TMEM47 Gene
protein-coding GIFtS : 46
GCID: GC0X M034555
transmembrane protein 47 (Previous name: transmembrane 4 superfamily member 10 ) (Previous symbol: TM4SF10 )
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Aliasesfor TMEM47 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Transmembrane Protein 47 1 2 Brain Cell Membrane Protein 12 3 BCMP11 2 3 5 DKFZP761J171211 Transmembrane 4 Superfamily Member 101 2 3 DKFZp564E1531 TM4SF101 2 3
Export aliases for TMEM47 gene to outside databases Previous GC identifers: GC0XM034405 GC0XM032387
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Summariesfor TMEM47 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for TMEM47 : This gene encodes a member of the PMP22/EMP/claudin protein family. The encoded protein is localized to the ER and the plasma membrane. In dogs, transcripts of this gene exist at high levels in the brain. (provided by RefSeq, Jul 2008) Gene Wiki entry for TMEM47
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Genomic Viewsfor TMEM47 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000023.10 NC_018934.1 NT_167197.1 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TMEM47 gene promoter: NF-YB LHX3b/Lhx3b CBF-B CBF-A NF-YA FOXD1 LHX3a/Lhx3a CP1A NF-Y CBF(2) Other transcription factors Search SABiosciences Chromatin IP Primers for TMEM47 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TMEM47
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xp11.4 Ensembl cytogenetic band: Xp21.1 HGNC cytogenetic band: Xp11.4 TMEM47 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XM034555: view genomic region
(about GC identifiers )
Start:
34,645,181 bp from pter
End:
34,675,405 bp from pter
Size:
30,225 bases
Orientation:
minus strand
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Proteinsfor TMEM47 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
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R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
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Biochemical Assays by
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Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
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Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TMM47_HUMAN, Q9BQJ4 (See
protein sequence )Recommended Name: Transmembrane protein 47 Size : 181 amino acids; 19998 Da
Subcellular location : Membrane; Multi-pass membrane protein (Potential). Cell junction (By similarity)
Secondary accessions : Q5JR44Explore the universe of human proteins at neXtProt for TMEM47: NX_Q9BQJ4 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9BQJ4 TMEM47 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_113630.1 ENSEMBL proteins: ENSP00000275954 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
TMEM47 for ontologies About GeneDecksing TMEM47 Antibody Products: Assay Products for TMEM47:
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Protein
Domains / Familiesfor TMEM47 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TMEM47 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q9BQJ4 ProtoNet protein and cluster: Q9BQJ4
UniProtKB/Swiss-Prot: TMM47_HUMAN, Q9BQJ4 Similarity : Belongs to the TMEM47 family
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Functionfor TMEM47 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM47 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM47OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TMEM47 (NM_031442 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM47 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM47
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM47
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Pathways & Interactionsfor TMEM47 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM47
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Drugs & Compoundsfor TMEM47 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TMEM47 Search CenterWatch for drugs/clinical trials and news about TMEM47 / TMM47
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Transcriptsfor TMEM47 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
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QIAGEN
)About This Section REFSEQ mRNAs for TMEM47 gene: NM_031442.3 Unigene Cluster for TMEM47:
Transmembrane protein 47 Hs.8769 [show with all ESTs ] Unigene Representative Sequence: BC039242 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000275954 (uc010ngs.3 uc004ddh.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM47 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM47OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TMEM47 (NM_031442 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM47 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM47
Additional cDNA sequence: AK311054.1 AL049257.1 AL136550.1 BC039242.1
3 DOTS entries : DT.444207 DT.100677273
DT.121317734 24/138 AceView cDNA sequences (see all 138 ):
BM473165 BF432364 AI242051 CA448924 NM_031442 BX507431 BX115088 AK090917 BF970047 AI687906 AA995781 AA337388 CA446372 BQ888559 AI276509 CD677528 BG029824 N45018 AI278278 AL136550 BI856930 AW469164 N34856 AA133963 GeneLoc Exon Structure
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Expression for TMEM47 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TMEM47 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AAGTCATCTA
About this image TMEM47 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See TMEM47 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TMEM47 SOURCE GeneReport for Unigene cluster: Hs.8769 SABiosciences Custom PCR Arrays for TMEM47 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TMEM47Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TMEM47 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TMEM47 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TMEM47 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM47
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Orthologsfor TMEM47 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for TMEM47 gene from 7/19 species (see all 19 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
mouse (Mus musculus)
Mammalia
Tmem471 , 5
transmembrane protein 471, 5
93.19(n) 1 98.9(a) 1
 
