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Aliases for TMEM56 Gene

Aliases for TMEM56 Gene

  • Transmembrane Protein 56 2 3 5

External Ids for TMEM56 Gene

Previous GeneCards Identifiers for TMEM56 Gene

  • GC01P095296
  • GC01P095582
  • GC01P093704

Summaries for TMEM56 Gene

GeneCards Summary for TMEM56 Gene

TMEM56 (Transmembrane Protein 56) is a Protein Coding gene. An important paralog of this gene is TMEM56-RWDD3.

Additional gene information for TMEM56 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM56 Gene

Genomics for TMEM56 Gene

Regulatory Elements for TMEM56 Gene

Enhancers for TMEM56 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H095232 1.1 ENCODE 30.3 +141.2 141244 2 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 TMEM56 ENSG00000228852 LOC101928118 GC01M095126 ENSG00000206679
GH01H095179 1.5 FANTOM5 ENCODE dbSUPER 21 +87.2 87184 1 HDAC1 PKNOX1 ATF1 TBL1XR1 ARNT CHAMP1 TCF12 GATA2 EGR1 ATF7 TMEM56 TMEM56-RWDD3 RWDD3 ENSG00000206679 GC01M095126 LOC101928118
GH01H095227 0.9 Ensembl ENCODE 18 +135.3 135284 0 ELF3 SOX5 SOX13 SAP130 FOXA3 CEBPB MAX CEBPG HMG20A ZNF384 TMEM56 ENSG00000231992 LOC101928118 GC01M095126 ENSG00000206679
GH01H095041 1.5 FANTOM5 Ensembl ENCODE 10.1 -49.9 -49885 2 HDGF FOXA2 ARID4B FEZF1 YBX1 ZNF2 SLC30A9 ZNF143 RUNX3 DEK SLC44A3-AS1 SLC44A3 TMEM56 ENSG00000231992 ENSG00000228852 LOC102723661 LOC105378863 LOC101928098
GH01H095167 0.9 Ensembl 12.9 +75.2 75184 0 HDAC1 PKNOX1 NFIB FEZF1 CHAMP1 TCF12 GLIS2 ZNF366 SCRT2 OVOL3 TMEM56 ENSG00000206679 GC01M095126 LOC101928118
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM56 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM56 Gene

Chromosome:
1
Start:
95,092,517 bp from pter
End:
95,197,607 bp from pter
Size:
105,091 bases
Orientation:
Plus strand

Genomic View for TMEM56 Gene

Genes around TMEM56 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM56 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM56 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM56 Gene

Proteins for TMEM56 Gene

  • Protein details for TMEM56 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MV1-TMM56_HUMAN
    Recommended name:
    Transmembrane protein 56
    Protein Accession:
    Q96MV1
    Secondary Accessions:
    • B2RPI2
    • D3DT48

    Protein attributes for TMEM56 Gene

    Size:
    263 amino acids
    Molecular mass:
    30041 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM56 Gene

Post-translational modifications for TMEM56 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM56 Gene

No data available for DME Specific Peptides for TMEM56 Gene

Domains & Families for TMEM56 Gene

Gene Families for TMEM56 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM56 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM56 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96MV1

UniProtKB/Swiss-Prot:

TMM56_HUMAN :
  • Belongs to the TMEM56 family.
Family:
  • Belongs to the TMEM56 family.
genes like me logo Genes that share domains with TMEM56: view

Function for TMEM56 Gene

Phenotypes From GWAS Catalog for TMEM56 Gene

Gene Ontology (GO) - Molecular Function for TMEM56 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM56: view

Phenotypes for TMEM56 Gene

genes like me logo Genes that share phenotypes with TMEM56: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM56
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM56 Gene

Localization for TMEM56 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM56 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM56 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM56 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM56: view

Pathways & Interactions for TMEM56 Gene

SuperPathways for TMEM56 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM56 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM56: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM56 Gene

Drugs & Compounds for TMEM56 Gene

No Compound Related Data Available

Transcripts for TMEM56 Gene

Unigene Clusters for TMEM56 Gene

Transmembrane protein 56:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM56
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM56 Gene

No ASD Table

Relevant External Links for TMEM56 Gene

GeneLoc Exon Structure for
TMEM56
ECgene alternative splicing isoforms for
TMEM56

Expression for TMEM56 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM56 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM56 Gene

This gene is overexpressed in Liver (x8.1).

