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Aliases for TMEM61 Gene

Aliases for TMEM61 Gene

  • Transmembrane Protein 61 2 3 5

External Ids for TMEM61 Gene

Previous GeneCards Identifiers for TMEM61 Gene

  • GC01P055159
  • GC01P055446
  • GC01P053560

Summaries for TMEM61 Gene

GeneCards Summary for TMEM61 Gene

TMEM61 (Transmembrane Protein 61) is a Protein Coding gene.

Additional gene information for TMEM61 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM61 Gene

Genomics for TMEM61 Gene

Regulatory Elements for TMEM61 Gene

Enhancers for TMEM61 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H054945 1.3 FANTOM5 Ensembl ENCODE 23.5 -35.0 -35007 1 ELF3 CTCF KLF1 IRF2 SAP130 MAX ZNF2 RAD21 POLR2A SCRT2 TMEM61 ENSG00000233271 ENSG00000242396 ENSG00000233203 DHCR24 TTC22 ENSG00000237453 USP24 PIR41856 GC01M054936
GH01H054949 1.2 Ensembl ENCODE 24.6 -29.9 -29851 1 ELF3 HDGF FOXA2 RB1 NFIB ARID4B SIN3A RAD21 RARA YY1 TMEM61 PIR41856 GC01M054958
GH01H054970 1.2 FANTOM5 ENCODE 17.6 -9.2 -9194 1 PKNOX1 BATF SCRT2 ZNF143 ZNF207 ATF7 FOS ETV6 RUNX3 CREM TMEM61 LOC105378736 GC01P054966
GH01H055038 1.5 FANTOM5 Ensembl ENCODE 11.2 +59.4 59404 2 PKNOX1 ATF1 ARID4B DMAP1 BRCA1 YY1 GATA2 ATF7 SP5 ZHX2 TMEM61 PCSK9 GC01P055065
GH01H054972 1 Ensembl ENCODE 16.7 -7.5 -7468 1 CTCF PKNOX1 TFAP4 CEBPG RAD21 ZNF664 POLR2A SMC3 MAFK STAT1 TMEM61 LOC105378736 GC01P054966
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM61 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM61 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000006719 105 601 SUZ12 REST ZFX EZH2

Genomic Location for TMEM61 Gene

Chromosome:
1
Start:
54,980,595 bp from pter
End:
54,992,293 bp from pter
Size:
11,699 bases
Orientation:
Plus strand

Genomic View for TMEM61 Gene

Genes around TMEM61 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM61 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM61 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM61 Gene

Proteins for TMEM61 Gene

  • Protein details for TMEM61 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0U2-TMM61_HUMAN
    Recommended name:
    Transmembrane protein 61
    Protein Accession:
    Q8N0U2

    Protein attributes for TMEM61 Gene

    Size:
    210 amino acids
    Molecular mass:
    22170 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM61 Gene

Post-translational modifications for TMEM61 Gene

No Post-translational modifications

Other Protein References for TMEM61 Gene

No data available for DME Specific Peptides for TMEM61 Gene

Domains & Families for TMEM61 Gene

Gene Families for TMEM61 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM61 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM61 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM61: view

No data available for UniProtKB/Swiss-Prot for TMEM61 Gene

Function for TMEM61 Gene

Phenotypes From GWAS Catalog for TMEM61 Gene

genes like me logo Genes that share phenotypes with TMEM61: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM61
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM61 Gene

Localization for TMEM61 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM61 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM61 gene
Compartment Confidence
plasma membrane 3
extracellular 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM61: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM61 Gene

Pathways & Interactions for TMEM61 Gene

SuperPathways for TMEM61 Gene

No Data Available

Interacting Proteins for TMEM61 Gene

Gene Ontology (GO) - Biological Process for TMEM61 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM61 Gene

Drugs & Compounds for TMEM61 Gene

No Compound Related Data Available

Transcripts for TMEM61 Gene

mRNA/cDNA for TMEM61 Gene

(4) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM61 Gene

Transmembrane protein 61:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM61
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM61 Gene

No ASD Table

Relevant External Links for TMEM61 Gene

GeneLoc Exon Structure for
TMEM61
ECgene alternative splicing isoforms for
TMEM61

Expression for TMEM61 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM61 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM61 Gene

This gene is overexpressed in Pituitary (x13.6) and Kidney - Cortex (x5.9).

NURSA nuclear receptor signaling pathways regulating expression of TMEM61 Gene:

TMEM61

SOURCE GeneReport for Unigene cluster for TMEM61 Gene:

Hs.663950

Evidence on tissue expression from TISSUES for TMEM61 Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with TMEM61: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM61 Gene

Orthologs for TMEM61 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM61 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM61 33 34
  • 97.54 (n)
cow
(Bos Taurus)
Mammalia TMEM61 33 34
  • 79.52 (n)
dog
(Canis familiaris)
Mammalia TMEM61 33 34
  • 76.85 (n)
mouse
(Mus musculus)
Mammalia Tmem61 33 16
  • 66.67 (n)
rat
(Rattus norvegicus)
Mammalia LOC100909776 33
  • 66.67 (n)
chicken
(Gallus gallus)
Aves TMEM61 33 34
  • 63.33 (n)
Species where no ortholog for TMEM61 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM61 Gene

ENSEMBL:
Gene Tree for TMEM61 (if available)
TreeFam:
Gene Tree for TMEM61 (if available)

Paralogs for TMEM61 Gene

Pseudogenes.org Pseudogenes for TMEM61 Gene

genes like me logo Genes that share paralogs with TMEM61: view

No data available for Paralogs for TMEM61 Gene

Variants for TMEM61 Gene

Sequence variations from dbSNP and Humsavar for TMEM61 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000674943 -- 54,981,942(+) TCTCA(G/T)TCTGA intron-variant, upstream-variant-2KB
rs1000766761 -- 54,982,248(+) GAGGT(-/G)GGGGC intron-variant, upstream-variant-2KB
rs1000821385 -- 54,981,271(+) GAACA(A/G)GAACA intron-variant, upstream-variant-2KB
rs1001422617 -- 54,980,135(+) TCTCC(A/G)GGGCC nc-transcript-variant, upstream-variant-2KB
rs1001896181 -- 54,984,403(+) GGGGC(A/C)GGTGA intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM61 Gene

Variant ID Type Subtype PubMed ID
dgv167n100 CNV gain 25217958
nsv817614 CNV gain 22305530
nsv829915 CNV gain 17160897

Variation tolerance for TMEM61 Gene

Residual Variation Intolerance Score: 77.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.76; 57.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM61 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM61

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM61 Gene

Disorders for TMEM61 Gene

Relevant External Links for TMEM61

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM61

No disorders were found for TMEM61 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM61 Gene

Publications for TMEM61 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 60

Products for TMEM61 Gene

Sources for TMEM61 Gene

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