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Aliases for TMEM55A Gene

Aliases for TMEM55A Gene

  • Transmembrane Protein 55A 2 3 4 5
  • EC 4 63
  • Type II Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 2
  • Type 2 PtdIns-4,5-P2 4-Ptase 4
  • PtdIns-4,5-P2 4-Ptase II 4

External Ids for TMEM55A Gene

Previous GeneCards Identifiers for TMEM55A Gene

  • GC08M092076
  • GC08M092006
  • GC08M087216

Summaries for TMEM55A Gene

Entrez Gene Summary for TMEM55A Gene

  • TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TMEM55A Gene

TMEM55A (Transmembrane Protein 55A) is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism (KEGG) and 3-phosphoinositide degradation. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is TMEM55B.

UniProtKB/Swiss-Prot for TMEM55A Gene

  • Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM55A Gene

Genomics for TMEM55A Gene

Regulatory Elements for TMEM55A Gene

Enhancers for TMEM55A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM55A on UCSC Golden Path with GeneCards custom track

Promoters for TMEM55A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM55A on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM55A Gene

90,993,796 bp from pter
91,041,064 bp from pter
47,269 bases
Minus strand

Genomic View for TMEM55A Gene

Genes around TMEM55A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM55A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM55A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM55A Gene

Proteins for TMEM55A Gene

  • Protein details for TMEM55A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
    Protein Accession:
    Secondary Accessions:
    • B2R9H4
    • Q68CU2

    Protein attributes for TMEM55A Gene

    257 amino acids
    Molecular mass:
    28081 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM55A Gene

Proteomics data for TMEM55A Gene at MOPED

Selected DME Specific Peptides for TMEM55A Gene

Post-translational modifications for TMEM55A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM55A Gene

Domains & Families for TMEM55A Gene

Gene Families for TMEM55A Gene

Protein Domains for TMEM55A Gene


Suggested Antigen Peptide Sequences for TMEM55A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM55A: view

No data available for UniProtKB/Swiss-Prot for TMEM55A Gene

Function for TMEM55A Gene

Molecular function for TMEM55A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate.

Enzyme Numbers (IUBMB) for TMEM55A Gene

Phenotypes for TMEM55A Gene

genes like me logo Genes that share phenotypes with TMEM55A: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM55A Gene

Localization for TMEM55A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM55A Gene

Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM55A Gene COMPARTMENTS Subcellular localization image for TMEM55A gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM55A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 16365287
genes like me logo Genes that share ontologies with TMEM55A: view

Pathways & Interactions for TMEM55A Gene

genes like me logo Genes that share pathways with TMEM55A: view

Pathways by source for TMEM55A Gene

Interacting Proteins for TMEM55A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000285419 Q8N4L2-TM55A_HUMAN for TMEM55A Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TMEM55A Gene


No data available for SIGNOR curated interactions for TMEM55A Gene

Drugs & Compounds for TMEM55A Gene

(381) Additional Compounds for TMEM55A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1w7)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoic acid
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phosphoinositol
genes like me logo Genes that share compounds with TMEM55A: view

Transcripts for TMEM55A Gene

Unigene Clusters for TMEM55A Gene

Transmembrane protein 55A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM55A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - -
SP2: -
SP3: -
SP4: - - - - - -

Relevant External Links for TMEM55A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM55A Gene

mRNA expression in normal human tissues for TMEM55A Gene

Protein differential expression in normal tissues from HIPED for TMEM55A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.7) and Platelet (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM55A Gene

SOURCE GeneReport for Unigene cluster for TMEM55A Gene Hs.202517

mRNA Expression by UniProt/SwissProt for TMEM55A Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with TMEM55A: view

Protein tissue co-expression partners for TMEM55A Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TMEM55A Gene

Orthologs for TMEM55A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM55A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM55A 35
  • 91.44 (n)
  • 95.72 (a)
TMEM55A 36
  • 96 (a)
(Canis familiaris)
Mammalia TMEM55A 35
  • 91.96 (n)
  • 95.61 (a)
TMEM55A 36
  • 97 (a)
(Mus musculus)
Mammalia Tmem55a 35
  • 90.53 (n)
  • 96.5 (a)
Tmem55a 16
Tmem55a 36
  • 96 (a)
(Pan troglodytes)
Mammalia TMEM55A 35
  • 99.74 (n)
  • 100 (a)
TMEM55A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tmem55a 35
  • 89.49 (n)
  • 96.11 (a)
(Monodelphis domestica)
Mammalia TMEM55A 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM55A 36
  • 87 (a)
(Gallus gallus)
Aves TMEM55A 35
  • 85.99 (n)
  • 93.77 (a)
TMEM55A 36
  • 94 (a)
(Anolis carolinensis)
Reptilia TMEM55A 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem55a 35
  • 79.95 (n)
  • 90.62 (a)
(Danio rerio)
Actinopterygii tmem55a 35
  • 75.88 (n)
  • 89.88 (a)
tmem55a 36
  • 90 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6707 36
  • 42 (a)
(Caenorhabditis elegans)
Secernentea Y71H2AM.2 36
  • 36 (a)
Species with no ortholog for TMEM55A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM55A Gene

Gene Tree for TMEM55A (if available)
Gene Tree for TMEM55A (if available)

Paralogs for TMEM55A Gene

Paralogs for TMEM55A Gene

(1) SIMAP similar genes for TMEM55A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMEM55A: view

Variants for TMEM55A Gene

Sequence variations from dbSNP and Humsavar for TMEM55A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2054805 -- 91,008,808(+) ATAAA(C/G/T)AAAGA intron-variant
rs7831333 -- 91,006,090(+) AACTT(A/G)AAACT intron-variant
rs7837371 -- 90,994,435(+) TAAAA(C/T)ATTAG utr-variant-3-prime
rs7837376 -- 91,024,722(+) TGGAA(A/G)AGTCT intron-variant
rs7846412 -- 91,032,300(+) GGAAA(A/G)GAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM55A Gene

Variant ID Type Subtype PubMed ID
nsv891185 CNV Loss 21882294
essv220 CNV CNV 17122850
esv2443764 CNV Deletion 19546169
nsv831390 CNV Gain 17160897
nsv6300 CNV Insertion 18451855

Variation tolerance for TMEM55A Gene

Residual Variation Intolerance Score: 26.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.60% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM55A Gene

Disorders for TMEM55A Gene

Relevant External Links for TMEM55A

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM55A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM55A Gene

Publications for TMEM55A Gene

  1. The identification and characterization of two phosphatidylinositol- 4,5-bisphosphate 4-phosphatases. (PMID: 16365287) Ungewickell A. … Majerus P.W. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3 4 67
  2. A novel LZAP-binding protein, NLBP, inhibits cell invasion. (PMID: 20164180) Kwon J. … Kim H. (J. Biol. Chem. 2010) 3
  3. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PMID: 19953087) Persaud A. … Rotin D. (Mol. Syst. Biol. 2009) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for TMEM55A Gene

Sources for TMEM55A Gene