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TMEM55A Gene

protein-coding   GIFtS: 50
GCID: GC08M092006

Transmembrane Protein 55A

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 55A1 2 3     PtdIns-4,5-P(2) 4-Phosphatase Type II2
PtdIns-4,5-P2 4-Ptase II2 3     Type 2 Phosphatidylinositol 4,5-Bisphosphate 4-Phosphatase2
Type 2 PtdIns-4,5-P2 4-Ptase2 3     Type II Phosphatidylinositol 4,5-Bisphosphate 4-Phosphatase2
EC 3.1.3.783 8     

External Ids:    HGNC: 254521   Entrez Gene: 555292   Ensembl: ENSG000001550997   OMIM: 6098645   UniProtKB: Q8N4L23   

Export aliases for TMEM55A gene to outside databases

Previous GC identifers: GC08M092076 GC08M087216


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TMEM55A Gene:
TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the
4-phosphate (Ungewickell et al., 2005 (PubMed 16365287)).(supplied by OMIM, Mar 2008)

GeneCards Summary for TMEM55A Gene:
TMEM55A (transmembrane protein 55A) is a protein-coding gene. Diseases associated with TMEM55A include parkinson's disease. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is TMEM55B.

UniProtKB/Swiss-Prot: TM55A_HUMAN, Q8N4L2
Function: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not
hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol
3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol
4-monophosphate and phosphatidylinositol 3-monophosphate




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM55A gene promoter:
         HFH-3   TBP   AML1a   Roaz   MEF-2A   FOXI1   TFIID   Sox9   aMEF-2   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM55A promoter sequence
   Search Chromatin IP Primers for TMEM55A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM55A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.3   Ensembl cytogenetic band:  8q21.3   HGNC cytogenetic band: 8q21.3

TMEM55A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM55A gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M092006:  view genomic region     (about GC identifiers)

Start:
92,006,024 bp from pter      End:
92,053,292 bp from pter
Size:
47,269 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TM55A_HUMAN, Q8N4L2 (See protein sequence)
Recommended Name: Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase  
Size: 257 amino acids; 28081 Da
Secondary accessions: B2R9H4 Q68CU2

Explore the universe of human proteins at neXtProt for TMEM55A: NX_Q8N4L2

Explore proteomics data for TMEM55A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TMEM55A (Q8N4L2) (see all 7)
     RIINLGP  ERSPLLS  HQHVVKC  RACYWGAI 


    See TMEM55A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061180.1  
    ENSEMBL proteins: 
     ENSP00000285419   ENSP00000430707   ENSP00000429280   ENSP00000427974   ENSP00000429112  

    TMEM55A Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for TMEM55A
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    Novus Biologicals TMEM55A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMEM55A

    TMEM55A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for TMEM55A
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    TMEM55A Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TMEM55A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TMEM55A
    Cloud-Clone Corp. CLIAs for TMEM55A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019178 Transmembrane_protein_55A/B

    Graphical View of Domain Structure for InterPro Entry Q8N4L2

    ProtoNet protein and cluster: Q8N4L2


    TMEM55A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TM55A_HUMAN, Q8N4L2
    Function: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not
    hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol
    3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol
    4-monophosphate and phosphatidylinositol 3-monophosphate
    Catalytic activity: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol
    5-phosphate + phosphate
    Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol
    5-phosphate + phosphate

         Enzyme Number (IUBMB): EC 3.1.3.781 2

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity IEA--
         
    TMEM55A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM55A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMEM55A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM55A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM55A

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMEM55A:
    hsa-mir-375 (MIRT019749)

    Block miRNA regulation of human, mouse, rat TMEM55A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMEM55A (see all 29):
    hsa-miR-448 hsa-miR-137 hsa-miR-15a hsa-miR-503 hsa-miR-301a hsa-miR-449a hsa-miR-424 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidTMEM55A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TMEM55A
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM55A

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TMEM55A

    Clone
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    OriGene clones in human, mouse for TMEM55A (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMEM55A (NM_018710)
    Sino Biological Human cDNA Clone for TMEM55A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM55A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM55A

