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Aliases for TMEM42 Gene

Aliases for TMEM42 Gene

  • Transmembrane Protein 42 2 3 5

External Ids for TMEM42 Gene

Previous GeneCards Identifiers for TMEM42 Gene

  • GC03P044879
  • GC03P044904
  • GC03P044905
  • GC03P044907
  • GC03P044909
  • GC03P044863
  • GC03P044866
  • GC03P044868
  • GC03P044911
  • GC03P044948
  • GC03P044991
  • GC03P045029

Summaries for TMEM42 Gene

GeneCards Summary for TMEM42 Gene

TMEM42 (Transmembrane Protein 42) is a Protein Coding gene.

Additional gene information for TMEM42 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM42 Gene

Genomics for TMEM42 Gene

GeneHancer (GH) Regulatory Elements for TMEM42 Gene

Promoters and enhancers for TMEM42 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I044860 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 555.7 +0.3 260 2.1 ARID4B DMAP1 ZNF48 YY1 ZNF121 GLIS2 ZNF207 ZNF143 FOS RUNX3 TMEM42 GC03P045070 MIR564 GC03P045071 ZNF502 PPIAP18 KIF15
GH03I045052 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.5 +197.8 197806 13.7 HDGF PKNOX1 ARNT YY1 POLR2B ZNF766 E2F8 ZNF143 FOS REST ZNF502 ZNF852 RN7SL145P CLEC3B ZNF35 CDCP1 ZNF197 ZNF660 EXOSC7 RNU5B-3P
GH03I044980 Enhancer 1.1 Ensembl ENCODE dbSUPER 5.8 +120.8 120843 4.2 HDGF MEIS2 PKNOX1 TEAD4 CEBPG EBF1 GATA2 FOS IKZF2 RUNX3 EXOSC7 ZNF660 RNU5B-3P ENSG00000235845 TGM4 TMEM42 ZDHHC3 CLEC3B
GH03I044359 Enhancer 0.9 ENCODE 5.4 -502.0 -501973 1.4 FOXA2 MLX ARID4B ETS1 YY1 RXRA SP5 MIER2 REST PPARG ZNF445 ZNF197 TMEM42 LOC105377055 TCAIM LINC01988
GH03I045680 Enhancer 0.8 ENCODE dbSUPER 4.9 +820.2 820194 2.3 SMARCA5 BCOR MEIS2 PKNOX1 LEF1 ZMYM3 OSR2 NFIC HDAC2 ADNP PIR47827 SACM1L LIMD1 TMEM42 ZNF502 LIMD1-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM42 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM42 gene promoter:

Genomic Locations for TMEM42 Gene

Genomic Locations for TMEM42 Gene
chr3:44,861,723-44,865,670
(GRCh38/hg38)
Size:
3,948 bases
Orientation:
Plus strand
chr3:44,903,361-44,907,162
(GRCh37/hg19)

Genomic View for TMEM42 Gene

Genes around TMEM42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM42 Gene

Proteins for TMEM42 Gene

  • Protein details for TMEM42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q69YG0-TMM42_HUMAN
    Recommended name:
    Transmembrane protein 42
    Protein Accession:
    Q69YG0
    Secondary Accessions:
    • Q8WUQ6

    Protein attributes for TMEM42 Gene

    Size:
    159 amino acids
    Molecular mass:
    16991 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM42 Gene

Post-translational modifications for TMEM42 Gene

No Post-translational modifications

Other Protein References for TMEM42 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM42 Gene

Domains & Families for TMEM42 Gene

Gene Families for TMEM42 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM42 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM42: view

No data available for UniProtKB/Swiss-Prot for TMEM42 Gene

Function for TMEM42 Gene

genes like me logo Genes that share phenotypes with TMEM42: view

Animal Models for TMEM42 Gene

MGI Knock Outs for TMEM42:

Animal Model Products

miRNA for TMEM42 Gene

miRTarBase miRNAs that target TMEM42

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM42 Gene

Localization for TMEM42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM42 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM42 gene
Compartment Confidence
plasma membrane 3
nucleus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM42: view

Pathways & Interactions for TMEM42 Gene

SuperPathways for TMEM42 Gene

No Data Available

Interacting Proteins for TMEM42 Gene

Gene Ontology (GO) - Biological Process for TMEM42 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM42 Gene

Drugs & Compounds for TMEM42 Gene

No Compound Related Data Available

Transcripts for TMEM42 Gene

mRNA/cDNA for TMEM42 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(85) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM42 Gene

Transmembrane protein 42:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM42 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e
SP1: -
SP2:
SP3:
SP4: -
SP5: - -

Relevant External Links for TMEM42 Gene

GeneLoc Exon Structure for
TMEM42
ECgene alternative splicing isoforms for
TMEM42

Expression for TMEM42 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM42 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM42 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM42 Gene:

TMEM42

SOURCE GeneReport for Unigene cluster for TMEM42 Gene:

Hs.646856
genes like me logo Genes that share expression patterns with TMEM42: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM42 Gene

Orthologs for TMEM42 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM42 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM42 33 34
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia TMEM42 33 34
  • 88.68 (n)
cow
(Bos Taurus)
Mammalia TMEM42 33 34
  • 88.05 (n)
rat
(Rattus norvegicus)
Mammalia Tmem42 33
  • 84.29 (n)
mouse
(Mus musculus)
Mammalia Tmem42 33 16 34
  • 83.86 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM42 34
  • 33 (a)
OneToOne
Species where no ortholog for TMEM42 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM42 Gene

ENSEMBL:
Gene Tree for TMEM42 (if available)
TreeFam:
Gene Tree for TMEM42 (if available)

Paralogs for TMEM42 Gene

No data available for Paralogs for TMEM42 Gene

Variants for TMEM42 Gene

Sequence variations from dbSNP and Humsavar for TMEM42 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000817454 -- 44,865,062(+) A/G coding_sequence_variant, missense_variant
rs1000861034 -- 44,861,605(+) G/A upstream_transcript_variant
rs1000909091 -- 44,864,673(+) G/C intron_variant
rs1001819457 -- 44,863,647(+) G/A intron_variant
rs1001914306 -- 44,863,351(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM42 Gene

Variant ID Type Subtype PubMed ID
nsv3792 CNV deletion 18451855
nsv834675 CNV gain 17160897

Variation tolerance for TMEM42 Gene

Residual Variation Intolerance Score: 74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM42 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM42

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM42 Gene

Disorders for TMEM42 Gene

Additional Disease Information for TMEM42

No disorders were found for TMEM42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM42 Gene

Publications for TMEM42 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini AA … Barker JN (Nature communications 2014) 3 58
  3. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Systematic identification of pathological lamin A interactors. (PMID: 24623722) Dittmer TA … Misteli T (Molecular biology of the cell 2014) 3

Products for TMEM42 Gene

Sources for TMEM42 Gene

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