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Aliases for TMEM42 Gene

Aliases for TMEM42 Gene

  • Transmembrane Protein 42 2 3 5

External Ids for TMEM42 Gene

Previous GeneCards Identifiers for TMEM42 Gene

  • GC03P044879
  • GC03P044904
  • GC03P044905
  • GC03P044907
  • GC03P044909
  • GC03P044863
  • GC03P044866

Summaries for TMEM42 Gene

GeneCards Summary for TMEM42 Gene

TMEM42 (Transmembrane Protein 42) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM42 Gene

Genomics for TMEM42 Gene

Regulatory Elements for TMEM42 Gene

Enhancers for TMEM42 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM42 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM42 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM42 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM42 Gene

44,861,723 bp from pter
44,865,670 bp from pter
3,948 bases
Plus strand

Genomic View for TMEM42 Gene

Genes around TMEM42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM42 Gene

Proteins for TMEM42 Gene

  • Protein details for TMEM42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 42
    Protein Accession:
    Secondary Accessions:
    • Q8WUQ6

    Protein attributes for TMEM42 Gene

    159 amino acids
    Molecular mass:
    16991 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM42 Gene

Proteomics data for TMEM42 Gene at MOPED

Post-translational modifications for TMEM42 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM42 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM42 Gene

Domains & Families for TMEM42 Gene

Protein Domains for TMEM42 Gene


Suggested Antigen Peptide Sequences for TMEM42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM42: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM42 Gene

Function for TMEM42 Gene

genes like me logo Genes that share phenotypes with TMEM42: view

Animal Model Products

miRNA for TMEM42 Gene

miRTarBase miRNAs that target TMEM42

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM42 Gene

Localization for TMEM42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM42 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM42 Gene COMPARTMENTS Subcellular localization image for TMEM42 gene
Compartment Confidence
plasma membrane 3
nucleus 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM42 Gene

Pathways & Interactions for TMEM42 Gene

SuperPathways for TMEM42 Gene

No Data Available

Interacting Proteins for TMEM42 Gene

Gene Ontology (GO) - Biological Process for TMEM42 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM42 Gene

Drugs & Compounds for TMEM42 Gene

No Compound Related Data Available

Transcripts for TMEM42 Gene

mRNA/cDNA for TMEM42 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(85) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM42 Gene

Transmembrane protein 42:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM42 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e
SP1: -
SP4: -
SP5: - -

Relevant External Links for TMEM42 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM42 Gene

mRNA expression in normal human tissues for TMEM42 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM42 Gene

SOURCE GeneReport for Unigene cluster for TMEM42 Gene Hs.646856

genes like me logo Genes that share expression patterns with TMEM42: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM42 Gene

Orthologs for TMEM42 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM42 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM42 35
  • 88.05 (n)
  • 86.16 (a)
TMEM42 36
  • 86 (a)
(Canis familiaris)
Mammalia TMEM42 35
  • 88.68 (n)
  • 86.16 (a)
TMEM42 36
  • 86 (a)
(Mus musculus)
Mammalia Tmem42 35
  • 83.86 (n)
  • 82.17 (a)
Tmem42 16
Tmem42 36
  • 82 (a)
(Pan troglodytes)
Mammalia TMEM42 35
  • 99.79 (n)
  • 100 (a)
TMEM42 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tmem42 35
  • 84.29 (n)
  • 84.08 (a)
(Monodelphis domestica)
Mammalia TMEM42 36
  • 33 (a)
Species with no ortholog for TMEM42:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM42 Gene

Gene Tree for TMEM42 (if available)
Gene Tree for TMEM42 (if available)

Paralogs for TMEM42 Gene

No data available for Paralogs for TMEM42 Gene

Variants for TMEM42 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM42 Gene

Variant ID Type Subtype PubMed ID
nsv834675 CNV Gain 17160897
nsv3792 CNV Loss 18451855

Variation tolerance for TMEM42 Gene

Residual Variation Intolerance Score: 74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for TMEM42 Gene

Disorders for TMEM42 Gene

Relevant External Links for TMEM42

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM42 Gene

Publications for TMEM42 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3

Products for TMEM42 Gene

Sources for TMEM42 Gene