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Aliases for TMEM56-RWDD3 Gene

Aliases for TMEM56-RWDD3 Gene

  • TMEM56-RWDD3 Readthrough 2 3

External Ids for TMEM56-RWDD3 Gene

Previous GeneCards Identifiers for TMEM56-RWDD3 Gene

  • GC01U903134
  • GC01P095583

Summaries for TMEM56-RWDD3 Gene

Entrez Gene Summary for TMEM56-RWDD3 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring TMEM56 (transmembrane protein 56) and RWDD3 (RWD domain containing 3) genes on chromosome 1. The read-through transcript encodes a protein that shares sequence identity with the upstream gene product, but it contains a distinct C-terminus due to frameshifts versus the downstream gene coding sequence. [provided by RefSeq, Dec 2010]

GeneCards Summary for TMEM56-RWDD3 Gene

TMEM56-RWDD3 (TMEM56-RWDD3 Readthrough) is a Protein Coding gene. An important paralog of this gene is TMEM56.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM56-RWDD3 Gene

Genomics for TMEM56-RWDD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM56-RWDD3 Gene

95,117,923 bp from pter
95,247,225 bp from pter
129,303 bases
Plus strand

Genomic View for TMEM56-RWDD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM56-RWDD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM56-RWDD3 Gene

No data available for Regulatory Elements for TMEM56-RWDD3 Gene

Proteins for TMEM56-RWDD3 Gene

  • Protein details for TMEM56-RWDD3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein TMEM56-RWDD3
    Protein Accession:

    Protein attributes for TMEM56-RWDD3 Gene

    108 amino acids
    Molecular mass:
    12115 Da
    Quaternary structure:
    No Data Available
  • Protein details for TMEM56-RWDD3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein TMEM56-RWDD3
    Protein Accession:

    Protein attributes for TMEM56-RWDD3 Gene

    201 amino acids
    Molecular mass:
    22715 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM56-RWDD3 Gene

Proteomics data for TMEM56-RWDD3 Gene at MOPED

Post-translational modifications for TMEM56-RWDD3 Gene

No Post-translational modifications

Other Protein References for TMEM56-RWDD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM56-RWDD3 Gene

Domains & Families for TMEM56-RWDD3 Gene

Protein Domains for TMEM56-RWDD3 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM56-RWDD3: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TMEM56-RWDD3 Gene

Function for TMEM56-RWDD3 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM56-RWDD3 Gene

Localization for TMEM56-RWDD3 Gene

Gene Ontology (GO) - Cellular Components for TMEM56-RWDD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with TMEM56-RWDD3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for TMEM56-RWDD3 Gene

Pathways & Interactions for TMEM56-RWDD3 Gene

SuperPathways for TMEM56-RWDD3 Gene

No Data Available

Interacting Proteins for TMEM56-RWDD3 Gene

Gene Ontology (GO) - Biological Process for TMEM56-RWDD3 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM56-RWDD3 Gene

Drugs & Compounds for TMEM56-RWDD3 Gene

No Compound Related Data Available

Transcripts for TMEM56-RWDD3 Gene

mRNA/cDNA for TMEM56-RWDD3 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM56-RWDD3 Gene

No ASD Table

Relevant External Links for TMEM56-RWDD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM56-RWDD3 Gene

mRNA expression in normal human tissues for TMEM56-RWDD3 Gene

genes like me logo Genes that share expression patterns with TMEM56-RWDD3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM56-RWDD3 Gene

Orthologs for TMEM56-RWDD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM56-RWDD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 48 (a)
(Canis familiaris)
Mammalia -- 36
  • 51 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
(Mus musculus)
Mammalia Tmem56 36
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 21 (a)
-- 36
  • 16 (a)
-- 36
  • 60 (a)
(Pan troglodytes)
Mammalia -- 36
  • 63 (a)
(Gallus gallus)
Aves TMEM56 36
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
(Danio rerio)
Actinopterygii si:dkey-10f21.4 36
  • 33 (a)
tmem56a 36
  • 34 (a)
tmem56b 36
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
-- 36
  • 19 (a)
CSA.1291 36
  • 21 (a)
Species with no ortholog for TMEM56-RWDD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM56-RWDD3 Gene

Gene Tree for TMEM56-RWDD3 (if available)
Gene Tree for TMEM56-RWDD3 (if available)

Paralogs for TMEM56-RWDD3 Gene

Paralogs for TMEM56-RWDD3 Gene

(1) SIMAP similar genes for TMEM56-RWDD3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMEM56-RWDD3: view

Variants for TMEM56-RWDD3 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM56-RWDD3 Gene

Variant ID Type Subtype PubMed ID
nsv830636 CNV Loss 17160897
nsv823609 CNV Loss 20364138
nsv870669 CNV Loss 21882294
esv2714995 CNV Deletion 23290073
esv2672109 CNV Deletion 23128226
esv2641534 CNV Deletion 19546169
esv2291039 CNV Deletion 18987734
esv2715006 CNV Deletion 23290073
esv4625 CNV Deletion 18987735
nsv160810 CNV Loss 16902084
nsv483022 CNV Gain 15286789

Variation tolerance for TMEM56-RWDD3 Gene

Residual Variation Intolerance Score: 46.24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM56-RWDD3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TMEM56-RWDD3 Gene

Disorders for TMEM56-RWDD3 Gene

Relevant External Links for TMEM56-RWDD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMEM56-RWDD3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM56-RWDD3 Gene

Publications for TMEM56-RWDD3 Gene

  1. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu J.H. … Mozaffarian D. (Circ Cardiovasc Genet 2013) 67
  2. Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. (PMID: 20708005) Chalasani N. … Rotter J.I. (Gastroenterology 2010) 67
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 67
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for TMEM56-RWDD3 Gene

Sources for TMEM56-RWDD3 Gene

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