Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM60 Gene

Aliases for TMEM60 Gene

  • Transmembrane Protein 60 2 3 5
  • C7orf35 3 4
  • Chromosome 7 Open Reading Frame 35 2
  • DC32 3

External Ids for TMEM60 Gene

Previous HGNC Symbols for TMEM60 Gene

  • C7orf35

Previous GeneCards Identifiers for TMEM60 Gene

  • GC07M077068
  • GC07M077260
  • GC07M077423
  • GC07M072026

Summaries for TMEM60 Gene

GeneCards Summary for TMEM60 Gene

TMEM60 (Transmembrane Protein 60) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM60 Gene

Genomics for TMEM60 Gene

Regulatory Elements for TMEM60 Gene

Enhancers for TMEM60 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G077695 1.1 ENCODE 21.2 +101.0 100987 4.4 HDGF PKNOX1 FOXA2 MLX ARNT AGO1 ZFP64 WRNIP1 ARID4B SIN3A APTR PMS2P9 TMEM60 DTX2P1 FAM185BP SPDYE18 PHTF2 PTPN12
GH07G077833 1.2 Ensembl ENCODE 11.8 -36.0 -35953 2.2 HDGF PKNOX1 FOXA2 ATF1 CREB3L1 ARNT ZNF766 ELK1 GATA2 FOS PTPN12 TMEM60 PHTF2 APTR GC07P077851
GH07G077759 1 Ensembl ENCODE 11.7 +39.0 38988 0.8 CTCF ARID4B CEBPG CHD7 RAD21 RFX5 ARID3A ZNF316 FOXK2 ZNF143 APTR RSBN1L TMEM60 PHTF2
GH07G077823 0.9 Ensembl ENCODE 12.9 -25.6 -25590 1.5 BCOR ZMYM3 ATF2 RAD21 FOXA1 NR2F2 CBX8 JUND CBX5 ZBTB33 APTR TMEM60 PHTF2 PTPN12 GC07P077851
GH07G077866 1 Ensembl ENCODE 11.3 -68.6 -68632 2.1 FOXA2 ZNF792 JUN CEBPG ZNF316 ZNF366 FOS MAFK HOMEZ MIXL1 APTR PTPN12 PHTF2 TMEM60 GC07P077851 GC07P077896
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM60 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM60 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000214094 -120 3001 PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for TMEM60 Gene

Chromosome:
7
Start:
77,793,728 bp from pter
End:
77,798,580 bp from pter
Size:
4,853 bases
Orientation:
Minus strand

Genomic View for TMEM60 Gene

Genes around TMEM60 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM60 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM60 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM60 Gene

Proteins for TMEM60 Gene

  • Protein details for TMEM60 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2L4-TMM60_HUMAN
    Recommended name:
    Transmembrane protein 60
    Protein Accession:
    Q9H2L4
    Secondary Accessions:
    • A4D1C3
    • Q86UM0

    Protein attributes for TMEM60 Gene

    Size:
    133 amino acids
    Molecular mass:
    15500 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH65930.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMEM60 Gene

Post-translational modifications for TMEM60 Gene

No Post-translational modifications

Other Protein References for TMEM60 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM60 Gene

Domains & Families for TMEM60 Gene

Protein Domains for TMEM60 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM60 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM60: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM60 Gene

Function for TMEM60 Gene

genes like me logo Genes that share phenotypes with TMEM60: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM60

miRNA for TMEM60 Gene

miRTarBase miRNAs that target TMEM60

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM60 Gene

Localization for TMEM60 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM60 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM60 gene
Compartment Confidence
plasma membrane 2
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM60: view

Pathways & Interactions for TMEM60 Gene

SuperPathways for TMEM60 Gene

No Data Available

Interacting Proteins for TMEM60 Gene

Selected Interacting proteins: Q9H2L4-TMM60_HUMAN for TMEM60 Gene via IID

Symbol External ID(s) Details
SSTR5

Gene Ontology (GO) - Biological Process for TMEM60 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM60 Gene

Drugs & Compounds for TMEM60 Gene

No Compound Related Data Available

Transcripts for TMEM60 Gene

mRNA/cDNA for TMEM60 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(121) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM60 Gene

Transmembrane protein 60:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM60 Gene

No ASD Table

Relevant External Links for TMEM60 Gene

GeneLoc Exon Structure for
TMEM60
ECgene alternative splicing isoforms for
TMEM60

Expression for TMEM60 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM60 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM60 Gene:

TMEM60

SOURCE GeneReport for Unigene cluster for TMEM60 Gene:

Hs.19025

Evidence on tissue expression from TISSUES for TMEM60 Gene

  • Lymph node(4.2)
  • Spleen(4.2)
  • Blood(4)
  • Eye(4)
genes like me logo Genes that share expression patterns with TMEM60: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM60 Gene

Orthologs for TMEM60 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM60 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM60 34 35
  • 99.75 (n)
cow
(Bos Taurus)
Mammalia TMEM60 35 35
  • 98 (a)
OneToMany
LOC100295750 34
  • 96.74 (n)
dog
(Canis familiaris)
Mammalia TMEM60 34 35
  • 96.49 (n)
mouse
(Mus musculus)
Mammalia Tmem60 34 16 35
  • 94.74 (n)
rat
(Rattus norvegicus)
Mammalia Tmem60 34
  • 92.48 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM60 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM60 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM60 34 35
  • 81.82 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM60 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem60 34
  • 76.77 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:91811 34
  • 67.17 (n)
Species where no ortholog for TMEM60 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM60 Gene

ENSEMBL:
Gene Tree for TMEM60 (if available)
TreeFam:
Gene Tree for TMEM60 (if available)

Paralogs for TMEM60 Gene

No data available for Paralogs for TMEM60 Gene

Variants for TMEM60 Gene

Sequence variations from dbSNP and Humsavar for TMEM60 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000437122 -- 77,797,066(+) CCCGG(A/C)CAGAG intron-variant, upstream-variant-2KB
rs1001528735 -- 77,793,445(+) TCAAG(C/T)GATTC downstream-variant-500B
rs1002109094 -- 77,798,689(+) AGTTT(C/T)CGTGC upstream-variant-2KB
rs1002131340 -- 77,795,473(+) TTGCA(C/T)ACTGC intron-variant
rs1002526919 -- 77,795,093(+) AGGCC(A/G)CAGTG intron-variant

Variation tolerance for TMEM60 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM60 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM60

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM60 Gene

Disorders for TMEM60 Gene

Relevant External Links for TMEM60

Genetic Association Database (GAD)
TMEM60
Human Genome Epidemiology (HuGE) Navigator
TMEM60
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM60

No disorders were found for TMEM60 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM60 Gene

Publications for TMEM60 Gene

  1. New loci associated with kidney function and chronic kidney disease. (PMID: 20383146) KAPttgen A. … Fox C.S. (Nat. Genet. 2010) 3 46 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64

Products for TMEM60 Gene

Sources for TMEM60 Gene

Content
Loading form....