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Aliases for TMEM55B Gene

Aliases for TMEM55B Gene

  • Transmembrane Protein 55B 2 3 4 5
  • Type I Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 2 3
  • Type 1 PtdIns-4,5-P2 4-Ptase 3 4
  • PtdIns-4,5-P2 4-Ptase I 3 4
  • EC 3.1.3.78 4 63
  • C14orf9 3 4
  • PtdIns-4,5-P(2) 4-Phosphatase Type I 3
  • Chromosome 14 Open Reading Frame 9 2

External Ids for TMEM55B Gene

Previous HGNC Symbols for TMEM55B Gene

  • C14orf9

Previous GeneCards Identifiers for TMEM55B Gene

  • GC14M019996
  • GC14M020926
  • GC14M001047

Summaries for TMEM55B Gene

Entrez Gene Summary for TMEM55B Gene

  • TMEM55B catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TMEM55B Gene

TMEM55B (Transmembrane Protein 55B) is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism (KEGG) and 3-phosphoinositide degradation. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is TMEM55A.

UniProtKB/Swiss-Prot for TMEM55B Gene

  • Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM55B Gene

Genomics for TMEM55B Gene

Regulatory Elements for TMEM55B Gene

Enhancers for TMEM55B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM55B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM55B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM55B on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TMEM55B gene promoter:

Genomic Location for TMEM55B Gene

Chromosome:
14
Start:
20,457,719 bp from pter
End:
20,461,612 bp from pter
Size:
3,894 bases
Orientation:
Minus strand

Genomic View for TMEM55B Gene

Genes around TMEM55B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM55B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM55B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM55B Gene

Proteins for TMEM55B Gene

  • Protein details for TMEM55B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86T03-TM55B_HUMAN
    Recommended name:
    Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
    Protein Accession:
    Q86T03
    Secondary Accessions:
    • B2RA35
    • Q86U09
    • Q8WUC0
    • Q9BU67
    • Q9NSU8

    Protein attributes for TMEM55B Gene

    Size:
    277 amino acids
    Molecular mass:
    29470 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB70896.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD62347.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM55B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM55B Gene

Proteomics data for TMEM55B Gene at MOPED

Post-translational modifications for TMEM55B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM55B Gene

Domains & Families for TMEM55B Gene

Gene Families for TMEM55B Gene

Protein Domains for TMEM55B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM55B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM55B: view

No data available for UniProtKB/Swiss-Prot for TMEM55B Gene

Function for TMEM55B Gene

Molecular function for TMEM55B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate.

Enzyme Numbers (IUBMB) for TMEM55B Gene

Phenotypes for TMEM55B Gene

genes like me logo Genes that share phenotypes with TMEM55B: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM55B Gene

Localization for TMEM55B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM55B Gene

Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM55B Gene COMPARTMENTS Subcellular localization image for TMEM55B gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM55B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 16365287
genes like me logo Genes that share ontologies with TMEM55B: view

Pathways & Interactions for TMEM55B Gene

genes like me logo Genes that share pathways with TMEM55B: view

Pathways by source for TMEM55B Gene

Interacting Proteins for TMEM55B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000381102%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000381102 Q86T03-TM55B_HUMAN for TMEM55B Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TMEM55B Gene

None

No data available for SIGNOR curated interactions for TMEM55B Gene

Drugs & Compounds for TMEM55B Gene

(381) Additional Compounds for TMEM55B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
PI(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
PI(16:0/16:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1w7)
PI(16:0/16:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoic acid
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phosphoinositol
genes like me logo Genes that share compounds with TMEM55B: view

Transcripts for TMEM55B Gene

Unigene Clusters for TMEM55B Gene

Transmembrane protein 55B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM55B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for TMEM55B Gene

GeneLoc Exon Structure for
TMEM55B
ECgene alternative splicing isoforms for
TMEM55B

Expression for TMEM55B Gene

mRNA expression in normal human tissues for TMEM55B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM55B Gene

This gene is overexpressed in Nasal epithelium (34.4) and Breast (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TMEM55B Gene



SOURCE GeneReport for Unigene cluster for TMEM55B Gene Hs.7001

mRNA Expression by UniProt/SwissProt for TMEM55B Gene

Q86T03-TM55B_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with TMEM55B: view

Protein tissue co-expression partners for TMEM55B Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for TMEM55B Gene

Orthologs for TMEM55B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM55B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM55B 35
  • 93.98 (n)
  • 99.64 (a)
TMEM55B 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM55B 35
  • 86.15 (n)
  • 91.9 (a)
TMEM55B 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem55b 35
  • 89.44 (n)
  • 97.18 (a)
Tmem55b 16
Tmem55b 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM55B 35
  • 99.77 (n)
  • 100 (a)
TMEM55B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem55b 35
  • 89.79 (n)
  • 96.48 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM55B 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM55B 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM55B 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11869 35
tmem55b 35
  • 67.51 (n)
  • 77.7 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:123304 35
  • 65.3 (n)
  • 70.63 (a)
TMEM55B (1 of 2) 36
  • 70 (a)
OneToMany
TMEM55B (2 of 2) 36
  • 73 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006243 35
  • 56.32 (n)
  • 54.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6707 35
  • 53.33 (n)
  • 51.9 (a)
CG6707 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.2 35
  • 50.85 (n)
  • 47.45 (a)
Y71H2AM.2 36
  • 38 (a)
OneToMany
Species with no ortholog for TMEM55B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM55B Gene

ENSEMBL:
Gene Tree for TMEM55B (if available)
TreeFam:
Gene Tree for TMEM55B (if available)

Paralogs for TMEM55B Gene

Paralogs for TMEM55B Gene

(1) SIMAP similar genes for TMEM55B Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for TMEM55B Gene

genes like me logo Genes that share paralogs with TMEM55B: view

Variants for TMEM55B Gene

Sequence variations from dbSNP and Humsavar for TMEM55B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1629478 -- 20,462,916(-) GGTTA(C/G)TAGCT upstream-variant-2KB
rs1713461 -- 20,461,066(-) GGTGC(C/G)GGACT intron-variant
rs1713462 -- 20,459,618(-) GGAAG(A/C/G)GGTAT intron-variant
rs8020101 -- 20,461,396(+) gccac(C/T)gccac utr-variant-5-prime
rs1760941 -- 20,461,879(-) AGAAG(G/T)AAAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM55B Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV Gain+Loss 19812545

Variation tolerance for TMEM55B Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 18.02% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM55B Gene

Disorders for TMEM55B Gene

Relevant External Links for TMEM55B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM55B

No disorders were found for TMEM55B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM55B Gene

Publications for TMEM55B Gene

  1. The identification and characterization of two phosphatidylinositol- 4,5-bisphosphate 4-phosphatases. (PMID: 16365287) Ungewickell A. … Majerus P.W. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3 4 67
  2. Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis. (PMID: 17940011) Zou J. … Majerus P.W. (Proc. Natl. Acad. Sci. U.S.A. 2007) 2 3
  3. Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus. (PMID: 25338677) Kariuki S.N. … Niewold T.B. (Genes Immun. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for TMEM55B Gene

Sources for TMEM55B Gene

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