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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TMEM45B Gene

protein-coding GIFtS: 45
GCID: GC11P129688

transmembrane protein 45B

Explore 1 disease affiliated with
TMEM45B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transmembrane Protein 45B¹ ²
BC016153¹
FLJ40787¹

External Ids:	HGNC: 25194¹	Entrez Gene: 120224²	Ensembl: ENSG00000151715⁷	UniProtKB: Q96B21³

Export aliases for TMEM45B gene to outside databases

Previous GC identifers: GC11P129191 GC11P125638

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TMEM45B gene promoter:
C/EBPbeta HNF-1 HNF-1A C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMEM45B promoter sequence

Search SABiosciences Chromatin IP Primers for TMEM45B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM45B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.3 Ensembl cytogenetic band: 11q24.3 HGNC cytogenetic band: 11q24.3

TMEM45B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM45B gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P129688: view genomic region (about GC identifiers)

Start:	129,685,714 bp from pter	End:	129,729,898 bp from pter
Size:	44,185 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TM45B_HUMAN, Q96B21 (See protein sequence)

Recommended Name: Transmembrane protein 45B

Size: 275 amino acids; 31826 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: A8K2L8

Explore the universe of human proteins at neXtProt for TMEM45B: NX_Q96B21

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96B21

TMEM45B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_620143.1

ENSEMBL proteins:

ENSP00000281441 ENSP00000436293

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

TMEM45B for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for TMEM45B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TMEM45B for domains About GeneDecksing

1 InterPro domain/family:

IPR006904 DUF716_TMEM45

Graphical View of Domain Structure for InterPro Entry Q96B21

ProtoNet protein and cluster: Q96B21

UniProtKB/Swiss-Prot: TM45B_HUMAN, Q96B21

Similarity: Belongs to the TMEM45 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA Products:		OriGene 3'-UTR Clone: TMEM45B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM45B
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM45B

Animal Models:
Mouse knock-out Tmem45b^tm1.1Hsue for TMEM45B
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Tmem45b):

no phenotypic analysis

TMEM45B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TMEM45B

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for TMEM45B (ENSP00000281441⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TINAG	ENSP00000259782⁴	STRING: ENSP00000259782
UBE2G2	ENSP00000338348⁴	STRING: ENSP00000338348

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM45B
Search CenterWatch for drugs/clinical trials and news about TMEM45B / TM45B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for TMEM45B gene:

NM_138788.3

Unigene Cluster for TMEM45B:

Transmembrane protein 45B

Hs.504301 [show with all ESTs]

Unigene Representative Sequence: AK098106

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000281441(uc001qfe.1 uc001qff.1) ENST00000525709 ENST00000527754

ENST00000529381 ENST00000524567

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		4 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM45B:
		hsa-miR-653 hsa-miR-548k hsa-miR-205* hsa-miR-1252
		SwitchGear 3'UTR luciferase reporter plasmid: TMEM45B 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM45B

Additional cDNA sequence:

AK098106.1 AK290283.1 AK292058.1 BC016153.1

10 DOTS entries:

DT.438794 DT.100751648 DT.97829262 DT.99929312 DT.120752401 DT.120752363 DT.75187624 DT.92422843

DT.209217 DT.91641524

24/128 AceView cDNA sequences (see all 128):

BX282180 BM827924 BF000269 NM_138788 AK098106 AW662394 BU076544 BU674569

CB850847 BQ082344 AA860541 BU076284 BC016153 AA627508 AA470716 BM741999

AW295567 BI256410 BE715066 BF001637 BG529108 BG288324 BI254444 BG674373

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM45B (see all 6) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9
SP1:			-		-		-		-
SP2:							-		-
SP3:					-		-		-
SP4:			-				-		-
SP5:			-				-

ECgene alternative splicing isoforms for TMEM45B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM45B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATGAATCCG

About this image

TMEM45B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Renal Collecting Duct System

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Cardiomyocyte-like cells (Spontaneous differen...)

