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Aliases for TMEM44 Gene

Aliases for TMEM44 Gene

  • Transmembrane Protein 44 2 3 5

External Ids for TMEM44 Gene

Previous GeneCards Identifiers for TMEM44 Gene

  • GC03M195790
  • GC03M194308
  • GC03M191688

Summaries for TMEM44 Gene

GeneCards Summary for TMEM44 Gene

TMEM44 (Transmembrane Protein 44) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM44 Gene

Genomics for TMEM44 Gene

Regulatory Elements for TMEM44 Gene

Promoters for TMEM44 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM44 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM44 Gene

Chromosome:
3
Start:
194,587,673 bp from pter
End:
194,633,780 bp from pter
Size:
46,108 bases
Orientation:
Minus strand

Genomic View for TMEM44 Gene

Genes around TMEM44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM44 Gene

Proteins for TMEM44 Gene

  • Protein details for TMEM44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2T9K0-TMM44_HUMAN
    Recommended name:
    Transmembrane protein 44
    Protein Accession:
    Q2T9K0
    Secondary Accessions:
    • A1L3V7
    • B7ZLZ5
    • B7ZLZ6
    • C9JJ62
    • E9PGA9
    • Q0P6F7
    • Q6ZT47
    • Q8IXR1
    • Q8N4G3

    Protein attributes for TMEM44 Gene

    Size:
    475 amino acids
    Molecular mass:
    52201 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH34353.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86747.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM44 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM44 Gene

Proteomics data for TMEM44 Gene at MOPED

Post-translational modifications for TMEM44 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM44 Gene

Domains & Families for TMEM44 Gene

Protein Domains for TMEM44 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM44 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM44: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM44 Gene

Function for TMEM44 Gene

Phenotypes for TMEM44 Gene

genes like me logo Genes that share phenotypes with TMEM44: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM44 Gene

Localization for TMEM44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM44 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM44 Gene COMPARTMENTS Subcellular localization image for TMEM44 gene
Compartment Confidence
cytosol 3
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for TMEM44 Gene

Pathways & Interactions for TMEM44 Gene

SuperPathways for TMEM44 Gene

No Data Available

Interacting Proteins for TMEM44 Gene

Selected Interacting proteins: Q2T9K0-TMM44_HUMAN for TMEM44 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for TMEM44 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM44 Gene

Drugs & Compounds for TMEM44 Gene

No Compound Related Data Available

Transcripts for TMEM44 Gene

Unigene Clusters for TMEM44 Gene

Transmembrane protein 44:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM44 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - - - -
SP5: - - -
SP6: -
SP7:

Relevant External Links for TMEM44 Gene

GeneLoc Exon Structure for
TMEM44
ECgene alternative splicing isoforms for
TMEM44

Expression for TMEM44 Gene

mRNA expression in normal human tissues for TMEM44 Gene

Protein differential expression in normal tissues from HIPED for TMEM44 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM44 Gene



SOURCE GeneReport for Unigene cluster for TMEM44 Gene Hs.478729

genes like me logo Genes that share expression patterns with TMEM44: view

Protein tissue co-expression partners for TMEM44 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM44 Gene

Orthologs for TMEM44 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM44 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM44 35
  • 84.17 (n)
  • 79.68 (a)
TMEM44 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem44 35
  • 81.46 (n)
  • 77.93 (a)
Tmem44 16
Tmem44 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM44 35
  • 98.63 (n)
  • 98.17 (a)
TMEM44 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem44 35
  • 82.44 (n)
  • 77.75 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM44 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem44 35
  • 52.89 (n)
  • 43.42 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem44 35
  • 44.52 (n)
  • 30.48 (a)
tmem44 36
  • 26 (a)
OneToOne
Species with no ortholog for TMEM44:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM44 Gene

ENSEMBL:
Gene Tree for TMEM44 (if available)
TreeFam:
Gene Tree for TMEM44 (if available)

Paralogs for TMEM44 Gene

genes like me logo Genes that share paralogs with TMEM44: view

No data available for Paralogs for TMEM44 Gene

Variants for TMEM44 Gene

Sequence variations from dbSNP and Humsavar for TMEM44 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1675955 - 194,633,146(-) CCCGC(A/C)ACCGC intron-variant, reference, missense
rs12695036 - 194,617,694(+) GAGAA(C/T)GTGAG intron-variant, reference, missense
rs922282 - 194,617,172(-) CGACC(A/G)GCACC intron-variant, reference, missense
rs711981 -- 194,608,753(-) ccagc(C/T)tggac intron-variant
rs711989 -- 194,622,177(-) CCACG(C/T)GCGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM44 Gene

Variant ID Type Subtype PubMed ID
dgv310n21 CNV Loss 19592680
nsv508268 CNV Loss 20534489
esv24185 CNV Loss 19812545
esv2726438 CNV Deletion 23290073

Variation tolerance for TMEM44 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.66; 94.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM44 Gene

HapMap Linkage Disequilibrium report
TMEM44

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM44 Gene

Disorders for TMEM44 Gene

Relevant External Links for TMEM44

Genetic Association Database (GAD)
TMEM44
Human Genome Epidemiology (HuGE) Navigator
TMEM44
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM44

No disorders were found for TMEM44 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM44 Gene

Publications for TMEM44 Gene

  1. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. (PMID: 20031603) Marroni F. … Pramstaller P.P. (Circ Cardiovasc Genet 2009) 3 48 67
  2. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  3. Expression of genes encoding multi-transmembrane proteins in specific primate taste cell populations. (PMID: 19997627) Moyer B.D. … Zlotnik A. (PLoS ONE 2009) 23
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM44 Gene

Sources for TMEM44 Gene

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