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Aliases for TMEM51 Gene

Aliases for TMEM51 Gene

  • Transmembrane Protein 51 2 3 5
  • C1orf72 3 4
  • Chromosome 1 Open Reading Frame 72 2

External Ids for TMEM51 Gene

Previous HGNC Symbols for TMEM51 Gene

  • C1orf72

Previous GeneCards Identifiers for TMEM51 Gene

  • GC01P015352
  • GC01P015479
  • GC01P013998

Summaries for TMEM51 Gene

GeneCards Summary for TMEM51 Gene

TMEM51 (Transmembrane Protein 51) is a Protein Coding gene.

Additional gene information for TMEM51 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM51 Gene

Genomics for TMEM51 Gene

GeneHancer (GH) Regulatory Elements for TMEM51 Gene

Promoters and enhancers for TMEM51 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I015150 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 569.1 +2.9 2870 9.3 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF207 ZNF143 FOS TMEM51 TMEM51-AS1 ENSG00000237938 SPEN C1orf195
GH01I015175 Enhancer 1.4 Ensembl ENCODE dbSUPER 18.1 +26.1 26118 6.3 PKNOX1 ATF1 FOXA2 SIN3A TCF12 FOS SP5 ZNF623 SMARCA4 GLIS1 TMEM51 TMEM51-AS1 C1orf195 LOC100420251
GH01I015145 Enhancer 1.1 ENCODE dbSUPER 15.4 -6.7 -6682 1.2 ELF3 FOXA2 MLX ARID4B RARA ATF7 CREM THAP11 MIXL1 SP5 TMEM51 FHAD1 TMEM51-AS1 GC01M015029
GH01I015245 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7 +94.1 94057 2.3 SIN3A ZNF121 GLIS2 ZNF143 ZNF207 KLF13 SP3 ZNF623 RFX3 GLIS1 FHAD1 LOC101927417 PLEKHM2 TMEM51 EFHD2 CASP9 PIR39012
GH01I015137 Enhancer 1.1 ENCODE dbSUPER 14.5 -13.4 -13371 3.6 MLX ARID4B SIN3A ZNF48 ETS1 FOS SP5 NFYC MIER2 PPARG TMEM51 FHAD1 TMEM51-AS1 GC01M015029
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM51 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM51 gene promoter:

Genomic Locations for TMEM51 Gene

Genomic Locations for TMEM51 Gene
chr1:15,152,532-15,220,480
(GRCh38/hg38)
Size:
67,949 bases
Orientation:
Plus strand
chr1:15,479,028-15,546,976
(GRCh37/hg19)

Genomic View for TMEM51 Gene

Genes around TMEM51 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM51 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM51 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM51 Gene

Proteins for TMEM51 Gene

  • Protein details for TMEM51 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NW97-TMM51_HUMAN
    Recommended name:
    Transmembrane protein 51
    Protein Accession:
    Q9NW97
    Secondary Accessions:
    • A8K819

    Protein attributes for TMEM51 Gene

    Size:
    253 amino acids
    Molecular mass:
    27759 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM51 Gene

Post-translational modifications for TMEM51 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM51 Gene

Domains & Families for TMEM51 Gene

Gene Families for TMEM51 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM51 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM51 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM51: view

No data available for UniProtKB/Swiss-Prot for TMEM51 Gene

Function for TMEM51 Gene

Phenotypes From GWAS Catalog for TMEM51 Gene

Gene Ontology (GO) - Molecular Function for TMEM51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM51: view
genes like me logo Genes that share phenotypes with TMEM51: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM51 Gene

Localization for TMEM51 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM51 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM51 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 2
plasma membrane 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM51: view

Pathways & Interactions for TMEM51 Gene

SuperPathways for TMEM51 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM51: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM51 Gene

Drugs & Compounds for TMEM51 Gene

No Compound Related Data Available

Transcripts for TMEM51 Gene

Unigene Clusters for TMEM51 Gene

Transmembrane protein 51:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM51 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6
SP1: - - - -
SP2:
SP3:
SP4: - - - - -
SP5: -
SP6: - -
SP7: - -

Relevant External Links for TMEM51 Gene

GeneLoc Exon Structure for
TMEM51
ECgene alternative splicing isoforms for
TMEM51

Expression for TMEM51 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM51 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM51 Gene

This gene is overexpressed in Pancreas (x4.2).

Protein differential expression in normal tissues from HIPED for TMEM51 Gene

This gene is overexpressed in Pancreas (52.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM51 Gene



Protein tissue co-expression partners for TMEM51 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM51 Gene:

TMEM51

SOURCE GeneReport for Unigene cluster for TMEM51 Gene:

Hs.465305

Evidence on tissue expression from TISSUES for TMEM51 Gene

  • Kidney(4.3)
  • Eye(4)
  • Nervous system(2.8)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with TMEM51: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM51 Gene

Orthologs for TMEM51 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM51 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM51 33 34
  • 98.81 (n)
cow
(Bos Taurus)
Mammalia TMEM51 33 34
  • 86.83 (n)
dog
(Canis familiaris)
Mammalia TMEM51 33 34
  • 86.13 (n)
rat
(Rattus norvegicus)
Mammalia Tmem51 33
  • 83.94 (n)
mouse
(Mus musculus)
Mammalia Tmem51 33 16 34
  • 82.2 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM51 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM51 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM51 33 34
  • 67.9 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM51 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem51 33
  • 59.58 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem51a 33 34
  • 51.43 (n)
tmem51b 34
  • 34 (a)
OneToMany
Species where no ortholog for TMEM51 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM51 Gene

ENSEMBL:
Gene Tree for TMEM51 (if available)
TreeFam:
Gene Tree for TMEM51 (if available)

Paralogs for TMEM51 Gene

No data available for Paralogs for TMEM51 Gene

Variants for TMEM51 Gene

Sequence variations from dbSNP and Humsavar for TMEM51 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000008473 -- 15,167,394(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000033727 -- 15,174,665(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000039642 -- 15,207,656(+) C/G intron_variant
rs1000205154 -- 15,184,219(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000207571 -- 15,205,084(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM51 Gene

Variant ID Type Subtype PubMed ID
esv2664046 CNV deletion 23128226
esv2750811 CNV gain 17911159
esv2764256 CNV loss 21179565
esv3585302 CNV loss 21293372
esv3585305 CNV loss 21293372
nsv1005708 CNV gain 25217958
nsv1012018 CNV gain 25217958
nsv159446 CNV deletion 16902084
nsv437203 CNV loss 16327808
nsv441682 CNV loss 18776908
nsv460550 CNV gain 19166990
nsv508913 CNV insertion 20534489
nsv519926 CNV loss 19592680
nsv545593 CNV gain 21841781
nsv833425 CNV gain 17160897

Variation tolerance for TMEM51 Gene

Residual Variation Intolerance Score: 73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM51 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM51

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM51 Gene

Disorders for TMEM51 Gene

Additional Disease Information for TMEM51

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM51 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM51 Gene

Publications for TMEM51 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58

Products for TMEM51 Gene

Sources for TMEM51 Gene

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