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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TMEM50B Gene

protein-coding GIFtS: 45
GCID: GC21M034804

transmembrane protein 50B

(Previous name: chromosome 21 open reading frame 4 )
(Previous symbol: C21orf4)

Explore 1 disease affiliated with
TMEM50B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transmembrane Protein 50B¹ ²
C21orf4¹ ² ³
HCV P7-Trans-Regulated Protein 3² ³
Chromosome 21 Open Reading Frame 4¹
HCVP7TP3²
HCV P7-Transregulated Protein 3²

External Ids:	HGNC: 1280¹	Entrez Gene: 757²	Ensembl: ENSG00000142188⁷	UniProtKB: P56557³

ORGUL members:
	NONCODE:n411545 n337395

Export aliases for TMEM50B gene to outside databases

Previous GC identifers: GC21M033727 GC21M033743 GC21M020291

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000021.8 NC_018932.1 NT_011512.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TMEM50B gene promoter:
AhR Nkx2-2 Nkx2-5 CBF-C Arnt CBF-B CBF-A CP1A CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMEM50B promoter sequence

Search SABiosciences Chromatin IP Primers for TMEM50B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM50B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11 Ensembl cytogenetic band: 21q22.11 HGNC cytogenetic band: 21q22.1

TMEM50B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM50B gene location

GeneLoc information about chromosome 21 GeneLoc Exon Structure

GeneLoc location for GC21M034804: view genomic region (about GC identifiers)

Start:	34,804,792 bp from pter	End:	34,853,499 bp from pter
Size:	48,708 bases	Orientation:	minus strand

1 alternative location:

Chr21-,PATCHES 34,816,669-34,857,059

ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TMEM50B

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TM50B_HUMAN, P56557 (See protein sequence)

Recommended Name: Transmembrane protein 50B

Size: 158 amino acids; 17936 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: B2R4L4 D3DSF1 O60537 Q5PY47

Explore the universe of human proteins at neXtProt for TMEM50B: NX_P56557

TMEM50B Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_006125.2

ENSEMBL proteins:

ENSP00000397773 ENSP00000439768 ENSP00000398859 ENSP00000409942 ENSP00000387622

ENSP00000411248

Human Recombinant Protein Products for TMEM50B:

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	Novus Biologicals TMEM50B Protein Novus Biologicals TMEM50B Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TMEM50B

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IDA	--
GO:0005886	plasma membrane	IDA	16780588
GO:0016021	integral to membrane	IEA	--

TMEM50B for ontologies About GeneDecksing

TMEM50B Antibody Products:

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	Uscn Antibodies for TMEM50B
	ThermoFisher Antibodies for TMEM50B

Assay Products for TMEM50B:

	Browse Kits and Assays available from EMD Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TMEM50B
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TMEM50B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TMEM50B for domains About GeneDecksing

1 InterPro domain/family:

IPR007919 UPF0220

Graphical View of Domain Structure for InterPro Entry P56557

ProtoNet protein and cluster: P56557

1 Blocks protein family: IPB007919 Protein of unknown function UPF0220

UniProtKB/Swiss-Prot: TM50B_HUMAN, P56557

Similarity: Belongs to the UPF0220 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--

TMEM50B for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for TMEM50B:

Increased HPV18 LCR reporter a

1 MGI phenotypic allele

for Tmem50b (no phenotypes)

TMEM50B for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TMEM50B

miRNA Products:		OriGene 3'-UTR Clone: TMEM50B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM50B
		8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM50B (see all 49):
		hsa-miR-607 hsa-miR-3664-5p hsa-miR-188-5p hsa-miR-106a hsa-miR-25 hsa-miR-301a hsa-miR-3653 hsa-miR-519a

		SwitchGear 3'UTR luciferase reporter plasmid: TMEM50B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM50B (see all 7) OriGene shRNA RFP: TMEM50B OriGene siRNA: TMEM50B
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		Sirion Biotech Custom design and validation of potent shRNA sequences against TMEM50B

