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Aliases for TMEM54 Gene

Aliases for TMEM54 Gene

  • Transmembrane Protein 54 2 3
  • Beta-Casein-Like Protein 3 4
  • Protein CAC-1 3 4
  • CAC1 3 4
  • BCLP 3 4
  • CAC-1 3

External Ids for TMEM54 Gene

Summaries for TMEM54 Gene

GeneCards Summary for TMEM54 Gene

TMEM54 is a Protein Coding gene. Diseases associated with TMEM54 include hard palate cancer. An important paralog of this gene is KRTCAP3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM54 Gene

Genomics for TMEM54 Gene

Genomic Location for TMEM54 Gene

Start:
32,894,594 bp from pter
End:
32,901,440 bp from pter
Size:
6,847 bases
Orientation:
Minus strand

Genomic View for TMEM54 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM54 Gene

Regulatory Elements for TMEM54 Gene

Proteins for TMEM54 Gene

  • Protein details for TMEM54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969K7-TMM54_HUMAN
    Recommended name:
    Transmembrane protein 54
    Protein Accession:
    Q969K7
    Secondary Accessions:
    • Q6UV18
    • Q8IVD0
    • Q9UM12

    Protein attributes for TMEM54 Gene

    Size:
    222 amino acids
    Molecular mass:
    23772 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA87335.1; Type=Frameshift; Positions=106, 165, 168, 222; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM54 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM54 Gene

Proteomics data for TMEM54 Gene at MOPED

Post-translational modifications for TMEM54 Gene

No Post-translational modifications

Other Protein References for TMEM54 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM54 Gene

Domains for TMEM54 Gene

Protein Domains for TMEM54 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TMM54_HUMAN
Family:
  • Belongs to the TMEM54 family.:
    • Q969K7
genes like me logo Genes that share domains with TMEM54: view

No data available for Gene Families for TMEM54 Gene

Function for TMEM54 Gene

Gene Ontology (GO) - Molecular Function for TMEM54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM54: view

miRNA for TMEM54 Gene

miRTarBase miRNAs that target TMEM54

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM54 Gene

Localization for TMEM54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM54 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM54 Gene COMPARTMENTS Subcellular localization image for TMEM54 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM54: view

Pathways for TMEM54 Gene

SuperPathways for TMEM54 Gene

No Data Available

Interacting Proteins for TMEM54 Gene

Gene Ontology (GO) - Biological Process for TMEM54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM54: view

No data available for Pathways by source for TMEM54 Gene

Transcripts for TMEM54 Gene

Unigene Clusters for TMEM54 Gene

Transmembrane protein 54:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM54 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8
SP1: - -
SP2:
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: - -

Relevant External Links for TMEM54 Gene

GeneLoc Exon Structure for
TMEM54
ECgene alternative splicing isoforms for
TMEM54

Expression for TMEM54 Gene

mRNA expression in normal human tissues for TMEM54 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM54 Gene

This gene is overexpressed in Colon - Transverse (9.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMEM54 Gene

SOURCE GeneReport for Unigene cluster for TMEM54 Gene Hs.534521

mRNA Expression by UniProt/SwissProt for TMEM54 Gene

Q969K7-TMM54_HUMAN
Tissue specificity: Ubiquitously expressed in cancer cell lines.
genes like me logo Genes that share expressions with TMEM54: view

Orthologs for TMEM54 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM54 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM54 36
  • 99.54 (n)
  • 99.54 (a)
TMEM54 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM54 36
  • 86.34 (n)
  • 85.59 (a)
TMEM54 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM54 36
  • 88.74 (n)
  • 90.54 (a)
TMEM54 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem54 36
  • 79.42 (n)
  • 76.5 (a)
Tmem54 16
Tmem54 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM54 37
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM54 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem54 36
  • 79.94 (n)
  • 76.85 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM54 37
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem54 36
  • 52.24 (n)
  • 45.77 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem54 37
  • 24 (a)
OneToMany
TMEM54 (2 of 2) 37
  • 26 (a)
OneToMany
Species with no ortholog for TMEM54:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM54 Gene

ENSEMBL:
Gene Tree for TMEM54 (if available)
TreeFam:
Gene Tree for TMEM54 (if available)

Paralogs for TMEM54 Gene

Paralogs for TMEM54 Gene

Selected SIMAP similar genes for TMEM54 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM54: view

Variants for TMEM54 Gene

Sequence variations from dbSNP and Humsavar for TMEM54 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs942242 -- 32,898,494(-) ATCCC(A/G)AACCC intron-variant
rs1746664 -- 32,902,583(+) CACAC(C/T)GTGGC upstream-variant-2KB
rs1796774 -- 32,903,258(+) aaaat(A/C)caaaa upstream-variant-2KB
rs1796775 -- 32,903,297(+) GCGTG(G/T)TGACG upstream-variant-2KB
rs2274063 -- 32,898,324(+) CCTGT(G/T)GGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM54 Gene

Variant ID Type Subtype PubMed ID
nsv516302 CNV Loss 19592680
dgv212n71 CNV Loss 21882294

Relevant External Links for TMEM54 Gene

HapMap Linkage Disequilibrium report
TMEM54

Disorders for TMEM54 Gene

(1) MalaCards Diseases for TMEM54 Gene

Search for TMEM54 Gene in MalaCards »

(3) University of Copenhagen DISEASES for TMEM54 Gene

genes like me logo Genes that share disorders with TMEM54: view

No data available for UniProtKB/Swiss-Prot for TMEM54 Gene

Publications for TMEM54 Gene

  1. Cloning and characterization of a cDNA fragment coding beta-casein- like protein preferentially expressed in cervical adenocarcinoma cell line CAC-1. (PMID: 9500206) Suzuki T. … Kudo R. (Cancer Lett. 1998) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Identification and characterization of CAC1 as a novel CDK2- associated cullin. (PMID: 19829063) Kong Y. … Yin Y. (Cell Cycle 2009) 3 23
  4. Cloning and characterization of a tumor-associated antigen, beta- casein-like protein. (PMID: 11394883) Baba T. … Kudo R. (Biochem. Biophys. Res. Commun. 2001) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM54 Gene

Sources for TMEM54 Gene

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