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TMEM53 Gene

protein-coding   GIFtS: 45
GCID: GC01M045100

Transmembrane Protein 53

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 531 2
NET42
Novel DUF829 Domain-Containing Protein2

External Ids:    HGNC: 261861   Entrez Gene: 796392   Ensembl: ENSG000001261067   UniProtKB: Q6P2H83   

Export aliases for TMEM53 gene to outside databases

Previous GC identifers: GC01M044789 GC01M044892 GC01M043233


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM53 Gene:
TMEM53 (transmembrane protein 53) is a protein-coding gene. Diseases associated with TMEM53 include lyme disease, and acrodermatitis.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM53 gene promoter:
         Pax-5   CUTL1   LCR-F1   Cdc5   MEF-2A   E2F-1   E2F   POU2F1   POU2F1a   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM53 promoter sequence
   Search Chromatin IP Primers for TMEM53

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM53


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p34.1

TMEM53 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM53 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M045100:  view genomic region     (about GC identifiers)

Start:
45,100,910 bp from pter      End:
45,140,227 bp from pter
Size:
39,318 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TMM53_HUMAN, Q6P2H8 (See protein sequence)
Recommended Name: Transmembrane protein 53  
Size: 277 amino acids; 31630 Da
Secondary accessions: B4DKG0 Q5JPH2 Q6IA07 Q9H6E2
Alternative splicing: 2 isoforms:  Q6P2H8-1   Q6P2H8-2   

Explore the universe of human proteins at neXtProt for TMEM53: NX_Q6P2H8

Explore proteomics data for TMEM53 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TMEM53 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078863.2  
    ENSEMBL proteins: 
     ENSP00000361316   ENSP00000361317   ENSP00000361318   ENSP00000361311   ENSP00000361309  
     ENSP00000391576  

    TMEM53 Human Recombinant Protein Products:

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    OriGene Purified Protein for TMEM53
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    Novus Biologicals TMEM53 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMEM53

    TMEM53 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TMEM53
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TMEM53
    Novus Biologicals TMEM53 Antibody
    Abcam antibodies for TMEM53
    Cloud-Clone Corp. Antibodies for TMEM53
    Search ThermoFisher Antibodies for TMEM53
    LSBio Antibodies in human, mouse, rat for TMEM53

    TMEM53 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TMEM53
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TMEM53
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TMEM53
    Cloud-Clone Corp. CLIAs for TMEM53


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008547 DUF829_TMEM53

    Graphical View of Domain Structure for InterPro Entry Q6P2H8

    ProtoNet protein and cluster: Q6P2H8

    UniProtKB/Swiss-Prot: TMM53_HUMAN, Q6P2H8
    Similarity: Belongs to the TMEM53 family


    TMEM53 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for TMEM53:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM53
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMEM53

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM53
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM53

    miRNA
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    miRTarBase miRNAs that target TMEM53:
    hsa-mir-335-5p (MIRT018747)

    Block miRNA regulation of human, mouse, rat TMEM53 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate TMEM53:
    hsa-miR-4291 hsa-miR-214 hsa-miR-922 hsa-miR-516b hsa-miR-761 hsa-miR-1299 hsa-miR-34a*
    SwitchGear 3'UTR luciferase reporter plasmidTMEM53 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TMEM53
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM53

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TMEM53

    Clone
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    OriGene clones in human, mouse for TMEM53 (see all 6)
    OriGene ORF clones in mouse, rat for TMEM53
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMEM53 (NM_024587)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM53
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM53

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TMEM53
    Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM53 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM53


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMM53_HUMAN, Q6P2H8: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane2
    cytosol1
    extracellular1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    TMEM53 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM53
    Interactions:

        Search GeneGlobe Interaction Network for TMEM53

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TMEM53 (ENSP000003613114) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ECHDC3ENSP000003685174STRING: ENSP00000368517
    AGLENSP000002947244STRING: ENSP00000294724
    AK2ENSP000003469214STRING: ENSP00000346921
    AKR7A2ENSP000002358354STRING: ENSP00000235835
    APH1AENSP000003581054STRING: ENSP00000358105
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM53 (TMM53)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMEM53 gene: 
    NM_024587.2  

    Unigene Cluster for TMEM53:

    Transmembrane protein 53
    Hs.22157  [show with all ESTs]
    Unigene Representative Sequence: AL832539
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372242 ENST00000372243 ENST00000372244 ENST00000495630 ENST00000476724(uc001cmd.3)
    ENST00000468117 ENST00000372237(uc010ola.1 uc009vxh.1 uc001cmc.3)
    ENST00000372235 ENST00000420706
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMEM53 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate TMEM53:
    hsa-miR-4291 hsa-miR-214 hsa-miR-922 hsa-miR-516b hsa-miR-761 hsa-miR-1299 hsa-miR-34a*
    SwitchGear 3'UTR luciferase reporter plasmidTMEM53 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMEM53
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM53
    Clone
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    OriGene clones in human, mouse for TMEM53 (see all 6)
    OriGene ORF clones in mouse, rat for TMEM53
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMEM53 (NM_024587)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM53
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM53
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMEM53
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM53
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM53
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM53
      QuantiFast Probe-based Assays in human, mouse, rat TMEM53