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM55A 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM55A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TM55A_HUMAN, Q8N4L2: Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane
    protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    lysosome5
    vacuole5
    plasma membrane3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0031902late endosome membrane IEA--

    TMEM55A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TMEM55A About    
    See pathways by source

    SuperPathContained pathways About
    1Inositol phosphate metabolism (KEGG)
    superpathway of inositol phosphate compounds0.60
    D-myo-inositol-5-phosphate metabolism0.00
    23-phosphoinositide degradation
    3-phosphoinositide degradation


    3 BioSystems Pathways for TMEM55A
        D-myo-inositol-5-phosphate metabolism
    3-phosphoinositide degradation
    superpathway of inositol phosphate compounds



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM55A
    Interactions:

        Search GeneGlobe Interaction Network for TMEM55A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for TMEM55A (Q8N4L23 ENSP000002854194) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK5RAP3Q96JB53, ENSP000003446834I2D: score=1 STRING: ENSP00000344683
    PIP4K2CENSP000003470324STRING: ENSP00000347032
    PIP5K1CENSP000003353334STRING: ENSP00000335333
    PIP4K2AENSP000003657574STRING: ENSP00000365757
    PIP4K2BENSP000002695544STRING: ENSP00000269554
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM55A (TM55A)

    Selected HMDB Compounds for TMEM55A (see all 379)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PI(16:0/16:0)Phosphatidylinositol(32:0) (see all 8)----
    PI(16:0/16:1(9Z))Phosphatidylinositol(32:1) (see all 14)----
    PI(16:0/16:2(9Z,12Z))Phosphatidylinositol(16:0/16:2n4) (see all 18)----
    PI(16:0/18:0)Phosphatidylinositol(16:0/18:0) (see all 8)----
    PI(16:0/18:1(11Z))Phosphatidylinositol(16:0/18:1w7) (see all 14)----
    PI(16:0/18:1(9Z))Phosphatidylinositol(16:0/18:1) (see all 14)----
    PI(16:0/18:2(9Z,12Z))PIno(16:0/18:2) (see all 14)----
    PI(16:0/20:0)PI(16:0/20:0) (see all 8)----
    PI(16:0/20:2(11Z,14Z))Phosphatidylinositol(16:0/20:2n6) (see all 14)----
    PI(16:0/20:3(5Z,8Z,11Z))Phosphatidylinositol(36:3) (see all 14)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMEM55A gene: 
    NM_018710.2  

    Unigene Cluster for TMEM55A:

    Transmembrane protein 55A
    Hs.202517  [show with all ESTs]
    Unigene Representative Sequence: NM_018710
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000285419(uc003yes.3) ENST00000520709 ENST00000518359 ENST00000520014
    ENST00000518869
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMEM55A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMEM55A (see all 29):
    hsa-miR-448 hsa-miR-137 hsa-miR-15a hsa-miR-503 hsa-miR-301a hsa-miR-449a hsa-miR-424 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidTMEM55A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMEM55A
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM55A
    Clone
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    OriGene clones in human, mouse for TMEM55A (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMEM55A (NM_018710)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM55A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM55A
    Primer
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    OriGene qPCR primer pairs and template standards for TMEM55A
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM55A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM55A
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM55A
      QuantiFast Probe-based Assays in human, mouse, rat TMEM55A

    Additional mRNA sequence: 

    AK313783.1 BC033892.1 CR749733.1 

    4 DOTS entries:

    DT.100778261  DT.95376141  DT.100778259  DT.100660303 

    Selected AceView cDNA sequences (see all 102):

    AW269065 CR603128 AL359591 CR749733 AF086030 BI761178 BQ423159 AA825408 
    BF149415 BU625406 BF512370 AA883397 BG031142 BF058047 AW583509 BU735858 
    AI660800 BQ434858 AA604382 BI324839 BM703778 AA970033 AW298825 AI290792 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM55A    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:        -     -                                                   
    SP2:              -                                                   
    SP3:        -                                                         
    SP4:        -     -     -     -     -           -                     


    ECgene alternative splicing isoforms for TMEM55A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM55A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACACTTCAA
    TMEM55A Expression
    About this image

