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Aliases for TMEM59L Gene

Aliases for TMEM59L Gene

  • Transmembrane Protein 59 Like 2 3 5
  • Brain-Specific Membrane-Anchored Protein 3 4
  • C19orf4 3 4
  • BSMAP 3 4
  • Chromosome 19 Open Reading Frame 4 2
  • Transmembrane Protein 59-Like 3

External Ids for TMEM59L Gene

Previous HGNC Symbols for TMEM59L Gene

  • C19orf4

Previous GeneCards Identifiers for TMEM59L Gene

  • GC19P018585
  • GC19P018723
  • GC19P018286
  • GC19P018725

Summaries for TMEM59L Gene

Entrez Gene Summary for TMEM59L Gene

  • This gene encodes a predicted type-I membrane glycoprotein. The encoded protein may play a role in functioning of the central nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMEM59L Gene

TMEM59L (Transmembrane Protein 59 Like) is a Protein Coding gene. An important paralog of this gene is TMEM59.

UniProtKB/Swiss-Prot for TMEM59L Gene

  • Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM59L Gene

Genomics for TMEM59L Gene

Regulatory Elements for TMEM59L Gene

Enhancers for TMEM59L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F018893 1.3 FANTOM5 ENCODE 8.4 +287.1 287057 2.6 ARID4B ZNF48 RAD21 GLIS2 ZNF143 CREM DEK EGR2 THAP11 ZBTB2 GDF1 TMEM59L CRTC1 HAPLN4 HOMER3 NCAN SUGP2 KLHL26 SLC25A42 ENSG00000269694
GH19F018761 1.5 FANTOM5 Ensembl ENCODE 6.1 +156.1 156121 4.1 PKNOX1 SIN3A FEZF1 RAD21 ZNF121 GATA2 FOS CREM EGR2 ZNF680 GMIP LPAR2 COMP CRLF1 TMEM59L HAPLN4 KXD1 GC19P019206 GC19M018784
GH19F018611 1.2 FANTOM5 ENCODE 3.4 +4.2 4169 0.7 THRB ZNF48 RARA GLIS2 EGR1 EGR2 HMG20B SP3 SP5 PPARG TMEM59L GDF1 CRTC1 RAB3A PDE4C GC19P019197 RN7SL155P
GH19F018671 0.8 Ensembl ENCODE 4.4 +65.2 65158 1.5 CTCF POLR2A REST RAD21 C19orf60 CRTC1 SNORA68 TMEM59L KLHL26
GH19F018725 0.5 ENCODE 4.6 +118.6 118628 0.8 PKNOX1 SMARCA4 ATF2 CRLF1 TMEM59L GC19M018715 PIR61287
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM59L on UCSC Golden Path with GeneCards custom track

Promoters for TMEM59L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001647223 -1030 2001 ZNF48 ZNF2 GLIS2 ZNF366 EGR2 SP3 KLF16 HNF4A ZBTB33 ZBTB26

Genomic Location for TMEM59L Gene

18,607,430 bp from pter
18,621,039 bp from pter
13,610 bases
Plus strand

Genomic View for TMEM59L Gene

Genes around TMEM59L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM59L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM59L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM59L Gene

Proteins for TMEM59L Gene

  • Protein details for TMEM59L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 59-like
    Protein Accession:

    Protein attributes for TMEM59L Gene

    342 amino acids
    Molecular mass:
    37619 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM59L Gene

Post-translational modifications for TMEM59L Gene

  • Glycosylation at Asn 97
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM59L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM59L Gene

Domains & Families for TMEM59L Gene

Protein Domains for TMEM59L Gene


Suggested Antigen Peptide Sequences for TMEM59L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM59 family.
  • Belongs to the TMEM59 family.
genes like me logo Genes that share domains with TMEM59L: view

No data available for Gene Families for TMEM59L Gene

Function for TMEM59L Gene

Molecular function for TMEM59L Gene

UniProtKB/Swiss-Prot Function:
Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.
genes like me logo Genes that share phenotypes with TMEM59L: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM59L Gene

Localization for TMEM59L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM59L Gene

