TMEM56 Gene
protein-coding GIFtS : 44
GCID: GC01 P095582
transmembrane protein 56
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Aliasesfor TMEM56 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Transmembrane Protein 56 1 2 FLJ318421
Export aliases for TMEM56 gene to outside databases Previous GC identifers: GC01P095296 GC01P093704
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Summariesfor TMEM56 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor TMEM56 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_032977.9 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TMEM56 gene promoter: Pax-2 Olf-1 Pax-2a XBP-1 Arnt Max Pax-2b Pax-4a ATF6 c-Myc Other transcription factors Search SABiosciences Chromatin IP Primers for TMEM56 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TMEM56
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p21.3 Ensembl cytogenetic band: 1p21.3 HGNC cytogenetic band: 1p21.3 TMEM56 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P095582: view genomic region
(about GC identifiers )
Start:
95,582,894 bp from pter
End:
95,663,163 bp from pter
Size:
80,270 bases
Orientation:
plus strand
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Proteinsfor TMEM56 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TMM56_HUMAN, Q96MV1 (See
protein sequence )Recommended Name: Transmembrane protein 56 Size : 263 amino acids; 30041 Da
Subcellular location : Membrane; Multi-pass membrane protein (Potential)
Secondary accessions : B2RPI2 D3DT48Explore the universe of human proteins at neXtProt for TMEM56: NX_Q96MV1 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96MV1 TMEM56 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001186608.1 NP_689700.1 ENSEMBL proteins: ENSP00000359222 ENSP00000395364 ENSP00000417043 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005575 cellular_component
ND -- GO:0016021 integral to membrane
IEA --
TMEM56 for ontologies About GeneDecksing TMEM56 Antibody Products: Assay Products for TMEM56:
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Protein
Domains / Familiesfor TMEM56 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TMEM56 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q96MV1 ProtoNet protein and cluster: Q96MV1
1 Blocks protein family : IPB006634 TRAM UniProtKB/Swiss-Prot: TMM56_HUMAN, Q96MV1 Similarity : Belongs to the TMEM56 familySimilarity : Contains 1 TLC (TRAM/LAG1/CLN8) domain
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Functionfor TMEM56 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM56 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM56OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): TMEM56 (NM_001199679 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM56 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM56
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM56
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003674 molecular_function
ND --
TMEM56 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for TMEM56 :
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Pathways & Interactionsfor TMEM56 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM56 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for TMEM56 (ENSP00000359222 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0008150 biological_process
ND --
TMEM56 for ontologies About GeneDecksing
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Drugs & Compoundsfor TMEM56 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TMEM56 Search CenterWatch for drugs/clinical trials and news about TMEM56 / TMM56
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Transcriptsfor TMEM56 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TMEM56 gene (2 alternative transcripts): NM_001199679.1 NM_152487.2 Unigene Cluster for TMEM56:
Transmembrane protein 56 Hs.483512 [show with all ESTs ] Unigene Representative Sequence: NM_001199679 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000370203 (uc021oqe.1 uc001drb.3 ) ENST00000456991 ENST00000455656 ENST00000463375 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM56 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM56OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): TMEM56 (NM_001199679 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM56 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM56
Additional cDNA sequence: AK056404.1 AK126344.1 BC019700.1 BC108263.1 BC137457.1 BC137458.1 BC139737.1 BX537731.1
10 DOTS entries : DT.210832 DT.95368674
DT.100024370 DT.100787551 DT.212473 DT.100778957 DT.409497 DT.100778956 DT.91824373 DT.100024371 24/211 AceView cDNA sequences (see all 211 ):
AA961117 AA336662 AL598818 AW613686 AA825527 AA328801 BX956929 BQ045393 BU782509 AA452629 BX096742 BG566223 BU683936 CD676564 CR613763 AI033315 AA699431 BC019700 AK126344 AI033223 AA935999 AI187083 CK430207 N77031 GeneLoc Exon Structure
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Expression for TMEM56 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TMEM56 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AAAACCTTGG
About this image TMEM56 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See TMEM56 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TMEM56 SOURCE GeneReport for Unigene cluster: Hs.483512 SABiosciences Custom PCR Arrays for TMEM56 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TMEM56Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TMEM56 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TMEM56 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TMEM56 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM56
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Orthologsfor TMEM56 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for TMEM56 gene from 7/21 species (see all 21 ) About this table
ENSEMBL Gene Tree for TMEM56 (if available)TreeFam Gene Tree for TMEM56 (if available)
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Paralogsfor TMEM56 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TMEM56 gene
TMEM56 for paralogs About GeneDecksing 2 Pseudogenes.org Pseudogenes for TMEM56 PGOHUM00000245091 PGOHUM00000245488
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Genomic Variantsfor TMEM56 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TMEM56 (95582894 - 95663163 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for TMEM56 1 CNV : 4235
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TMEM56
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Disorders
/ Diseasesfor TMEM56 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section TMEM56 for disorders About MalaCards
TMEM56 for disorders About GeneDecksing Human Genome Epidemiology (HuGE) Navigator: TMEM56 (1 document)Export disorders for TMEM56 gene to outside databases
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Publicationsfor TMEM56 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TMEM56 gene integrated from 9 sources : (articles sorted by number of sources associating them with TMEM56) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861) 2 Choudhary C.... Mann M. (2009) Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201) 1 Abdelmohsen K....Gorospe M. (2009) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548) 1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for TMEM56 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TMEM56 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TMEM56 gene
(According to HUGE )
About This Section --
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Specialized Databases showing TMEM56 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TMEM56 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TMEM56 gene: Search GeneIP for patents involving TMEM56 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TMEM56 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TMEM56 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TMEM56 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TMEM56 OriGene Protein Over-expression Lysate for TMEM56 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TMEM56 OriGene 3'-UTR Clone for TMEM56 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM56 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM56 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TMEM56 OriGene Custom Protein Services for TMEM56 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM56 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TMEM56 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TMEM56 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TMEM56 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TMEM56 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TMEM56
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TMEM56 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM56
Search ThermoFisher Antibodies for TMEM56
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM56
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Genomic Views for TMEM56
Intellectual Property for TMEM56
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