See TMEM45B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM45B

SOURCE GeneReport for Unigene cluster: Hs.504301

SABiosciences Custom PCR Arrays for TMEM45B

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TMEM45B gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TMEM45B¹	transmembrane protein 45B	67.4(n) 59.49(a)		419725 XM_417866.3 XP_417866.1
lizard (Anolis carolinensis)	Reptilia	TMEM45B⁶ --	--	61(a) 38(a)	1 ↔ many 1 ↔ many	GL343396.1(960524-963805) GL343197.1(47798-51495)
African clawed frog (Xenopus laevis)	Amphibia	48014478²	--	73.62(n)		48014478
zebrafish (Danio rerio)	Actinopterygii	tmem45b¹	transmembrane protein 45B	61.17(n) 55.68(a)		402977 NM_205677.1 NP_991240.1

ENSEMBL Gene Tree for TMEM45B (if available)
TreeFam Gene Tree for TMEM45B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TMEM45B gene

TMEM45A² TEDDM1²

1 SIMAP similar gene for TMEM45B using alignment to 1 protein entry: TM45B_HUMAN:

TMEM45A

TMEM45B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs139764419^1,2		--	129683741(+)	`TGCCAA/GTGCCC`	1	--	us2k¹		0	--	--	--	--
rs184163348^1,2		--	129683758(+)	`GTGGAA/TTAAGC`	1	--	us2k¹		0	--	--	--	--
rs145271725^1,2		--	129683771(+)	`CCAGGC/GATCTT`	1	--	us2k¹		0	--	--	--	--
rs59839790^1,2	C,	--	129683804(+)	`CAACCC/TCCACT`	1	--	us2k¹		1		WA	2
rs181083797^1,2		--	129683882(+)	`GGGAGC/GCTTAA`	1	--	us2k¹		0	--	--	--	--
rs113796943^1,2	C,	--	129683928(+)	`GGGAA-/ACACACA`	1	--	us2k¹		1		CSA	2
rs60972584^1,2	C	--	129683943(+)	`ACACA-/CAGTGCA`	1	--	us2k¹		0	--	--	--	--
rs115271121^1,2		--	129683949(+)	`GTGCAG/AAACCA`	1	--	us2k¹		1		WA	118
rs485341^1,2	C,F,A,H,	--	129683971(+)	`TGTGTG/ATCCGG`	1	--	us2k¹		16		NS EA NA WA CSA	790
rs184869907^1,2		--	129683974(+)	`GTATCA/CGGAAT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TMEM45B (129685714 - 129729898 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMEM45B
1 CNV: 5651

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM45B

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TMEM45B for disorders About GeneDecksing

1 disease for TMEM45B: About MalaCards

epididymitis

Human Genome Epidemiology (HuGE) Navigator: TMEM45B (2 documents)

Export disorders for TMEM45B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TMEM45B gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM45B)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
A genome-wide association search for type 2 diabetes g enes in African Americans. (PubMed id 22238593)¹ Palmer N.D....Sladek R. (2012)
Genome-wide association study in east Asians identifie s novel susceptibility loci for breast cancer. (PubMed id 22383897)¹ Long J....Zheng W. (2012)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)¹ Hosgood H.D....Lan Q. (2009)
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)² Daub H.... Mann M. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 120224	HGNC: 25194	AceView: LOC120224	Ensembl:ENSG00000151715	euGenes: HUgn120224
ECgene: TMEM45B	H-InvDB: TMEM45B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TMEM45B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TMEM45B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TMEM45B gene:
Search GeneIP for patents involving TMEM45B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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TMEM45B Gene

transmembrane protein 45B

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TMEM45B Gene

transmembrane protein 45B

Aliasesfor TMEM45B gene

Summariesfor TMEM45B gene

Genomic Viewsfor TMEM45B gene

Proteinsfor TMEM45B gene

Protein Domains /Familiesfor TMEM45B gene

Functionfor TMEM45B gene

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Genome Databases showing TMEM45B gene

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Specialized Databases showing TMEM45B gene

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for TMEM45B gene

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for TMEM45B gene

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for TMEM45B gene

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for TMEM45B gene

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