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Aliases for TMEM55A Gene

Aliases for TMEM55A Gene

  • Transmembrane Protein 55A 2 3 4 5
  • EC 3.1.3.78 4 61
  • Type II Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 2
  • Type 2 PtdIns-4,5-P2 4-Ptase 4
  • PtdIns-4,5-P2 4-Ptase II 4

External Ids for TMEM55A Gene

Previous GeneCards Identifiers for TMEM55A Gene

  • GC08M092076
  • GC08M092006
  • GC08M087216

Summaries for TMEM55A Gene

Entrez Gene Summary for TMEM55A Gene

  • TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TMEM55A Gene

TMEM55A (Transmembrane Protein 55A) is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism (KEGG) and 3-phosphoinositide degradation. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is TMEM55B.

UniProtKB/Swiss-Prot for TMEM55A Gene

  • Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM55A Gene

Genomics for TMEM55A Gene

Regulatory Elements for TMEM55A Gene

Enhancers for TMEM55A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F091031 1.4 FANTOM5 Ensembl ENCODE 4.5 +7.9 7928 3.5 HLF CEBPB CEBPG TBX21 GATA3 CEBPA IKZF1 MLLT1 SPI1 OTUD6B-AS1 SLC26A7 LRRC69 TMEM55A GS1-251I9.3
GH08F091036 1.3 Ensembl ENCODE 0.8 +4.4 4436 0.7 ZNF558 OTUD6B-AS1 TMEM55A GS1-251I9.3
GH08F091044 0.2 Ensembl 0.8 -3.5 -3537 0.8 HLF OTUD6B-AS1 TMEM55A ENSG00000254219
GH08F091037 0.7 ENCODE 0.8 +3.5 3507 0.1 CEBPB FOXP2 SLC26A7 TMEM55A GS1-251I9.3
GH08F091038 0.9 ENCODE 0.8 +0.9 920 4.3 ARID4B SIN3A ZNF48 ZNF2 ETS1 GLIS2 GATA2 FOS ZNF263 SP3 OTUD6B-AS1 SLC26A7 LRRC69 LOC105375634 TMEM55A GS1-251I9.3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM55A on UCSC Golden Path with GeneCards custom track

Promoters for TMEM55A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001396102 864 2801 ARID4B SIN3A ZNF48 ZNF2 ETS1 GLIS2 GATA2 FOS ZNF263 SP3

Genomic Location for TMEM55A Gene

Chromosome:
8
Start:
90,993,796 bp from pter
End:
91,041,064 bp from pter
Size:
47,269 bases
Orientation:
Minus strand

Genomic View for TMEM55A Gene

Genes around TMEM55A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM55A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM55A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM55A Gene

Proteins for TMEM55A Gene

  • Protein details for TMEM55A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4L2-TM55A_HUMAN
    Recommended name:
    Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
    Protein Accession:
    Q8N4L2
    Secondary Accessions:
    • B2R9H4
    • Q68CU2

    Protein attributes for TMEM55A Gene

    Size:
    257 amino acids
    Molecular mass:
    28081 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM55A Gene

Selected DME Specific Peptides for TMEM55A Gene

Q8N4L2:
  • VCNEATPIK
  • GKKYVRCPCNCLLICK
  • RIINLGP
  • SSVGSALPRRRCC
  • RACYWGAI
  • HQHVVKC
  • ERSPLLS

Post-translational modifications for TMEM55A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM55A Gene

Domains & Families for TMEM55A Gene

Gene Families for TMEM55A Gene

Protein Domains for TMEM55A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM55A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM55A: view

No data available for UniProtKB/Swiss-Prot for TMEM55A Gene

Function for TMEM55A Gene

Molecular function for TMEM55A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate.

Enzyme Numbers (IUBMB) for TMEM55A Gene

Gene Ontology (GO) - Molecular Function for TMEM55A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IEA,IDA 16365287
genes like me logo Genes that share ontologies with TMEM55A: view

Phenotypes for TMEM55A Gene

genes like me logo Genes that share phenotypes with TMEM55A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM55A Gene

Localization for TMEM55A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM55A Gene

Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM55A Gene COMPARTMENTS Subcellular localization image for TMEM55A gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM55A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 16365287
GO:0005768 endosome IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031902 late endosome membrane IDA 16365287
genes like me logo Genes that share ontologies with TMEM55A: view