X (38.38 cM) 5 192216 1 NM_138751.2 1 NP_620090.1 1 81070698 5
chicken (Gallus gallus)
Aves
TMEM471
transmembrane protein 47
86.92(n) 96.13(a)
 
418585 XM_416786.3 XP_416786.1
lizard (Anolis carolinensis)
Reptilia
TMEM476
--
91(a)
1 ↔ 1
3(130977533-131023488)
African clawed frog (Xenopus laevis)
Amphibia
Xl.100792
Xenopus laevis transcribed sequence
83.48(n)
 
BG731749.1
zebrafish (Danio rerio)
Actinopterygii
wufb99e012
Danio rerio cDNA clone MGC63990 IMAGE6792533, complete more
73.52(n)
 
BC057424.1
fruit fly (Drosophila melanogaster)
Insecta
CG69826
--
22(a)
1 → many
3R(18552691-18558084)
worm (Caenorhabditis elegans)
Secernentea
vab-96
Variable ABnormal morphology family member (vab-9)...
21(a)
1 → many
II(8636208-8637661)
ENSEMBL Gene Tree for TMEM47 (if available)TreeFam Gene Tree for TMEM47 (if available)
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Paralogsfor TMEM47 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TMEM47 gene PERP 2 1 SIMAP similar gene for TMEM47 using alignment to 1 protein entry: TMM47_HUMAN :PERP
TMEM47 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for TMEM47 PGOHUM00000241705
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Genomic Variantsfor TMEM47 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr X pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TMEM47 (34645181 - 34675405 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 5 variations for TMEM47 5 Indels : 96582 83444 96580 96581 83443
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TMEM47
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Disorders
/ Diseasesfor TMEM47 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TMEM47 for disorders About GeneDecksing
OMIM gene information: 300698
OMIM disorders : --1 disease for TMEM47 : About MalaCards ewing's family of tumors Export disorders for TMEM47 gene to outside databases
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Publicationsfor TMEM47 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TMEM47 gene, integrated from 9 sources (see all 13 ): (articles sorted by number of sources associating them with TMEM47) Utopia : connect your pdf to the dynamic world of online information
Identification of the gene encoding Brain Cell Membrane Protein 1 (BCMP1), a putative four-transmembrane protein distantly related to the Peripheral Myelin Protein 22 / Epithelial Membrane Proteins and the Claudins. (PubMed id 11472633) 1 , 3, 9 Christophe-Hobertus C....Christophe D. (2001) The DNA sequence of the human X chromosome. (PubMed id 15772651) 1 , 2 Ross M.T.... Bentley D.R. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166) 1 , 2 Wiemann S.... Poustka A. (2001) TM4SF10 gene sequencing in XLMR patients identifies common polymorphisms but no disease-associated mutation. (PubMed id 15345028) 1 , 9 Christophe-Hobertus C....Christophe D. (2004) Novel markers of subclinical disease for Ewing family tumors from gene expression profiling. (PubMed id 18056173) 1 , 9 Cheung I.Y....Cheung N.K. (2007) TM4SF10 and ADAP interaction in podocytes: role in Fy n activity and nephrin phosphorylation. (PubMed id 21881001) 1 Azhibekov T.A....Simske J.S. (2011) The LIFEdb database in 2006. (PubMed id 16381901) 1 Mehrle A....Wiemann S. (2006) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 Ota T.... Sugano S. (2004) From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336) 1 Wiemann S....Poustka A. (2004)
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External Searches for TMEM47 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TMEM47 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TMEM47 gene
(According to HUGE )
About This Section --
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Specialized Databases showing TMEM47 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TMEM47 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TMEM47 gene: Search GeneIP for patents involving TMEM47 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TMEM47 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TMEM47 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TMEM47 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TMEM47 OriGene Protein Over-expression Lysate for TMEM47 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TMEM47 OriGene 3'-UTR Clone for TMEM47 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM47 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM47 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TMEM47 OriGene Custom Protein Services for TMEM47 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM47 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TMEM47 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TMEM47 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TMEM47 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TMEM47 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TMEM47
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TMEM47 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM47
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM47
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