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Aliases for TMEM61 Gene

Aliases for TMEM61 Gene

  • Transmembrane Protein 61 2 3 5

External Ids for TMEM61 Gene

Previous GeneCards Identifiers for TMEM61 Gene

  • GC01P055159
  • GC01P055446
  • GC01P053560

Summaries for TMEM61 Gene

GeneCards Summary for TMEM61 Gene

TMEM61 (Transmembrane Protein 61) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM61 Gene

Genomics for TMEM61 Gene

Regulatory Elements for TMEM61 Gene

Enhancers for TMEM61 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F054945 1.3 FANTOM5 Ensembl ENCODE 23.5 -35.0 -35007 1.2 ELF3 CTCF KLF1 SAP130 MAX ZNF2 RAD21 SCRT2 ZNF143 SMC3 TMEM61 ENSG00000233271 DHCR24 ENSG00000233203 ENSG00000242396 TTC22 ENSG00000237453 USP24 PIR41856 GC01M054936
GH01F054949 1.1 Ensembl ENCODE 24.6 -29.9 -29851 1.6 ELF3 WRNIP1 ARID4B RAD21 RARA YY1 ZNF143 CREM THAP11 ZNF263 TMEM61 PIR41856 GC01M054958
GH01F054970 1.5 FANTOM5 Ensembl ENCODE 17.6 -9.2 -9194 1.6 PKNOX1 WRNIP1 RARA CBX5 SCRT2 ZNF143 ZNF207 ETV6 FOS CREM TMEM61 GC01P054966 LOC105378736
GH01F054965 1.3 FANTOM5 Ensembl ENCODE 15.6 -13.9 -13895 2.6 PKNOX1 USF1 ETV1 ZNF175 NFYB NR2F6 FOS GATAD2A NFYA FOXA3 TMEM61 GC01P054966 LOC105378736
GH01F054972 1.1 Ensembl ENCODE 16.7 -7.5 -7468 1.8 PKNOX1 RAD21 RARA CREM CEBPB NFIL3 SMARCA4 CEBPA STAT3 KDM1A TMEM61 GC01P054966 LOC105378736
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM61 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM61 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001745129 205 801 SUZ12 KDM1A REST

Genomic Location for TMEM61 Gene

Chromosome:
1
Start:
54,980,595 bp from pter
End:
54,992,293 bp from pter
Size:
11,699 bases
Orientation:
Plus strand

Genomic View for TMEM61 Gene

Genes around TMEM61 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM61 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM61 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM61 Gene

Proteins for TMEM61 Gene

  • Protein details for TMEM61 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0U2-TMM61_HUMAN
    Recommended name:
    Transmembrane protein 61
    Protein Accession:
    Q8N0U2

    Protein attributes for TMEM61 Gene

    Size:
    210 amino acids
    Molecular mass:
    22170 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM61 Gene

Post-translational modifications for TMEM61 Gene

No Post-translational modifications

Other Protein References for TMEM61 Gene

No data available for DME Specific Peptides for TMEM61 Gene

Domains & Families for TMEM61 Gene

Protein Domains for TMEM61 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM61 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM61: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM61 Gene

Function for TMEM61 Gene

genes like me logo Genes that share phenotypes with TMEM61: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM61 Gene

Localization for TMEM61 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM61 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM61 gene
Compartment Confidence
plasma membrane 3
extracellular 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM61: view

Pathways & Interactions for TMEM61 Gene

SuperPathways for TMEM61 Gene

No Data Available

Interacting Proteins for TMEM61 Gene

Gene Ontology (GO) - Biological Process for TMEM61 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM61 Gene

Transcripts for TMEM61 Gene

mRNA/cDNA for TMEM61 Gene

(4) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM61 Gene

Transmembrane protein 61:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM61 Gene

No ASD Table

Relevant External Links for TMEM61 Gene

GeneLoc Exon Structure for
TMEM61
ECgene alternative splicing isoforms for
TMEM61

Expression for TMEM61 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM61 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM61 Gene

This gene is overexpressed in Pituitary (x13.6) and Kidney - Cortex (x5.9).

NURSA nuclear receptor signaling pathways regulating expression of TMEM61 Gene:

TMEM61

SOURCE GeneReport for Unigene cluster for TMEM61 Gene:

Hs.663950
genes like me logo Genes that share expression patterns with TMEM61: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TMEM61 Gene

Orthologs for TMEM61 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM61 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM61 34 35
  • 97.54 (n)
cow
(Bos Taurus)
Mammalia TMEM61 34 35
  • 79.52 (n)
dog
(Canis familiaris)
Mammalia TMEM61 34 35
  • 76.85 (n)
mouse
(Mus musculus)
Mammalia Tmem61 34 16
  • 66.67 (n)
rat
(Rattus norvegicus)
Mammalia LOC100909776 34
  • 66.67 (n)
chicken
(Gallus gallus)
Aves TMEM61 34 35
  • 63.33 (n)
Species where no ortholog for TMEM61 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM61 Gene

ENSEMBL:
Gene Tree for TMEM61 (if available)
TreeFam:
Gene Tree for TMEM61 (if available)

Paralogs for TMEM61 Gene

Pseudogenes.org Pseudogenes for TMEM61 Gene

genes like me logo Genes that share paralogs with TMEM61: view

No data available for Paralogs for TMEM61 Gene

Variants for TMEM61 Gene

Sequence variations from dbSNP and Humsavar for TMEM61 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1006756 -- 54,990,164(+) TTCCT(C/G)GGCTG intron-variant
rs10157431 -- 54,992,667(+) cctca(C/G)cctcc downstream-variant-500B
rs1015979 -- 54,983,600(+) ttcac(C/T)ttttt intron-variant, utr-variant-5-prime
rs1015980 -- 54,983,644(+) TTCAT(A/C)TGGCC intron-variant, utr-variant-5-prime
rs1025239 -- 54,982,741(+) AAATA(C/T)TGATA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM61 Gene

Variant ID Type Subtype PubMed ID
nsv829915 CNV gain 17160897
nsv817614 CNV gain 22305530
dgv167n100 CNV gain 25217958

Variation tolerance for TMEM61 Gene

Residual Variation Intolerance Score: 77.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.76; 57.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM61 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM61

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM61 Gene

Disorders for TMEM61 Gene

Relevant External Links for TMEM61

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM61

No disorders were found for TMEM61 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM61 Gene

Publications for TMEM61 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64

Products for TMEM61 Gene

Sources for TMEM61 Gene

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