Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM50B Gene

Aliases for TMEM50B Gene

  • Transmembrane Protein 50B 2 3 5
  • HCV P7-Trans-Regulated Protein 3 3 4
  • C21orf4 3 4
  • Chromosome 21 Open Reading Frame 4 2
  • HCV P7-Transregulated Protein 3 3
  • HCVP7TP3 3

External Ids for TMEM50B Gene

Previous HGNC Symbols for TMEM50B Gene

  • C21orf4

Previous GeneCards Identifiers for TMEM50B Gene

  • GC21M033727
  • GC21M033743
  • GC21M034804
  • GC21M020291

Summaries for TMEM50B Gene

GeneCards Summary for TMEM50B Gene

TMEM50B (Transmembrane Protein 50B) is a Protein Coding gene. An important paralog of this gene is TMEM50A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM50B Gene

Genomics for TMEM50B Gene

Regulatory Elements for TMEM50B Gene

Promoters for TMEM50B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM50B on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM50B Gene

Chromosome:
21
Start:
33,432,485 bp from pter
End:
33,480,011 bp from pter
Size:
47,527 bases
Orientation:
Minus strand

Genomic View for TMEM50B Gene

Genes around TMEM50B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM50B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM50B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM50B Gene

Proteins for TMEM50B Gene

  • Protein details for TMEM50B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56557-TM50B_HUMAN
    Recommended name:
    Transmembrane protein 50B
    Protein Accession:
    P56557
    Secondary Accessions:
    • B2R4L4
    • D3DSF1
    • O60537
    • Q5PY47

    Protein attributes for TMEM50B Gene

    Size:
    158 amino acids
    Molecular mass:
    17936 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM50B Gene

Proteomics data for TMEM50B Gene at MOPED

Post-translational modifications for TMEM50B Gene

No Post-translational modifications

Other Protein References for TMEM50B Gene

No data available for DME Specific Peptides for TMEM50B Gene

Domains & Families for TMEM50B Gene

Protein Domains for TMEM50B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM50B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56557

UniProtKB/Swiss-Prot:

TM50B_HUMAN :
  • Belongs to the UPF0220 family.
Family:
  • Belongs to the UPF0220 family.
genes like me logo Genes that share domains with TMEM50B: view

No data available for Gene Families for TMEM50B Gene

Function for TMEM50B Gene

Phenotypes for TMEM50B Gene

genes like me logo Genes that share phenotypes with TMEM50B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM50B Gene

Localization for TMEM50B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM50B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM50B Gene COMPARTMENTS Subcellular localization image for TMEM50B gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4

Gene Ontology (GO) - Cellular Components for TMEM50B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 16780588
genes like me logo Genes that share ontologies with TMEM50B: view

Pathways & Interactions for TMEM50B Gene

SuperPathways for TMEM50B Gene

No Data Available

Interacting Proteins for TMEM50B Gene

Gene Ontology (GO) - Biological Process for TMEM50B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM50B Gene

Drugs & Compounds for TMEM50B Gene

No Compound Related Data Available

Transcripts for TMEM50B Gene

Unigene Clusters for TMEM50B Gene

Transmembrane protein 50B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM50B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2:
SP3: - -

Relevant External Links for TMEM50B Gene

GeneLoc Exon Structure for
TMEM50B
ECgene alternative splicing isoforms for
TMEM50B

Expression for TMEM50B Gene

mRNA expression in normal human tissues for TMEM50B Gene

Protein differential expression in normal tissues from HIPED for TMEM50B Gene

This gene is overexpressed in Retina (18.1), Testis (14.3), and Frontal cortex (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM50B Gene



SOURCE GeneReport for Unigene cluster for TMEM50B Gene Hs.433668

genes like me logo Genes that share expression patterns with TMEM50B: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM50B Gene

Orthologs for TMEM50B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM50B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM50B 35
  • 100 (n)
  • 100 (a)
TMEM50B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM50B 36
  • 100 (a)
OneToOne
TMEM50B 35
  • 93.46 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia LOC100856546 35
  • 94.94 (n)
  • 100 (a)
-- 36
  • 100 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tmem50b 36
  • 98 (a)
OneToOne
Tmem50b 16
Tmem50b 35
  • 87.9 (n)
  • 98.73 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM50B 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM50B 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem50b 35
  • 86.62 (n)
  • 98.73 (a)
chicken
(Gallus gallus)
Aves TMEM50B 35
  • 82.59 (n)
  • 95.54 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM50B 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68857 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.683 35
tmem50b 35
  • 77 (n)
  • 87.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15012 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y74C10AL.2 36
  • 49 (a)
OneToMany
Y74C10AL.2 35
  • 56.64 (n)
  • 52.29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
OneToMany
Species with no ortholog for TMEM50B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TMEM50B Gene

ENSEMBL:
Gene Tree for TMEM50B (if available)
TreeFam:
Gene Tree for TMEM50B (if available)

Paralogs for TMEM50B Gene

Paralogs for TMEM50B Gene

(2) SIMAP similar genes for TMEM50B Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for TMEM50B Gene

genes like me logo Genes that share paralogs with TMEM50B: view

Variants for TMEM50B Gene

Sequence variations from dbSNP and Humsavar for TMEM50B Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs16442 -- 33,449,342(+) CTCTC(-/AA)GAGAG nc-transcript-variant, utr-variant-3-prime
rs743334 -- 33,467,226(+) TGGGT(A/G)CAGAG intron-variant
rs743335 -- 33,468,211(-) AAAGC(A/T)GAGAG intron-variant
rs928739 -- 33,451,896(+) GCTTG(C/T)AAGGA intron-variant
rs971134 -- 33,480,112(+) CGCTC(C/T)TCGCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM50B Gene

Variant ID Type Subtype PubMed ID
nsv834087 CNV Gain 17160897
nsv913724 CNV Loss 21882294
nsv528264 CNV Gain 19592680
nsv3497 CNV Insertion 18451855
nsv524420 CNV Loss 19592680
nsv509795 CNV Insertion 20534489
nsv191 CNV Insertion 15895083
esv1700579 CNV Insertion 17803354
esv1009907 CNV Insertion 20482838

Variation tolerance for TMEM50B Gene

Residual Variation Intolerance Score: 53.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM50B Gene

HapMap Linkage Disequilibrium report
TMEM50B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM50B Gene

Disorders for TMEM50B Gene

Relevant External Links for TMEM50B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM50B

No disorders were found for TMEM50B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM50B Gene

Publications for TMEM50B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  3. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 3
  4. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PMID: 17567994) Denoeud F. … Reymond A. (Genome Res. 2007) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for TMEM50B Gene

Sources for TMEM50B Gene

Back to Top

Content