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Aliases for TMEM45B Gene

Aliases for TMEM45B Gene

  • Transmembrane Protein 45B 2 3

External Ids for TMEM45B Gene

Previous GeneCards Identifiers for TMEM45B Gene

  • GC11P129191
  • GC11P129688
  • GC11P125638

Summaries for TMEM45B Gene

GeneCards Summary for TMEM45B Gene

TMEM45B is a Protein Coding gene. An important paralog of this gene is TEDDM1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM45B Gene

Genomics for TMEM45B Gene

Regulatory Elements for TMEM45B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM45B Gene

Start:
129,815,819 bp from pter
End:
129,860,003 bp from pter
Size:
44,185 bases
Orientation:
Plus strand

Genomic View for TMEM45B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM45B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM45B Gene

Proteins for TMEM45B Gene

  • Protein details for TMEM45B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B21-TM45B_HUMAN
    Recommended name:
    Transmembrane protein 45B
    Protein Accession:
    Q96B21
    Secondary Accessions:
    • A8K2L8

    Protein attributes for TMEM45B Gene

    Size:
    275 amino acids
    Molecular mass:
    31826 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM45B Gene

Proteomics data for TMEM45B Gene at MOPED

Post-translational modifications for TMEM45B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM45B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM45B Gene

Domains for TMEM45B Gene

Protein Domains for TMEM45B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM45B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96B21

UniProtKB/Swiss-Prot:

TM45B_HUMAN :
  • Q96B21
Family:
  • Belongs to the TMEM45 family.
genes like me logo Genes that share domains with TMEM45B: view

No data available for Gene Families for TMEM45B Gene

Function for TMEM45B Gene

Phenotypes for TMEM45B Gene

MGI mutant phenotypes for TMEM45B:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with TMEM45B: view

Animal Models for TMEM45B Gene

MGI Knock Outs for TMEM45B:

Animal Model Products

CRISPR Products

miRNA for TMEM45B Gene

miRTarBase miRNAs that target TMEM45B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targeting and HOMER Transcription for TMEM45B Gene

Localization for TMEM45B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM45B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM45B Gene COMPARTMENTS Subcellular localization image for TMEM45B gene
Compartment Confidence
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TMEM45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM45B: view

Pathways for TMEM45B Gene

SuperPathways for TMEM45B Gene

No Data Available

Interacting Proteins for TMEM45B Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000281441%0d%0a9606.ENSP00000378426%0d%0a9606.ENSP00000338348%0d%0a9606.ENSP00000259782%0d%0a
Selected Interacting proteins: ENSP00000281441 for TMEM45B Gene via STRING

Gene Ontology (GO) - Biological Process for TMEM45B Gene

None

No data available for Pathways by source for TMEM45B Gene

Transcripts for TMEM45B Gene

Unigene Clusters for TMEM45B Gene

Transmembrane protein 45B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM45B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM45B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9
SP1: - - - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - -
SP6:

Relevant External Links for TMEM45B Gene

GeneLoc Exon Structure for
TMEM45B
ECgene alternative splicing isoforms for
TMEM45B

Expression for TMEM45B Gene

mRNA expression in normal human tissues for TMEM45B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM45B Gene

This gene is overexpressed in Colon - Transverse (10.9), Esophagus - Mucosa (8.4), and Small Intestine - Terminal Ileum (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMEM45B Gene

SOURCE GeneReport for Unigene cluster for TMEM45B Gene Hs.504301

genes like me logo Genes that share expressions with TMEM45B: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM45B Gene

Orthologs for TMEM45B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM45B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM45B 35
  • 99.39 (n)
  • 99.64 (a)
TMEM45B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM45B 35
  • 80.97 (n)
  • 78.18 (a)
TMEM45B 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM45B 35
  • 85.52 (n)
  • 84.67 (a)
TMEM45B 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem45b 35
  • 81.82 (n)
  • 80.36 (a)
Tmem45b 16
Tmem45b 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM45B 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM45B 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem45b 35
  • 79.88 (n)
  • 77.82 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 52 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
TMEM45B 35
  • 67.4 (n)
  • 59.49 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem45b 35
  • 65.94 (n)
  • 63.64 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem45b 35
  • 61.29 (n)
  • 55.68 (a)
tmem45b 36
  • 53 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8817 36
  • 31 (a)
OneToMany
Species with no ortholog for TMEM45B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM45B Gene

ENSEMBL:
Gene Tree for TMEM45B (if available)
TreeFam:
Gene Tree for TMEM45B (if available)

Paralogs for TMEM45B Gene

Paralogs for TMEM45B Gene

Selected SIMAP similar genes for TMEM45B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM45B: view

Variants for TMEM45B Gene

Sequence variations from dbSNP and Humsavar for TMEM45B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs478290 -- 129,842,280(-) AATAT(C/T)TTTCA intron-variant
rs481688 -- 129,818,423(+) ATAAT(A/G)GGGCT intron-variant
rs482590 -- 129,834,288(-) acgcc(G/T)ggata intron-variant
rs483924 -- 129,841,659(-) agatc(A/G)cgtca intron-variant
rs485341 -- 129,814,076(+) TGTGT(A/G)TCCGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM45B Gene

Variant ID Type Subtype PubMed ID
nsv39607 CNV Loss 16902084

Relevant External Links for TMEM45B Gene

HapMap Linkage Disequilibrium report
TMEM45B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM45B Gene

Disorders for TMEM45B Gene

Relevant External Links for TMEM45B

Genetic Association Database (GAD)
TMEM45B
Human Genome Epidemiology (HuGE) Navigator
TMEM45B
genes like me logo Genes that share disorders with TMEM45B: view

No data available for UniProtKB/Swiss-Prot for TMEM45B Gene

Publications for TMEM45B Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for TMEM45B Gene

Sources for TMEM45B Gene

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