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Aliases for TMEM52B Gene

Aliases for TMEM52B Gene

  • Transmembrane Protein 52B 2 3
  • C12orf59 3 4
  • Chromosome 12 Open Reading Frame 59 2

External Ids for TMEM52B Gene

Previous HGNC Symbols for TMEM52B Gene

  • C12orf59

Previous GeneCards Identifiers for TMEM52B Gene

  • GC12P010323

Summaries for TMEM52B Gene

GeneCards Summary for TMEM52B Gene

TMEM52B is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM52B Gene

Genomics for TMEM52B Gene

Genomic Location for TMEM52B Gene

Start:
10,170,542 bp from pter
End:
10,191,804 bp from pter
Size:
21,263 bases
Orientation:
Plus strand

Genomic View for TMEM52B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM52B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM52B Gene

No data available for Regulatory Elements for TMEM52B Gene

Proteins for TMEM52B Gene

  • Protein details for TMEM52B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4KMG9-TM52B_HUMAN
    Recommended name:
    Transmembrane protein 52B
    Protein Accession:
    Q4KMG9
    Secondary Accessions:
    • Q96NA7

    Protein attributes for TMEM52B Gene

    Size:
    183 amino acids
    Molecular mass:
    20002 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM52B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM52B Gene

Proteomics data for TMEM52B Gene at MOPED

Post-translational modifications for TMEM52B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM52B Gene

No data available for DME Specific Peptides for TMEM52B Gene

Domains for TMEM52B Gene

Protein Domains for TMEM52B Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM52B: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TMEM52B Gene

Function for TMEM52B Gene

Gene Ontology (GO) - Molecular Function for TMEM52B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM52B: view

Phenotypes for TMEM52B Gene

GenomeRNAi human phenotypes for TMEM52B:
genes like me logo Genes that share phenotypes with TMEM52B: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM52B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM52B Gene

Localization for TMEM52B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM52B Gene

Membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM52B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TMEM52B: view

No data available for Subcellular locations from COMPARTMENTS for TMEM52B Gene

Pathways for TMEM52B Gene

SuperPathways for TMEM52B Gene

No Data Available

Interacting Proteins for TMEM52B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000298530%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000298530 for TMEM52B Gene via STRING

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for TMEM52B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM52B: view

No data available for Pathways by source for TMEM52B Gene

Transcripts for TMEM52B Gene

Unigene Clusters for TMEM52B Gene

Transmembrane protein 52B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM52B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TMEM52B
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM52B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for TMEM52B Gene

GeneLoc Exon Structure for
TMEM52B
ECgene alternative splicing isoforms for
TMEM52B

Expression for TMEM52B Gene

mRNA expression in normal human tissues for TMEM52B Gene

mRNA differential expression in normal tissues according to GTEx for TMEM52B Gene

This gene is overexpressed in Kidney - Cortex (43.7).

SOURCE GeneReport for Unigene cluster for TMEM52B Gene Hs.226422

genes like me logo Genes that share expressions with TMEM52B: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for TMEM52B Gene

Orthologs for TMEM52B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM52B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM52B 35
  • 99.11 (n)
  • 98.67 (a)
TMEM52B 36
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM52B 35
  • 86.26 (n)
  • 86.06 (a)
TMEM52B 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM52B 35
  • 85.12 (n)
  • 85.31 (a)
TMEM52B 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem52b 35
  • 83.52 (n)
  • 83.91 (a)
Tmem52b 16
Tmem52b 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM52B 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem52b 35
  • 82.76 (n)
  • 81.61 (a)
chicken
(Gallus gallus)
Aves C1H12ORF59 35
  • 62.65 (n)
  • 60.84 (a)
TMEM52B 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM52B 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem52b 35
  • 57.42 (n)
  • 56.77 (a)
Species with no ortholog for TMEM52B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM52B Gene

ENSEMBL:
Gene Tree for TMEM52B (if available)
TreeFam:
Gene Tree for TMEM52B (if available)

Paralogs for TMEM52B Gene

No data available for Paralogs for TMEM52B Gene

Variants for TMEM52B Gene

Sequence variations from dbSNP and Humsavar for TMEM52B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2130007 -- 10,179,692(+) GAAGA(A/G)TCTGA intron-variant
rs2130008 -- 10,179,759(+) AATGA(A/G)TAAAC intron-variant
rs2291481 -- 10,179,598(+) GTCGT(G/T)GCGGC reference, synonymous-codon, missense
rs2401643 -- 10,180,375(+) GCCTT(C/G)TCTTC intron-variant
rs2537749 -- 10,185,854(-) AGGTT(G/T)GTCAG intron-variant

Relevant External Links for TMEM52B Gene

HapMap Linkage Disequilibrium report
TMEM52B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM52B Gene

Disorders for TMEM52B Gene

No disorders were found for TMEM52B Gene.

No data available for UniProtKB/Swiss-Prot for TMEM52B Gene

Publications for TMEM52B Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for TMEM52B Gene

Sources for TMEM52B Gene

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