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TMEM55B Gene

protein-coding   GIFtS: 50
GCID: GC14M020926

Transmembrane Protein 55B

(Previous name: chromosome 14 open reading frame 9)
(Previous symbol: C14orf9)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 55B1 2 3     EC 3.1.3.783 8
C14orf91 2 3     Chromosome 14 Open Reading Frame 91
PtdIns-4,5-P2 4-Ptase I2 3     PtdIns-4,5-P(2) 4-Phosphatase Type I2
Type 1 PtdIns-4,5-P2 4-Ptase2 3     Type 1 Phosphatidylinositol 4,5-Bisphosphate 4-Phosphatase2

External Ids:    HGNC: 192991   Entrez Gene: 908092   Ensembl: ENSG000001657827   OMIM: 6098655   UniProtKB: Q86T033   

Export aliases for TMEM55B gene to outside databases

Previous GC identifers: GC14M019996 GC14M001047


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TMEM55B Gene:
TMEM55B catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the
4-phosphate (Ungewickell et al., 2005 (PubMed 16365287)).(supplied by OMIM, Mar 2008)

GeneCards Summary for TMEM55B Gene:
TMEM55B (transmembrane protein 55B) is a protein-coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is TMEM55A.

UniProtKB/Swiss-Prot: TM55B_HUMAN, Q86T03
Function: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not
hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol
3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol
4-monophosphate and phosphatidylinositol 3-monophosphate




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM55B gene promoter:
         GR   AP-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM55B promoter sequence
   Search Chromatin IP Primers for TMEM55B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM55B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.1

TMEM55B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM55B gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M020926:  view genomic region     (about GC identifiers)

Start:
20,925,878 bp from pter      End:
20,929,771 bp from pter
Size:
3,894 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TM55B_HUMAN, Q86T03 (See protein sequence)
Recommended Name: Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase  
Size: 277 amino acids; 29470 Da
Sequence caution: Sequence=CAB70896.1; Type=Erroneous initiation; Sequence=CAD62347.1; Type=Erroneous initiation;
Secondary accessions: B2RA35 Q86U09 Q8WUC0 Q9BU67 Q9NSU8
Alternative splicing: 3 isoforms:  Q86T03-1   Q86T03-2   Q86T03-3   (May be due to intron retention.)

Explore the universe of human proteins at neXtProt for TMEM55B: NX_Q86T03

Explore proteomics data for TMEM55B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TMEM55B (Q86T03) (see all 9)
     RIINLGP  HQHVVKC  ERSPLLS  GPLSPEPQP 


    See TMEM55B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001094284.1  NP_653169.2  

    ENSEMBL proteins: 
     ENSP00000250489   ENSP00000451014   ENSP00000381102   ENSP00000451350   ENSP00000452508  

    TMEM55B Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for TMEM55B
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    Novus Biologicals TMEM55B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMEM55B

     
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    LSBio Antibodies in human, mouse, rat for TMEM55B

    TMEM55B Assay Products:

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    Cloud-Clone Corp. ELISAs for TMEM55B
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    Search eBioscience for ELISAs for TMEM55B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019178 Transmembrane_protein_55A/B

    Graphical View of Domain Structure for InterPro Entry Q86T03

    ProtoNet protein and cluster: Q86T03


    Find genes that share domains with TMEM55B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TM55B_HUMAN, Q86T03
    Function: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not
    hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol
    3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol
    4-monophosphate and phosphatidylinositol 3-monophosphate
    Catalytic activity: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol
    5-phosphate + phosphate
    Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol
    5-phosphate + phosphate

         Enzyme Number (IUBMB): EC 3.1.3.781 2

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity IEA--
         
    Find genes that share ontologies with TMEM55B           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM55B
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    miRNA
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    miRTarBase miRNAs that target TMEM55B:
    hsa-let-7b-5p (MIRT052148), hsa-mir-16-5p (MIRT031583), hsa-mir-103a-3p (MIRT027112), hsa-mir-92a-3p (MIRT049299)

    Block miRNA regulation of human, mouse, rat TMEM55B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMEM55B (see all 39):
    hsa-miR-3685 hsa-miR-3616-5p hsa-miR-15a hsa-miR-503 hsa-let-7a-2* hsa-miR-301a hsa-miR-519a hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidTMEM55B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TMEM55B
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM55B