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TMEM50B
			Sirion Biotech Customized adenovirus for overexpression of TMEM50B Sirion Biotech Customized adenovirus for potent knockdown of TMEM50B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM50B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM50B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TMEM50B (NM_006134)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM50B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM50B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TMEM50B
		Search LifeMap BioReagents cell lines for TMEM50B
		Sirion Biotech Customized stable knockdown cell line services for TMEM50B Sirion Biotech Customized inducible knockdown cell line services for TMEM50B Sirion Biotech Customized stable overexpressing cell line services for TMEM50B Sirion Biotech Customized inducible overexpressing cell line services for TMEM50B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM50B

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TMEM50B

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

TMEM50B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM50B
Search CenterWatch for drugs/clinical trials and news about TMEM50B / TM50B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMEM50B gene:

NM_006134.6

Unigene Cluster for TMEM50B:

Transmembrane protein 50B

Hs.433668 [show with all ESTs]

Unigene Representative Sequence: NR_040016

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000484377 ENST00000420455(uc002yrs.2 uc010gmb.2) ENST00000470682

ENST00000468874 ENST00000542230 ENST00000441128 ENST00000442441 ENST00000474272

ENST00000432504 ENST00000435619 ENST00000459909

miRNA Products:		OriGene 3'-UTR Clone: TMEM50B Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM50B
		8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM50B (see all 49):
		hsa-miR-607 hsa-miR-3664-5p hsa-miR-188-5p hsa-miR-106a hsa-miR-25 hsa-miR-301a hsa-miR-3653 hsa-miR-519a

		SwitchGear 3'UTR luciferase reporter plasmid: TMEM50B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM50B (see all 7) OriGene shRNA RFP: TMEM50B OriGene siRNA: TMEM50B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM50B
		Sirion Biotech Custom design and validation of potent shRNA sequences against TMEM50B

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM50B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM50B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TMEM50B (NM_006134)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM50B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM50B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM50B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TMEM50B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM50B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM50B

Additional cDNA sequence:

AF045606.2 AF086280.1 AK309977.1 AK310701.1 AK311870.1 AL355685.1 AY358634.1 AY820138.1

BC000569.2 DQ286229.1 DQ655932.2 DQ655933.2 DQ656043.2 NR_040016.1

13 DOTS entries:

DT.455857 DT.415722 DT.121131398 DT.95274525 DT.100665691 DT.95086970 DT.121131426 DT.75145105

DT.85104623 DT.95274524 DT.100775772 DT.101983537 DT.95165204

24/281 AceView cDNA sequences (see all 281):

AI499969 BQ888972 AU122747 BI916178 AI277739 AI521497 BC000569 AA515501

BQ776181 AA115204 Z41281 AL711021 AI090946 AW138034 BM675292 AA938897

AA115462 F19175 BE045450 BM750497 CD622027 BQ773084 BP342830 BP376916

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM50B About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7	^	8	^	9
SP1:					-		-						-
SP2:
SP3:					-		-

ECgene alternative splicing isoforms for TMEM50B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM50B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

TMEM50B expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/12 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 12)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Stylopod

Mesenchymal Condensate Cells

Bone, Cartilage

Bone

Autopod Long Bone

Bone

Endochondral Facial Bones

Bone

Bone

Bone

Bone

Cartilage

Limb

Limb

Mesencephalic Ventricular Zone

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Genevestigator expression for TMEM50B

SOURCE GeneReport for Unigene cluster: Hs.433668

SABiosciences Custom PCR Arrays for TMEM50B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM50B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TMEM50B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM50B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM50B

