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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TMEM59 Gene

protein-coding GIFtS: 52
GCID: GC01M054497

transmembrane protein 59

(Previous name: chromosome 1 open reading frame 8 )
(Previous symbol: C1orf8)

Explore 1 disease affiliated with
TMEM59 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transmembrane Protein 59¹ ²
C1orf8¹ ² ³
HSPC001¹ ²
Liver Membrane-Bound Protein² ³
Chromosome 1 Open Reading Frame 8¹

External Ids:	HGNC: 1239¹	Entrez Gene: 9528²	Ensembl: ENSG00000116209⁷	UniProtKB: Q9BXS4³

Export aliases for TMEM59 gene to outside databases

Previous GC identifers: GC01M054210 GC01M054269 GC01M052613

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TMM59_HUMAN, Q9BXS4

Function: Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A,

MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and

ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex

N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP.

Inhibits APP transport to the cell surface and further shedding

Gene Wiki entry for TMEM59

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TMEM59 gene promoter:
Spz1 HNF-3beta LCR-F1 Cdc5 Evi-1 FOXL1 IRF-7A STAT3 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMEM59 promoter sequence

Search SABiosciences Chromatin IP Primers for TMEM59

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM59

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3 Ensembl cytogenetic band: 1p32.3 HGNC cytogenetic band: 1p32.3

TMEM59 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM59 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M054497: view genomic region (about GC identifiers)

Start:	54,497,347 bp from pter	End:	54,519,177 bp from pter
Size:	21,831 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TMM59_HUMAN, Q9BXS4 (See protein sequence)

Recommended Name: Transmembrane protein 59 precursor

Size: 323 amino acids; 36223 Da

Subunit: Interacts with ATG16L1

Subcellular location: Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type

I membrane protein. Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I

membrane protein. Note=Mainly localizes to late endosomes/lysosomes. Probably first exported to the cell surface and

then actively endocytosed to transiently localize in early endosomes on its way to the late endosomal/lysosomal

compartment where it becomes quickly degraded

Sequence caution: Sequence=AAC39890.1; Type=Frameshift; Positions=6; Sequence=AAH03106.1; Type=Erroneous initiation;

Note=Translation N-terminally extended;

Secondary accessions: B3KQL7 O75393 Q4VBP9 Q5T705 Q96KX7

Explore the universe of human proteins at neXtProt for TMEM59: NX_Q9BXS4

Post-translational modifications:

N-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BXS4

TMEM59 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004863.2

ENSEMBL proteins:

ENSP00000360399 ENSP00000360395 ENSP00000234831 ENSP00000360392 ENSP00000413792

ENSP00000399761 ENSP00000397772 ENSP00000360388

Human Recombinant Protein Products:

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	Novus Biologicals TMEM59 Proteins Novus Biologicals TMEM59 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TMEM59

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

TMEM59 for ontologies About GeneDecksing

TMEM59 Antibody Products:

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	GenScript Custom Assay Services for TMEM59
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	Uscn ELISAs and CLIAs for TMEM59

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TMEM59 for domains About GeneDecksing

1 InterPro domain/family:

IPR022065 Uncharacterised_TMEM59

Graphical View of Domain Structure for InterPro Entry Q9BXS4

ProtoNet protein and cluster: Q9BXS4

UniProtKB/Swiss-Prot: TMM59_HUMAN, Q9BXS4

Domain: The ATG16L1-binding motif mediates interaction with ATG16L1 and promotes autophagy (PubMed:23376921)

Similarity: Belongs to the TMEM59 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TMM59_HUMAN, Q9BXS4

Function: Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A,

MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and

ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex

N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP.

