TMEM53 Gene
protein-coding GIFtS: 43
GCID: GC01M045100
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|
transmembrane protein 53
| |
Aliases
for TMEM53 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 531 2 | | NET41 2 | | FLJ223531 | | Novel DUF829 Domain-Containing Protein2 |
Export aliases for TMEM53 gene to outside databasesPrevious GC identifers: GC01M044789 GC01M044892 GC01M043233 |
Summaries
for TMEM53 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM53 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM53 gene promoter:
Pax-5 CUTL1 LCR-F1 Cdc5 MEF-2A E2F-1 E2F POU2F1 POU2F1a Cart-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM53
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM53 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p34.1 Ensembl cytogenetic band: 1p34.1 HGNC cytogenetic band: 1p34.1TMEM53 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M045100: view genomic region
(about GC identifiers)
Start:
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45,100,910 bp from pter |
End:
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45,140,227 bp from pter |
Size:
|
39,318 bases |
Orientation:
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minus strand |
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Proteins
for TMEM53 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TMM53_HUMAN, Q6P2H8 (See
protein sequence)Recommended Name: Transmembrane protein 53 Size: 277 amino acids; 31630 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: B4DKG0 Q5JPH2 Q6IA07 Q9H6E2Alternative splicing: 2 isoforms: Q6P2H8-1 Q6P2H8-2 Explore the universe of human proteins at neXtProt for TMEM53: NX_Q6P2H8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P2H8
TMEM53 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_078863.2
ENSEMBL proteins: ENSP00000361316 ENSP00000361317 ENSP00000361318 ENSP00000361311 ENSP00000361309 ENSP00000391576
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM53 for ontologies About GeneDecksing
TMEM53 Antibody Products:
Assay Products for TMEM53: |
Protein
Domains /
Families
for TMEM53 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM53 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6P2H8ProtoNet protein and cluster: Q6P2H8 UniProtKB/Swiss-Prot: TMM53_HUMAN, Q6P2H8Similarity: Belongs to the TMEM53 family |
Function
for TMEM53 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM53 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM53
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM53 (NM_024587) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM53 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM53 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM53 |
1 GenomeRNAi human phenotype for TMEM53:
|
Pathways & Interactions
for TMEM53 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM53
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/36 Interacting proteins for TMEM53 (ENSP000003613114) via UniProtKB, MINT, STRING, and/or I2D (see all 36)About this table
|
Drugs & Compounds
for TMEM53 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM53
Search CenterWatch for drugs/clinical trials and news about TMEM53 / TMM53
|
Transcripts
for TMEM53 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM53 gene: NM_024587.2 Unigene Cluster for TMEM53: Transmembrane protein 53 Hs.22157 [show with all ESTs]Unigene Representative Sequence: AL8325399 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372242 ENST00000372243 ENST00000372244 ENST00000495630 ENST00000476724(uc001cmd.3)
ENST00000468117 ENST00000372237(uc010ola.1 uc009vxh.1 uc001cmc.3)
ENST00000372235 ENST00000420706
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM53 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM53
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM53 (NM_024587) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM53 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM53 |
Additional cDNA sequence: AK026006.1 AK225405.1 AK295356.1 AK296548.1 AK310016.1 AL832539.1 BC007521.1 BC064520.1 CR457348.1 14 DOTS entries: DT.100778587 DT.97840244 DT.86853330 DT.109248 DT.100778584 DT.92070465 DT.100738273 DT.91860241 DT.95134844 DT.100797112 DT.100840037 DT.121353056 DT.92438503 DT.97854207 24/110 AceView cDNA sequences (see all 110): BX358556 NM_024587 CR592706 BU733005 AW015308 BU626217 BX341326 CD364736 BQ016303 CR608781 AL832539 AW243898 BC064520 BM806701 AI422998 AI636091 BM453250 BQ576262 BQ631203 BQ184166 BM678872 BF971496 AI927023 BM713172
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM53 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | · | 3f |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM53
|
Expression
for TMEM53 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM53 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGCAACTGCG
About this image
See TMEM53 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM53
SOURCE GeneReport for Unigene cluster: Hs.22157
SABiosciences Custom PCR Arrays for TMEM53
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM53
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM53 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM53 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM53 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM53 |
Orthologs
for TMEM53 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TMEM53 gene from 9/23 species (see all 23) About this table
ENSEMBL Gene Tree for TMEM53 (if available)
TreeFam Gene Tree for TMEM53 (if available) |
Paralogs
for TMEM53 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM53 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM53 (45100910 - 45140227 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM53: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM53 |
|
Disorders
/ Diseases
for TMEM53 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM53 for disorders About GeneDecksing
2  diseases for TMEM53: About MalaCardsacrodermatitis lyme disease
Export disorders for TMEM53 gene to outside databases
|
Publications
for TMEM53 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM53 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM53) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Nuclear membrane proteins with potential disease links found by subtractive proteomics. (PubMed id 12958361)1, 3 Schirmer E.C....Gerace L. (2003)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
|
External Searches for TMEM53 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM53 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM53 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM53 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM53 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM53 gene:
Search GeneIP for patents involving TMEM53
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM53 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM53 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM53 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM53 | | | OriGene Protein Over-expression Lysate for TMEM53 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM53 | | OriGene 3'-UTR Clone for TMEM53 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM53 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM53 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TMEM53 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM53 | | OriGene Custom Protein Services for TMEM53 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM53 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM53 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM53 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM53 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM53 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM53 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TMEM53 |
| |  |  |  |  | | | | |
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 | | | TMEM53 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM53 |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM53 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM53 |
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