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM50B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM50B gene from 7/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TMEM50B¹	transmembrane protein 50B	82.59(n) 95.54(a)		418503 XM_416711.2 XP_416711.1
lizard (Anolis carolinensis)	Reptilia	TMEM50B⁶	--	94(a)	1 ↔ 1	3(143151348-143162666)
African clawed frog (Xenopus laevis)	Amphibia	MGC68857²	hypothetical protein MGC68857	80.6(n)		BC055980.1
fruit fly (Drosophila melanogaster)	Insecta	CG15012⁶	--	36(a)	1 → many	3L(4291208-4292246)
worm (Caenorhabditis elegans)	Secernentea	Y74C10AL.2¹	Protein Y74C10AL.2	56.64(n) 52.29(a)		171806 NM_058584.5 NP_490985.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G36980⁶	uncharacterized protein	28(a)	1 → many	1(14025028-14026941)
rice (Oryza sativa)	Liliopsida	-- -- (see all 3)	salt tolerant protein, putative, expressed (see all 3)	28(a) 24(a) (see all 3)	many ↔ many many ↔ many (see all 3)	9(16986938-16989466) 2(21552903-21554894)

ENSEMBL Gene Tree for TMEM50B (if available)
TreeFam Gene Tree for TMEM50B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TMEM50B gene

TMEM50A²

2 SIMAP similar genes for TMEM50B using alignment to 5 protein entries: TM50B_HUMAN (see all proteins):

SMP1 TMEM50A

TMEM50B for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for TMEM50B
PGOHUM00000234390

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 21 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs121913214^1,2	C	untested	34804816(+)	`AGGCTA/CCCAGA`	2	--	int¹ nc-transcript-variant		0	--	--	--	--
rs121913215^1,2	C	untested	34804930(+)	`CAGGAA/TTGCTC`	2	--	nc-transcript-variantint¹		0	--	--	--	--
rs121913216^1,2	C	untested	34804979(+)	`TTGTGC/TGTAGG`	2	--	int¹ nc-transcript-variant		0	--	--	--	--
rs193922682^1,2	C	unknown	34805197(+)	`CATCT-/CTTTTT`	2	--	int¹		0	--	--	--	--
rs41351148^1,2	C	--	34804650(+)	`TAAAAT/CATACC`	2	--	ds500¹ int¹		3		NA WA EU	1487
rs143277613^1,2	C	--	34804685(+)	`AAAAGA/CATACT`	2	--	int¹ ds500¹		0	--	--	--	--
rs151260100^1,2	C	--	34804691(+)	`ATACTC/TCTCCA`	2	--	int¹ ds500¹		0	--	--	--	--
rs188226451^1,2		--	34804846(+)	`TTCATC/TACAGG`	2	--	nc-transcript-variantint¹		0	--	--	--	--
rs1532^1,2	C,F,A,H	--	34804966(+)	`ACTGAC/TGTTTG`	2	--	nc-transcript-variantint¹		25		MN NS EA NA WA CSA	2517
rs201322939^1,2		--	34805195(+)	`ACATC-/TTCTTT`	2	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TMEM50B (34804792 - 34853499 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for TMEM50B
10 CNVs: 35967 35964 0542 35962 23640 35966 35969 35968 35965 35963

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM50B

DNA2.0 Custom Variant and Variant Library Synthesis for TMEM50B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TMEM50B for disorders About GeneDecksing

1 disease for TMEM50B: About MalaCards

down syndrome

Export disorders for TMEM50B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TMEM50B gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with TMEM50B)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Comparative genomic analysis of the interferon/interleukin-10 receptor gene cluster. (PubMed id 10077530)^{1, 2} Reboul J.... Lutfalla G. (1999)
Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PubMed id 17567994)¹ Denoeud F....Reymond A. (2007)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. (PubMed id 16780588)¹ Hu Y.H....Janitz M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)¹ Simpson J.C.... Wiemann S. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 757	HGNC: 1280	AceView: C21orf4	Ensembl:ENSG00000142188	euGenes: HUgn757
ECgene: TMEM50B	H-InvDB: TMEM50B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TMEM50B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TMEM50B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TMEM50B gene:
Search GeneIP for patents involving TMEM50B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	Regulatory tfbs in TMEM50B promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM50B

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ThermoFisher Antibodies for TMEM50B

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM50B

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TMEM50B

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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TMEM50B Gene

transmembrane protein 50B

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TMEM50B Gene

transmembrane protein 50B

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Intellectual Property
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