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TMEM50B Gene

protein-coding   GIFtS: 44
GCID: GC21M034804

Transmembrane Protein 50B

(Previous name: chromosome 21 open reading frame 4)
(Previous symbol: C21orf4)
  Search for TMEM50B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 50B1 2
C21orf41 2 3
HCV P7-Trans-Regulated Protein 32 3
Chromosome 21 Open Reading Frame 41
HCVP7TP32
HCV P7-Transregulated Protein 32

External Ids:    HGNC: 12801   Entrez Gene: 7572   Ensembl: ENSG000001421887   UniProtKB: P565573   

Export aliases for TMEM50B gene to outside databases

Previous GC identifers: GC21M033727 GC21M033743 GC21M020291


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM50B Gene:
TMEM50B (transmembrane protein 50B) is a protein-coding gene. An important paralog of this gene is TMEM50A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM50B gene promoter:
         AhR   Nkx2-2   Nkx2-5   CBF-C   Arnt   CBF-B   CBF-A   CP1A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM50B promoter sequence
   Search Chromatin IP Primers for TMEM50B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM50B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.1

TMEM50B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM50B gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M034804:  view genomic region     (about GC identifiers)

Start:
34,804,792 bp from pter      End:
34,852,318 bp from pter
Size:
47,527 bases      Orientation:
minus strand

1 alternative location:
Chr21-,NW_003315970 27,059-84,139     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TM50B_HUMAN, P56557 (See protein sequence)
Recommended Name: Transmembrane protein 50B  
Size: 158 amino acids; 17936 Da
Secondary accessions: B2R4L4 D3DSF1 O60537 Q5PY47

Explore the universe of human proteins at neXtProt for TMEM50B: NX_P56557

Explore proteomics data for TMEM50B at MOPED


See TMEM50B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_006125.2  
ENSEMBL proteins: 
 ENSP00000397773   ENSP00000439768   ENSP00000398859   ENSP00000409942   ENSP00000387622  

TMEM50B Human Recombinant Protein Products:

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Novus Biologicals TMEM50B Protein
Novus Biologicals TMEM50B Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
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Cloud-Clone Corp. Proteins for TMEM50B

 
Search eBioscience for Proteins for TMEM50B 

TMEM50B Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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Novus Biologicals TMEM50B Antibody
Abcam antibodies for TMEM50B
Cloud-Clone Corp. Antibodies for TMEM50B
ThermoFisher Antibodies for TMEM50B
Search LSBio for Antibodies for TMEM50B

TMEM50B Assay Products:

Browse Kits and Assays available from EMD Millipore
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GenScript Custom Assay Services for TMEM50B
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for TMEM50B
Cloud-Clone Corp. CLIAs for TMEM50B
Search eBioscience for ELISAs for TMEM50B 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR007919 UPF0220

Graphical View of Domain Structure for InterPro Entry P56557

ProtoNet protein and cluster: P56557

1 Blocks protein domain: IPB007919 Protein of unknown function UPF0220

UniProtKB/Swiss-Prot: TM50B_HUMAN, P56557
Similarity: Belongs to the UPF0220 family


Find genes that share domains with TMEM50B           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
     
Find genes that share ontologies with TMEM50B           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for TMEM50B:
 Increased HPV18 LCR reporter a 

     1 MGI phenotypic allele for Tmem50b (no phenotypes)

Find genes that share phenotypes with TMEM50B           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM50B
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMEM50B

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM50B
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM50B

miRNA
Products:
    
miRTarBase miRNAs that target TMEM50B:
hsa-mir-26b-5p (MIRT029204)

Block miRNA regulation of human, mouse, rat TMEM50B using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate TMEM50B (see all 49):
hsa-miR-607 hsa-miR-3664-5p hsa-miR-188-5p hsa-miR-106a hsa-miR-25 hsa-miR-301a hsa-miR-3653 hsa-miR-519a
SwitchGear 3'UTR luciferase reporter plasmidTMEM50B 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for TMEM50B
Predesigned siRNA for gene silencing in human, mouse, rat TMEM50B

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for TMEM50B

Clone
Products:
     
OriGene clones in human, mouse for TMEM50B (see all 6)
OriGene ORF clones in mouse, rat for TMEM50B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TMEM50B (NM_006134)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM50B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM50B

