11Minor allele frequency- T:0.00EU 1323
rs1472968981,2
C--53558674(+) TCAGGC/TTAAGG 1 -- us2k10--------
rs1857415341,2
--53558739(+) ACAGAC/TAAAGA 1 -- us2k10--------
rs1404497291,2
C--53558963(+) ATTTTA/GACCAG 1 -- us2k10--------
rs20596871,2
C,A,H--53559093(+) GCCAGT/CGGCCT 1 -- us2k17Minor allele frequency- C:0.45NA CSA WA EA 366
rs20596881,2
C,F,O,A,H--53559151(+) GTCTCA/GGCTCT 1 -- us2k121Minor allele frequency- G:0.46MN NS EA NA CSA WA 2528
rs1442836611,2
--53559183(+) TGTGCC/TCTTCT 1 -- us2k10--------
rs729076081,2
C,F--53559213(+) TGGGAC/TATTTC 1 -- us2k11Minor allele frequency- T:0.50WA 2
rs1511530381,2
C--53559269(+) TCTGTC/GACTTG 1 -- us2k10--------
rs20596891,2
C,A--53559314(+) CCTGCT/CGGCCA 1 -- us2k18Minor allele frequency- C:0.45NA CSA WA EA 368

HapMap Linkage Disequilibrium report for TMEM61 (55446465 - 55457966 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for TMEM61:    About this table    
Variant IDTypeSubtypePubMed ID
nsv817614CNV Gain22305530
nsv829915CNV Gain17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TMEM61 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TMEM61)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 199964 HGNC: 27296 AceView: LOC199964 Ensembl:ENSG00000143001 euGenes: HUgn199964
ECgene: TMEM61 H-InvDB: TMEM61

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TMEM61 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TMEM61 gene:
Search GeneIP for patents involving TMEM61

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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