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Aliases for TMEM55B Gene

Aliases for TMEM55B Gene

  • Transmembrane Protein 55B 2 3 4 5
  • Type I Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 2 3
  • Type 1 PtdIns-4,5-P2 4-Ptase 3 4
  • PtdIns-4,5-P2 4-Ptase I 3 4
  • EC 3.1.3.78 4 61
  • C14orf9 3 4
  • Type 1 Phosphatidylinositol 4,5-Bisphosphate 4-Phosphatase 3
  • PtdIns-4,5-P(2) 4-Phosphatase Type I 3
  • Chromosome 14 Open Reading Frame 9 2

External Ids for TMEM55B Gene

Previous HGNC Symbols for TMEM55B Gene

  • C14orf9

Previous GeneCards Identifiers for TMEM55B Gene

  • GC14M019996
  • GC14M020926
  • GC14M001047

Summaries for TMEM55B Gene

Entrez Gene Summary for TMEM55B Gene

  • TMEM55B catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TMEM55B Gene

TMEM55B (Transmembrane Protein 55B) is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism (KEGG) and Regulation of TP53 Activity. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is TMEM55A.

UniProtKB/Swiss-Prot for TMEM55B Gene

  • Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM55B Gene

Genomics for TMEM55B Gene

Regulatory Elements for TMEM55B Gene

Enhancers for TMEM55B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G020679 1.9 FANTOM5 ENCODE dbSUPER 21.3 -222.9 -222921 9.8 MLX CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 CHD8 SUPT16H ENSG00000258515 METTL3 TTC5 ENSG00000258768 PARP2 TMEM55B RNASE4 RAB2B
GH14G020453 1.2 ENCODE 28.5 +6.1 6070 3.9 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF263 SP3 NFYC TBX21 OSGEP ENSG00000258515 SUPT16H TMEM55B APEX1 ENSG00000258768 TTC5 TEP1 PARP2
GH14G020426 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.6 +33.5 33505 2.7 NFIB ARID4B EGR1 FOS RELB ETV6 IKZF2 CREM SMARCA5 SP5 OSGEP PNP TMEM55B APEX1 RNASE11 TEP1 KLHL33 RNASE6 RNASE3 GC14P020415
GH14G021092 2 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -639.8 -639815 18.3 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SUPT16H ENSG00000258768 ENSG00000258515 CHD8 ARHGEF40 OSGEP TTC5 TMEM55B RAB2B PARP2
GH14G020488 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -28.8 -28809 3.7 HDGF PKNOX1 TBL1XR1 RARA RELB ETV6 IKZF2 CREM EGR2 ELF4 PNP TMEM55B TEP1 RNA5SP382 OR4L1 ENSG00000258908 RNASE10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM55B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM55B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066363 112 1801 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1

Transcription factor binding sites by QIAGEN in the TMEM55B gene promoter:

Genomic Location for TMEM55B Gene

Chromosome:
14
Start:
20,457,719 bp from pter
End:
20,461,612 bp from pter
Size:
3,894 bases
Orientation:
Minus strand

Genomic View for TMEM55B Gene

Genes around TMEM55B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM55B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM55B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM55B Gene

Proteins for TMEM55B Gene

  • Protein details for TMEM55B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86T03-TM55B_HUMAN
    Recommended name:
    Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
    Protein Accession:
    Q86T03
    Secondary Accessions:
    • B2RA35
    • Q86U09
    • Q8WUC0
    • Q9BU67
    • Q9NSU8

    Protein attributes for TMEM55B Gene

    Size:
    277 amino acids
    Molecular mass:
    29470 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB70896.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD62347.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM55B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM55B Gene

Selected DME Specific Peptides for TMEM55B Gene

Q86T03:
  • GEDPPPYSPLTSP
  • DRTLARCPHCRKVSSIG
  • VCNEATPIK
  • GKKYVRCPCNCLLICK
  • GVRVICGHCKN
  • RIINLGP
  • GPLSPEPQP
  • HQHVVKC
  • ERSPLLS

Post-translational modifications for TMEM55B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM55B Gene

Domains & Families for TMEM55B Gene

Gene Families for TMEM55B Gene

Protein Domains for TMEM55B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM55B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM55B: view

No data available for UniProtKB/Swiss-Prot for TMEM55B Gene

Function for TMEM55B Gene

Molecular function for TMEM55B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate.

