TMEM57 Gene
protein-coding GIFtS: 45
GCID: GC01P025758
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transmembrane protein 57
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Aliases
for TMEM57 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 571 2 3 | | FLJ107471 | | MACOILIN2 | | Macoilin1 |
Export aliases for TMEM57 gene to outside databasesPrevious GC identifers: GC01P025503 GC01P025629 GC01P024014 |
Summaries
for TMEM57 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM57 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM57 gene promoter:
CREB AREB6 Pax-4a NF-Y CBF(2) C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM57
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM57 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.11|1p36.11 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p36.11TMEM57 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P025758: view genomic region
(about GC identifiers)
Start:
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25,757,388 bp from pter |
End:
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25,826,700 bp from pter |
Size:
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69,313 bases |
Orientation:
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plus strand |
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Proteins
for TMEM57 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MACOI_HUMAN, Q8N5G2 (See
protein sequence)Recommended Name: Macoilin Size: 664 amino acids; 76178 Da
Subcellular location: Nucleus membrane; Multi-pass membrane protein (By similarity). Cell projection, axon (Bysimilarity). Note=Detected in the nucleus membrane of non-neuronal cells and in axonal outgrowths of neuronal cells(By similarity)
Secondary accessions: B1AK00 Q2TLX5 Q2TLX6 Q9NVG6Alternative splicing: 3 isoforms: Q8N5G2-1 Q8N5G2-2 Q8N5G2-3 Explore the universe of human proteins at neXtProt for TMEM57: NX_Q8N5G2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N5G2
TMEM57 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060672.2
ENSEMBL proteins: ENSP00000363463 ENSP00000382668 ENSP00000382666
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
TMEM57 for ontologies About GeneDecksing
TMEM57 Antibody Products:
Assay Products for TMEM57: |
Protein
Domains /
Families
for TMEM57 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM57 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N5G2ProtoNet protein and cluster: Q8N5G2 UniProtKB/Swiss-Prot: MACOI_HUMAN, Q8N5G2Similarity: Belongs to the macoilin family |
Function
for TMEM57 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM57 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM57 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM57 (NM_018202) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM57 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM57 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM57 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
TMEM57 for ontologies About GeneDecksing
|
Pathways & Interactions
for TMEM57 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM57
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
3 Interacting proteins for TMEM57 (Q8N5G22, 3 ENSP000003634634) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007420 | brain development |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
TMEM57 for ontologies About GeneDecksing
|
Drugs & Compounds
for TMEM57 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM57
Search CenterWatch for drugs/clinical trials and news about TMEM57 / MACOI
|
Transcripts
for TMEM57 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM57 gene: NM_018202.4 Unigene Cluster for TMEM57: Transmembrane protein 57 Hs.189782 [show with all ESTs]Unigene Representative Sequence: NM_0182024 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374343(uc009vrt.2 uc001bkk.3) ENST00000470035 ENST00000399766(uc009vru.3)
ENST00000399763(uc009vrv.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM57 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM57 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM57 (NM_018202) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM57 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM57 |
Additional cDNA sequence: AK001609.1 AK311472.1 AY845015.1 AY845035.1 AY845036.1 BC007687.1 BC020801.1 BC032427.1 9 DOTS entries: DT.213218 DT.101544 DT.97846089 DT.92459454 DT.92459458 DT.95242268 DT.97846087 DT.40130016 DT.91836134 8 AceView cDNA sequences: BM786697 AU130984 BM837961 AL560159 BC007687 BE795477 BI918282 AK001609
GeneLoc Exon Structure
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Expression
for TMEM57 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM57 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAATTGTC
About this image
See TMEM57 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM57
SOURCE GeneReport for Unigene cluster: Hs.189782
SABiosciences Expression via Pathway-Focused PCR Arrays including TMEM57:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM57
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM57 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM57 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM57 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM57 |
Orthologs
for TMEM57 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM57 gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for TMEM57 (if available)
TreeFam Gene Tree for TMEM57 (if available) |
Paralogs
for TMEM57 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM57 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM57 (25757388 - 25826700 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMEM57
1 CNV: 97323 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM57 |
|
Disorders
/ Diseases
for TMEM57 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM57 for disorders About GeneDecksing
OMIM gene information: 610301
OMIM disorders: --
2  diseases for TMEM57: About MalaCardscoronary heart disease neuronitis
Human Genome Epidemiology (HuGE) Navigator: TMEM57 (4 documents)
Export disorders for TMEM57 gene to outside databases
|
Publications
for TMEM57 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM57 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with TMEM57) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a novel brain-specific and Reelin-regulated gene that encodes a protein colocalized with synapsin. (PubMed id 15255972)1, 3 Kuvbachieva A....Simonneau M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Entire sequence of a mouse chromosomal segment containing the gene Rhced and a comparative analysis of the homologous human sequence. (PubMed id 12459264)1, 3 Kumada M....Kajii E. (2002)
- Complement receptor 1 gene variants are associated wi th erythrocyte sedimentation rate. (PubMed id 21700265)1 Kullo I.J....Chute C.G. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)1 Teslovich T.M....Kathiresan S. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
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External Searches for TMEM57 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM57 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM57 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM57 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM57 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TMEM57 gene:
Search GeneIP for patents involving TMEM57
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM57 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM57 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM57 | | | OriGene Protein Over-expression Lysate for TMEM57 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM57 | | OriGene 3'-UTR Clone for TMEM57 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM57 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM57 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TMEM57 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM57 | | OriGene Custom Protein Services for TMEM57 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM57 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM57 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM57 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM57 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM57 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM57 |
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 |  |  |  | |
| | | | Search Tocris compounds for TMEM57 |
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 | | | TMEM57 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM57 |
|  |  |  | | | | ThermoFisher Antibodies for TMEM57 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM57 |
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