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Aliases for TMEM47 Gene

Aliases for TMEM47 Gene

  • Transmembrane Protein 47 2 3 5
  • Transmembrane 4 Superfamily Member 10 2 3 4
  • Brain Cell Membrane Protein 1 3 4
  • TM4SF10 3 4
  • BCMP1 3 4

External Ids for TMEM47 Gene

Previous HGNC Symbols for TMEM47 Gene

  • TM4SF10

Previous GeneCards Identifiers for TMEM47 Gene

  • GC0XM034405
  • GC0XM032387

Summaries for TMEM47 Gene

Entrez Gene Summary for TMEM47 Gene

  • This gene encodes a member of the PMP22/EMP/claudin protein family. The encoded protein is localized to the ER and the plasma membrane. In dogs, transcripts of this gene exist at high levels in the brain. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMEM47 Gene

TMEM47 (Transmembrane Protein 47) is a Protein Coding gene. An important paralog of this gene is PERP.

Gene Wiki entry for TMEM47 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM47 Gene

Genomics for TMEM47 Gene

Regulatory Elements for TMEM47 Gene

Enhancers for TMEM47 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM47 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM47 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM47 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM47 Gene

34,627,064 bp from pter
34,657,288 bp from pter
30,225 bases
Minus strand

Genomic View for TMEM47 Gene

Genes around TMEM47 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM47 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM47 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM47 Gene

Proteins for TMEM47 Gene

  • Protein details for TMEM47 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 47
    Protein Accession:
    Secondary Accessions:
    • Q5JR44

    Protein attributes for TMEM47 Gene

    181 amino acids
    Molecular mass:
    19998 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM47 Gene

Proteomics data for TMEM47 Gene at MOPED

Post-translational modifications for TMEM47 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM47 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM47 Gene

Domains & Families for TMEM47 Gene

Protein Domains for TMEM47 Gene


Suggested Antigen Peptide Sequences for TMEM47 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM47 family.
  • Belongs to the TMEM47 family.
genes like me logo Genes that share domains with TMEM47: view

No data available for Gene Families for TMEM47 Gene

Function for TMEM47 Gene

Phenotypes for TMEM47 Gene

GenomeRNAi human phenotypes for TMEM47:
genes like me logo Genes that share phenotypes with TMEM47: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM47 Gene

Localization for TMEM47 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM47 Gene

Membrane; Multi-pass membrane protein. Cell junction.

Subcellular locations from

Jensen Localization Image for TMEM47 Gene COMPARTMENTS Subcellular localization image for TMEM47 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TMEM47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
GO:0005911 cell-cell junction IEA --
GO:0030054 cell junction IBA --
genes like me logo Genes that share ontologies with TMEM47: view

Pathways & Interactions for TMEM47 Gene

SuperPathways for TMEM47 Gene

No Data Available

Interacting Proteins for TMEM47 Gene

Gene Ontology (GO) - Biological Process for TMEM47 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM47 Gene

Drugs & Compounds for TMEM47 Gene

No Compound Related Data Available

Transcripts for TMEM47 Gene

mRNA/cDNA for TMEM47 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(138) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM47 Gene

Transmembrane protein 47:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM47 Gene

No ASD Table

Relevant External Links for TMEM47 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM47 Gene

mRNA expression in normal human tissues for TMEM47 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM47 Gene

This gene is overexpressed in Artery - Tibial (x4.5) and Artery - Aorta (x4.5).

Protein differential expression in normal tissues from HIPED for TMEM47 Gene

This gene is overexpressed in Heart (20.7), Frontal cortex (9.4), and Fetal heart (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM47 Gene

SOURCE GeneReport for Unigene cluster for TMEM47 Gene Hs.8769

genes like me logo Genes that share expression patterns with TMEM47: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM47 Gene

Orthologs for TMEM47 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM47 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM47 35
  • 96.13 (n)
  • 100 (a)
TMEM47 36
  • 100 (a)
(Canis familiaris)
Mammalia TMEM47 35
  • 96.87 (n)
  • 100 (a)
TMEM47 36
  • 100 (a)
(Mus musculus)
Mammalia Tmem47 35
  • 93.19 (n)
  • 98.9 (a)
Tmem47 16
Tmem47 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmem47 35
  • 92.63 (n)
  • 98.34 (a)
(Monodelphis domestica)
Mammalia TMEM47 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM47 36
  • 60 (a)
(Pan troglodytes)
Mammalia TMEM47 36
  • 100 (a)
(Gallus gallus)
Aves TMEM47 35
  • 86.92 (n)
  • 96.13 (a)
TMEM47 36
  • 96 (a)
(Anolis carolinensis)
Reptilia TMEM47 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75754 35
tmem47 35
  • 79.33 (n)
  • 92.18 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10079 35
(Danio rerio)
Actinopterygii tmem47 35
  • 72.93 (n)
  • 82.32 (a)
wufb99e01 35
tmem47 36
  • 82 (a)
Species with no ortholog for TMEM47:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM47 Gene

Gene Tree for TMEM47 (if available)
Gene Tree for TMEM47 (if available)

Paralogs for TMEM47 Gene

Paralogs for TMEM47 Gene

(1) SIMAP similar genes for TMEM47 Gene using alignment to 1 proteins: Pseudogenes for TMEM47 Gene

genes like me logo Genes that share paralogs with TMEM47: view

Variants for TMEM47 Gene

Sequence variations from dbSNP and Humsavar for TMEM47 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747708736 -- 34,642,364(+) TATAG(C/T)GAGAG intron-variant
rs747754747 -- 34,649,568(+) GAGGA(-/G)GGAGA intron-variant
rs747846234 -- 34,656,833(+) GCCAG(A/C)TGTCC reference, missense
rs747849500 -- 34,645,993(+) AAGTA(C/T)AGTGC intron-variant
rs747887759 -- 34,637,027(+) CTGAA(A/C)CTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM47 Gene

Variant ID Type Subtype PubMed ID
esv2664433 CNV Deletion 23128226
nsv519268 CNV Gain 19592680
nsv6857 CNV Insertion 18451855

Variation tolerance for TMEM47 Gene

Residual Variation Intolerance Score: 35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.10; 2.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM47 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM47 Gene

Disorders for TMEM47 Gene

Relevant External Links for TMEM47

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM47 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM47 Gene

Publications for TMEM47 Gene

  1. Identification of the gene encoding Brain Cell Membrane Protein 1 (BCMP1), a putative four-transmembrane protein distantly related to the Peripheral Myelin Protein 22 / Epithelial Membrane Proteins and the Claudins. (PMID: 11472633) Christophe-Hobertus C. … Christophe D. (BMC Genomics 2001) 2 3 23 67
  2. Novel markers of subclinical disease for Ewing family tumors from gene expression profiling. (PMID: 18056173) Cheung I.Y. … Cheung N.K. (Clin. Cancer Res. 2007) 3 23
  3. TM4SF10 gene sequencing in XLMR patients identifies common polymorphisms but no disease-associated mutation. (PMID: 15345028) Christophe-Hobertus C. … Christophe D. (BMC Med. Genet. 2004) 3 23
  4. A genome-wide association study of brain lesion distribution in multiple sclerosis. (PMID: 23412934) Gourraud P.A. … Baranzini S.E. (Brain 2013) 3
  5. TM4SF10 and ADAP interaction in podocytes: role in Fyn activity and nephrin phosphorylation. (PMID: 21881001) Azhibekov T.A. … Simske J.S. (Am. J. Physiol., Cell Physiol. 2011) 3

Products for TMEM47 Gene

Sources for TMEM47 Gene