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TMEM5 Gene

protein-coding   GIFtS: 50
GCID: GC12P064173

Transmembrane Protein 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 51 2
MDDGA102 5
HP104812
Type II Membrane Protein2

External Ids:    HGNC: 135301   Entrez Gene: 103292   Ensembl: ENSG000001186007   OMIM: 6058625   UniProtKB: Q9Y2B13   

Export aliases for TMEM5 gene to outside databases

Previous GC identifers: GC12P063812 GC12P064228 GC12P062459 GC12P061224


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TMEM5 Gene:
This gene encodes a type II transmembrane protein that is thought to have glycosyltransferase function. Mutations
in this gene result in cobblestone lissencephaly. Alternative splicing results in multiple transcript variants
encoding different isoforms. (provided by RefSeq, May 2013)

GeneCards Summary for TMEM5 Gene:
TMEM5 (transmembrane protein 5) is a protein-coding gene. Diseases associated with TMEM5 include muscular dystrophy-dystroglycanopathy , type a, 10, and muscular dystrophy-dystroglycanopathy , type a, 7.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM5 gene promoter:
         Max1   Pbx1a   GATA-3   AP-1   Evi-1   HNF-1A   GATA-1   GATA-2   HNF-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM5 promoter sequence
   Search Chromatin IP Primers for TMEM5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.2   Ensembl cytogenetic band:  12q14.2   HGNC cytogenetic band: 12q14.1

TMEM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM5 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P064173:  view genomic region     (about GC identifiers)

Start:
64,173,583 bp from pter      End:
64,203,338 bp from pter
Size:
29,756 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TMEM5_HUMAN, Q9Y2B1 (See protein sequence)
Recommended Name: Transmembrane protein 5  
Size: 443 amino acids; 51146 Da
Sequence caution: Sequence=AAH02596.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: A8K017 Q6PKD6

Explore the universe of human proteins at neXtProt for TMEM5: NX_Q9Y2B1

Explore proteomics data for TMEM5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TMEM5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001265166.1  NP_055069.1  

    ENSEMBL proteins: 
     ENSP00000261234   ENSP00000440845   ENSP00000440280  

    TMEM5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TMEM5
    OriGene Protein Over-expression Lysate for TMEM5
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    OriGene Custom Protein Services for TMEM5
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMEM5

    TMEM5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TMEM5
    OriGene Custom Antibody Services for TMEM5
    Novus Biologicals TMEM5 Antibodies
    Abcam antibodies for TMEM5
    Cloud-Clone Corp. Antibodies for TMEM5
    ThermoFisher Antibodies for TMEM5
    LSBio Antibodies in human, mouse, rat for TMEM5

    TMEM5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TMEM5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TMEM5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TMEM5
    Cloud-Clone Corp. CLIAs for TMEM5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9Y2B1

    UniProtKB/Swiss-Prot: TMEM5_HUMAN, Q9Y2B1
    Similarity: Belongs to the TMEM5 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMEM5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM5

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMEM5:
    hsa-mir-124-3p (MIRT022274)

    Block miRNA regulation of human, mouse, rat TMEM5 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TMEM5
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TMEM5
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TMEM5

    Clone
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    OriGene clones in human, mouse for TMEM5 (see all 7)
    OriGene ORF clones in mouse, rat for TMEM5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMEM5 (NM_006134)
    Sino Biological Human cDNA Clone for TMEM5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TMEM5
    Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMEM5_HUMAN, Q9Y2B1: Membrane; Single-pass type II membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    golgi apparatus3
    cytosol1
    endoplasmic reticulum1
    extracellular1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS10072769
    GO:0016021integral component of membrane ----

    TMEM5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM5
    Interactions:

        Search GeneGlobe Interaction Network for TMEM5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TMEM5 (ENSP000002612344) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPR3ENSP000003631364STRING: ENSP00000363136
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMEM5 gene (2 alternative transcripts): 
    NM_001278237.1  NM_014254.2  

    Unigene Cluster for TMEM5:

    Transmembrane protein 5
    Hs.216386  [show with all ESTs]
    Unigene Representative Sequence: BX647170
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261234(uc001srq.1) ENST00000536219 ENST00000543342 ENST00000537982
    ENST00000537373(uc001srs.1) ENST00000535963 ENST00000433461
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMEM5 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TMEM5
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMEM5
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM5
    Clone
    Products:
         
    OriGene clones in human, mouse for TMEM5 (see all 7)
    OriGene ORF clones in mouse, rat for TMEM5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMEM5 (NM_006134)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMEM5
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM5
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM5
      QuantiFast Probe-based Assays in human, mouse, rat TMEM5

    Additional mRNA sequence: 

    AB015633.1 AK124211.1 AK289382.1 BC002596.2 BC013152.1 BX647105.1 BX647170.1 BX647419.1 

    9 DOTS entries:

    DT.310873  DT.101983369  DT.95275967  DT.101983368  DT.92425807  DT.101983367  DT.95275966  DT.99945581 
    DT.97775329 

    Selected AceView cDNA sequences (see all 133):

    AW205385 BM510089 CR613360 BU509681 BE783494 BM547839 CA488705 BQ015677 
    CR622234 BU077881 AI478525 BM675923 CR606653 BC002596 AI139074 AV654805 
    BM711979 BQ003262 AI701453 CR619804 CR616450 BX647105 BX647170 BQ774066 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM5    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
    SP1:        -           -           -               
    SP2:                    -                           
    SP3:                                                
    SP4:                                                


