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Aliases for TMEM57 Gene

Aliases for TMEM57 Gene

  • Transmembrane Protein 57 2 3 4
  • MACOILIN 3
  • FLJ10747 6

External Ids for TMEM57 Gene

Summaries for TMEM57 Gene

GeneCards Summary for TMEM57 Gene

TMEM57 is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM57 Gene

Genomics for TMEM57 Gene

Genomic Location for TMEM57 Gene

Start:
25,430,858 bp from pter
End:
25,500,209 bp from pter
Size:
69,352 bases
Orientation:
Plus strand

Genomic View for TMEM57 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM57 Gene

Regulatory Elements for TMEM57 Gene

Proteins for TMEM57 Gene

  • Protein details for TMEM57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5G2-MACOI_HUMAN
    Recommended name:
    Macoilin
    Protein Accession:
    Q8N5G2
    Secondary Accessions:
    • B1AK00
    • Q2TLX5
    • Q2TLX6
    • Q9NVG6

    Protein attributes for TMEM57 Gene

    Size:
    664 amino acids
    Molecular mass:
    76178 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM57 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM57 Gene

Proteomics data for TMEM57 Gene at MOPED

Post-translational modifications for TMEM57 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys242, Lys296, Lys365, Lys438, and Lys579
  • Glycosylation at Asn324, Asn340, Asn452, and Asn655

Other Protein References for TMEM57 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM57 Gene

Domains for TMEM57 Gene

Protein Domains for TMEM57 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MACOI_HUMAN
Family:
  • Belongs to the macoilin family.:
    • Q8N5G2
genes like me logo Genes that share domains with TMEM57: view

No data available for Gene Families for TMEM57 Gene

Function for TMEM57 Gene

Gene Ontology (GO) - Molecular Function for TMEM57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM57: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM57 Gene

Localization for TMEM57 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM57 Gene

Nucleus membrane; Multi-pass membrane protein. Cell projection, axon. Note=Detected in the nucleus membrane of non-neuronal cells and in axonal outgrowths of neuronal cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM57 Gene COMPARTMENTS Subcellular localization image for TMEM57 gene
Compartment Confidence
nucleus 5
plasma membrane 3
golgi apparatus 2
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS 12459264
GO:0016021 integral component of membrane IEA --
GO:0030424 axon IEA --
GO:0031965 nuclear membrane ISS 15255972
GO:0043005 neuron projection --
genes like me logo Genes that share ontologies with TMEM57: view

Pathways for TMEM57 Gene

SuperPathways for TMEM57 Gene

No Data Available

Interacting Proteins for TMEM57 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000363463%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000347184%0d%0a
Selected Interacting proteins: Q8N5G2-MACOI_HUMAN ENSP00000363463 for TMEM57 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for TMEM57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007420 brain development IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM57: view

No data available for Pathways by source for TMEM57 Gene

Transcripts for TMEM57 Gene

mRNA/cDNA for TMEM57 Gene

(4) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM57 Gene

Transmembrane protein 57:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM57 Gene

No ASD Table

Relevant External Links for TMEM57 Gene

GeneLoc Exon Structure for
TMEM57
ECgene alternative splicing isoforms for
TMEM57

Expression for TMEM57 Gene

mRNA expression in normal human tissues for TMEM57 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM57 Gene

SOURCE GeneReport for Unigene cluster for TMEM57 Gene Hs.189782

genes like me logo Genes that share expressions with TMEM57: view

Orthologs for TMEM57 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM57 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM57 36
  • 99.7 (n)
  • 99.85 (a)
TMEM57 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM57 36
  • 94.83 (n)
  • 99.7 (a)
TMEM57 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM57 36
  • 94.98 (n)
  • 100 (a)
TMEM57 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem57 36
  • 92.02 (n)
  • 99.25 (a)
Tmem57 16
Tmem57 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM57 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM57 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem57 36
  • 91.92 (n)
  • 98.49 (a)
chicken
(Gallus gallus)
Aves TMEM57 36
  • 84.59 (n)
  • 94.41 (a)
TMEM57 37
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM57 37
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10082 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9809 36
tmem57 36
  • 77.64 (n)
  • 90.14 (a)
zebrafish
(Danio rerio)
Actinopterygii TMEM57 (3 of 3) 37
  • 43 (a)
OneToMany
tmem57a 36
  • 74.54 (n)
  • 84.6 (a)
tmem57a 37
  • 84 (a)
OneToMany
tmem57b 37
  • 78 (a)
OneToMany
zgc56620 36
fruit fly
(Drosophila melanogaster)
Insecta CG30389 36
  • 51.5 (n)
  • 48.26 (a)
CG30389 37
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea maco-1 36
  • 45.82 (n)
  • 31.55 (a)
maco-1 37
  • 18 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8852 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8754 37
  • 41 (a)
OneToOne
Species with no ortholog for TMEM57:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM57 Gene

ENSEMBL:
Gene Tree for TMEM57 (if available)
TreeFam:
Gene Tree for TMEM57 (if available)

Paralogs for TMEM57 Gene

No data available for Paralogs for TMEM57 Gene

Variants for TMEM57 Gene

Sequence variations from dbSNP and Humsavar for TMEM57 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs873308 -- 25,432,164(-) TAAGC(C/T)TACAT intron-variant
rs873309 -- 25,431,928(-) GGATG(A/G)AAAAA intron-variant
rs909834 -- 25,431,505(+) CGGCC(A/G)TGCCG intron-variant
rs1137689 -- 25,458,843(+) TAATG(A/G)AAAAC intron-variant, missense, reference
rs1534954 -- 25,435,433(+) AAGTG(A/T)TTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM57 Gene

Variant ID Type Subtype PubMed ID
nsv834469 CNV Gain+Loss 17160897
nsv9768 CNV Gain+Loss 18304495
nsv834480 CNV Gain 17160897
nsv870470 CNV Gain 21882294
nsv870937 CNV Loss 21882294
nsv870664 CNV Loss 21882294
esv2570786 CNV Deletion 19546169

Relevant External Links for TMEM57 Gene

HapMap Linkage Disequilibrium report
TMEM57

Disorders for TMEM57 Gene

Relevant External Links for TMEM57

Genetic Association Database (GAD)
TMEM57
Human Genome Epidemiology (HuGE) Navigator
TMEM57
genes like me logo Genes that share disorders with TMEM57: view

No data available for UniProtKB/Swiss-Prot for TMEM57 Gene

Publications for TMEM57 Gene

  1. Entire sequence of a mouse chromosomal segment containing the gene Rhced and a comparative analysis of the homologous human sequence. (PMID: 12459264) Kumada M. … Kajii E. (Gene 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Identification of a novel brain-specific and Reelin-regulated gene that encodes a protein colocalized with synapsin. (PMID: 15255972) Kuvbachieva A. … Simonneau M. (Eur. J. Neurosci. 2004) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (PMID: 19060911) Aulchenko Y.S. … Peltonen L. (Nat. Genet. 2009) 3 49

Products for TMEM57 Gene

  • antibodies-online peptides for TMEM57
  • antibodies-online antibodies for TMEM57
  • antibodies-online kits for TMEM57

Sources for TMEM57 Gene

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