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Aliases for TMEM45B Gene

Aliases for TMEM45B Gene

  • Transmembrane Protein 45B 2 3 5

External Ids for TMEM45B Gene

Previous GeneCards Identifiers for TMEM45B Gene

  • GC11P129191
  • GC11P129688
  • GC11P125638

Summaries for TMEM45B Gene

GeneCards Summary for TMEM45B Gene

TMEM45B (Transmembrane Protein 45B) is a Protein Coding gene. An important paralog of this gene is TMEM45A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM45B Gene

Genomics for TMEM45B Gene

Regulatory Elements for TMEM45B Gene

Enhancers for TMEM45B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G129823 1.8 FANTOM5 Ensembl ENCODE dbSUPER 20.2 +9.0 8991 3.2 RB1 ARID4B GLI4 RAD21 RARA ZNF335 GLIS2 SCRT2 ZNF143 FOS TMEM45B NFRKB APLP2 ARHGAP32 GC11M129824 PIR42447 GC11P129833
GH11G129826 1.4 Ensembl ENCODE dbSUPER 21.2 +12.9 12941 3.7 FOXA2 MLX ARID4B ZNF48 YY1 SLC30A9 GATA2 FOS ZHX2 MIER2 TMEM45B NFRKB ARHGAP32 GC11P129833 GC11M129824 PIR42447
GH11G129815 1.4 Ensembl ENCODE dbSUPER 21 +1.8 1783 5.1 ELF3 PKNOX1 MLX DMAP1 ZNF48 ZSCAN9 RARA YY1 SLC30A9 PCBP1 TMEM45B NFRKB PRDM10 PIR42447 GC11M129824 GC11M129801
GH11G129860 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +45.8 45780 2.6 ELF3 PKNOX1 FOXA2 SIN3A RAD21 RFX5 FOS CREM MIXL1 PAF1 NFRKB TMEM45B ST14 GC11M129886 GC11P129833
GH11G129802 0.8 ENCODE dbSUPER 20.9 -12.2 -12192 1.5 NFIC FOXA2 NFIB NFE2 NFE2L2 TMEM45B NFRKB GC11M129799
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM45B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM45B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000047014 119 201 ELF3 DRAP1 SAP130 DMAP1 ZNF48 ZSCAN9 RARA TEAD3 SLC30A9 POLR2A

Genomic Location for TMEM45B Gene

Chromosome:
11
Start:
129,815,781 bp from pter
End:
129,860,003 bp from pter
Size:
44,223 bases
Orientation:
Plus strand

Genomic View for TMEM45B Gene

Genes around TMEM45B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM45B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM45B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM45B Gene

Proteins for TMEM45B Gene

  • Protein details for TMEM45B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B21-TM45B_HUMAN
    Recommended name:
    Transmembrane protein 45B
    Protein Accession:
    Q96B21
    Secondary Accessions:
    • A8K2L8

    Protein attributes for TMEM45B Gene

    Size:
    275 amino acids
    Molecular mass:
    31826 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM45B Gene

Post-translational modifications for TMEM45B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM45B Gene

Domains & Families for TMEM45B Gene

Protein Domains for TMEM45B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM45B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96B21

UniProtKB/Swiss-Prot:

TM45B_HUMAN :
  • Belongs to the TMEM45 family.
Family:
  • Belongs to the TMEM45 family.
genes like me logo Genes that share domains with TMEM45B: view

No data available for Gene Families for TMEM45B Gene

Function for TMEM45B Gene

genes like me logo Genes that share phenotypes with TMEM45B: view

Animal Models for TMEM45B Gene

MGI Knock Outs for TMEM45B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM45B Gene

Localization for TMEM45B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM45B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM45B gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM45B: view

Pathways & Interactions for TMEM45B Gene

SuperPathways for TMEM45B Gene

No Data Available

Interacting Proteins for TMEM45B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000281441%0d%0a9606.ENSP00000259782%0d%0a
Selected Interacting proteins: ENSP00000281441 Q96B21-TM45B_HUMAN for TMEM45B Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM45B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM45B Gene

Transcripts for TMEM45B Gene

Unigene Clusters for TMEM45B Gene

Transmembrane protein 45B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM45B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9
SP1: - - - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - -
SP6:

Relevant External Links for TMEM45B Gene

GeneLoc Exon Structure for
TMEM45B
ECgene alternative splicing isoforms for
TMEM45B

Expression for TMEM45B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM45B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM45B Gene

This gene is overexpressed in Colon - Transverse (x10.9), Esophagus - Mucosa (x8.4), and Small Intestine - Terminal Ileum (x6.3).

Protein differential expression in normal tissues from HIPED for TMEM45B Gene

This gene is overexpressed in Fetal gut (35.5) and Frontal cortex (33.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM45B Gene



Protein tissue co-expression partners for TMEM45B Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM45B Gene:

TMEM45B

SOURCE GeneReport for Unigene cluster for TMEM45B Gene:

Hs.504301

Evidence on tissue expression from TISSUES for TMEM45B Gene

  • Intestine(4.6)
genes like me logo Genes that share expression patterns with TMEM45B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM45B Gene

Orthologs for TMEM45B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM45B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM45B 34 35
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia TMEM45B 34 35
  • 85.52 (n)
mouse
(Mus musculus)
Mammalia Tmem45b 34 16 35
  • 81.82 (n)
cow
(Bos Taurus)
Mammalia TMEM45B 34 35
  • 80.97 (n)
rat
(Rattus norvegicus)
Mammalia Tmem45b 34
  • 79.88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM45B 35
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM45B 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM45B 34
  • 67.4 (n)
-- 35
  • 52 (a)
OneToMany
-- 35
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 59 (a)
OneToMany
-- 35
  • 39 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem45b 34
  • 65.94 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem45b 34 35
  • 61.29 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8817 35
  • 31 (a)
OneToMany
Species where no ortholog for TMEM45B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM45B Gene

ENSEMBL:
Gene Tree for TMEM45B (if available)
TreeFam:
Gene Tree for TMEM45B (if available)

Paralogs for TMEM45B Gene

Paralogs for TMEM45B Gene

(1) SIMAP similar genes for TMEM45B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM45B: view

Variants for TMEM45B Gene

Sequence variations from dbSNP and Humsavar for TMEM45B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000057972 -- 129,830,713(+) GATGC(C/T)CAACA intron-variant
rs1000071978 -- 129,837,582(+) GCACT(A/G)GGCTT intron-variant
rs1000202642 -- 129,859,387(+) AGAAG(A/T)TCTGA downstream-variant-500B, utr-variant-3-prime
rs1000225718 -- 129,843,886(+) TGTGG(A/C)GGTTT intron-variant
rs1000257925 -- 129,856,360(+) GTGCC(A/C)GCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM45B Gene

Variant ID Type Subtype PubMed ID
esv2760198 CNV loss 21179565
esv3579968 CNV loss 25503493
esv3628071 CNV loss 21293372
esv3892108 CNV loss 25118596
nsv1042946 CNV loss 25217958
nsv1122679 CNV deletion 24896259
nsv39607 CNV deletion 16902084
nsv983077 CNV duplication 23825009

Variation tolerance for TMEM45B Gene

Residual Variation Intolerance Score: 62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM45B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM45B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM45B Gene

Disorders for TMEM45B Gene

Relevant External Links for TMEM45B

Genetic Association Database (GAD)
TMEM45B
Human Genome Epidemiology (HuGE) Navigator
TMEM45B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM45B

No disorders were found for TMEM45B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM45B Gene

Publications for TMEM45B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for TMEM45B Gene

Sources for TMEM45B Gene

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