    ECgene alternative splicing isoforms for TMEM5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGCTCCCT
    TMEM5 Expression
    About this image

    TMEM5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.216386
        Custom PCR Arrays for TMEM5
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TMEM5
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM5
    QuantiTect SYBR Green Assays in human, mouse, rat TMEM5
    QuantiFast Probe-based Assays in human, mouse, rat TMEM5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM5 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem51 , 5 transmembrane protein 51, 5 85.67(n)1
    83.48(a)1
      10 (70.25 cM)5
    2163951  NM_153059.11  NP_694699.11 
     1220781145 
    chicken
    (Gallus gallus)
    Aves TMEM51 transmembrane protein 5 73.17(n)
    69.72(a)
      417820  NM_001199557.1  NP_001186486.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM56
    transmembrane protein 5
    62(a)
    1 ↔ 1
    GL344278.1(24639-41258)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.297092 Xenopus laevis transcribed sequences 75.94(n)    BJ072197.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmem51 transmembrane protein 5 56.52(n)
    56.44(a)
      557187  NM_001075112.1  NP_001068580.1 


    ENSEMBL Gene Tree for TMEM5 (if available)
    TreeFam Gene Tree for TMEM5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM5 (see all 525)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0697384
    Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A10 (MDDGA10)4--see VAR_0697382 Y C mis40--------
    VAR_0697394
    Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A10 (MDDGA10)4--see VAR_0697392 R L mis40--------
    rs1124152611,2
    C,F--64171690(+) CACAGC/AAGCTT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1862984671,2
    --64171829(+) AGCGTA/GTACTA 1 -- us2k10--------
    rs1179362571,2
    C,F--64171972(+) TAATTC/TATCTC 1 -- us2k11Minor allele frequency- T:0.05NA 120
    rs1383956841,2
    --64172035(+) TCCCTA/GTATGC 1 -- us2k10--------
    rs1427136871,2
    --64172037(+) CCTATA/GTGCGG 1 -- us2k10--------
    rs1469270211,2
    C--64172077(+) TGTCTC/GCCCCT 1 -- us2k10--------
    rs38253041,2
    C,F,H--64172337(+) GCCCTC/ATCCCC 1 -- us2k1 trp35Minor allele frequency- A:0.01NS EA NA 414
    rs1140020051,2
    F--64172367(+) TGCATA/GTTAGT 1 -- us2k11Minor allele frequency- G:0.01WA 118

    HapMap Linkage Disequilibrium report for TMEM5 (64173583 - 64203338 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TMEM5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832441CNV Loss17160897
    nsv899171CNV Loss21882294
    nsv746CNV Loss18451855
    esv2751110CNV Gain17911159
    dgv517e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): TMEM5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM5
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605862   
    OMIM disorders: 615041  
    UniProtKB/Swiss-Prot: TMEM5_HUMAN, Q9Y2B1
  • Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A10 (MDDGA10) [MIM:615041]:
    An autosomal recessive disorder characterized by congenital muscular dystrophy associated with cobblestone
    lissencephaly and other brain anomalies, eye malformations, profound mental retardation, and death usually in the
    first years of life. Included diseases are the more severe Walker-Warburg syndrome and the slightly less severe
    muscle-eye-brain disease. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 4 diseases for TMEM5:    
    About MalaCards
    muscular dystrophy-dystroglycanopathy , type a, 10    muscular dystrophy-dystroglycanopathy , type a, 7    lissencephaly    walker-warburg syndrome

    1 disease from the University of Copenhagen DISEASES database for TMEM5:
    Walker-Warburg syndrome

    TMEM5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMEM5
    Human Genome Epidemiology (HuGE) Navigator: TMEM5 (2 documents)

    Export disorders for TMEM5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMEM5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of mutations in TMEM5 and ISPD as a cause of severe cobblestone lissencephaly. (PubMed id 23217329)1, 2, 3 Vuillaumier-Barrot S....Seta N. (Am. J. Hum. Genet. 2012)
    2. Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank. (PubMed id 10072769)1, 2, 3 Yokoyama-Kobayashi M.... Kato S. (Gene 1999)
    3. Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry. (PubMed id 23519211)1, 2 Jae L.T....Brummelkamp T.R. (Science 2013)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10329 HGNC: 13530 AceView: TMEM5 Ensembl:ENSG00000118600 euGenes: HUgn10329
    ECgene: TMEM5 H-InvDB: TMEM5

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM5 gene:
    Search GeneIP for patents involving TMEM5

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TMEM5   OriGene RNAi products in human, mouse, rat for TMEM5  
     OriGene qPCR primer pairs and template standards for TMEM5   OriGene Protein Over-expression Lysate for TMEM5  
     OriGene MassSpec something-or-other for TMEM5   OriGene clones in human, mouse for TMEM5  
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     OriGene Custom Antibody Services for TMEM5   OriGene Custom Protein Services for TMEM5  

     
     
     Block miRNA regulation of human, mouse, rat TMEM5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TMEM5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM5 Predesigned siRNA for gene silencing in human, mouse, rat TMEM5
     QuantiFast Probe-based Assays in human, mouse, rat TMEM5 QuantiTect SYBR Green Assays in human, mouse, rat TMEM5
     Custom PCR Arrays for TMEM5 Search Chromatin IP Primers for TMEM5
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     Search Tocris compounds for TMEM5
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM5
     Gene Synthesis
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMEM5
     LSBio Antibodies in human, mouse, rat for TMEM5
    Customized transgenic rodents for:
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     Browse compounds at ApexBio
           
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