Pathways & Interactions for TMEM55A Gene

genes like me logo Genes that share pathways with TMEM55A: view

Pathways by source for TMEM55A Gene

Interacting Proteins for TMEM55A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000285419%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000344683%0d%0a
Selected Interacting proteins: ENSP00000285419 Q8N4L2-TM55A_HUMAN for TMEM55A Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM55A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046856 phosphatidylinositol dephosphorylation IEA,IDA 16365287
genes like me logo Genes that share ontologies with TMEM55A: view

No data available for SIGNOR curated interactions for TMEM55A Gene

Drugs & Compounds for TMEM55A Gene

(2) Drugs for TMEM55A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(379) Additional Compounds for TMEM55A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
PI(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
PI(16:0/16:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1w7)
PI(16:0/16:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoic acid
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phosphoinositol
PI(16:0/18:0)
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/18:0)
  • Phosphatidylinositol(34:0)
  • PI(16:0/18:0)
genes like me logo Genes that share compounds with TMEM55A: view

Transcripts for TMEM55A Gene

Unigene Clusters for TMEM55A Gene

Transmembrane protein 55A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM55A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - -
SP2: -
SP3: -
SP4: - - - - - -

Relevant External Links for TMEM55A Gene

GeneLoc Exon Structure for
TMEM55A
ECgene alternative splicing isoforms for
TMEM55A

Expression for TMEM55A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM55A Gene

Protein differential expression in normal tissues from HIPED for TMEM55A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.7) and Platelet (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM55A Gene



Protein tissue co-expression partners for TMEM55A Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM55A Gene:

TMEM55A

SOURCE GeneReport for Unigene cluster for TMEM55A Gene:

Hs.202517

mRNA Expression by UniProt/SwissProt for TMEM55A Gene:

Q8N4L2-TM55A_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with TMEM55A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TMEM55A Gene

Orthologs for TMEM55A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM55A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM55A 34 35
  • 99.74 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM55A 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM55A 34 35
  • 91.96 (n)
cow
(Bos Taurus)
Mammalia TMEM55A 34 35
  • 91.44 (n)
mouse
(Mus musculus)
Mammalia Tmem55a 34 16 35
  • 90.53 (n)
rat
(Rattus norvegicus)
Mammalia Tmem55a 34
  • 89.49 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM55A 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM55A 34 35
  • 85.99 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM55A 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem55a 34
  • 79.95 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem55a 34 35
  • 75.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6707 35
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.2 35
  • 36 (a)
OneToMany
Species where no ortholog for TMEM55A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM55A Gene

ENSEMBL:
Gene Tree for TMEM55A (if available)
TreeFam:
Gene Tree for TMEM55A (if available)

Paralogs for TMEM55A Gene

Paralogs for TMEM55A Gene

(1) SIMAP similar genes for TMEM55A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMEM55A: view

Variants for TMEM55A Gene

Sequence variations from dbSNP and Humsavar for TMEM55A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10081409 -- 91,011,360(+) TGTTC(A/C)GTTGT intron-variant
rs10096420 -- 91,037,502(+) GCATA(C/T)ATTTC intron-variant
rs10106570 -- 90,998,249(+) AGTCA(A/G)AAGTT intron-variant
rs10106732 -- 91,037,268(+) TCCTA(C/T)TGCTG intron-variant
rs10108486 -- 91,003,375(+) TAAAA(C/T)GTCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM55A Gene

Variant ID Type Subtype PubMed ID
esv2443764 CNV deletion 19546169
esv2759629 CNV loss 17122850
esv3618011 CNV loss 21293372
nsv1028201 CNV loss 25217958
nsv475564 CNV novel sequence insertion 20440878
nsv6300 CNV insertion 18451855
nsv831390 CNV gain 17160897

Variation tolerance for TMEM55A Gene

Residual Variation Intolerance Score: 26.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM55A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM55A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM55A Gene

Disorders for TMEM55A Gene

Relevant External Links for TMEM55A

Genetic Association Database (GAD)
TMEM55A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM55A

No disorders were found for TMEM55A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM55A Gene

Publications for TMEM55A Gene

  1. The identification and characterization of two phosphatidylinositol- 4,5-bisphosphate 4-phosphatases. (PMID: 16365287) Ungewickell A. … Majerus P.W. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  5. A novel LZAP-binding protein, NLBP, inhibits cell invasion. (PMID: 20164180) Kwon J. … Kim H. (J. Biol. Chem. 2010) 3 64

Products for TMEM55A Gene

Sources for TMEM55A Gene

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