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): TMEM55B (NM_144568)
    Sino Biological Human cDNA Clone for TMEM55B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM55B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM55B

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM55B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TM55B_HUMAN, Q86T03: Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane
    protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    lysosome5
    vacuole5
    plasma membrane3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0031902late endosome membrane IEA--

    Find genes that share ontologies with TMEM55B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TMEM55B About    
    See pathways by source

    SuperPathContained pathways About
    1Inositol phosphate metabolism (KEGG)
    superpathway of inositol phosphate compounds0.60
    D-myo-inositol-5-phosphate metabolism0.00
    23-phosphoinositide degradation
    3-phosphoinositide degradation


    3 BioSystems Pathways for TMEM55B
        D-myo-inositol-5-phosphate metabolism
    3-phosphoinositide degradation
    superpathway of inositol phosphate compounds



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM55B
    Interactions:

        Search GeneGlobe Interaction Network for TMEM55B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for TMEM55B (Q86T033 ENSP000003811024) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARL6IP5O759153I2D: score=4 
    CSE1LP550603I2D: score=4 
    ENO1P067333I2D: score=4 
    MCRS1Q96EZ83I2D: score=4 
    NUP88Q995673I2D: score=4 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM55B (TM55B)

    Selected HMDB Compounds for TMEM55B (see all 379)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PI(16:0/16:0)Phosphatidylinositol(32:0) (see all 8)----
    PI(16:0/16:1(9Z))Phosphatidylinositol(32:1) (see all 14)----
    PI(16:0/16:2(9Z,12Z))Phosphatidylinositol(16:0/16:2n4) (see all 18)----
    PI(16:0/18:0)Phosphatidylinositol(16:0/18:0) (see all 8)----
    PI(16:0/18:1(11Z))Phosphatidylinositol(16:0/18:1w7) (see all 14)----
    PI(16:0/18:1(9Z))Phosphatidylinositol(16:0/18:1) (see all 14)----
    PI(16:0/18:2(9Z,12Z))PIno(16:0/18:2) (see all 14)----
    PI(16:0/20:0)PI(16:0/20:0) (see all 8)----
    PI(16:0/20:2(11Z,14Z))Phosphatidylinositol(16:0/20:2n6) (see all 14)----
    PI(16:0/20:3(5Z,8Z,11Z))Phosphatidylinositol(36:3) (see all 14)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMEM55B gene (2 alternative transcripts): 
    NM_001100814.2  NM_144568.3  

    Unigene Cluster for TMEM55B:

    Transmembrane protein 55B
    Hs.7001  [show with all ESTs]
    Unigene Representative Sequence: NM_001100814
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250489(uc001vxl.2) ENST00000553460 ENST00000557041 ENST00000398020(uc001vxk.2)
    ENST00000554028 ENST00000553602 ENST00000556093
    miRNA
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    Block miRNA regulation of human, mouse, rat TMEM55B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMEM55B (see all 39):
    hsa-miR-3685 hsa-miR-3616-5p hsa-miR-15a hsa-miR-503 hsa-let-7a-2* hsa-miR-301a hsa-miR-519a hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidTMEM55B 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): TMEM55B (NM_144568)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM55B
    Primer
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    OriGene qPCR primer pairs and template standards for TMEM55B
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM55B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM55B
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM55B
      QuantiFast Probe-based Assays in human, mouse, rat TMEM55B

    Additional mRNA sequence: 

    AK314021.1 BC002867.1 BC020947.1 BX161490.1 BX248025.1 

    16 DOTS entries:

    DT.117122  DT.100724282  DT.100813346  DT.95308767  DT.91749137  DT.100813350  DT.102837776  DT.97859296 
    DT.100692044  DT.100702130  DT.120733027  DT.91749130  DT.100813344  DT.120732962  DT.91749138  DT.95087404 

    Selected AceView cDNA sequences (see all 221):

