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Aliases for TMEM44 Gene

Aliases for TMEM44 Gene

  • Transmembrane Protein 44 2 3 5

External Ids for TMEM44 Gene

Previous GeneCards Identifiers for TMEM44 Gene

  • GC03M195790
  • GC03M194308
  • GC03M191688

Summaries for TMEM44 Gene

GeneCards Summary for TMEM44 Gene

TMEM44 (Transmembrane Protein 44) is a Protein Coding gene.

Additional gene information for TMEM44 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM44 Gene

Genomics for TMEM44 Gene

Regulatory Elements for TMEM44 Gene

Enhancers for TMEM44 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H194620 1.3 FANTOM5 ENCODE 6.3 +12.6 12582 1 TBP NFIB INSM2 FEZF1 ZSCAN9 RAD21 RARA ZNF366 ATF7 ZNF362 ATP13A3 TMEM44 LSG1 ENSG00000229334 LOC105374291
GH03H194632 1.1 ENCODE 6.1 +0.5 453 1 ATF1 ARID4B SIN3A DMAP1 ZBTB7B ETS1 GLIS2 CBX5 ZNF143 ATF7 ENSG00000233987 LINC01972 ENSG00000238031 ENSG00000229964 ATP13A3 TMEM44 ENSG00000229334
GH03H194598 1.1 FANTOM5 ENCODE dbSUPER 5.3 +34.8 34849 1 CHD1 MAX SIN3A FOS MYC ATP13A3 TMEM44 LRRC15 LOC105374291 TMEM44-AS1
GH03H194639 0.8 Ensembl ENCODE 5.4 -6.7 -6734 1 CTCF JUND POLR2A JUN MAX REST NR2F2 LSG1 ATP13A3 TMEM44 PIR50405 PIR52601
GH03H194675 0.7 Ensembl 5.2 -41.9 -41859 0 BCOR ZMYM3 BATF ZFHX2 GLIS2 EGR1 IKZF2 EGR2 HLF ZEB2 TMEM44 LSG1 FAM43A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM44 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM44 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000164142 380 1601 ATF1 ARID4B SIN3A DMAP1 ZBTB7B ETS1 GLIS2 CBX5 ZNF143 ATF7

Genomic Location for TMEM44 Gene

Chromosome:
3
Start:
194,587,673 bp from pter
End:
194,633,780 bp from pter
Size:
46,108 bases
Orientation:
Minus strand

Genomic View for TMEM44 Gene

Genes around TMEM44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM44 Gene

Proteins for TMEM44 Gene

  • Protein details for TMEM44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2T9K0-TMM44_HUMAN
    Recommended name:
    Transmembrane protein 44
    Protein Accession:
    Q2T9K0
    Secondary Accessions:
    • A1L3V7
    • B7ZLZ5
    • B7ZLZ6
    • C9JJ62
    • E9PGA9
    • Q0P6F7
    • Q6ZT47
    • Q8IXR1
    • Q8N4G3

    Protein attributes for TMEM44 Gene

    Size:
    475 amino acids
    Molecular mass:
    52201 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH34353.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86747.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM44 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM44 Gene

Post-translational modifications for TMEM44 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM44 Gene

Domains & Families for TMEM44 Gene

Gene Families for TMEM44 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TMEM44 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM44 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM44: view

No data available for UniProtKB/Swiss-Prot for TMEM44 Gene

Function for TMEM44 Gene

Phenotypes From GWAS Catalog for TMEM44 Gene

Gene Ontology (GO) - Molecular Function for TMEM44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015174 NOT basic amino acid transmembrane transporter activity IBA --
GO:0015181 NOT arginine transmembrane transporter activity IBA --
GO:0015189 NOT L-lysine transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with TMEM44: view

Phenotypes for TMEM44 Gene

genes like me logo Genes that share phenotypes with TMEM44: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM44 Gene