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for TMEM50B
Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM50B 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM50B


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TM50B_HUMAN, P56557: Membrane; Multi-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5
endoplasmic reticulum4
golgi apparatus1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005783endoplasmic reticulum IDA--
GO:0005886plasma membrane IDA16780588
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with TMEM50B           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM50B
Interactions:

    Search GeneGlobe Interaction Network for TMEM50B

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008150biological_process ND--

Find genes that share ontologies with TMEM50B           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TMEM50B (TM50B)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TMEM50B gene: 
NM_006134.6  

Unigene Cluster for TMEM50B:

Transmembrane protein 50B
Hs.433668  [show with all ESTs]
Unigene Representative Sequence: NR_040016
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000484377 ENST00000420455(uc002yrs.2 uc010gmb.2) ENST00000470682
ENST00000468874 ENST00000542230 ENST00000441128 ENST00000442441 ENST00000474272
ENST00000432504 ENST00000459909
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat TMEM50B using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate TMEM50B (see all 49):
hsa-miR-607 hsa-miR-3664-5p hsa-miR-188-5p hsa-miR-106a hsa-miR-25 hsa-miR-301a hsa-miR-3653 hsa-miR-519a
SwitchGear 3'UTR luciferase reporter plasmidTMEM50B 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for TMEM50B
Predesigned siRNA for gene silencing in human, mouse, rat TMEM50B
Clone
Products:
     
OriGene clones in human, mouse for TMEM50B (see all 6)
OriGene ORF clones in mouse, rat for TMEM50B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TMEM50B (NM_006134)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM50B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM50B
Primer
Products:
    
OriGene qPCR primer pairs and template standards for TMEM50B
OriGene qSTAR qPCR primer pairs in human, mouse for TMEM50B
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM50B
  QuantiTect SYBR Green Assays in human, mouse, rat TMEM50B
  QuantiFast Probe-based Assays in human, mouse, rat TMEM50B

Additional mRNA sequence: 

AF045606.2 AF086280.1 AK309977.1 AK310701.1 AK311870.1 AL355685.1 AY358634.1 AY820138.1 
BC000569.2 DQ286229.1 DQ655932.2 DQ655933.2 DQ656043.2 NR_040016.1 

13 DOTS entries:

DT.455857  DT.415722  DT.121131398  DT.95274525  DT.100665691  DT.95086970  DT.121131426  DT.75145105 
DT.85104623  DT.95274524  DT.100775772  DT.101983537  DT.95165204 

Selected AceView cDNA sequences (see all 281):

CD622027 AI565451 BI916178 BQ888972 BQ217746 AF086280 CR613027 AA115204 
AW305215 AI498344 AL355685 AW611695 AA938897 AI499969 BQ776181 BM675292 
AA515501 AA678042 BQ184758 AA115462 BQ773084 BM750497 Z41281 BM931900 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM50B    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:              -     -                 -                                 
SP2:                                                                        
SP3:              -     -                                                   


ECgene alternative splicing isoforms for TMEM50B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TMEM50B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TMEM50B Expression
About this image


TMEM50B expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 9) fully expand
 
 Bone (Muscoskeletal System)    fully expand to see all 7 entries
         Mesenchymal Condensate Cells Stylopod
         Zeugopod Long Bone
 
 Brain (Nervous System)    fully expand to see all 5 entries
         Cerebral Cortex
 
 Limb (Muscoskeletal System)    fully expand to see all 4 entries
         Mesenchymal Condensate Cells Stylopod
         Pelvic Girdle
 
 Neural Tube (Nervous System)    fully expand to see all 4 entries
         Metencephalon
 
 Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
         Mesenchymal Condensate Cells Stylopod
         Meckel's Cartilage
TMEM50B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TMEM50B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.433668
    Custom PCR Arrays for TMEM50B
Primer
Products:
OriGene qPCR primer pairs and template standards for TMEM50B
OriGene qSTAR qPCR primer pairs in human, mouse for TMEM50B
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM50B
QuantiTect SYBR Green Assays in human, mouse, rat TMEM50B
QuantiFast Probe-based Assays in human, mouse, rat TMEM50B
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM50B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for TMEM50B gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmem50b1 , 5 transmembrane protein 50B1, 5 87.9(n)1
98.73(a)1
  16 (53.11 cM)5
779751  NM_030018.31  NP_084294.11 
 915745035 
chicken
(Gallus gallus)
Aves TMEM50B1 transmembrane protein 50B 82.59(n)
95.54(a)
  418503  XM_003640492.2  XP_003640540.1 
lizard
(Anolis carolinensis)
Reptilia TMEM50B6
transmembrane protein 50B
85(a)
1 ↔ 1
3(143151283-143162708)
African clawed frog
(Xenopus laevis)
Amphibia MGC688572 hypothetical protein MGC68857 80.6(n)    BC055980.1 
fruit fly
(Drosophila melanogaster)
Insecta CG150126
--
35(a)
1 → many
3L(4291208-4292246)
worm
(Caenorhabditis elegans)
Secernentea Y74C10AL.21 Y74C10AL.2 56.64(n)
52.29(a)
  171806  NM_058584.6  NP_490985.1 


ENSEMBL Gene Tree for TMEM50B (if available)
TreeFam Gene Tree for TMEM50B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TMEM50B gene
TMEM50A2  
2 SIMAP similar genes for TMEM50B using alignment to 4 protein entries:     TM50B_HUMAN (see all proteins):
SMP1    TMEM50A

Find genes that share paralogs with TMEM50B           About GenesLikeMe


1 Pseudogenes.org Pseudogene for TMEM50B
PGOHUM00000234390


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TMEM50B (see all 992)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 21 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs48164521,2
C,F,A--34810330(+) CTCATA/GCCTGT 1 -- int18Minor allele frequency- G:0.40NA NS WA CSA 94
rs1833355881,2
--34810348(+) GCACTA/TTGGGA 1 -- int10--------
rs1882720091,2
--34810372(+) GGATCA/GCTTGA 1 -- int10--------
rs1921143161,2
--34810455(+) TCGTGG/TTGGTG 1 -- int10--------
rs1471484881,2
--34810671(+) TCACAC/TTGTGT 1 -- int10--------
rs178799561,2
C,F--34810938(+) TGTCTC/TCACTA 1 -- int15Minor allele frequency- T:0.24NS CSA NA EA 320
rs3691648891,2
C--34811038(+) GTGGC-/TTTTTT 1 -- int10--------
rs731958291,2
C--34811050(+) TTTTTC/TTTTTG 1 -- int10--------
rs1831019311,2
--34811099(+) TGGCGC/TGATCT 1 -- int10--------
rs1879312121,2
--34811192(+) CCACTA/GTGCCT 1 -- int10--------

HapMap Linkage Disequilibrium report for TMEM50B (34804792 - 34852318 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for TMEM50B:    About this table    
Variant IDTypeSubtypePubMed ID
esv1700579CNV Insertion17803354
nsv191CNV Insertion15895083
nsv509795CNV Insertion20534489
nsv3497CNV Insertion18451855
esv1009907CNV Insertion20482838
nsv524420CNV Loss19592680
nsv913724CNV Loss21882294
nsv834087CNV Gain17160897
nsv528264CNV Gain19592680

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TMEM50B
DNA2.0 Custom Variant and Variant Library Synthesis for TMEM50B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TMEM50B gene, integrated from 10 sources (see all 14):
(articles sorted by number of sources associating them with TMEM50B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  3. Comparative genomic analysis of the interferon/interleukin-10 receptor gene cluster. (PubMed id 10077530)1, 2 Reboul J.... Lutfalla G. (Genome Res. 1999)
  4. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
  5. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
  6. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PubMed id 17567994)1 Denoeud F....Reymond A. (Genome Res. 2007)
  7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
  8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  9. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. (PubMed id 16780588)1 Hu Y.H....Janitz M. (BMC Genomics 2006)
  10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 757 HGNC: 1280 AceView: C21orf4 Ensembl:ENSG00000142188 euGenes: HUgn757
ECgene: TMEM50B H-InvDB: TMEM50B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TMEM50B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TMEM50B gene:
Search GeneIP for patents involving TMEM50B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Block miRNA regulation of human, mouse, rat TMEM50B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TMEM50B
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 Search Addgene for plasmids for TMEM50B
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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