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Aliases for TMEM52B Gene

Aliases for TMEM52B Gene

  • Transmembrane Protein 52B 2 3 5
  • C12orf59 3 4
  • Chromosome 12 Open Reading Frame 59 2

External Ids for TMEM52B Gene

Previous HGNC Symbols for TMEM52B Gene

  • C12orf59

Previous GeneCards Identifiers for TMEM52B Gene

  • GC12P010323

Summaries for TMEM52B Gene

GeneCards Summary for TMEM52B Gene

TMEM52B (Transmembrane Protein 52B) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM52B Gene

Genomics for TMEM52B Gene

Regulatory Elements for TMEM52B Gene

Enhancers for TMEM52B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F010242 0.5 Ensembl 11 +72.2 72159 0.2 MTA2 CBFB TRIM22 JUNB BMI1 TBX21 RAD51 IKZF1 ZNF207 NBN ENSG00000255958 GABARAPL1 TMEM52B STYK1 KLRD1 LOC105369656
GH12F010030 0.8 Ensembl ENCODE 10.2 -139.0 -138974 2.7 STAT1 JUN BHLHE40 MAFG ARID1B MAFF POLR2A KDM1A FOS NFE2 CLEC7A CLEC12B TMEM52B OLR1 CLEC1A STYK1 CLEC9A LOC100421202
GH12F010027 1 Ensembl ENCODE 9.9 -142.7 -142742 1.2 RNF2 IKZF1 MAX FOS CLEC7A LOC400002 CLEC12A TMEM52B LOC100506159 LOC728715 LOC102724020 GC12P010023
GH12F010562 0.4 ENCODE 9.8 +392.0 391975 0.2 CTCF ZNF654 CBX5 ZFP64 SMC3 TRIM22 REST RAD21 ZNF264 LOC255308 ENSG00000256682 ENSG00000213443 KLRK1 STYK1 TAS2R43 ENSG00000256981 KLRC1 TAS2R50 TMEM52B
GH12F010182 1 FANTOM5 Ensembl ENCODE 7.8 +14.2 14159 5.4 JUN BHLHE40 CEBPB EP300 JUND STAT3 FOS PRDM1 MAFK TCF7L2 OLR1 CLEC12A TMEM52B CLEC7A GABARAPL1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM52B on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM52B Gene

Chromosome:
12
Start:
10,170,542 bp from pter
End:
10,191,804 bp from pter
Size:
21,263 bases
Orientation:
Plus strand

Genomic View for TMEM52B Gene

Genes around TMEM52B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM52B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM52B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM52B Gene

Proteins for TMEM52B Gene

  • Protein details for TMEM52B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4KMG9-TM52B_HUMAN
    Recommended name:
    Transmembrane protein 52B
    Protein Accession:
    Q4KMG9
    Secondary Accessions:
    • Q96NA7

    Protein attributes for TMEM52B Gene

    Size:
    183 amino acids
    Molecular mass:
    20002 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM52B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM52B Gene

Post-translational modifications for TMEM52B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM52B Gene

No data available for DME Specific Peptides for TMEM52B Gene

Domains & Families for TMEM52B Gene

Protein Domains for TMEM52B Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM52B: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TMEM52B Gene

Function for TMEM52B Gene

Gene Ontology (GO) - Molecular Function for TMEM52B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM52B: view
genes like me logo Genes that share phenotypes with TMEM52B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM52B Gene

Localization for TMEM52B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM52B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM52B Gene COMPARTMENTS Subcellular localization image for TMEM52B gene
Compartment Confidence
extracellular 5
plasma membrane 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TMEM52B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TMEM52B: view

Pathways & Interactions for TMEM52B Gene

SuperPathways for TMEM52B Gene

No Data Available

Interacting Proteins for TMEM52B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000298530%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: Q4KMG9-TM52B_HUMAN ENSP00000298530 for TMEM52B Gene via IID STRING

Gene Ontology (GO) - Biological Process for TMEM52B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM52B: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM52B Gene

Transcripts for TMEM52B Gene

Unigene Clusters for TMEM52B Gene

Transmembrane protein 52B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM52B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for TMEM52B Gene

GeneLoc Exon Structure for
TMEM52B
ECgene alternative splicing isoforms for
TMEM52B

Expression for TMEM52B Gene

mRNA expression in normal human tissues for TMEM52B Gene

mRNA differential expression in normal tissues according to GTEx for TMEM52B Gene

This gene is overexpressed in Kidney - Cortex (x43.7).

NURSA nuclear receptor signaling pathways regulating expression of TMEM52B Gene:

TMEM52B

SOURCE GeneReport for Unigene cluster for TMEM52B Gene:

Hs.226422
genes like me logo Genes that share expression patterns with TMEM52B: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TMEM52B Gene

Orthologs for TMEM52B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM52B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM52B 34 35
  • 99.11 (n)
cow
(Bos Taurus)
Mammalia TMEM52B 34 35
  • 86.26 (n)
dog
(Canis familiaris)
Mammalia TMEM52B 34 35
  • 85.12 (n)
mouse
(Mus musculus)
Mammalia Tmem52b 34 16 35
  • 83.52 (n)
rat
(Rattus norvegicus)
Mammalia Tmem52b 34
  • 82.76 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM52B 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H12ORF59 34
  • 62.65 (n)
TMEM52B 35
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM52B 35
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem52b 34
  • 57.42 (n)
Species where no ortholog for TMEM52B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM52B Gene

ENSEMBL:
Gene Tree for TMEM52B (if available)
TreeFam:
Gene Tree for TMEM52B (if available)

Paralogs for TMEM52B Gene

No data available for Paralogs for TMEM52B Gene

Variants for TMEM52B Gene

Sequence variations from dbSNP and Humsavar for TMEM52B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10431295 -- 10,190,412(+) AAGGT(A/G)TCTTG utr-variant-3-prime
rs10505752 -- 10,180,748(-) ATAAC(C/T)TGAGT intron-variant
rs10546349 -- 10,179,217(+) CACAT(-/AT)GTCCT intron-variant, utr-variant-5-prime
rs10631520 -- 10,177,815(+) ATAAT(-/AA/AATAA)TTTTT intron-variant, upstream-variant-2KB
rs10772235 -- 10,182,044(+) AACAA(A/C)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM52B Gene

Variant ID Type Subtype PubMed ID
esv3580102 CNV loss 25503493
esv3628526 CNV loss 21293372
esv3628528 CNV loss 21293372

Variation tolerance for TMEM52B Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM52B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM52B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM52B Gene

Disorders for TMEM52B Gene

Relevant External Links for TMEM52B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM52B

No disorders were found for TMEM52B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM52B Gene

Publications for TMEM52B Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3 64
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64

Products for TMEM52B Gene

Sources for TMEM52B Gene

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