    Additional mRNA sequence: 

    AK026006.1 AK225405.1 AK295356.1 AK296548.1 AK310016.1 AL832539.1 BC007521.1 BC064520.1 
    CR457348.1 

    13 DOTS entries:

    DT.100778587  DT.97840244  DT.86853330  DT.109248  DT.100778584  DT.92070465  DT.100738273  DT.91860241 
    DT.95134844  DT.100840037  DT.121353056  DT.92438503  DT.97854207 

    Selected AceView cDNA sequences (see all 110):

    NM_024587 AI422998 BF971496 BX358556 AI347190 BU626217 AW243898 BQ631203 
    AK026006 BM453250 CR608781 BU733005 CD364736 BM713172 BQ016303 CR592706 
    AI927023 BC064520 BM678872 BQ184166 BX341326 AL832539 BM806701 AI131304 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM53    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f
    SP1:                                                                  
    SP2:                                -                                 
    SP3:                                -                                 
    SP4:                          -     -                                 
    SP5:                          -                                       


    ECgene alternative splicing isoforms for TMEM53

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM53 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCAACTGCG
    TMEM53 Expression
    About this image


    TMEM53 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Gonad
             Primordial Germ Cells Allantois
     
     Placenta (Extraembryonic Tissues)
             Primordial Germ Cells Allantois
     
     Testis (Reproductive System)
     
     Liver (Hepatobiliary System)
    TMEM53 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM53 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.22157
        Custom PCR Arrays for TMEM53
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TMEM53
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM53
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    QuantiTect SYBR Green Assays in human, mouse, rat TMEM53
    QuantiFast Probe-based Assays in human, mouse, rat TMEM53
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM53

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TMEM53 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem531 , 5 transmembrane protein 531, 5 84.36(n)1
    85.92(a)1
      4 (53.43 cM)5
    687771  NM_001285812.11  NP_001272741.11 
     1172519515 
    chicken
    (Gallus gallus)
    Aves TMEM531 transmembrane protein 53 61.98(n)
    58.52(a)
      424581  NM_001277580.1  NP_001264509.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM536
    transmembrane protein 53
    53(a)
    1 ↔ 1
    4(110004629-110013082)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.231662 Xenopus laevis transcribed sequence with weak similarity more 74.62(n)    BX844279.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.137102 Transcribed sequence with weak similarity to protein more 70.95(n)    AL922784.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG82451 CG8245 45.25(n)
    35.36(a)
      35503  NM_136334.3  NP_610178.2 
    worm
    (Caenorhabditis elegans)
    Secernentea C09B8.41 C09B8.4 38.18(n)
    29.52(a)
      180870  NM_076605.4  NP_509006.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G199701 AT3G19970 43.25(n)
    34.3(a)
      821535  NM_112887.2  NP_566652.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g07303001 Os06g0730300 46.77(n)
    37.76(a)
      4342146  NM_001065190.1  NP_001058655.1 


    ENSEMBL Gene Tree for TMEM53 (if available)
    TreeFam Gene Tree for TMEM53 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM53 (see all 393)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs39083941,2
    H--45119119(+) CTTTAG/TGGCTT 1 -- int1 ese35Minor allele frequency- T:0.00MN NS EA 604
    rs1162569781,2
    F--45119172(+) TCCTGC/TCCCCC 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1487828021,2
    --45119176(+) GCCCCC/GCACTG 1 -- int10--------
    rs14071441,2
    C,F,A,H--45119390(-) TTTGCT/CCCAGC 1 -- int1 ese311Minor allele frequency- C:0.29NA EA MN NS CSA WA 878
    rs557507521,2
    C--45119448(+) CTTCCC/TTCTGG 1 -- int10--------
    rs799551211,2
    C,F--45119542(+) GATGAA/CGTTCT 1 -- ut311Minor allele frequency- C:0.19WA 118
    rs1463506361,2
    --45119578(+) CAGTTC/GTAGAG 1 -- ut310--------
    rs1396331191,2
    C--45119590(+) TCTGCC/TGTGCA 1 -- ut310--------
    rs1850446331,2
    --45119702(+) GCTGAA/GGTGGG 1 -- ut310--------
    rs1442641631,2
    --45119725(+) GCCTGA/GGAGGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TMEM53 (45100910 - 45140227 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TMEM53:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv461395CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM53
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM53

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for TMEM53:    
    About MalaCards
    lyme disease    acrodermatitis    malaria


    TMEM53 for disorders           About GeneDecksing


    Export disorders for TMEM53 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM53 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with TMEM53)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nuclear membrane proteins with potential disease links found by subtractive proteomics. (PubMed id 12958361)1, 3 Schirmer E.C.... Gerace L. (Science 2003)
    2. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    4. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79639 HGNC: 26186 AceView: FLJ22353 Ensembl:ENSG00000126106 euGenes: HUgn79639
    ECgene: TMEM53 H-InvDB: TMEM53

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TMEM53 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TMEM53 gene:
    Search GeneIP for patents involving TMEM53

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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