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Aliases for TMEM56 Gene

Aliases for TMEM56 Gene

  • Transmembrane Protein 56 2 3 5

External Ids for TMEM56 Gene

Previous GeneCards Identifiers for TMEM56 Gene

  • GC01P095296
  • GC01P095582
  • GC01P093704

Summaries for TMEM56 Gene

GeneCards Summary for TMEM56 Gene

TMEM56 (Transmembrane Protein 56) is a Protein Coding gene. An important paralog of this gene is TMEM56-RWDD3.

Additional gene information for TMEM56 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM56 Gene

Genomics for TMEM56 Gene

GeneHancer (GH) Regulatory Elements for TMEM56 Gene

Promoters and enhancers for TMEM56 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I095116 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 556.2 +24.9 24859 2.1 ARID4B SIN3A ZNF2 GLIS2 ZNF143 ATF7 KLF13 SP3 REST ZNF592 TMEM56 TMEM56-RWDD3 RWDD3
GH01I095126 Promoter 0.5 EPDnew 550.3 +33.8 33781 0.1 GC01M095126 ENSG00000206679 TMEM56 ENSG00000231992 TMEM56-RWDD3 LOC101928118
GH01I095232 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 30.4 +141.4 141383 2.6 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B LOC101928118 RWDD3 TMEM56 ENSG00000228852 GC01M095227 ENSG00000206679 GC01M095126 TMEM56-RWDD3
GH01I095179 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 21 +87.2 87184 1.1 HDAC1 ATF1 PKNOX1 TAF9B ARNT CHAMP1 TCF12 GATA2 EGR1 ATF7 TMEM56 TMEM56-RWDD3 RWDD3 ENSG00000206679 GC01M095126 LOC101928118
GH01I095227 Enhancer 0.8 Ensembl ENCODE 18 +135.3 135284 0.4 ELF3 SOX5 SOX13 SAP130 FOXA3 CEBPB MAX ZNF384 CEBPG HMG20A TMEM56 ENSG00000231992 LOC101928118 GC01M095227 GC01M095126 ENSG00000206679 TMEM56-RWDD3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM56 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM56 gene promoter:

Genomic Locations for TMEM56 Gene

Genomic Locations for TMEM56 Gene
chr1:95,092,517-95,197,607
(GRCh38/hg38)
Size:
105,091 bases
Orientation:
Plus strand
chr1:95,582,894-95,663,163
(GRCh37/hg19)

Genomic View for TMEM56 Gene

Genes around TMEM56 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM56 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM56 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM56 Gene

Proteins for TMEM56 Gene

  • Protein details for TMEM56 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MV1-TMM56_HUMAN
    Recommended name:
    Transmembrane protein 56
    Protein Accession:
    Q96MV1
    Secondary Accessions:
    • B2RPI2
    • D3DT48

    Protein attributes for TMEM56 Gene

    Size:
    263 amino acids
    Molecular mass:
    30041 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM56 Gene

Post-translational modifications for TMEM56 Gene

No Post-translational modifications

Other Protein References for TMEM56 Gene

No data available for DME Specific Peptides for TMEM56 Gene

Domains & Families for TMEM56 Gene

Gene Families for TMEM56 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM56 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM56 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96MV1

UniProtKB/Swiss-Prot:

TMM56_HUMAN :
  • Belongs to the TMEM56 family.
Family:
  • Belongs to the TMEM56 family.
genes like me logo Genes that share domains with TMEM56: view

Function for TMEM56 Gene

Phenotypes From GWAS Catalog for TMEM56 Gene

Gene Ontology (GO) - Molecular Function for TMEM56 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM56: view

Phenotypes for TMEM56 Gene

genes like me logo Genes that share phenotypes with TMEM56: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM56 Gene

Localization for TMEM56 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM56 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM56 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM56 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM56: view

Pathways & Interactions for TMEM56 Gene

SuperPathways for TMEM56 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM56 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM56: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM56 Gene

Drugs & Compounds for TMEM56 Gene

No Compound Related Data Available

Transcripts for TMEM56 Gene

Unigene Clusters for TMEM56 Gene

Transmembrane protein 56:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM56 Gene

No ASD Table

Relevant External Links for TMEM56 Gene

GeneLoc Exon Structure for
TMEM56
ECgene alternative splicing isoforms for
TMEM56

Expression for TMEM56 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM56 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM56 Gene

This gene is overexpressed in Liver (x8.1).

Protein differential expression in normal tissues from HIPED for TMEM56 Gene

This gene is overexpressed in Liver (24.1), Heart (19.6), Frontal cortex (10.9), and Fetal Liver (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM56 Gene



Protein tissue co-expression partners for TMEM56 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM56 Gene:

TMEM56

SOURCE GeneReport for Unigene cluster for TMEM56 Gene:

Hs.483512

Evidence on tissue expression from TISSUES for TMEM56 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TMEM56: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM56 Gene

Orthologs for TMEM56 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM56 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
OneToMany
TMEM56 33
  • 99.87 (n)
dog
(Canis familiaris)
Mammalia TMEM56 33
  • 87.58 (n)
-- 34
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmem56 33
  • 80.48 (n)
mouse
(Mus musculus)
Mammalia Tmem56 33 16 34
  • 80.35 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 66 (a)
ManyToMany
-- 34
  • 60 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 65 (a)
OneToMany
chicken
(Gallus gallus)
Aves TMEM56 33 34
  • 71.06 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 37 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489043 33
  • 64.47 (n)
Str.18352 33
zebrafish
(Danio rerio)
Actinopterygii tmem56a 33 34
  • 61.07 (n)
si:dkey-10f21.4 34
  • 49 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11267 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TDA4 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G31300 33
  • 41.37 (n)
rice
(Oryza sativa)
Liliopsida Os03g0666700 33
  • 44.56 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
ManyToMany
CSA.1291 34
  • 30 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
Species where no ortholog for TMEM56 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM56 Gene

ENSEMBL:
Gene Tree for TMEM56 (if available)
TreeFam:
Gene Tree for TMEM56 (if available)

Paralogs for TMEM56 Gene

Paralogs for TMEM56 Gene

(1) SIMAP similar genes for TMEM56 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for TMEM56 Gene

genes like me logo Genes that share paralogs with TMEM56: view

Variants for TMEM56 Gene

Sequence variations from dbSNP and Humsavar for TMEM56 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000014289 -- 95,153,048(+) C/G intron_variant
rs1000017455 -- 95,136,425(+) A/G intron_variant
rs1000048224 -- 95,136,927(+) G/A intron_variant
rs1000084500 -- 95,101,972(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000133360 -- 95,193,378(+) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM56 Gene

Variant ID Type Subtype PubMed ID
esv2672109 CNV deletion 23128226
esv2714984 CNV deletion 23290073
esv2714995 CNV deletion 23290073
esv3566037 CNV deletion 23714750
esv3566070 CNV deletion 23714750
nsv823609 CNV loss 20364138
nsv830636 CNV loss 17160897

Variation tolerance for TMEM56 Gene

Residual Variation Intolerance Score: 29.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM56 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM56

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM56 Gene

Disorders for TMEM56 Gene

Additional Disease Information for TMEM56

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM56 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM56 Gene

Publications for TMEM56 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu JH … Mozaffarian D (Circulation. Cardiovascular genetics 2013) 3 58

Products for TMEM56 Gene

Sources for TMEM56 Gene

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