Protein differential expression in normal tissues from HIPED for TMEM56 Gene

This gene is overexpressed in Liver (24.1), Heart (19.6), Frontal cortex (10.9), and Fetal Liver (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM56 Gene



Protein tissue co-expression partners for TMEM56 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM56 Gene:

TMEM56

SOURCE GeneReport for Unigene cluster for TMEM56 Gene:

Hs.483512

Evidence on tissue expression from TISSUES for TMEM56 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TMEM56: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM56 Gene

Orthologs for TMEM56 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM56 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
OneToMany
TMEM56 33
  • 99.87 (n)
dog
(Canis familiaris)
Mammalia TMEM56 33
  • 87.58 (n)
-- 34
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmem56 33
  • 80.48 (n)
mouse
(Mus musculus)
Mammalia Tmem56 33 16 34
  • 80.35 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 66 (a)
ManyToMany
-- 34
  • 60 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 65 (a)
OneToMany
chicken
(Gallus gallus)
Aves TMEM56 33 34
  • 71.06 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 37 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489043 33
  • 64.47 (n)
Str.18352 33
zebrafish
(Danio rerio)
Actinopterygii tmem56a 33 34
  • 61.07 (n)
si:dkey-10f21.4 34
  • 49 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11267 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TDA4 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G31300 33
  • 41.37 (n)
rice
(Oryza sativa)
Liliopsida Os03g0666700 33
  • 44.56 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
ManyToMany
CSA.1291 34
  • 30 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
Species where no ortholog for TMEM56 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM56 Gene

ENSEMBL:
Gene Tree for TMEM56 (if available)
TreeFam:
Gene Tree for TMEM56 (if available)

Paralogs for TMEM56 Gene

Paralogs for TMEM56 Gene

(1) SIMAP similar genes for TMEM56 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for TMEM56 Gene

genes like me logo Genes that share paralogs with TMEM56: view

Variants for TMEM56 Gene

Sequence variations from dbSNP and Humsavar for TMEM56 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000014289 -- 95,153,048(+) CCAAG(C/G)CCACC intron-variant
rs1000017455 -- 95,136,425(+) AATCA(A/G)GATAA intron-variant
rs1000048224 -- 95,136,927(+) TGGGC(A/G)AAGTA intron-variant
rs1000084500 -- 95,101,972(+) TGTAG(A/G)TTTGA intron-variant
rs1000133360 -- 95,193,378(+) ATTAT(A/G)TATTT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM56 Gene

Variant ID Type Subtype PubMed ID
esv2672109 CNV deletion 23128226
esv2714984 CNV deletion 23290073
esv2714995 CNV deletion 23290073
esv3566037 CNV deletion 23714750
esv3566070 CNV deletion 23714750
nsv823609 CNV loss 20364138
nsv830636 CNV loss 17160897

Variation tolerance for TMEM56 Gene

Residual Variation Intolerance Score: 29.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM56 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM56

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM56 Gene

Disorders for TMEM56 Gene

Relevant External Links for TMEM56

Genetic Association Database (GAD)
TMEM56
Human Genome Epidemiology (HuGE) Navigator
TMEM56
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM56

No disorders were found for TMEM56 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM56 Gene

Publications for TMEM56 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu JH … Mozaffarian D (Circulation. Cardiovascular genetics 2013) 3 60

Products for TMEM56 Gene

Sources for TMEM56 Gene

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