Inhibits APP transport to the cell surface and further shedding

miRNA Products:		miRTarBase miRNAs that target TMEM59: hsa-mir-30a (MIRT005138)

		OriGene 3'-UTR Clone: TMEM59 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM59
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM59:
		hsa-miR-3671 hsa-miR-142-3p hsa-miR-513a-3p hsa-miR-590-3p
		SwitchGear 3'UTR luciferase reporter plasmid: TMEM59 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM59 (see all 3) OriGene siRNA: TMEM59
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM59

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TMEM59

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM59 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM59 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TMEM59 (NM_004872)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TMEM59
		Search LifeMap BioReagents cell lines for TMEM59

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM59

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004175	endopeptidase activity	IEA	--

TMEM59 for ontologies About GeneDecksing

Animal Models:
1 MGI phenotypic allele

for Tmem59 (no phenotypes)

TMEM59 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TMEM59

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/9 Interacting proteins for TMEM59 (Q9BXS4^{2, 3} ENSP00000234831⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PARP2	Q9UGN5²^,³, ENSP00000250416⁴	MINT-8201916 I2D: score=1 STRING: ENSP00000250416
RYK	P34925³, ENSP00000296084⁴	I2D: score=1 STRING: ENSP00000296084
ARHGAP21	ENSP00000379709⁴	STRING: ENSP00000379709
RAB3GAP2	ENSP00000351832⁴	STRING: ENSP00000351832
ZMYM1	ENSP00000352920⁴	STRING: ENSP00000352920

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM59
Search CenterWatch for drugs/clinical trials and news about TMEM59 / TMM59

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMEM59 gene:

NM_004872.3

Unigene Cluster for TMEM59:

Transmembrane protein 59

Hs.523262 [show with all ESTs]

Unigene Representative Sequence: AK074636

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000371348(uc001cwo.3) ENST00000371344(uc001cwn.3) ENST00000234831(uc001cwp.3 uc001cwq.3)

ENST00000371341 ENST00000470395 ENST00000420738 ENST00000440019 ENST00000452421

ENST00000371337

miRNA Products:		OriGene 3'-UTR Clone: TMEM59 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM59
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM59:
		hsa-miR-3671 hsa-miR-142-3p hsa-miR-513a-3p hsa-miR-590-3p
		SwitchGear 3'UTR luciferase reporter plasmid: TMEM59 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM59 (see all 3) OriGene siRNA: TMEM59
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM59

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM59 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM59 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TMEM59 (NM_004872)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM59

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM59 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM59
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM59

Additional cDNA sequence:

AF047439.1 AF290615.1 AK074636.1 AK075187.1 AK075505.1 AK123445.1 AK124967.1 AK225624.1

AY359029.1 BC003106.1 BC016374.1 BC062738.1 BC095464.1

24/38 DOTS entries (see all 38):

DT.452650 DT.99935461 DT.100890036 DT.92461754 DT.100890046 DT.40248675 DT.91990765 DT.121431006

DT.95270743 DT.87012616 DT.121431121 DT.121431017 DT.121431028 DT.92461745 DT.121431053 DT.100890010

DT.101985465 DT.95270742 DT.100034844 DT.422981 DT.100035394 DT.100890011 DT.121431148 DT.100890015

24/945 AceView cDNA sequences (see all 945):

AA873205 BM353479 BG328608 BU727855 CR610199 BM668898 AA099356 BM823631

BU682552 AI114577 AI291056 CD369996 AA807393 BG330542 BP356146 BQ267866

BP351479 CB269559 AA293817 BC003106 BM993457 AI554213 BM829949 AI394450

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM59 (see all 17) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	·	2d	·	2e	^	3	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	·	8c	·	8d	^	9a	·	9b	^	10a	·	10b	·	10c	·
SP1:																			-		-
SP2:									-		-		-		-		-		-		-
SP3:									-		-		-		-		-		-		-
SP4:																			-		-
SP5:																			-		-		-

ExUns:	10d	·	10e	·	10f
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for TMEM59

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM59 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGAAGCAGG

About this image

TMEM59 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Stylopod Long Bone

Bone

Thoracic Rib

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TMEM59 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM59

