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Aliases for TMEM55B Gene

Aliases for TMEM55B Gene

  • Transmembrane Protein 55B 2 3 4 5
  • Type I Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 2 3
  • Type 1 PtdIns-4,5-P2 4-Ptase 3 4
  • PtdIns-4,5-P2 4-Ptase I 3 4
  • EC 3.1.3.78 4 61
  • C14orf9 3 4
  • Type 1 Phosphatidylinositol 4,5-Bisphosphate 4-Phosphatase 3
  • PtdIns-4,5-P(2) 4-Phosphatase Type I 3
  • Chromosome 14 Open Reading Frame 9 2

External Ids for TMEM55B Gene

Previous HGNC Symbols for TMEM55B Gene

  • C14orf9

Previous GeneCards Identifiers for TMEM55B Gene

  • GC14M019996
  • GC14M020926
  • GC14M001047

Summaries for TMEM55B Gene

Entrez Gene Summary for TMEM55B Gene

  • TMEM55B catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TMEM55B Gene

TMEM55B (Transmembrane Protein 55B) is a Protein Coding gene. Among its related pathways are Metabolism and Gene Expression. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is TMEM55A.

UniProtKB/Swiss-Prot for TMEM55B Gene

  • Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM55B Gene

Genomics for TMEM55B Gene

Regulatory Elements for TMEM55B Gene

Enhancers for TMEM55B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F020453 0.2 ENCODE 28.5 +6.1 6070 3.9 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 OSGEP SUPT16H ENSG00000258515 APEX1 TMEM55B TEP1 RNASE9 RNASE12 LOC105370394 OR11G2
GH14F020798 0.2 ENCODE 23.3 -339.3 -339295 5.6 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 METTL3 SUPT16H CHD8 ENSG00000258515 TMEM55B OSGEP ENSG00000222489 PARP2 RAB2B APEX1
GH14F021089 1.6 FANTOM5 Ensembl ENCODE 23 -638.5 -638501 21.0 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SUPT16H CHD8 ENSG00000258515 METTL3 TMEM55B ENSG00000258768 OSGEP RAB2B TTC5 RNASE4
GH14F020341 0.6 ENCODE 21.3 +118.4 118409 3.0 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 APEX1 TEP1 PARP2 TMEM55B ENSG00000258768 ENSG00000222489 ENSG00000258515 METTL17 RPPH1 CCNB1IP1
GH14F020679 1.2 FANTOM5 Ensembl ENCODE 21.3 -222.9 -222921 9.8 CREB3L1 MLX ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC PPARGC1A SUPT16H METTL3 CHD8 ENSG00000258515 ENSG00000258768 PARP2 TMEM55B RNASE4 TEP1 OSGEP
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM55B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM55B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000651571 12 2001 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9

Transcription factor binding sites by QIAGEN in the TMEM55B gene promoter:

Genomic Location for TMEM55B Gene

Chromosome:
14
Start:
20,457,719 bp from pter
End:
20,461,612 bp from pter
Size:
3,894 bases
Orientation:
Minus strand

Genomic View for TMEM55B Gene

Genes around TMEM55B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM55B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM55B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM55B Gene

Proteins for TMEM55B Gene

  • Protein details for TMEM55B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86T03-TM55B_HUMAN
    Recommended name:
    Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
    Protein Accession:
    Q86T03
    Secondary Accessions:
    • B2RA35
    • Q86U09
    • Q8WUC0
    • Q9BU67
    • Q9NSU8

    Protein attributes for TMEM55B Gene

    Size:
    277 amino acids
    Molecular mass:
    29470 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB70896.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD62347.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM55B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM55B Gene

Selected DME Specific Peptides for TMEM55B Gene

Q86T03:
  • GEDPPPYSPLTSP
  • DRTLARCPHCRKVSSIG
  • VCNEATPIK
  • GKKYVRCPCNCLLICK
  • GVRVICGHCKN
  • RIINLGP
  • GPLSPEPQP
  • HQHVVKC
  • ERSPLLS

Post-translational modifications for TMEM55B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM55B Gene

Domains & Families for TMEM55B Gene

Gene Families for TMEM55B Gene

Protein Domains for TMEM55B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM55B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM55B: view

No data available for UniProtKB/Swiss-Prot for TMEM55B Gene

Function for TMEM55B Gene

Molecular function for TMEM55B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate.

