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Aliases for TMEM50B Gene

Aliases for TMEM50B Gene

  • HCV P7-Trans-Regulated Protein 3 3 4
  • Transmembrane Protein 50B 2 3
  • C21orf4 3 4
  • Chromosome 21 Open Reading Frame 4 2
  • HCV P7-Transregulated Protein 3 3
  • HCVP7TP3 3

External Ids for TMEM50B Gene

Previous HGNC Symbols for TMEM50B Gene

  • C21orf4

Previous GeneCards Identifiers for TMEM50B Gene

  • GC21M033727
  • GC21M033743
  • GC21M034804
  • GC21M020291

Summaries for TMEM50B Gene

GeneCards Summary for TMEM50B Gene

TMEM50B is a Protein Coding gene. An important paralog of this gene is TMEM50A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM50B Gene

Genomics for TMEM50B Gene

Regulatory Elements for TMEM50B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM50B Gene

Start:
33,432,485 bp from pter
End:
33,480,011 bp from pter
Size:
47,527 bases
Orientation:
Minus strand

Genomic View for TMEM50B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM50B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM50B Gene

Proteins for TMEM50B Gene

  • Protein details for TMEM50B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56557-TM50B_HUMAN
    Recommended name:
    Transmembrane protein 50B
    Protein Accession:
    P56557
    Secondary Accessions:
    • B2R4L4
    • D3DSF1
    • O60537
    • Q5PY47

    Protein attributes for TMEM50B Gene

    Size:
    158 amino acids
    Molecular mass:
    17936 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM50B Gene

Proteomics data for TMEM50B Gene at MOPED

Post-translational modifications for TMEM50B Gene

No Post-translational modifications

Other Protein References for TMEM50B Gene

No data available for DME Specific Peptides for TMEM50B Gene

Domains for TMEM50B Gene

Protein Domains for TMEM50B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM50B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56557

UniProtKB/Swiss-Prot:

TM50B_HUMAN :
  • P56557
Family:
  • Belongs to the UPF0220 family.
genes like me logo Genes that share domains with TMEM50B: view

No data available for Gene Families for TMEM50B Gene

Function for TMEM50B Gene

Gene Ontology (GO) - Molecular Function for TMEM50B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM50B: view

Phenotypes for TMEM50B Gene

GenomeRNAi human phenotypes for TMEM50B:
genes like me logo Genes that share phenotypes with TMEM50B: view

Animal Model Products

CRISPR Products

miRNA for TMEM50B Gene

miRTarBase miRNAs that target TMEM50B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM50B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM50B Gene

Localization for TMEM50B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM50B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM50B Gene COMPARTMENTS Subcellular localization image for TMEM50B gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM50B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005886 plasma membrane IDA 16780588
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM50B: view

Pathways for TMEM50B Gene

SuperPathways for TMEM50B Gene

No Data Available

Interacting Proteins for TMEM50B Gene

Gene Ontology (GO) - Biological Process for TMEM50B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM50B: view

No data available for Pathways by source for TMEM50B Gene

Transcripts for TMEM50B Gene

Unigene Clusters for TMEM50B Gene

Transmembrane protein 50B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM50B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM50B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2:
SP3: - -

Relevant External Links for TMEM50B Gene

GeneLoc Exon Structure for
TMEM50B
ECgene alternative splicing isoforms for
TMEM50B

Expression for TMEM50B Gene

mRNA expression in normal human tissues for TMEM50B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM50B Gene

SOURCE GeneReport for Unigene cluster for TMEM50B Gene Hs.433668

genes like me logo Genes that share expressions with TMEM50B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM50B Gene

Orthologs for TMEM50B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM50B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM50B 35
  • 100 (n)
  • 100 (a)
TMEM50B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM50B 35
  • 93.46 (n)
  • 100 (a)
TMEM50B 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 100 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
LOC100856546 35
  • 94.94 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Tmem50b 35
  • 87.9 (n)
  • 98.73 (a)
Tmem50b 16
Tmem50b 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM50B 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM50B 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem50b 35
  • 86.62 (n)
  • 98.73 (a)
chicken
(Gallus gallus)
Aves TMEM50B 35
  • 82.59 (n)
  • 95.54 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM50B 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68857 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.683 35
tmem50b 35
  • 77 (n)
  • 87.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15012 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y74C10AL.2 35
  • 56.64 (n)
  • 52.29 (a)
Y74C10AL.2 36
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
OneToMany
Species with no ortholog for TMEM50B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TMEM50B Gene

ENSEMBL:
Gene Tree for TMEM50B (if available)
TreeFam:
Gene Tree for TMEM50B (if available)

Paralogs for TMEM50B Gene

Paralogs for TMEM50B Gene

Selected SIMAP similar genes for TMEM50B Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for TMEM50B Gene

genes like me logo Genes that share paralogs with TMEM50B: view

Variants for TMEM50B Gene

Sequence variations from dbSNP and Humsavar for TMEM50B Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs16442 -- 33,449,342(+) CTCTC(-/AA)GAGAG utr-variant-3-prime, nc-transcript-variant
rs743334 -- 33,467,226(+) TGGGT(A/G)CAGAG intron-variant
rs743335 -- 33,468,211(-) AAAGC(A/T)GAGAG intron-variant
rs928739 -- 33,451,896(+) GCTTG(C/T)AAGGA intron-variant
rs928779 -- 33,445,015(+) GCTAC(C/T)TGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM50B Gene

Variant ID Type Subtype PubMed ID
nsv834087 CNV Gain 17160897
nsv913724 CNV Loss 21882294
nsv528264 CNV Gain 19592680
nsv3497 CNV Insertion 18451855
nsv524420 CNV Loss 19592680
nsv509795 CNV Insertion 20534489
nsv191 CNV Insertion 15895083
esv1700579 CNV Insertion 17803354
esv1009907 CNV Insertion 20482838

Relevant External Links for TMEM50B Gene

HapMap Linkage Disequilibrium report
TMEM50B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM50B Gene

Disorders for TMEM50B Gene

No disorders were found for TMEM50B Gene.

No data available for UniProtKB/Swiss-Prot for TMEM50B Gene

Publications for TMEM50B Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Comparative genomic analysis of the interferon/interleukin-10 receptor gene cluster. (PMID: 10077530) Reboul J. … Lutfalla G. (Genome Res. 1999) 3 4
  4. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3
  5. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PMID: 11256614) Simpson J.C. … Wiemann S. (EMBO Rep. 2000) 3

Products for TMEM50B Gene

Sources for TMEM50B Gene

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