SOURCE GeneReport for Unigene cluster: Hs.523262

SABiosciences Custom PCR Arrays for TMEM59

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM59 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM59

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM59

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TMEM59 gene from 4/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TMEM59¹	transmembrane protein 59	77.04(n) 81.45(a)		424656 NM_001006541.1 NP_001006541.1
lizard (Anolis carolinensis)	Reptilia	TMEM59⁶	--	71(a)	1 ↔ 1	4(105124741-105134163)
African clawed frog (Xenopus laevis)	Amphibia	Xl.29361²	Xenopus laevis transcribed sequence with weak similarity more	73.49(n)		CA982671.1
zebrafish (Danio rerio)	Actinopterygii	Dr.5932²	Transcribed sequence with weak similarity to protein more	73.25(n)		CF348672.1

ENSEMBL Gene Tree for TMEM59 (if available)
TreeFam Gene Tree for TMEM59 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TMEM59 gene

TMEM59L²

1 SIMAP similar gene for TMEM59 using alignment to 7 protein entries: TMM59_HUMAN (see all proteins):

TMEM59L

TMEM59 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs59566166^1,2		--	54496880(+)	`GATCAC/TACCAT`	1	--	int¹		0	--	--	--	--
rs145212116^1,2		--	54497004(+)	`TAAAAC/TGAGTT`	1	--	int¹		0	--	--	--	--
rs1547467^1,2	C,F,A,H,	--	54497040(-)	`GTGATG/ACAGAA`	1	--	int¹		23		NS EA NA WA CSA	2348
rs147916006^1,2		--	54497093(+)	`ATATGC/TTTACC`	1	--	int¹		0	--	--	--	--
rs114816695^1,2		--	54497507(+)	`ACAGTA/GTCATG`	1	--	ut3¹		1		WA	118
rs141637937^1,2		--	54497600(+)	`TACAGA/TTATTA`	1	--	ut3¹		0	--	--	--	--
rs183023114^1,2		--	54497670(+)	`ATAAAA/GTTATA`	1	--	ut3¹		0	--	--	--	--
rs11539455^1,2	C,	--	54497787(+)	`TTTTAC/G/TATGTC`	2	--	ut3¹		0	--	--	--	--
rs71765470^1,2	C,	--	54497796(+)	`TCTATTACA/- CTTGT`	1	--	ut3¹		1		CSA	2
rs139391660^1,2	C,F,	--	54497895(+)	`TTAGAT/CCTAAC`	2	/R	syn¹		1		NA	4516

HapMap Linkage Disequilibrium report for TMEM59 (54497347 - 54519177 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM59: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM59

DNA2.0 Custom Variant and Variant Library Synthesis for TMEM59

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TMEM59 for disorders About GeneDecksing

1 disease for TMEM59: About MalaCards

liver disease

Human Genome Epidemiology (HuGE) Navigator: TMEM59 (1 document)

Export disorders for TMEM59 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TMEM59 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with TMEM59)

Utopia: connect your pdf to the dynamic
world of online information

The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein. (PubMed id 20427278)^{1, 2} Ullrich S....Lichtenthaler S.F. (2010)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)^{1, 2} Zhang Q.-H.... Chen Z. (2000)
Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)^{1, 3} Mao M.... Chen Z. (1998)
TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3. (PubMed id 23376921)² Boada-Romero E....Pimentel-Muinos F.X. (2013)
Genome-wide DNA methylation differences between late-o nset Alzheimer's disease and cognitively normal controls in human frontal cortex . (PubMed id 22451312)¹ Bakulski K.M....Rozek L.S. (2012)
Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)¹ Oshikawa K....Nakayama K.I. (2012)

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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9528	HGNC: 1239	AceView: C1orf8	Ensembl:ENSG00000116209	euGenes: HUgn9528
ECgene: TMEM59	H-InvDB: TMEM59

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TMEM59	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TMEM59 gene
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Patent Information for TMEM59 gene:
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GeneCards and IP:
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transmembrane protein 59

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