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Aliases for TMEM45A Gene

Aliases for TMEM45A Gene

  • Transmembrane Protein 45A 2 3 5
  • DNA Polymerase-Transactivated Protein 4 3 4
  • DNAPTP4 3 4
  • DERP7 3 4
  • Dermal Papilla Derived Protein 7 3
  • Dermal Papilla-Derived Protein 7 4

External Ids for TMEM45A Gene

Previous GeneCards Identifiers for TMEM45A Gene

  • GC03P101695
  • GC03P100211
  • GC03P097579

Summaries for TMEM45A Gene

GeneCards Summary for TMEM45A Gene

TMEM45A (Transmembrane Protein 45A) is a Protein Coding gene. An important paralog of this gene is TMEM45B.

Additional gene information for TMEM45A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM45A Gene

Genomics for TMEM45A Gene

GeneHancer (GH) Regulatory Elements for TMEM45A Gene

Promoters and enhancers for TMEM45A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I100491 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 568.9 0.0 -33 2 PKNOX1 ATF1 ARID4B DMAP1 ZNF48 YY1 SLC30A9 GLIS2 ZNF213 ELK1 TMEM45A GC03P100474
GH03I100517 Promoter 0.5 EPDnew 550.3 +25.1 25086 0.1 TMEM45A GC03P100533
GH03I100525 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 18.5 +33.4 33398 2 PKNOX1 FEZF1 ZIC2 POLR2A SCRT2 RCOR1 ZNF600 FOS CHD2 SCRT1 TMEM45A GC03P100533
GH03I100520 Enhancer 0.8 dbSUPER 16.6 +29.4 29352 3.1 FOXA2 TAF1 MAX EBF1 RAD21 YY1 GATA3 POLR3A ATF7 IKZF2 TMEM45A TFG GC03P100533
GH03I100560 Enhancer 1 Ensembl ENCODE dbSUPER 12.1 +69.5 69454 2.2 MAX DPF2 YY1 JUND GATA3 ATF3 FOS HNF4A TCF7L2 GC03P100561 TMEM45A GC03P100580
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM45A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM45A gene promoter:

Genomic Locations for TMEM45A Gene

Genomic Locations for TMEM45A Gene
chr3:100,492,619-100,577,453
(GRCh38/hg38)
Size:
84,835 bases
Orientation:
Plus strand
chr3:100,211,463-100,296,288
(GRCh37/hg19)

Genomic View for TMEM45A Gene

Genes around TMEM45A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM45A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM45A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM45A Gene

Proteins for TMEM45A Gene

  • Protein details for TMEM45A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWC5-TM45A_HUMAN
    Recommended name:
    Transmembrane protein 45A
    Protein Accession:
    Q9NWC5
    Secondary Accessions:
    • Q53YW5

    Protein attributes for TMEM45A Gene

    Size:
    275 amino acids
    Molecular mass:
    31680 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM45A Gene

Post-translational modifications for TMEM45A Gene

  • Ubiquitination at posLast=4343 and posLast=263263

Other Protein References for TMEM45A Gene

No data available for DME Specific Peptides for TMEM45A Gene

Domains & Families for TMEM45A Gene

Gene Families for TMEM45A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM45A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM45A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NWC5

UniProtKB/Swiss-Prot:

TM45A_HUMAN :
  • Belongs to the TMEM45 family.
Family:
  • Belongs to the TMEM45 family.
genes like me logo Genes that share domains with TMEM45A: view

Function for TMEM45A Gene

Phenotypes From GWAS Catalog for TMEM45A Gene

genes like me logo Genes that share phenotypes with TMEM45A: view

Animal Model Products

CRISPR Products

miRNA for TMEM45A Gene

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM45A Gene

Localization for TMEM45A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM45A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM45A gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM45A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM45A: view

Pathways & Interactions for TMEM45A Gene

SuperPathways for TMEM45A Gene

No Data Available

Interacting Proteins for TMEM45A Gene

Selected Interacting proteins: Q9NWC5-TM45A_HUMAN for TMEM45A Gene via UniProtKB IID

Gene Ontology (GO) - Biological Process for TMEM45A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM45A Gene

Drugs & Compounds for TMEM45A Gene

No Compound Related Data Available

Transcripts for TMEM45A Gene

Unigene Clusters for TMEM45A Gene

Transmembrane protein 45A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM45A Gene

No ASD Table

Relevant External Links for TMEM45A Gene

GeneLoc Exon Structure for
TMEM45A
ECgene alternative splicing isoforms for
TMEM45A

Expression for TMEM45A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM45A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM45A Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x15.1) and Skin - Not Sun Exposed (Suprapubic) (x12.9).

NURSA nuclear receptor signaling pathways regulating expression of TMEM45A Gene:

TMEM45A

SOURCE GeneReport for Unigene cluster for TMEM45A Gene:

Hs.658956

Evidence on tissue expression from TISSUES for TMEM45A Gene

  • Skin(4.6)
genes like me logo Genes that share expression patterns with TMEM45A: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM45A Gene

Orthologs for TMEM45A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM45A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM45A 33 34
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia TMEM45A 33 34
  • 83.14 (n)
cow
(Bos Taurus)
Mammalia TMEM45A 33
  • 81.01 (n)
-- 34
  • 74 (a)
OneToMany
-- 34
  • 66 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100911041 33
  • 74.05 (n)
mouse
(Mus musculus)
Mammalia Tmem45a 33 16 34
  • 73.51 (n)
2310005G13Rik 34
  • 47 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM45A 34
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM45A 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM45A 34
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM45A 34
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TMEM45A 34
  • 46 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8817 34
  • 30 (a)
OneToMany
Species where no ortholog for TMEM45A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM45A Gene

ENSEMBL:
Gene Tree for TMEM45A (if available)
TreeFam:
Gene Tree for TMEM45A (if available)

Paralogs for TMEM45A Gene

Paralogs for TMEM45A Gene

(1) SIMAP similar genes for TMEM45A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMEM45A: view

Variants for TMEM45A Gene

Sequence variations from dbSNP and Humsavar for TMEM45A Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000011637 -- 100,576,008(+) T/C intron_variant
rs1000032369 -- 100,544,810(+) G/A intron_variant
rs1000097879 -- 100,542,458(+) A/G intron_variant
rs1000102076 -- 100,575,798(+) A/G intron_variant
rs1000118276 -- 100,538,201(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM45A Gene

Variant ID Type Subtype PubMed ID
nsv1115642 CNV duplication 24896259
nsv1150548 CNV duplication 26484159

Variation tolerance for TMEM45A Gene

Residual Variation Intolerance Score: 33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM45A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM45A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM45A Gene

Disorders for TMEM45A Gene

Additional Disease Information for TMEM45A

No disorders were found for TMEM45A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM45A Gene

Publications for TMEM45A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  5. Knockdown of TMEM45A inhibits the proliferation, migration and invasion of glioma cells. (PMID: 26722455) Sun W … Hu G (International journal of clinical and experimental pathology 2015) 3 58

Products for TMEM45A Gene

Sources for TMEM45A Gene

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