Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM55A Gene

Aliases for TMEM55A Gene

  • Transmembrane Protein 55A 2 3 4
  • EC 3.1.3.78 4 63
  • Type 2 PtdIns-4,5-P2 4-Ptase 4
  • PtdIns-4,5-P2 4-Ptase II 4

External Ids for TMEM55A Gene

Previous GeneCards Identifiers for TMEM55A Gene

  • GC08M092076
  • GC08M092006
  • GC08M087216

Summaries for TMEM55A Gene

Entrez Gene Summary for TMEM55A Gene

  • TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TMEM55A Gene

TMEM55A is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism (KEGG) and 3-phosphoinositide degradation. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is TMEM55B.

UniProtKB/Swiss-Prot for TMEM55A Gene

  • Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM55A Gene

Genomics for TMEM55A Gene

Regulatory Elements for TMEM55A Gene

Genomic Location for TMEM55A Gene

Start:
90,993,796 bp from pter
End:
91,041,064 bp from pter
Size:
47,269 bases
Orientation:
Minus strand

Genomic View for TMEM55A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM55A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM55A Gene

Proteins for TMEM55A Gene

  • Protein details for TMEM55A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4L2-TM55A_HUMAN
    Recommended name:
    Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
    Protein Accession:
    Q8N4L2
    Secondary Accessions:
    • B2R9H4
    • Q68CU2

    Protein attributes for TMEM55A Gene

    Size:
    257 amino acids
    Molecular mass:
    28081 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM55A Gene

Proteomics data for TMEM55A Gene at MOPED

Selected DME Specific Peptides for TMEM55A Gene

Post-translational modifications for TMEM55A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM55A Gene

Domains for TMEM55A Gene

Protein Domains for TMEM55A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM55A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM55A: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM55A Gene

Function for TMEM55A Gene

Molecular function for TMEM55A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate
UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate.

Enzyme Numbers (IUBMB) for TMEM55A Gene

Gene Ontology (GO) - Molecular Function for TMEM55A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TMEM55A: view

Animal Model Products

CRISPR Products

miRNA for TMEM55A Gene

miRTarBase miRNAs that target TMEM55A

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM55A

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM55A Gene

Localization for TMEM55A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM55A Gene

Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM55A Gene COMPARTMENTS Subcellular localization image for TMEM55A gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM55A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome --
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome --
GO:0016021 integral component of membrane IEA --
GO:0031902 late endosome membrane IEA --
genes like me logo Genes that share ontologies with TMEM55A: view

Pathways for TMEM55A Gene

genes like me logo Genes that share pathways with TMEM55A: view

Pathways by source for TMEM55A Gene

Interacting Proteins for TMEM55A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000285419%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000344683%0d%0a
Selected Interacting proteins: ENSP00000285419 Q8N4L2-TM55A_HUMAN for TMEM55A Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TMEM55A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with TMEM55A: view

Compounds for TMEM55A Gene

(379) HMDB Compounds for TMEM55A Gene

Compound Synonyms Cas Number PubMed IDs
Phosphatidylinositol-3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
Not Available
PI(16:0/16:0)
  • Phosphatidylinositol(32:0)
Not Available
PI(16:0/16:1(9Z))
  • Phosphatidylinositol(32:1)
Not Available
PI(16:0/16:2(9Z,12Z))
  • Phosphatidylinositol(16:0/16:2n4)
Not Available
PI(16:0/18:0)
  • Phosphatidylinositol(16:0/18:0)
Not Available
genes like me logo Genes that share compounds with TMEM55A: view

Transcripts for TMEM55A Gene

mRNA/cDNA for TMEM55A Gene

Unigene Clusters for TMEM55A Gene

Transmembrane protein 55A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM55A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM55A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - -
SP2: -
SP3: -
SP4: - - - - - -

Relevant External Links for TMEM55A Gene

GeneLoc Exon Structure for
TMEM55A
ECgene alternative splicing isoforms for
TMEM55A

Expression for TMEM55A Gene

mRNA expression in normal human tissues for TMEM55A Gene

Protein differential expression in normal tissues for TMEM55A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.7) and Platelet (12.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM55A Gene

SOURCE GeneReport for Unigene cluster for TMEM55A Gene Hs.202517

mRNA Expression by UniProt/SwissProt for TMEM55A Gene

Q8N4L2-TM55A_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with TMEM55A: view

Expression partners for TMEM55A Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TMEM55A Gene

Orthologs for TMEM55A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM55A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM55A 35
  • 91.44 (n)
  • 95.72 (a)
TMEM55A 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM55A 35
  • 91.96 (n)
  • 95.61 (a)
TMEM55A 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem55a 35
  • 90.53 (n)
  • 96.5 (a)
Tmem55a 16
Tmem55a 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM55A 35
  • 99.74 (n)
  • 100 (a)
TMEM55A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem55a 35
  • 89.49 (n)
  • 96.11 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM55A 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM55A 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM55A 35
  • 85.99 (n)
  • 93.77 (a)
TMEM55A 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM55A 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem55a 35
  • 79.95 (n)
  • 90.62 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem55a 35
  • 75.88 (n)
  • 89.88 (a)
tmem55a 36
  • 90 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6707 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.2 36
  • 36 (a)
OneToMany
Species with no ortholog for TMEM55A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM55A Gene

ENSEMBL:
Gene Tree for TMEM55A (if available)
TreeFam:
Gene Tree for TMEM55A (if available)

Paralogs for TMEM55A Gene

Paralogs for TMEM55A Gene

Selected SIMAP similar genes for TMEM55A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMEM55A: view

Variants for TMEM55A Gene

Sequence variations from dbSNP and Humsavar for TMEM55A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1043286 -- 90,995,657(-) CAGTA(A/G)TGCAG utr-variant-3-prime
rs2054805 -- 91,008,808(+) ATAAA(C/T)AAAGA intron-variant
rs3084284 -- 91,011,063(+) ATAGA(-/TAGA)CAGAT intron-variant
rs4448231 -- 91,004,346(+) ccagc(C/G)aattg intron-variant
rs4529427 -- 91,022,180(+) ACAAG(C/T)AGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM55A Gene

Variant ID Type Subtype PubMed ID
nsv891185 CNV Loss 21882294
essv220 CNV CNV 17122850
esv2443764 CNV Deletion 19546169
nsv831390 CNV Gain 17160897
nsv6300 CNV Insertion 18451855

Relevant External Links for TMEM55A Gene

HapMap Linkage Disequilibrium report
TMEM55A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM55A Gene

Disorders for TMEM55A Gene

Relevant External Links for TMEM55A

Genetic Association Database (GAD)
TMEM55A

No disorders were found for TMEM55A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TMEM55A Gene

Publications for TMEM55A Gene

  1. The identification and characterization of two phosphatidylinositol- 4,5-bisphosphate 4-phosphatases. (PMID: 16365287) Ungewickell A. … Majerus P.W. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for TMEM55A Gene

Sources for TMEM55A Gene

Back to Top

Content