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Aliases for TMEM45A Gene

Aliases for TMEM45A Gene

  • Transmembrane Protein 45A 2 3
  • DNA Polymerase-Transactivated Protein 4 3 4
  • Dermal Papilla-Derived Protein 7 3 4
  • DERP7 3 4
  • Dermal Papilla Derived Protein 7 3
  • DNAPTP4 4

External Ids for TMEM45A Gene

Previous GeneCards Identifiers for TMEM45A Gene

  • GC03P101695
  • GC03P100211
  • GC03P097579

Summaries for TMEM45A Gene

GeneCards Summary for TMEM45A Gene

TMEM45A (Transmembrane Protein 45A) is a Protein Coding gene. An important paralog of this gene is TEDDM1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM45A Gene

Genomics for TMEM45A Gene

Regulatory Elements for TMEM45A Gene

Genomic Location for TMEM45A Gene

Chromosome:
3
Start:
100,492,619 bp from pter
End:
100,577,453 bp from pter
Size:
84,835 bases
Orientation:
Plus strand

Genomic View for TMEM45A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM45A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM45A Gene

Proteins for TMEM45A Gene

  • Protein details for TMEM45A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWC5-TM45A_HUMAN
    Recommended name:
    Transmembrane protein 45A
    Protein Accession:
    Q9NWC5
    Secondary Accessions:
    • Q53YW5

    Protein attributes for TMEM45A Gene

    Size:
    275 amino acids
    Molecular mass:
    31680 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM45A Gene

Proteomics data for TMEM45A Gene at MOPED

Post-translational modifications for TMEM45A Gene

  • Ubiquitination at Lys 43 and Lys 263
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM45A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM45A Gene

Domains & Families for TMEM45A Gene

Protein Domains for TMEM45A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM45A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NWC5

UniProtKB/Swiss-Prot:

TM45A_HUMAN :
  • Belongs to the TMEM45 family.
Family:
  • Belongs to the TMEM45 family.
genes like me logo Genes that share domains with TMEM45A: view

No data available for Gene Families for TMEM45A Gene

Function for TMEM45A Gene

Phenotypes for TMEM45A Gene

genes like me logo Genes that share phenotypes with TMEM45A: view

Animal Model Products

CRISPR Products

miRNA for TMEM45A Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM45A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM45A Gene

Localization for TMEM45A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM45A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM45A Gene COMPARTMENTS Subcellular localization image for TMEM45A gene
Compartment Confidence
cytoskeleton 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM45A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM45A: view

Pathways & Interactions for TMEM45A Gene

SuperPathways for TMEM45A Gene

No Data Available

Interacting Proteins for TMEM45A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000319009%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000319009 for TMEM45A Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for TMEM45A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM45A Gene

Drugs & Compounds for TMEM45A Gene

No Compound Related Data Available

Transcripts for TMEM45A Gene

Unigene Clusters for TMEM45A Gene

Transmembrane protein 45A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM45A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM45A Gene

No ASD Table

Relevant External Links for TMEM45A Gene

GeneLoc Exon Structure for
TMEM45A
ECgene alternative splicing isoforms for
TMEM45A

Expression for TMEM45A Gene

mRNA expression in normal human tissues for TMEM45A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM45A Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x15.1) and Skin - Not Sun Exposed (Suprapubic) (x12.9).

SOURCE GeneReport for Unigene cluster for TMEM45A Gene Hs.658956

genes like me logo Genes that share expression patterns with TMEM45A: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM45A Gene

Orthologs for TMEM45A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM45A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM45A 35
  • 81.01 (n)
  • 73.58 (a)
-- 36
  • 66 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TMEM45A 35
  • 83.14 (n)
  • 76.98 (a)
TMEM45A 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem45a 35
  • 73.51 (n)
  • 64.64 (a)
Tmem45a 16
2310005G13Rik 36
  • 47 (a)
OneToMany
Tmem45a 36
  • 65 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TMEM45A 35
  • 99.76 (n)
  • 100 (a)
TMEM45A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911041 35
  • 74.05 (n)
  • 66.79 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM45A 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM45A 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM45A 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM45A 36
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TMEM45A 36
  • 46 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8817 36
  • 30 (a)
OneToMany
Species with no ortholog for TMEM45A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM45A Gene

ENSEMBL:
Gene Tree for TMEM45A (if available)
TreeFam:
Gene Tree for TMEM45A (if available)

Paralogs for TMEM45A Gene

Paralogs for TMEM45A Gene

(1) SIMAP similar genes for TMEM45A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMEM45A: view

Variants for TMEM45A Gene

Sequence variations from dbSNP and Humsavar for TMEM45A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1132532 -- 100,577,278(+) TATCT(A/G)AAGTT utr-variant-3-prime
rs3924054 -- 100,528,321(+) CCTCA(A/G)GGGTG intron-variant
rs4073343 -- 100,520,985(-) GACTC(A/G)TGATC intron-variant
rs4075020 -- 100,520,180(+) CAGGG(A/T)AAATA intron-variant
rs4077302 -- 100,570,376(-) CACCC(A/G)GTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM45A Gene

Variant ID Type Subtype PubMed ID
nsv877218 CNV Gain 21882294

Variation tolerance for TMEM45A Gene

Residual Variation Intolerance Score: 33.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM45A Gene

HapMap Linkage Disequilibrium report
TMEM45A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM45A Gene

Disorders for TMEM45A Gene

Relevant External Links for TMEM45A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM45A
genes like me logo Genes that share disorders with TMEM45A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM45A Gene

Publications for TMEM45A Gene

  1. DNA polymerase 4 of Saccharomyces cerevisiae is important for accurate repair of methyl-methanesulfonate-induced DNA damage. (PMID: 16219787) Sterling C.H. … Sweasy J.B. (Genetics 2006) 23 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  3. High TMEM45A expression is correlated to epidermal keratinization. (PMID: 24689342) Hayez A. … Poumay Y. (Exp. Dermatol. 2014) 67
  4. TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells. (PMID: 22954140) Flamant L. … Michiels C. (BMC Cancer 2012) 67
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 67

Products for TMEM45A Gene

Sources for TMEM45A Gene

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