Enzyme Numbers (IUBMB) for TMEM55B Gene

Gene Ontology (GO) - Molecular Function for TMEM55B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IEA,TAS --
genes like me logo Genes that share ontologies with TMEM55B: view

Phenotypes for TMEM55B Gene

genes like me logo Genes that share phenotypes with TMEM55B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM55B Gene

Localization for TMEM55B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM55B Gene

Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM55B gene
Compartment Confidence
lysosome 5
endosome 5
nucleus 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM55B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IDA 16365287
GO:0005768 endosome IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TMEM55B: view

Pathways & Interactions for TMEM55B Gene

genes like me logo Genes that share pathways with TMEM55B: view

Gene Ontology (GO) - Biological Process for TMEM55B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0046856 phosphatidylinositol dephosphorylation IDA,IEA 16365287
genes like me logo Genes that share ontologies with TMEM55B: view

No data available for SIGNOR curated interactions for TMEM55B Gene

Drugs & Compounds for TMEM55B Gene

(2) Drugs for TMEM55B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(379) Additional Compounds for TMEM55B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
PI(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
PI(16:0/16:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1w7)
PI(16:0/16:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoic acid
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phosphoinositol
PI(16:0/18:0)
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/18:0)
  • Phosphatidylinositol(34:0)
  • PI(16:0/18:0)
genes like me logo Genes that share compounds with TMEM55B: view

Transcripts for TMEM55B Gene

Unigene Clusters for TMEM55B Gene

Transmembrane protein 55B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM55B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for TMEM55B Gene

GeneLoc Exon Structure for
TMEM55B
ECgene alternative splicing isoforms for
TMEM55B

Expression for TMEM55B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM55B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM55B Gene

This gene is overexpressed in Nasal epithelium (34.4) and Breast (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM55B Gene



Protein tissue co-expression partners for TMEM55B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM55B Gene:

TMEM55B

SOURCE GeneReport for Unigene cluster for TMEM55B Gene:

Hs.7001

mRNA Expression by UniProt/SwissProt for TMEM55B Gene:

Q86T03-TM55B_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TMEM55B Gene

  • Nervous system(4.6)
  • Lung(4.3)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with TMEM55B: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM55B Gene

Orthologs for TMEM55B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM55B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM55B 34 35
  • 99.77 (n)
cow
(Bos Taurus)
Mammalia TMEM55B 34 35
  • 93.98 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM55B 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem55b 34
  • 89.79 (n)
mouse
(Mus musculus)
Mammalia Tmem55b 34 16 35
  • 89.44 (n)
dog
(Canis familiaris)
Mammalia TMEM55B 34 35
  • 86.15 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM55B 35
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM55B 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem55b 34
  • 67.51 (n)
Str.11869 34
zebrafish
(Danio rerio)
Actinopterygii TMEM55B (2 of 2) 35
  • 73 (a)
OneToMany
TMEM55B (1 of 2) 35
  • 70 (a)
OneToMany
zgc:123304 34
  • 65.3 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006243 34
  • 56.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6707 34 35
  • 53.33 (n)
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.2 34 35
  • 50.85 (n)
Species where no ortholog for TMEM55B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM55B Gene

ENSEMBL:
Gene Tree for TMEM55B (if available)
TreeFam:
Gene Tree for TMEM55B (if available)

Paralogs for TMEM55B Gene

Paralogs for TMEM55B Gene

(1) SIMAP similar genes for TMEM55B Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for TMEM55B Gene

genes like me logo Genes that share paralogs with TMEM55B: view

Variants for TMEM55B Gene

Sequence variations from dbSNP and Humsavar for TMEM55B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000042220 -- 20,459,401(+) GCAGT(A/G)AGGAC reference, missense
rs1000166545 -- 20,463,520(+) CACTT(C/G)TAGCT upstream-variant-2KB
rs1000440103 -- 20,462,969(+) CTAAG(A/G)AAGCT upstream-variant-2KB
rs1000544014 -- 20,459,530(+) CATAG(A/C/G)ACAGA intron-variant
rs1000930278 -- 20,458,274(+) AAGGA(C/G)AAGGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM55B Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV gain+loss 19812545

Variation tolerance for TMEM55B Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 18.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM55B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM55B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM55B Gene

Disorders for TMEM55B Gene

Relevant External Links for TMEM55B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM55B

No disorders were found for TMEM55B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM55B Gene

Publications for TMEM55B Gene

  1. The identification and characterization of two phosphatidylinositol- 4,5-bisphosphate 4-phosphatases. (PMID: 16365287) Ungewickell A. … Majerus P.W. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3 4 64
  2. Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis. (PMID: 17940011) Zou J. … Majerus P.W. (Proc. Natl. Acad. Sci. U.S.A. 2007) 2 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis. (PMID: 26389662) Raman M. … Harper J.W. (Nat. Cell Biol. 2015) 3 64

Products for TMEM55B Gene

Sources for TMEM55B Gene

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