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TMEM60 Gene

protein-coding   GIFtS: 38
GCID: GC07M077423

Transmembrane Protein 60

(Previous name: chromosome 7 open reading frame 35)
(Previous symbol: C7orf35)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 601 2
C7orf351 2 3
Chromosome 7 Open Reading Frame 351

External Ids:    HGNC: 217541   Entrez Gene: 850252   Ensembl: ENSG000001352117   UniProtKB: Q9H2L43   

Export aliases for TMEM60 gene to outside databases

Previous GC identifers: GC07M077068 GC07M077260 GC07M072026


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM60 Gene:
TMEM60 (transmembrane protein 60) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM60 gene promoter:
         p300   Nkx2-5   STAT5A   E47   Evi-1   GATA-2   c-Ets-1   C/EBPalpha   MZF-1   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM60 promoter sequence
   Search Chromatin IP Primers for TMEM60

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM60


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.23

TMEM60 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM60 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M077423:  view genomic region     (about GC identifiers)

Start:
77,423,045 bp from pter      End:
77,427,897 bp from pter
Size:
4,853 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 76,756,108-76,760,810     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TMM60_HUMAN, Q9H2L4 (See protein sequence)
Recommended Name: Transmembrane protein 60  
Size: 133 amino acids; 15500 Da
Sequence caution: Sequence=AAH65930.1; Type=Erroneous initiation;
Secondary accessions: A4D1C3 Q86UM0

Explore the universe of human proteins at neXtProt for TMEM60: NX_Q9H2L4

Explore proteomics data for TMEM60 at MOPED


See TMEM60 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_116325.1  
ENSEMBL proteins: 
 ENSP00000257663  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR019396 TM_Fragile-X-F-assoc

Graphical View of Domain Structure for InterPro Entry Q9H2L4

ProtoNet protein and cluster: Q9H2L4


Find genes that share domains with TMEM60           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for TMEM60

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TMM60_HUMAN, Q9H2L4: Membrane; Multi-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular2
plasma membrane2
endoplasmic reticulum1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with TMEM60           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM60
Interactions:

    Search GeneGlobe Interaction Network for TMEM60

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TMEM60 (TMM60)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TMEM60 gene: 
NM_032936.3  

Unigene Cluster for TMEM60:

Transmembrane protein 60
Hs.19025  [show with all ESTs]
Unigene Representative Sequence: BQ052532
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000257663(uc003ugn.3)
miRNA
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Inhib. RNA
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  QuantiFast Probe-based Assays in human, mouse, rat TMEM60

Additional mRNA sequence: 

AF260336.1 BC012192.1 BC065930.1 

3 DOTS entries:

DT.215920  DT.75127600  DT.95345670 

Selected AceView cDNA sequences (see all 121):

CB143380 AW964440 BI762722 AI079679 AI248752 AI769624 AA831043 H95154 
BM852420 AI224359 CB164237 BM668659 AA574086 CR614492 AA890666 BX117806 
BX114739 AI081638 AI310417 BC065930 BM993224 AI338983 BU626030 BM693385 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TMEM60 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AATCTATCCT
TMEM60 Expression
About this image

TMEM60 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TMEM60 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.19025
    Custom PCR Arrays for TMEM60
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM60

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for TMEM60 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmem601 , 5 transmembrane protein 601, 5 94.74(n)1
99.25(a)1
  5 (9.83 cM)5
2120901  NM_177601.31  NP_808269.11 
 208821915 
chicken
(Gallus gallus)
Aves TMEM601 transmembrane protein 60 81.82(n)
90.15(a)
  417727  NM_001199477.1  NP_001186406.1 
lizard
(Anolis carolinensis)
Reptilia TMEM606
transmembrane protein 60
84(a)
1 ↔ 1
5(94842020-94842406)
tropical clawed frog
(Xenopus tropicalis)
Amphibia tmem601 transmembrane protein 60 76.77(n)
83.33(a)
  100144982  NM_001126548.1  NP_001120020.1 
zebrafish
(Danio rerio)
Actinopterygii zgc:918111 zgc:91811 67.17(n)
72.93(a)
  445087  NM_001003481.1  NP_001003481.1 


ENSEMBL Gene Tree for TMEM60 (if available)
TreeFam Gene Tree for TMEM60 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TMEM60 (see all 73)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1855606571,2
--77422568(+) TTTCAC/GGTTTT 1 -- int10--------
rs69736561,2
C,F,A,H--77422583(+) CCTTCA/GTAATT 1 -- int120Minor allele frequency- G:0.40NS EA NA WA CSA 2345
rs1892375361,2
--77422603(+) AAATGA/GCCATT 1 -- int10--------
rs1157560601,2
C,F--77422666(+) GGTTTT/GGTTTT 1 -- int11Minor allele frequency- G:0.04WA 118
rs1435549281,2
--77422683(+) GAGACA/GGAGTC 1 -- int10--------
rs1467913751,2
--77422827(+) GCTAAG/TTTTTG 1 -- int10--------
rs10454631,2
C,F,H--77423152(-) AAACAG/AGATTG 1 -- ut31 ese323Minor allele frequency- A:0.20MN NA NS EA WA 2662
rs1406957051,2
C,F--77423414(+) GAGTGC/TGAGGC 2 T A mis11Minor allele frequency- T:0.00NA 4550
rs2016687541,2
C--77423417(+) TGCGAG/AGCAGA 2 /L /F mis11Minor allele frequency- A:0.00EU 1323
rs1472341341,2
C,F--77423450(+) AATGAG/AGTACC 2 /L /F mis12Minor allele frequency- A:0.00NA EU 5873

HapMap Linkage Disequilibrium report for TMEM60 (77423045 - 77427897 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for TMEM60: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TMEM60
DNA2.0 Custom Variant and Variant Library Synthesis for TMEM60

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with TMEM60           About GenesLikeMe

Genetic Association Database (GAD): TMEM60
Human Genome Epidemiology (HuGE) Navigator: TMEM60 (1 document)

Export disorders for TMEM60 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TMEM60 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TMEM60)
    Utopia: connect your pdf to the dynamic
world of online information

  1. New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1, 4 KAPttgen A....Fox C.S. (Nat. Genet. 2010)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
  4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 85025 HGNC: 21754 AceView: C7orf35 Ensembl:ENSG00000135211 euGenes: HUgn85025
ECgene: TMEM60 H-InvDB: TMEM60

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TMEM60 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TMEM60 gene:
Search GeneIP for patents involving TMEM60

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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 antibodies-online kits for TMEM60 (4 products)
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 antibodies-online proteins for TMEM60
       
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