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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM60 Gene

protein-coding   GIFtS: 38
GCID: GC07M077423

Transmembrane Protein 60

(Previous name: chromosome 7 open reading frame 35)
(Previous symbol: C7orf35)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 601 2
C7orf351 2 3
Chromosome 7 Open Reading Frame 351

External Ids:    HGNC: 217541   Entrez Gene: 850252   Ensembl: ENSG000001352117   UniProtKB: Q9H2L43   

Export aliases for TMEM60 gene to outside databases

Previous GC identifers: GC07M077068 GC07M077260 GC07M072026


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM60 Gene: 
TMEM60 (transmembrane protein 60) is a protein-coding gene. Diseases associated with TMEM60 include kidney disease.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM60 gene promoter:
         p300   Nkx2-5   STAT5A   E47   Evi-1   GATA-2   c-Ets-1   C/EBPalpha   MZF-1   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM60 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM60

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM60


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.23

TMEM60 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM60 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M077423:  view genomic region     (about GC identifiers)

Start:
77,423,045 bp from pter      End:
77,427,897 bp from pter
Size:
4,853 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 76,756,108-76,760,810     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TMM60_HUMAN, Q9H2L4 (See protein sequence)
Recommended Name: Transmembrane protein 60  
Size: 133 amino acids; 15500 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAH65930.1; Type=Erroneous initiation;
Secondary accessions: A4D1C3 Q86UM0

Explore the universe of human proteins at neXtProt for TMEM60: NX_Q9H2L4

Explore proteomics data for TMEM60 at MOPED 

TMEM60 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TMEM60 Protein Expression

REFSEQ proteins: NP_116325.1  
ENSEMBL proteins: 
 ENSP00000257663  

Human Recombinant Protein Products for TMEM60: 
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Cloud-Clone Corp. Proteins for TMEM60 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

TMEM60 for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for TMEM60


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR019396 TM_Fragile-X-F-assoc

Graphical View of Domain Structure for InterPro Entry Q9H2L4

ProtoNet protein and cluster: Q9H2L4


TMEM60 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM60 
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SwitchGear 3'UTR luciferase reporter plasmidTMEM60 3' UTR sequence
Inhib. RNA
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM60

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM60 (TMM60)

Search CenterWatch for drugs/clinical trials and news about TMEM60 / TMM60

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMEM60 gene: 
NM_032936.3  

Unigene Cluster for TMEM60:

Transmembrane protein 60
Hs.19025  [show with all ESTs]
Unigene Representative Sequence: BQ052532
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000257663(uc003ugn.3)
miRNA
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SwitchGear 3'UTR luciferase reporter plasmidTMEM60 3' UTR sequence
Inhib. RNA
Products:
     
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                     Customized lentivirus expression plasmids for stable overexpression of TMEM60 
Primer
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM60

Additional mRNA sequence: 

AF260336.1 BC012192.1 BC065930.1 

3 DOTS entries:

DT.215920  DT.75127600  DT.95345670 

24/121 AceView cDNA sequences (see all 121):

AI338983 H95154 AA890666 AI769624 BM993224 BM668659 AW964440 AI224359 
CB164237 AI310417 BC065930 BI762722 CB143380 BX117806 AI248752 BM852420 
AA574086 AA831043 AI081638 CR614492 BX114739 AI079679 BM737724 CB178795 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM60 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AATCTATCCT
TMEM60 Expression
About this image


See TMEM60 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM60

SOURCE GeneReport for Unigene cluster: Hs.19025
    SABiosciences Custom PCR Arrays for TMEM60
Primer
Products:
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM60
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM60

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TMEM60 gene from 5/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmem601 , 5 transmembrane protein 601, 5 94.74(n)1
99.25(a)1
  5 (9.83 cM)5
2120901  NM_177601.31  NP_808269.11 
 208821915 
chicken
(Gallus gallus)
Aves TMEM601 transmembrane protein 60 81.82(n)
90.15(a)
  417727  NM_001199477.1  NP_001186406.1 
lizard
(Anolis carolinensis)
Reptilia TMEM606
Uncharacterized protein
84(a)
1 ↔ 1
5(94842020-94842406)
zebrafish
(Danio rerio)
Actinopterygii zgc:918111 zgc:91811 66.67(n)
71.97(a)
  445087  NM_001003481.1  NP_001003481.1 
fruit fly
(Drosophila melanogaster)
Insecta CG139196
--
30(a)
1 ↔ 1
3L(1645467-1645983)


ENSEMBL Gene Tree for TMEM60 (if available)
TreeFam Gene Tree for TMEM60 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/73 SNPs in TMEM60 are shown (see all 73)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1855606571,2
--77422568(+) TTTCAC/GGTTTT 1 -- int10--------
rs69736561,2
C,F,A,H--77422583(+) CCTTCA/GTAATT 1 -- int120Minor allele frequency- G:0.40NS EA NA WA CSA 2345
rs1892375361,2
--77422603(+) AAATGA/GCCATT 1 -- int10--------
rs1157560601,2
C,F--77422666(+) GGTTTT/GGTTTT 1 -- int11Minor allele frequency- G:0.04WA 118
rs1435549281,2
--77422683(+) GAGACA/GGAGTC 1 -- int10--------
rs1467913751,2
--77422827(+) GCTAAG/TTTTTG 1 -- int10--------
rs10454631,2
C,F,H--77423152(-) AAACAG/AGATTG 1 -- ut31 ese323Minor allele frequency- A:0.20MN NA NS EA WA 2662
rs1406957051,2
C,F--77423414(+) GAGTGC/TGAGGC 2 T A mis11Minor allele frequency- T:0.00NA 4550
rs2016687541,2
C--77423417(+) TGCGAG/AGCAGA 2 /L /F mis11Minor allele frequency- A:0.00EU 1323
rs1472341341,2
C,F--77423450(+) AATGAG/AGTACC 2 /L /F mis12Minor allele frequency- A:0.00NA EU 5873

HapMap Linkage Disequilibrium report for TMEM60 (77423045 - 77427897 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for TMEM60: --
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing TMEM60
DNA2.0 Custom Variant and Variant Library Synthesis for TMEM60

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for TMEM60:    About MalaCards
kidney disease    


TMEM60 for disorders           About GeneDecksing

Genetic Association Database (GAD): TMEM60
Human Genome Epidemiology (HuGE) Navigator: TMEM60 (1 document)

Export disorders for TMEM60 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TMEM60 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM60)
    Utopia: connect your pdf to the dynamic
world of online information

  1. New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1, 4 KAPttgen A....Fox C.S. (2010)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
  4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  6. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 85025 HGNC: 21754 AceView: C7orf35 Ensembl:ENSG00000135211 euGenes: HUgn85025
ECgene: TMEM60 H-InvDB: TMEM60

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TMEM60 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TMEM60 gene:
Search GeneIP for patents involving TMEM60

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 SwitchGear 3'UTR luciferase reporter plasmids for TMEM60
 SwitchGear Promoter luciferase reporter plasmids for TMEM60
 Search ThermoFisher Antibodies for TMEM60
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM60
 inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM60
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMEM60
Customized:
 lentivirus for stable overexpression of TMEM60
 lentivirus expression plasmids for stable overexpression of TMEM60
 adenovirus for overexpression of TMEM60
 Search LSBio for Antibodies for TMEM60
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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