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Aliases for TMEM53 Gene

Aliases for TMEM53 Gene

  • Transmembrane Protein 53 2 3
  • Novel DUF829 Domain-Containing Protein 3
  • NET4 3

External Ids for TMEM53 Gene

Previous GeneCards Identifiers for TMEM53 Gene

  • GC01M044789
  • GC01M044892
  • GC01M045100
  • GC01M043233

Summaries for TMEM53 Gene

GeneCards Summary for TMEM53 Gene

TMEM53 is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM53 Gene

Genomics for TMEM53 Gene

Regulatory Elements for TMEM53 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM53 Gene

44,635,238 bp from pter
44,674,579 bp from pter
39,342 bases
Minus strand

Genomic View for TMEM53 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM53 Gene

Proteins for TMEM53 Gene

  • Protein details for TMEM53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 53
    Protein Accession:
    Secondary Accessions:
    • B4DKG0
    • Q5JPH2
    • Q6IA07
    • Q9H6E2

    Protein attributes for TMEM53 Gene

    277 amino acids
    Molecular mass:
    31630 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM53 Gene


neXtProt entry for TMEM53 Gene

Proteomics data for TMEM53 Gene at MOPED

Post-translational modifications for TMEM53 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM53 Gene

Domains for TMEM53 Gene

Protein Domains for TMEM53 Gene


Suggested Antigen Peptide Sequences for TMEM53 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6P2H8
  • Belongs to the TMEM53 family.
genes like me logo Genes that share domains with TMEM53: view

No data available for Gene Families for TMEM53 Gene

Function for TMEM53 Gene

Phenotypes for TMEM53 Gene

GenomeRNAi human phenotypes for TMEM53:
genes like me logo Genes that share phenotypes with TMEM53: view

Animal Model Products

CRISPR Products

miRNA for TMEM53 Gene

miRTarBase miRNAs that target TMEM53

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM53 Gene

Localization for TMEM53 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM53 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM53 Gene COMPARTMENTS Subcellular localization image for TMEM53 gene
Compartment Confidence
plasma membrane 2
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM53: view

Pathways for TMEM53 Gene

SuperPathways for TMEM53 Gene

No Data Available

Interacting Proteins for TMEM53 Gene

Gene Ontology (GO) - Biological Process for TMEM53 Gene


No data available for Pathways by source for TMEM53 Gene

Transcripts for TMEM53 Gene

Unigene Clusters for TMEM53 Gene

Transmembrane protein 53:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM53

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM53 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f
SP2: -
SP3: -
SP4: - -
SP5: -

Relevant External Links for TMEM53 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM53 Gene

mRNA expression in normal human tissues for TMEM53 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM53 Gene

This gene is overexpressed in Liver (5.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMEM53 Gene

SOURCE GeneReport for Unigene cluster for TMEM53 Gene Hs.22157

genes like me logo Genes that share expressions with TMEM53: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM53 Gene

Orthologs for TMEM53 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM53 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM53 35
  • 99.4 (n)
  • 99.64 (a)
TMEM53 36
  • 100 (a)
(Bos Taurus)
Mammalia TMEM53 35
  • 87.97 (n)
  • 86.64 (a)
TMEM53 36
  • 82 (a)
(Canis familiaris)
Mammalia TMEM53 35
  • 88.93 (n)
  • 89.17 (a)
TMEM53 36
  • 79 (a)
(Mus musculus)
Mammalia Tmem53 35
  • 84.36 (n)
  • 85.92 (a)
Tmem53 16
Tmem53 36
  • 86 (a)
(Monodelphis domestica)
Mammalia TMEM53 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM53 36
  • 59 (a)
(Rattus norvegicus)
Mammalia Tmem53 35
  • 85.21 (n)
  • 86.55 (a)
(Gallus gallus)
Aves TMEM53 35
  • 61.98 (n)
  • 58.52 (a)
TMEM53 36
  • 56 (a)
(Anolis carolinensis)
Reptilia TMEM53 36
  • 53 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23166 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10692 35
tmem53 35
  • 54.68 (n)
  • 52.81 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4251 35
(Danio rerio)
Actinopterygii Dr.13710 35
tmem53 35
  • 56.43 (n)
  • 49.44 (a)
tmem53 36
  • 46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009586 35
  • 46.87 (n)
  • 36.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8245 35
  • 45.25 (n)
  • 35.36 (a)
CG8245 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea C09B8.4 35
  • 38.18 (n)
  • 29.52 (a)
C09B8.4 36
  • 23 (a)
T10B11.6 36
  • 21 (a)
T24H10.4 36
  • 21 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G19970 35
  • 43.25 (n)
  • 34.3 (a)
(Oryza sativa)
Liliopsida Os06g0730300 35
  • 46.77 (n)
  • 37.76 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4924 36
  • 33 (a)
Species with no ortholog for TMEM53:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM53 Gene

Gene Tree for TMEM53 (if available)
Gene Tree for TMEM53 (if available)

Paralogs for TMEM53 Gene

No data available for Paralogs for TMEM53 Gene

Variants for TMEM53 Gene

Sequence variations from dbSNP and Humsavar for TMEM53 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3444 -- 44,654,293(+) CCTGA(C/T)TGTTG utr-variant-3-prime
rs1045800 -- 44,654,504(-) CCCCA(A/C)AACCT utr-variant-3-prime
rs1276066 -- 44,671,892(+) CCACT(A/G)CACTC intron-variant
rs1407144 -- 44,653,718(-) TTTGC(C/T)CCAGC utr-variant-3-prime
rs1963490 -- 44,667,392(+) aacct(C/T)cgcct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM53 Gene

Variant ID Type Subtype PubMed ID
nsv461395 CNV Gain 19166990

Relevant External Links for TMEM53 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM53 Gene

Disorders for TMEM53 Gene

No disorders were found for TMEM53 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM53 Gene

Publications for TMEM53 Gene

  1. Nuclear membrane proteins with potential disease links found by subtractive proteomics. (PMID: 12958361) Schirmer E.C. … Gerace L. (Science 2003) 2 3
  2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for TMEM53 Gene

Sources for TMEM53 Gene

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