Enzyme Numbers (IUBMB) for TMEM55B Gene

Gene Ontology (GO) - Molecular Function for TMEM55B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IEA,IDA 16365287
genes like me logo Genes that share ontologies with TMEM55B: view

Phenotypes for TMEM55B Gene

genes like me logo Genes that share phenotypes with TMEM55B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM55B Gene

Localization for TMEM55B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM55B Gene

Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM55B Gene COMPARTMENTS Subcellular localization image for TMEM55B gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM55B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 16365287
GO:0005768 endosome IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031902 late endosome membrane IDA 16365287
genes like me logo Genes that share ontologies with TMEM55B: view

Pathways & Interactions for TMEM55B Gene

genes like me logo Genes that share pathways with TMEM55B: view

Interacting Proteins for TMEM55B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000381102%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000381102 Q86T03-TM55B_HUMAN for TMEM55B Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM55B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046856 phosphatidylinositol dephosphorylation IEA,IDA 16365287
genes like me logo Genes that share ontologies with TMEM55B: view

No data available for SIGNOR curated interactions for TMEM55B Gene

Drugs & Compounds for TMEM55B Gene

(2) Drugs for TMEM55B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(379) Additional Compounds for TMEM55B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
PI(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
PI(16:0/16:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1w7)
PI(16:0/16:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoic acid
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phosphoinositol
PI(16:0/18:0)
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/18:0)
  • Phosphatidylinositol(34:0)
  • PI(16:0/18:0)
genes like me logo Genes that share compounds with TMEM55B: view

Transcripts for TMEM55B Gene

Unigene Clusters for TMEM55B Gene

Transmembrane protein 55B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM55B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for TMEM55B Gene

GeneLoc Exon Structure for
TMEM55B
ECgene alternative splicing isoforms for
TMEM55B

Expression for TMEM55B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM55B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM55B Gene

This gene is overexpressed in Nasal epithelium (34.4) and Breast (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM55B Gene



Protein tissue co-expression partners for TMEM55B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM55B Gene:

TMEM55B

SOURCE GeneReport for Unigene cluster for TMEM55B Gene:

Hs.7001

mRNA Expression by UniProt/SwissProt for TMEM55B Gene:

Q86T03-TM55B_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with TMEM55B: view

Primer Products

No data available for mRNA differential expression in normal tissues for TMEM55B Gene

Orthologs for TMEM55B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM55B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM55B 34 35
  • 99.77 (n)
cow
(Bos Taurus)
Mammalia TMEM55B 34 35
  • 93.98 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM55B 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem55b 34
  • 89.79 (n)
mouse
(Mus musculus)
Mammalia Tmem55b 34 16 35
  • 89.44 (n)
dog
(Canis familiaris)
Mammalia TMEM55B 34 35
  • 86.15 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM55B 35
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM55B 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem55b 34
  • 67.51 (n)
Str.11869 34
zebrafish
(Danio rerio)
Actinopterygii TMEM55B (2 of 2) 35
  • 73 (a)
OneToMany
TMEM55B (1 of 2) 35
  • 70 (a)
OneToMany
zgc:123304 34
  • 65.3 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006243 34
  • 56.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6707 34 35
  • 53.33 (n)
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.2 34 35
  • 50.85 (n)
Species where no ortholog for TMEM55B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM55B Gene

ENSEMBL:
Gene Tree for TMEM55B (if available)
TreeFam:
Gene Tree for TMEM55B (if available)

Paralogs for TMEM55B Gene

Paralogs for TMEM55B Gene

(1) SIMAP similar genes for TMEM55B Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for TMEM55B Gene

genes like me logo Genes that share paralogs with TMEM55B: view

Variants for TMEM55B Gene

Sequence variations from dbSNP and Humsavar for TMEM55B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1049498 -- 20,457,693(+) TTTTT(A/T)AAAAA intron-variant, utr-variant-3-prime
rs1065749 -- 20,457,358(+) ACTTA(C/T)ATGAT downstream-variant-500B, reference, synonymous-codon
rs111637268 -- 20,458,339(+) AGACA(C/T)AGCAA utr-variant-3-prime
rs112100486 -- 20,459,494(+) ATGAG(A/G)ACCTT intron-variant
rs113056798 -- 20,457,488(+) CTATC(A/G)CCCTA downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TMEM55B Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV gain+loss 19812545

Variation tolerance for TMEM55B Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 18.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM55B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM55B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM55B Gene

Disorders for TMEM55B Gene

Relevant External Links for TMEM55B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM55B

No disorders were found for TMEM55B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM55B Gene

Publications for TMEM55B Gene

  1. The identification and characterization of two phosphatidylinositol- 4,5-bisphosphate 4-phosphatases. (PMID: 16365287) Ungewickell A. … Majerus P.W. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3 4 64
  2. Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis. (PMID: 17940011) Zou J. … Majerus P.W. (Proc. Natl. Acad. Sci. U.S.A. 2007) 2 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus. (PMID: 25338677) Kariuki S.N. … Niewold T.B. (Genes Immun. 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for TMEM55B Gene

Sources for TMEM55B Gene

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