Golgi apparatus membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM59L gene
Compartment Confidence
golgi apparatus 4
plasma membrane 2
extracellular 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TMEM59L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane TAS 10527841
GO:0016021 integral component of membrane IEA,TAS --
genes like me logo Genes that share ontologies with TMEM59L: view

Pathways & Interactions for TMEM59L Gene

SuperPathways for TMEM59L Gene

No Data Available

Interacting Proteins for TMEM59L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9UK28-TM59L_HUMAN ENSP00000262817 for TMEM59L Gene via IID STRING

Gene Ontology (GO) - Biological Process for TMEM59L Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM59L Gene

Transcripts for TMEM59L Gene

Unigene Clusters for TMEM59L Gene

Transmembrane protein 59-like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM59L Gene

No ASD Table

Relevant External Links for TMEM59L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM59L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM59L Gene

mRNA differential expression in normal tissues according to GTEx for TMEM59L Gene

This gene is overexpressed in Brain - Cortex (x6.7), Brain - Frontal Cortex (BA9) (x5.5), Brain - Anterior cingulate cortex (BA24) (x5.2), Brain - Hypothalamus (x4.4), Brain - Hippocampus (x4.4), and Brain - Cerebellum (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of TMEM59L Gene:


SOURCE GeneReport for Unigene cluster for TMEM59L Gene:


mRNA Expression by UniProt/SwissProt for TMEM59L Gene:

Tissue specificity: Expressed preferentially at high level in the brain.
genes like me logo Genes that share expression patterns with TMEM59L: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TMEM59L Gene

Orthologs for TMEM59L Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM59L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM59L 34 35
  • 99.04 (n)
(Canis familiaris)
Mammalia TMEM59L 34 35
  • 88.11 (n)
(Bos Taurus)
Mammalia TMEM59L 34 35
  • 86.88 (n)
(Mus musculus)
Mammalia Tmem59l 34 16 35
  • 77.96 (n)
(Rattus norvegicus)
Mammalia Tmem59l 34
  • 77.21 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM59L 35
  • 49 (a)
(Monodelphis domestica)
Mammalia TMEM59L 35
  • 43 (a)
(Gallus gallus)
Aves TMEM59L 35
  • 40 (a)
(Anolis carolinensis)
Reptilia TMEM59L 35
  • 79 (a)
(Danio rerio)
Actinopterygii tmem59l 35
  • 38 (a)
wufi68e12 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3043 35
  • 18 (a)
Species where no ortholog for TMEM59L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM59L Gene

Gene Tree for TMEM59L (if available)
Gene Tree for TMEM59L (if available)

Paralogs for TMEM59L Gene

Paralogs for TMEM59L Gene

(1) SIMAP similar genes for TMEM59L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMEM59L: view

Variants for TMEM59L Gene

Sequence variations from dbSNP and Humsavar for TMEM59L Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1043183 -- 18,620,574(+) GGGGC(C/T)CCTCG utr-variant-3-prime
rs1043190 -- 18,620,787(+) GTCTT(C/T)TATTG utr-variant-3-prime
rs1043192 -- 18,620,848(+) CTTCT(A/C)TGTCC utr-variant-3-prime
rs1043199 -- 18,620,947(+) AGCTT(C/T)TGAGA utr-variant-3-prime
rs10580494 -- 18,618,647(+) TATAC(-/GTGT)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM59L Gene

Variant ID Type Subtype PubMed ID
nsv833776 CNV loss 17160897
nsv952422 CNV deletion 24416366

Variation tolerance for TMEM59L Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM59L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM59L Gene

Disorders for TMEM59L Gene

Relevant External Links for TMEM59L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM59L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM59L Gene

Publications for TMEM59L Gene

  1. BSMAP, a novel protein expressed specifically in the brain whose gene is localized on chromosome 19p12. (PMID: 10527841) Elson G.C.A. … Gauchat J.-F. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein. (PMID: 20427278) Ullrich S. … Lichtenthaler S.F. (J. Biol. Chem. 2010) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TMEM59L Gene

Sources for TMEM59L Gene

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