Localization for TMEM44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM44 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM44 gene
Compartment Confidence
plasma membrane 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 NOT lysosomal membrane IBA --
GO:0016021 NOT integral component of membrane IBA,IEA --
genes like me logo Genes that share ontologies with TMEM44: view

Pathways & Interactions for TMEM44 Gene

SuperPathways for TMEM44 Gene

No Data Available

Interacting Proteins for TMEM44 Gene

Selected Interacting proteins: Q2T9K0-TMM44_HUMAN for TMEM44 Gene via MINT IID

Symbol External ID(s) Details
GSK3B

Gene Ontology (GO) - Biological Process for TMEM44 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM44 Gene

Drugs & Compounds for TMEM44 Gene

No Compound Related Data Available

Transcripts for TMEM44 Gene

Unigene Clusters for TMEM44 Gene

Transmembrane protein 44:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM44 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - - - -
SP5: - - -
SP6: -
SP7:

Relevant External Links for TMEM44 Gene

GeneLoc Exon Structure for
TMEM44
ECgene alternative splicing isoforms for
TMEM44

Expression for TMEM44 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM44 Gene

Protein differential expression in normal tissues from HIPED for TMEM44 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM44 Gene



Protein tissue co-expression partners for TMEM44 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM44 Gene:

TMEM44

SOURCE GeneReport for Unigene cluster for TMEM44 Gene:

Hs.478729

Evidence on tissue expression from TISSUES for TMEM44 Gene

  • Nervous system(4.3)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with TMEM44: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM44 Gene

Orthologs for TMEM44 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM44 33 34
  • 98.63 (n)
cow
(Bos Taurus)
Mammalia TMEM44 33 34
  • 84.17 (n)
rat
(Rattus norvegicus)
Mammalia Tmem44 33
  • 82.44 (n)
mouse
(Mus musculus)
Mammalia Tmem44 33 16 34
  • 81.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM44 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem44 33
  • 52.89 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem44 33 34
  • 44.52 (n)
Species where no ortholog for TMEM44 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM44 Gene

ENSEMBL:
Gene Tree for TMEM44 (if available)
TreeFam:
Gene Tree for TMEM44 (if available)

Paralogs for TMEM44 Gene

No data available for Paralogs for TMEM44 Gene

Variants for TMEM44 Gene

Sequence variations from dbSNP and Humsavar for TMEM44 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000067428 -- 194,592,617(+) CATTT(C/T)GACTT intron-variant
rs1000075936 -- 194,592,865(+) ACCTC(A/G)GCCTC intron-variant
rs1000141602 -- 194,626,985(+) GGCAC(A/G)ATCTC intron-variant
rs1000180390 -- 194,612,264(+) AATAT(A/T)TTGGC intron-variant
rs1000182667 -- 194,607,392(+) AGGAT(C/T)CTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM44 Gene

Variant ID Type Subtype PubMed ID
dgv310n21 CNV loss 19592680
esv24185 CNV loss 19812545
esv2726438 CNV deletion 23290073
esv3599207 CNV loss 21293372
esv3599208 CNV loss 21293372
esv3599209 CNV loss 21293372
nsv508268 CNV deletion 20534489

Variation tolerance for TMEM44 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.66; 94.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM44 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM44

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM44 Gene

Disorders for TMEM44 Gene

Relevant External Links for TMEM44

Genetic Association Database (GAD)
TMEM44
Human Genome Epidemiology (HuGE) Navigator
TMEM44
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM44

No disorders were found for TMEM44 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM44 Gene

Publications for TMEM44 Gene

  1. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. (PMID: 20031603) Marroni F … EUROSPAN Consortium (Circulation. Cardiovascular genetics 2009) 3 45 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 60
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A … Wanker EE (Science signaling 2011) 3 60
  5. Expression of genes encoding multi-transmembrane proteins in specific primate taste cell populations. (PMID: 19997627) Moyer BD … Zlotnik A (PloS one 2009) 22 60

Products for TMEM44 Gene

Sources for TMEM44 Gene

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