    BU552784 CR620252 BE267519 R55517 AA324671 CB111561 AA186923 BU556474 
    BM770384 AW628421 CB989104 AW467360 CR614912 CK823039 AA377340 BU538500 
    CR616831 AA953455 BQ926651 CR598955 AW014083 BX161490 CB960878 AW848510 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM55B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
    SP1:        -                       -                                 
    SP2:                                -                                 
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for TMEM55B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM55B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTCTAAAAA
    TMEM55B Expression
    About this image


    TMEM55B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Bone Marrow
    TMEM55B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM55B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.7001

    UniProtKB/Swiss-Prot: TM55B_HUMAN, Q86T03
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for TMEM55B
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM55B
    QuantiTect SYBR Green Assays in human, mouse, rat TMEM55B
    QuantiFast Probe-based Assays in human, mouse, rat TMEM55B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM55B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMEM55B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem55b1 , 5 transmembrane protein 55b1, 5 89.44(n)1
    97.18(a)1
      14 (26.30 cM)5
    2190241  NM_001033271.41  NP_001028443.11 
     509260705 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM55B6
    transmembrane protein 55B
    80(a)
    1 ↔ 1
    GL343220.1(1207614-1223360)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.118692 Transcribed sequence with weak similarity to protein more 77.1(n)    BX717570.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1233041 zgc:123304 65.3(n)
    70.63(a)
      556136  NM_001037376.1  NP_001032453.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG67071 CG6707 53.33(n)
    51.9(a)
      39168  NM_140115.2  NP_648372.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y71H2AM.21 Y71H2AM.2 50.85(n)
    47.45(a)
      190605  NM_065223.3  NP_497624.3 


    ENSEMBL Gene Tree for TMEM55B (if available)
    TreeFam Gene Tree for TMEM55B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEM55B gene
    TMEM55A2  
    1 SIMAP similar gene for TMEM55B using alignment to 4 protein entries:     TM55B_HUMAN (see all proteins):
    TMEM55A

    Find genes that share paralogs with TMEM55B           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TMEM55B
    PGOHUM00000242331


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM55B (see all 149)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1922756631,2
    --20926481(+) TTTGCC/TTACTT 2 -- ut310--------
    rs1116372681,2
    C,F--20926498(+) AGACAC/TAGCAA 2 -- ut312Minor allele frequency- T:0.02CSA WA 120
    rs1836450071,2
    C--20926499(+) GACACA/GGCAAC 2 -- ut310--------
    rs2011955761,2
    C--20926689(+) GGAGGA/GGCCAG 2 -- ut310--------
    rs2015713981,2
    C--20926698(+) AGGCAC/GAGTCT 2 -- ut311Minor allele frequency- G:0.00EU 1227
    rs17609431,2
    C,F,H--20926699(-) CAGACT/CGTGCC 2 -- ut31 ese315Minor allele frequency- C:0.07MN NS EA NA WA CSA EU 2901
    rs2003495491,2
    C--20926704(+) AGTCTG/ATGGGT 2 -- ut311Minor allele frequency- A:0.00EU 1253
    rs2022327741,2
    C--20926730(+) AAGTTC/GTGGAC 4 H Q mis11Minor allele frequency- G:0.00EU 1307
    rs1494844071,2
    C--20926774(+) AGCCCG/AGCCCA 4 /R /W mis11Minor allele frequency- A:0.00NA 4552
    rs1439802441,2
    C,F--20926796(+) GCCAAC/GAGGAT 4 L syn11Minor allele frequency- G:0.00NA 4552

    HapMap Linkage Disequilibrium report for TMEM55B (20925878 - 20929771 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TMEM55B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv23438CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TMEM55B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609865    OMIM disorders: --


    Find genes that share disorders with TMEM55B           About GenesLikeMe


    Export disorders for TMEM55B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM55B gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with TMEM55B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The identification and characterization of two phosphatidylinositol- 4,5-bisphosphate 4-phosphatases. (PubMed id 16365287)1, 2 Ungewickell A.... Majerus P.W. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    8. Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis. (PubMed id 17940011)1 Zou J....Majerus P.W. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    10. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90809 HGNC: 19299 AceView: C14orf9 Ensembl:ENSG00000165782 euGenes: HUgn90809
    ECgene: TMEM55B H-InvDB: TMEM55B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM55B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM55B gene:
    Search GeneIP for patents involving TMEM55B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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