TMEM54 Gene
protein-coding GIFtS : 47
GCID: GC01 M033360
transmembrane protein 54
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Aliasesfor TMEM54 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Transmembrane Protein 54 1 2 CAC-11 2 Beta-Casein-Like Protein2 3 Protein CAC-12 3 BCLP2 3 CAC12 3
Export aliases for TMEM54 gene to outside databases Previous GC identifers: GC01M033030 GC01M033133 GC01M031475
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Summariesfor TMEM54 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor TMEM54 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_032977.9 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TMEM54 gene promoter: NF-1 NF-1/L AP-1 MyoD CUTL1 PPAR-gamma1 NRF-2 IRF-7A PPAR-gamma2 RSRFC4 Other transcription factors Search SABiosciences Chromatin IP Primers for TMEM54 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TMEM54
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p35-p34 Ensembl cytogenetic band: 1p35.1 HGNC cytogenetic band: 1p35-p34 TMEM54 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M033360: view genomic region
(about GC identifiers )
Start:
33,360,195 bp from pter
End:
33,367,039 bp from pter
Size:
6,845 bases
Orientation:
minus strand
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Proteinsfor TMEM54 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TMM54_HUMAN, Q969K7 (See
protein sequence )Recommended Name: Transmembrane protein 54 Size : 222 amino acids; 23772 Da
Subcellular location : Membrane; Multi-pass membrane protein (Potential)
Sequence caution : Sequence=BAA87335.1; Type=Frameshift; Positions=106, 165, 168, 222;
Secondary accessions : Q6UV18 Q8IVD0 Q9UM12Alternative splicing : 3 isoforms : Q969K7-1 Q969K7-2 Q969K7-3 Explore the universe of human proteins at neXtProt for TMEM54: NX_Q969K7 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q969K7 TMEM54 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_277039.1 ENSEMBL proteins: ENSP00000362562 ENSP00000328630 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005575 cellular_component
ND -- GO:0016021 integral to membrane
IEA --
TMEM54 for ontologies About GeneDecksing TMEM54 Antibody Products: Assay Products for TMEM54:
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Protein
Domains / Familiesfor TMEM54 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TMEM54 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q969K7 ProtoNet protein and cluster: Q969K7
UniProtKB/Swiss-Prot: TMM54_HUMAN, Q969K7 Similarity : Belongs to the TMEM54 family
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Functionfor TMEM54 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM54 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM54OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TMEM54 (NM_033504 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM54 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM54
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM54
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003674 molecular_function
ND --
TMEM54 for ontologies About GeneDecksing
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Pathways & Interactionsfor TMEM54 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM54 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)3 Interacting proteins for TMEM54 (Q969K7 2 ENSP00000362562 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0008150 biological_process
ND --
TMEM54 for ontologies About GeneDecksing
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Drugs & Compoundsfor TMEM54 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TMEM54 Search CenterWatch for drugs/clinical trials and news about TMEM54 / TMM54
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Transcriptsfor TMEM54 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TMEM54 gene: NM_033504.2 Unigene Cluster for TMEM54:
Transmembrane protein 54 Hs.534521 [show with all ESTs ] Unigene Representative Sequence: BC020497 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000482771 ENST00000373463 (uc001bwi.1 uc001bwk.1 ) ENST00000329151 (uc001bwj.1 )ENST00000474144 ENST00000475208 ENST00000463914 ENST00000465967 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM54 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM54OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TMEM54 (NM_033504 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM54 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM54
Additional cDNA sequence: AB012692.1 AY027543.1 AY359883.1 BC001418.3 BC013953.2 BC020497.1 BC023260.1 BC127891.1
7 DOTS entries : DT.211888 DT.101983492
DT.97818557 DT.95267195 DT.95267191 DT.92057871 DT.102827261 24/133 AceView cDNA sequences (see all 133 ):
CA312902 BU506916 BM126893 AI623229 CR596164 BE907056 AI277081 BM759137 BC001418 BI093522 BG823019 CA435403 AJ572955 BU630426 BU627966 AI347181 BF812889 CA489748 BU944769 BC013953 BG824476 NM_033504 BG422949 BM976334 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM54 (see all 7 ) About this scheme ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 SP1 :           -   -               SP2 :                           SP3 :           -   -   -             SP4 :           -   -   -   -           SP5 :           -   -     -          
ECgene alternative splicing isoforms for TMEM54
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Expression for TMEM54 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TMEM54 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ATGCGGGAGA
