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Aliases for TMEM56 Gene

Aliases for TMEM56 Gene

  • Transmembrane Protein 56 2 3

External Ids for TMEM56 Gene

Previous GeneCards Identifiers for TMEM56 Gene

  • GC01P095296
  • GC01P095582
  • GC01P093704

Summaries for TMEM56 Gene

GeneCards Summary for TMEM56 Gene

TMEM56 is a Protein Coding gene. An important paralog of this gene is TMEM56-RWDD3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM56 Gene

Genomics for TMEM56 Gene

Regulatory Elements for TMEM56 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM56 Gene

Start:
95,117,338 bp from pter
End:
95,197,607 bp from pter
Size:
80,270 bases
Orientation:
Plus strand

Genomic View for TMEM56 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM56 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM56 Gene

Proteins for TMEM56 Gene

  • Protein details for TMEM56 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MV1-TMM56_HUMAN
    Recommended name:
    Transmembrane protein 56
    Protein Accession:
    Q96MV1
    Secondary Accessions:
    • B2RPI2
    • D3DT48

    Protein attributes for TMEM56 Gene

    Size:
    263 amino acids
    Molecular mass:
    30041 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM56 Gene

Proteomics data for TMEM56 Gene at MOPED

Post-translational modifications for TMEM56 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM56 Gene

No data available for DME Specific Peptides for TMEM56 Gene

Domains for TMEM56 Gene

Protein Domains for TMEM56 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM56 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96MV1

UniProtKB/Swiss-Prot:

TMM56_HUMAN :
  • Q96MV1
Domain:
  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.
Family:
  • Belongs to the TMEM56 family.
genes like me logo Genes that share domains with TMEM56: view

No data available for Gene Families for TMEM56 Gene

Function for TMEM56 Gene

Gene Ontology (GO) - Molecular Function for TMEM56 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM56: view

Phenotypes for TMEM56 Gene

GenomeRNAi human phenotypes for TMEM56:
genes like me logo Genes that share phenotypes with TMEM56: view

Animal Model Products

CRISPR Products

miRNA for TMEM56 Gene

miRTarBase miRNAs that target TMEM56

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM56

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM56 Gene

Localization for TMEM56 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM56 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM56 Gene COMPARTMENTS Subcellular localization image for TMEM56 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM56 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM56: view

Pathways for TMEM56 Gene

SuperPathways for TMEM56 Gene

No Data Available

Interacting Proteins for TMEM56 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359222%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000230449%0d%0a9606.ENSP00000411409%0d%0a9606.ENSP00000247970%0d%0a
Selected Interacting proteins: ENSP00000359222 for TMEM56 Gene via STRING

Gene Ontology (GO) - Biological Process for TMEM56 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM56: view

No data available for Pathways by source for TMEM56 Gene

Transcripts for TMEM56 Gene

Unigene Clusters for TMEM56 Gene

Transmembrane protein 56:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM56

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM56 Gene

No ASD Table

Relevant External Links for TMEM56 Gene

GeneLoc Exon Structure for
TMEM56
ECgene alternative splicing isoforms for
TMEM56

Expression for TMEM56 Gene

mRNA expression in normal human tissues for TMEM56 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM56 Gene

This gene is overexpressed in Liver (8.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM56 Gene

SOURCE GeneReport for Unigene cluster for TMEM56 Gene Hs.483512

genes like me logo Genes that share expressions with TMEM56: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM56 Gene

Orthologs for TMEM56 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM56 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 100 (a)
OneToMany
TMEM56 35
  • 99.87 (n)
  • 99.62 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 67 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 81 (a)
OneToMany
TMEM56 35
  • 87.58 (n)
  • 80.61 (a)
mouse
(Mus musculus)
Mammalia Tmem56 35
  • 80.35 (n)
  • 77.19 (a)
Tmem56 16
Tmem56 36
  • 74 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 65 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tmem56 35
  • 80.48 (n)
  • 76.05 (a)
chicken
(Gallus gallus)
Aves TMEM56 35
  • 71.06 (n)
  • 62.79 (a)
TMEM56 36
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489043 35
  • 64.47 (n)
  • 55.43 (a)
Str.18352 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11267 35
zebrafish
(Danio rerio)
Actinopterygii si:dkey-10f21.4 36
  • 49 (a)
ManyToMany
tmem56a 35
  • 61.07 (n)
  • 55.34 (a)
tmem56a 36
  • 53 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TDA4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G31300 35
  • 41.37 (n)
  • 27.64 (a)
rice
(Oryza sativa)
Liliopsida Os03g0666700 35
  • 44.56 (n)
  • 31.66 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
CSA.1291 36
  • 30 (a)
ManyToMany
Species with no ortholog for TMEM56:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM56 Gene

ENSEMBL:
Gene Tree for TMEM56 (if available)
TreeFam:
Gene Tree for TMEM56 (if available)

Paralogs for TMEM56 Gene

Paralogs for TMEM56 Gene

Selected SIMAP similar genes for TMEM56 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for TMEM56 Gene

genes like me logo Genes that share paralogs with TMEM56: view

Variants for TMEM56 Gene

Sequence variations from dbSNP and Humsavar for TMEM56 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4245670 -- 95,115,792(+) CTATC(A/G)GCCAC upstream-variant-2KB
rs4489612 -- 95,115,873(+) TTGGT(A/T)TTTTC upstream-variant-2KB
rs143252344 -- 95,115,786(+) GAGCT(A/G)CTATC upstream-variant-2KB
rs145345580 -- 95,115,556(+) TCTCA(C/T)AGCTC upstream-variant-2KB
rs146702901 -- 95,115,842(+) TGATA(C/T)AGACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM56 Gene

Variant ID Type Subtype PubMed ID
nsv830636 CNV Loss 17160897
nsv823609 CNV Loss 20364138
esv2714984 CNV Deletion 23290073
nsv870669 CNV Loss 21882294
esv2714995 CNV Deletion 23290073
esv2672109 CNV Deletion 23128226

Relevant External Links for TMEM56 Gene

HapMap Linkage Disequilibrium report
TMEM56

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM56 Gene

Disorders for TMEM56 Gene

Relevant External Links for TMEM56

Genetic Association Database (GAD)
TMEM56
Human Genome Epidemiology (HuGE) Navigator
TMEM56
genes like me logo Genes that share disorders with TMEM56: view

No data available for UniProtKB/Swiss-Prot for TMEM56 Gene

Publications for TMEM56 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu J.H. … Mozaffarian D. (Circ Cardiovasc Genet 2013) 3
  4. Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. (PMID: 20708005) Chalasani N. … Rotter J.I. (Gastroenterology 2010) 48
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for TMEM56 Gene

Sources for TMEM56 Gene

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