    TMEM55A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM55A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.202517

    UniProtKB/Swiss-Prot: TM55A_HUMAN, Q8N4L2
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for TMEM55A
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    QuantiFast Probe-based Assays in human, mouse, rat TMEM55A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM55A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMEM55A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem55a1 , 5 transmembrane protein 55A1, 5 90.53(n)1
    96.5(a)1
      4 (6.41 cM)5
    725191  NM_028264.41  NP_082540.11 
     148640765 
    chicken
    (Gallus gallus)
    Aves TMEM55A1 transmembrane protein 55A 85.99(n)
    93.77(a)
      420221  NM_001277420.1  NP_001264349.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM55A6
    transmembrane protein 55A
    92(a)
    1 ↔ 1
    4(21080763-21093996)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tmem55a1 transmembrane protein 55A 79.95(n)
    90.62(a)
      448483  NM_001005000.1  NP_001005000.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmem55a1 transmembrane protein 55A 75.88(n)
    89.88(a)
      566642  NM_001045112.3  NP_001038577.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG67076
    --
    42(a)
    1 → many
    3L(9887907-9891675)
    worm
    (Caenorhabditis elegans)
    Secernentea Y71H2AM.26
    Protein Y71H2AM.2 (Y71H2AM.2) mRNA, complete cds
    36(a)
    1 → many
    III(2819282-2824667) WBGene00022167


    ENSEMBL Gene Tree for TMEM55A (if available)
    TreeFam Gene Tree for TMEM55A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEM55A gene
    TMEM55B2  
    1 SIMAP similar gene for TMEM55A using alignment to 5 protein entries:     TM55A_HUMAN (see all proteins):
    TMEM55B

    TMEM55A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM55A (see all 839)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1426399171,2
    --92006012(+) ACATAA/TTCAAG 1 -- int10--------
    rs1884160131,2
    --92006069(+) TCATGC/TATATT 1 -- int10--------
    rs1929493241,2
    --92006163(+) TCTCAG/TAAAGT 1 -- int10--------
    rs1147761361,2
    F--92006249(+) ATTCAG/CTATAC 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1854061551,2
    C--92006377(+) TAGTAC/TAAAAA 1 -- int10--------
    rs1899345411,2
    --92006419(+) ACATTC/GCTAAA 1 -- int10--------
    rs1825721851,2
    --92006441(+) TACAGC/TAAGAT 1 -- int10--------
    rs1864387911,2
    --92006558(+) CTACAG/TCATTT 1 -- ut310--------
    rs78373711,2
    C,F,H--92006663(+) TAAAAT/CATTAG 1 -- ut31 ese37Minor allele frequency- C:0.01EA NS NA 780
    rs732999461,2
    C,F--92006768(+) TTTCTT/GTTTCA 1 -- ut315Minor allele frequency- G:0.13WA CSA NA EA 362

    HapMap Linkage Disequilibrium report for TMEM55A (92006024 - 92053292 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TMEM55A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2443764CNV Deletion19546169
    nsv6300CNV Insertion18451855
    nsv891185CNV Loss21882294
    nsv831390CNV Gain17160897
    essv220CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609864    OMIM disorders: --

    1 disease for TMEM55A:    
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    parkinson's disease


    TMEM55A for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMEM55A

    Export disorders for TMEM55A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM55A gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with TMEM55A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The identification and characterization of two phosphatidylinositol- 4,5-bisphosphate 4-phosphatases. (PubMed id 16365287)1, 2 Ungewickell A.... Majerus P.W. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    6. A novel LZAP-binding protein, NLBP, inhibits cell invasion. (PubMed id 20164180)1 Kwon J.... Kim H. (J. Biol. Chem. 2010)
    7. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (Mol. Syst. Biol. 2009)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55529 HGNC: 25452 AceView: DKFZp762O076 Ensembl:ENSG00000155099 euGenes: HUgn55529
    ECgene: TMEM55A H-InvDB: TMEM55A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM55A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM55A gene:
    Search GeneIP for patents involving TMEM55A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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