About this image TMEM54 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Kidney Podocyte Layer Podocytes Kidney Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See TMEM54 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TMEM54 SOURCE GeneReport for Unigene cluster: Hs.534521 UniProtKB/Swiss-Prot: TMM54_HUMAN, Q969K7 Tissue specificity : Ubiquitously expressed in cancer cell lines SABiosciences Custom PCR Arrays for TMEM54 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TMEM54Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TMEM54 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TMEM54 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TMEM54 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM54
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Orthologsfor TMEM54 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for TMEM54 gene from 3/9 species (see all 9 ) About this table
ENSEMBL Gene Tree for TMEM54 (if available)TreeFam Gene Tree for TMEM54 (if available)
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Paralogsfor TMEM54 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TMEM54 gene KRTCAP3 2 1 SIMAP similar gene for TMEM54 using alignment to 1 protein entry: TMM54_HUMAN :KRTCAP3
TMEM54 for paralogs About GeneDecksing
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Genomic Variantsfor TMEM54 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TMEM54 (33360195 - 33367039 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for TMEM54 2 CNVs : 48311 48310
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TMEM54
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Disorders
/ Diseasesfor TMEM54 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TMEM54 for disorders About GeneDecksing 4 diseases for TMEM54 : About MalaCards hard palate cancer cervical adenocarcinoma cervicitis adenocarcinoma 3 diseases from the University of Copenhagen DISEASES database for TMEM54 :Cleft lip Cleft palate Hard palate cancer Export disorders for TMEM54 gene to outside databases
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Publicationsfor TMEM54 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TMEM54 gene integrated from 9 sources : (articles sorted by number of sources associating them with TMEM54) Utopia : connect your pdf to the dynamic world of online information
Cloning and characterization of a cDNA fragment coding beta-casein- like protein preferentially expressed in cervical adenocarcinoma cell line CAC-1. (PubMed id 9500206) 1 , 2 , 3, 9 Suzuki T.... Kudo R. (1998) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Cloning and characterization of a tumor-associated antigen, beta- casein-like protein. (PubMed id 11394883) 1 , 2 Baba T.... Kudo R. (2001) Identification and characterization of CAC1 as a nove l CDK2-associated cullin. (PubMed id 19829063) 1 , 9 Kong Y....Yin Y. (2009) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Specific detection of circulating tumor cells by reverse transcriptase-polymerase chain reaction of a beta-casein-like protein, preferentially expressed in malignant neoplasms. (PubMed id 11724320) 9 Baba T....Kudo R. (2001) The dimerization domain of the HIV-1 capsid protein binds a capsid protein-derived peptide: a biophysical characterization. (PubMed id 15152086) 9 Garzon M.T....Neira J.L. (2004) Role of Saccharomyces cerevisiae chromatin assembly factor-I in repair of ultraviolet radiation damage in vivo. (PubMed id 9927445) 9 Game J.C. and Kaufman P.D. (1999) Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans. (PubMed id 12455973) 9 Alspaugh J.A....Heitman J. (2002) Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor-I. (PubMed id 9030687) 9 Kaufman P.D....Stillman B. (1997)
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External Searches for TMEM54 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TMEM54 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TMEM54 gene
(According to HUGE )
About This Section --
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Specialized Databases showing TMEM54 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TMEM54 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TMEM54 gene: Search GeneIP for patents involving TMEM54 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TMEM54 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TMEM54 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TMEM54 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TMEM54 OriGene Protein Over-expression Lysate for TMEM54 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TMEM54 OriGene 3'-UTR Clone for TMEM54 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM54 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM54 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TMEM54 OriGene Custom Protein Services for TMEM54 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM54 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TMEM54 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TMEM54 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TMEM54 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TMEM54 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TMEM54
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TMEM54 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM54
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM54
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Aliases for TMEM54
Databases for TMEM54
Disorders / Diseases for TMEM54
Domains / Families for TMEM54
Drugs / Compounds for TMEM54
Expression for TMEM54
Function for TMEM54
Genomic Views for TMEM54
Intellectual Property for TMEM54
Orthologs for TMEM54
Paralogs for TMEM54
Pathways / Interactions for TMEM54
Products for TMEM54
Proteins for TMEM54
Publications for TMEM54
Search Box for TMEM54
Summaries for TMEM54
Transcripts for TMEM54
Variants for TMEM54
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