Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM52 Gene

Aliases for TMEM52 Gene

  • Transmembrane Protein 52 2 3

External Ids for TMEM52 Gene

Previous GeneCards Identifiers for TMEM52 Gene

  • GC01M001882
  • GC01M001838
  • GC01M001126

Summaries for TMEM52 Gene

GeneCards Summary for TMEM52 Gene

TMEM52 is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM52 Gene

Genomics for TMEM52 Gene

Regulatory Elements for TMEM52 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM52 Gene

1,917,590 bp from pter
1,919,301 bp from pter
1,712 bases
Minus strand

Genomic View for TMEM52 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM52 Gene

Proteins for TMEM52 Gene

  • Protein details for TMEM52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 52
    Protein Accession:
    Secondary Accessions:
    • Q4VXS6
    • Q6UX25

    Protein attributes for TMEM52 Gene

    209 amino acids
    Molecular mass:
    22122 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM52 Gene


neXtProt entry for TMEM52 Gene

Proteomics data for TMEM52 Gene at MOPED

Post-translational modifications for TMEM52 Gene

No Post-translational modifications

Other Protein References for TMEM52 Gene

No data available for DME Specific Peptides for TMEM52 Gene

Domains for TMEM52 Gene

Protein Domains for TMEM52 Gene


Suggested Antigen Peptide Sequences for TMEM52 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM52: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM52 Gene

Function for TMEM52 Gene

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM52

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM52 Gene

Localization for TMEM52 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM52 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM52 Gene COMPARTMENTS Subcellular localization image for TMEM52 gene
Compartment Confidence
extracellular 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TMEM52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM52: view

Pathways for TMEM52 Gene

SuperPathways for TMEM52 Gene

No Data Available

Interacting Proteins for TMEM52 Gene

Gene Ontology (GO) - Biological Process for TMEM52 Gene


No data available for Pathways by source for TMEM52 Gene

Transcripts for TMEM52 Gene

Unigene Clusters for TMEM52 Gene

Transmembrane protein 52:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM52

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM52 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: -
SP3: -

Relevant External Links for TMEM52 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM52 Gene

mRNA expression in normal human tissues for TMEM52 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM52 Gene

This gene is overexpressed in Pancreas (18.9), Muscle - Skeletal (16.8), and Adrenal Gland (4.6).

SOURCE GeneReport for Unigene cluster for TMEM52 Gene Hs.123423

genes like me logo Genes that share expressions with TMEM52: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for TMEM52 Gene

Orthologs for TMEM52 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM52 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM52 35
  • 83.05 (n)
  • 76.44 (a)
TMEM52 36
  • 73 (a)
(Canis familiaris)
Mammalia TMEM52 35
  • 88.19 (n)
  • 87.5 (a)
TMEM52 36
  • 71 (a)
(Mus musculus)
Mammalia Tmem52 35
  • 80.57 (n)
  • 73.14 (a)
Tmem52 16
Tmem52 36
  • 70 (a)
(Pan troglodytes)
Mammalia TMEM52 35
  • 99.12 (n)
  • 99.34 (a)
TMEM52 36
  • 82 (a)
(Rattus norvegicus)
Mammalia Tmem52 35
  • 81.48 (n)
  • 74.27 (a)
(Gallus gallus)
Aves TMEM52 36
  • 33 (a)
(Anolis carolinensis)
Reptilia TMEM52 36
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6433 35
Species with no ortholog for TMEM52:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM52 Gene

Gene Tree for TMEM52 (if available)
Gene Tree for TMEM52 (if available)

Paralogs for TMEM52 Gene

No data available for Paralogs for TMEM52 Gene

Variants for TMEM52 Gene

Sequence variations from dbSNP and Humsavar for TMEM52 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1884455 -- 1,918,305(-) TGCGA(C/T)GTGGC reference, synonymous-codon
rs2295363 -- 1,918,989(-) ACGGG(C/T)GGCGA intron-variant
rs2474458 -- 1,920,497(-) CTTGT(G/T)GTAGG upstream-variant-2KB
rs2490548 -- 1,920,695(-) GTCAA(C/T)GTGGC upstream-variant-2KB
rs4459050 - 1,918,091(+) AGCCA(C/T)GGAGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TMEM52 Gene

Variant ID Type Subtype PubMed ID
dgv9e1 CNV Complex 17122850
nsv834335 CNV Loss 17160897
dgv55n71 CNV Loss 21882294
dgv56n71 CNV Loss 21882294
nsv871672 CNV Loss 21882294
nsv870914 CNV Loss 21882294
nsv10383 CNV Gain 18304495

Relevant External Links for TMEM52 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM52 Gene

Disorders for TMEM52 Gene

No disorders were found for TMEM52 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TMEM52 Gene

Publications for TMEM52 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4

Products for TMEM52 Gene

Sources for TMEM52 Gene

Back to Top