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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TMEM45A Gene

protein-coding GIFtS: 44
GCID: GC03P100211

transmembrane protein 45A

Explore 1 disease affiliated with
TMEM45A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transmembrane Protein 45A¹ ²		FLJ10134¹
DERP7¹ ² ³		Dermal Papilla Derived Protein 7²
Dermal Papilla-Derived Protein 7² ³		DNAPTP4³
DNA Polymerase-Transactivated Protein 4² ³

External Ids:	HGNC: 25480¹	Entrez Gene: 55076²	Ensembl: ENSG00000181458⁷	UniProtKB: Q9NWC5³

Export aliases for TMEM45A gene to outside databases

Previous GC identifers: GC03P101695 GC03P097579

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TMEM45A gene promoter:
NF-YB CBF-B CBF-A NF-YA NF-YC CP1C CP1A NF-Y CBF-C CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMEM45A promoter sequence

Search SABiosciences Chromatin IP Primers for TMEM45A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM45A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q12.2 Ensembl cytogenetic band: 3q12.2 HGNC cytogenetic band: 3q12.2

TMEM45A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM45A gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P100211: view genomic region (about GC identifiers)

Start:	100,211,463 bp from pter	End:	100,296,288 bp from pter
Size:	84,826 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TM45A_HUMAN, Q9NWC5 (See protein sequence)

Recommended Name: Transmembrane protein 45A

Size: 275 amino acids; 31680 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q53YW5

Explore the universe of human proteins at neXtProt for TMEM45A: NX_Q9NWC5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NWC5

TMEM45A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_060474.1

ENSEMBL proteins:

ENSP00000319009 ENSP00000385089 ENSP00000405597

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

TMEM45A for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TMEM45A for domains About GeneDecksing

1 InterPro domain/family:

IPR006904 DUF716_TMEM45

Graphical View of Domain Structure for InterPro Entry Q9NWC5

ProtoNet protein and cluster: Q9NWC5

UniProtKB/Swiss-Prot: TM45A_HUMAN, Q9NWC5

Similarity: Belongs to the TMEM45 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TMEM45A

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for TMEM45A (ENSP00000319009⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM45A
Search CenterWatch for drugs/clinical trials and news about TMEM45A / TM45A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for TMEM45A gene:

NM_018004.1

Unigene Cluster for TMEM45A:

Transmembrane protein 45A

Hs.658956 [show with all ESTs]

Unigene Representative Sequence: BX648832

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000323523(uc003dtz.1) ENST00000403410(uc003dua.1) ENST00000449609

ENST00000462884 ENST00000485260 ENST00000489060(uc003dub.1) ENST00000488904

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Additional cDNA sequence:

AB013911.1 AK000996.1 AK129789.1 AY450392.1 BC040355.1 BX648832.1

15 DOTS entries:

DT.85102274 DT.91766870 DT.100789006 DT.99971783 DT.100685375 DT.100717620 DT.100789007 DT.120866828

DT.91766872 DT.95171572 DT.100025371 DT.100789010 DT.120866860 DT.91766878 DT.100641952

24/204 AceView cDNA sequences (see all 204):

BX464856 AI333933 BM955726 BU674675 BG184756 T25086 BG697798 BM921741

BC040355 AB013911 AI474277 BG674271 BU688203 BG698931 BG676589 BG697945

AW316693 BG695847 BX091604 AA243811 CA390584 BG741352 AK129789 BG740917

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM45A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

TMEM45A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Visceral White Adipose

Adipose

Kidney

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

See TMEM45A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM45A

SOURCE GeneReport for Unigene cluster: Hs.658956

SABiosciences Custom PCR Arrays for TMEM45A

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TMEM45A gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tmem45a^{1 , 5}	transmembrane protein 45a^{1, 5}	73.87(n)¹ 65.2(a)¹		16 (34.22 cM)⁵ 56277¹ NM_019631.3¹ NP_062605.2¹ 56805161⁵
chicken (Gallus gallus)	Aves	TMEM45A¹	transmembrane protein 45A	62.79(n) 54.18(a)		418389 XM_416606.3 XP_416606.1
lizard (Anolis carolinensis)	Reptilia	TMEM45A⁶	--	54(a)	1 ↔ 1	3(174113989-174118387)
zebrafish (Danio rerio)	Actinopterygii	zgc:110647¹	zgc:110647	55.11(n) 46.72(a)		553643 NM_001020617.1 NP_001018453.1

ENSEMBL Gene Tree for TMEM45A (if available)
TreeFam Gene Tree for TMEM45A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TMEM45A gene

TEDDM1² TMEM45B²

1 SIMAP similar gene for TMEM45A using alignment to 3 protein entries: TM45A_HUMAN (see all proteins):

TMEM45B

TMEM45A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs13095422^1,2	C,H	--	100209517(+)	`TTTAGT/GGATTT`	1	--	us2k¹		5		NS EA NA	388
rs28416993^1,2	C,	--	100209543(+)	`TGCCTG/TTTGAT`	1	--	us2k¹		2		WA	120
rs147362011^1,2		--	100209544(+)	`GCCTGC/TTGATG`	1	--	us2k¹		0	--	--	--	--
rs11707581^1,2	C,F,A,H,	--	100209602(+)	`TTGAGC/TGGCTT`	1	--	us2k¹		22		NS EA NA WA	2642
rs75424083^1,2	C,F,	--	100209799(+)	`TGTGGG/TGGTCT`	1	--	us2k¹		3		CSA WA	122
rs73860669^1,2	C,F,	--	100209808(+)	`CTTACG/AGAGTT`	1	--	us2k¹		2		WA CSA	4
rs7618791^1,2	C,F,A,H,	--	100210150(+)	`aggatC/Ttagtt`	1	--	us2k¹		20		NS EA NA WA CSA	1212
rs74869471^1,2	C	--	100210242(+)	`TGTTGC/GGCAGC`	1	--	us2k¹		0	--	--	--	--
rs78191332^1,2	C,	--	100210243(+)	`GTTGCA/GCAGCA`	1	--	us2k¹		0	--	--	--	--
rs186869641^1,2		--	100210324(+)	`TCTGAA/CCCCTG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TMEM45A (100211463 - 100296288 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMEM45A
1 CNV: 34429

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TMEM45A for disorders About GeneDecksing

1 disease for TMEM45A: About MalaCards

epididymitis

Export disorders for TMEM45A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TMEM45A gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM45A)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)
DNA polymerase 4 of Saccharomyces cerevisiae is important for accurate repair of methyl-methanesulfonate-induced DNA damage. (PubMed id 16219787)⁹ Sterling C.H. and Sweasy J.B. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55076	HGNC: 25480	AceView: FLJ10134	Ensembl:ENSG00000181458	euGenes: HUgn55076
ECgene: TMEM45A	H-InvDB: TMEM45A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TMEM45A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TMEM45A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TMEM45A gene:
Search GeneIP for patents involving TMEM45A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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TMEM45A Gene

transmembrane protein 45A

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TMEM45A Gene

transmembrane protein 45A

Aliasesfor TMEM45A gene

Summariesfor TMEM45A gene

Genomic Viewsfor TMEM45A gene

Proteinsfor TMEM45A gene

Protein Domains /Familiesfor TMEM45A gene

Functionfor TMEM45A gene

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Genome Databases showing TMEM45A gene

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Specialized Databases showing TMEM45A gene

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for TMEM45A gene

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for TMEM45A gene

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for TMEM45A gene

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for TMEM45A gene

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