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Aliases for TMEM59L Gene

Aliases for TMEM59L Gene

  • Brain-Specific Membrane-Anchored Protein 3 4
  • Transmembrane Protein 59-Like 2 3
  • C19orf4 3 4
  • BSMAP 3 4
  • Chromosome 19 Open Reading Frame 4 2

External Ids for TMEM59L Gene

Previous HGNC Symbols for TMEM59L Gene

  • C19orf4

Previous GeneCards Identifiers for TMEM59L Gene

  • GC19P018585
  • GC19P018723
  • GC19P018286
  • GC19P018725

Summaries for TMEM59L Gene

Entrez Gene Summary for TMEM59L Gene

  • This gene encodes a predicted type-I membrane glycoprotein. The encoded protein may play a role in functioning of the central nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMEM59L Gene

TMEM59L is a Protein Coding gene. An important paralog of this gene is TMEM59.

UniProtKB/Swiss-Prot for TMEM59L Gene

  • Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM59L Gene

Genomics for TMEM59L Gene

Regulatory Elements for TMEM59L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM59L Gene

18,607,430 bp from pter
18,621,039 bp from pter
13,610 bases
Plus strand

Genomic View for TMEM59L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM59L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM59L Gene

Proteins for TMEM59L Gene

  • Protein details for TMEM59L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 59-like
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TMEM59L Gene

    342 amino acids
    Molecular mass:
    37619 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM59L Gene

Proteomics data for TMEM59L Gene at MOPED

Post-translational modifications for TMEM59L Gene

  • Glycosylation at Asn97
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM59L Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TMEM59L Gene

Domains for TMEM59L Gene

Protein Domains for TMEM59L Gene


Suggested Antigen Peptide Sequences for TMEM59L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM59 family.
  • Belongs to the TMEM59 family.
genes like me logo Genes that share domains with TMEM59L: view

No data available for Gene Families for TMEM59L Gene

Function for TMEM59L Gene

Molecular function for TMEM59L Gene

UniProtKB/Swiss-Prot Function:
Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.
genes like me logo Genes that share phenotypes with TMEM59L: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM59L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM59L Gene

Localization for TMEM59L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM59L Gene

Golgi apparatus membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM59L Gene COMPARTMENTS Subcellular localization image for TMEM59L gene
Compartment Confidence
golgi apparatus 5
extracellular 2
plasma membrane 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TMEM59L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus --
GO:0016020 membrane TAS 10527841
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM59L: view

Pathways for TMEM59L Gene

SuperPathways for TMEM59L Gene

No Data Available

Interacting Proteins for TMEM59L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000262817 for TMEM59L Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TMEM59L Gene


No data available for Pathways by source for TMEM59L Gene

Transcripts for TMEM59L Gene

Unigene Clusters for TMEM59L Gene

Transmembrane protein 59-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM59L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM59L Gene

No ASD Table

Relevant External Links for TMEM59L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM59L Gene

mRNA expression in normal human tissues for TMEM59L Gene

mRNA differential expression in normal tissues according to GTEx for TMEM59L Gene

This gene is overexpressed in Brain - Cortex (6.7), Brain - Frontal Cortex (BA9) (5.5), Brain - Anterior cingulate cortex (BA24) (5.2), Brain - Hypothalamus (4.4), Brain - Hippocampus (4.4), and Brain - Cerebellum (4.3).

SOURCE GeneReport for Unigene cluster for TMEM59L Gene Hs.329850

mRNA Expression by UniProt/SwissProt for TMEM59L Gene

Tissue specificity: Expressed preferentially at high level in the brain
genes like me logo Genes that share expressions with TMEM59L: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for TMEM59L Gene

Orthologs for TMEM59L Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM59L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM59L 35
  • 86.88 (n)
  • 88.89 (a)
TMEM59L 36
  • 83 (a)
(Canis familiaris)
Mammalia TMEM59L 35
  • 88.11 (n)
  • 92.04 (a)
TMEM59L 36
  • 86 (a)
(Mus musculus)
Mammalia Tmem59l 35
  • 77.96 (n)
  • 75.4 (a)
Tmem59l 16
Tmem59l 36
  • 72 (a)
(Pan troglodytes)
Mammalia TMEM59L 35
  • 99.04 (n)
  • 98.73 (a)
TMEM59L 36
  • 90 (a)
(Rattus norvegicus)
Mammalia Tmem59l 35
  • 77.21 (n)
  • 74.12 (a)
(Monodelphis domestica)
Mammalia TMEM59L 36
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM59L 36
  • 49 (a)
(Gallus gallus)
Aves TMEM59L 36
  • 40 (a)
(Anolis carolinensis)
Reptilia TMEM59L 36
  • 79 (a)
(Danio rerio)
Actinopterygii wufi68e12 35
tmem59l 36
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3043 36
  • 18 (a)
Species with no ortholog for TMEM59L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM59L Gene

Gene Tree for TMEM59L (if available)
Gene Tree for TMEM59L (if available)

Paralogs for TMEM59L Gene

Paralogs for TMEM59L Gene

(1) SIMAP similar genes for TMEM59L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMEM59L: view

Variants for TMEM59L Gene

Sequence variations from dbSNP and Humsavar for TMEM59L Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs709679 -- 18,616,046(+) GACCT(C/T)GTCAA synonymous-codon, reference
rs916791 -- 18,613,347(+) TAAGG(A/G)GCCGA intron-variant
rs1043183 -- 18,620,574(+) GGGGC(C/T)CCTCG utr-variant-3-prime
rs1043190 -- 18,620,787(+) GTCTT(C/T)TATTG utr-variant-3-prime
rs1043192 -- 18,620,848(+) CTTCT(A/C)TGTCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM59L Gene

Variant ID Type Subtype PubMed ID
nsv911281 CNV Loss 21882294
nsv911282 CNV Loss 21882294
nsv833776 CNV Loss 17160897
dgv3784n71 CNV Loss 21882294
dgv3785n71 CNV Loss 21882294
nsv911288 CNV Loss 21882294

Relevant External Links for TMEM59L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM59L Gene

Disorders for TMEM59L Gene

No disorders were found for TMEM59L Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TMEM59L Gene

Publications for TMEM59L Gene

  1. BSMAP, a novel protein expressed specifically in the brain whose gene is localized on chromosome 19p12. (PMID: 10527841) Elson G.C.A. … Gauchat J.-F. (Biochem. Biophys. Res. Commun. 1999) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein. (PMID: 20427278) Ullrich S. … Lichtenthaler S.F. (J. Biol. Chem. 2010) 4

Products for TMEM59L Gene

Sources for TMEM59L Gene

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