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Aliases for TMEM41B Gene

Aliases for TMEM41B Gene

  • Transmembrane Protein 41B 2 3 5
  • KIAA0033 4

External Ids for TMEM41B Gene

Previous GeneCards Identifiers for TMEM41B Gene

  • GC11M009259
  • GC11M008974

Summaries for TMEM41B Gene

GeneCards Summary for TMEM41B Gene

TMEM41B (Transmembrane Protein 41B) is a Protein Coding gene. An important paralog of this gene is TMEM41A.

UniProtKB/Swiss-Prot for TMEM41B Gene

  • Required for normal motor neuron development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM41B Gene

Genomics for TMEM41B Gene

Regulatory Elements for TMEM41B Gene

Enhancers for TMEM41B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F009317 1 Ensembl ENCODE 14.2 -3.9 -3853 2.9 HDAC1 ATF1 PKNOX1 ARNT KLF17 PTRF ZNF48 ZNF121 SCRT2 KLF13 TMEM41B IPO7 DENND5A SCUBE2 GC11P009354
GH11F009312 0.2 ENCODE 13.7 +0.2 226 3.2 HDGF PKNOX1 ARNT MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 TMEM41B KRT8P41 SCUBE2 DENND5A PRR13P2
GH11F009288 0.3 FANTOM5 13 +25.6 25610 0.3 POLR2A ZNF384 ZBTB40 TMEM41B KRT8P41 DENND5A NRIP3 ZNF143 ENSG00000273725 PRR13P2
GH11F009229 1.1 Ensembl ENCODE 11.1 +83.8 83780 4.0 KLF1 ZNF140 ZNF384 ZBTB40 YY1 ZNF7 FOXK2 CBX5 ZNF600 CREM DENND5A SCUBE2 TMEM41B SNORA3B GC11M009224 ENSG00000255097
GH11F009249 0.9 Ensembl ENCODE 10.9 +64.0 63980 2.8 PKNOX1 TBL1XR1 ETV1 CEBPG RELA ZNF121 CBX5 EED ZNF416 CREM TMEM41B SCUBE2 ENSG00000255097 DENND5A
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM41B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM41B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001568021 780 2801 HDGF PKNOX1 ARNT MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for TMEM41B Gene

Chromosome:
11
Start:
9,280,654 bp from pter
End:
9,314,780 bp from pter
Size:
34,127 bases
Orientation:
Minus strand

Genomic View for TMEM41B Gene

Genes around TMEM41B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM41B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM41B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM41B Gene

Proteins for TMEM41B Gene

  • Protein details for TMEM41B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5BJD5-TM41B_HUMAN
    Recommended name:
    Transmembrane protein 41B
    Protein Accession:
    Q5BJD5
    Secondary Accessions:
    • D3DQU9
    • E9PP29
    • Q15055
    • Q4G0P0

    Protein attributes for TMEM41B Gene

    Size:
    291 amino acids
    Molecular mass:
    32513 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA05062.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM41B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM41B Gene

Post-translational modifications for TMEM41B Gene

  • Ubiquitination at Lys 100 and Lys 185
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM41B Gene

No data available for DME Specific Peptides for TMEM41B Gene

Domains & Families for TMEM41B Gene

Protein Domains for TMEM41B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM41B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5BJD5

UniProtKB/Swiss-Prot:

TM41B_HUMAN :
  • Belongs to the TMEM41 family.
Family:
  • Belongs to the TMEM41 family.
genes like me logo Genes that share domains with TMEM41B: view

No data available for Gene Families for TMEM41B Gene

Function for TMEM41B Gene

Molecular function for TMEM41B Gene

UniProtKB/Swiss-Prot Function:
Required for normal motor neuron development.

Phenotypes for TMEM41B Gene

GenomeRNAi human phenotypes for TMEM41B:
genes like me logo Genes that share phenotypes with TMEM41B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM41B

miRNA for TMEM41B Gene

miRTarBase miRNAs that target TMEM41B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM41B Gene

Localization for TMEM41B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM41B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM41B Gene COMPARTMENTS Subcellular localization image for TMEM41B gene
Compartment Confidence
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM41B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM41B: view

Pathways & Interactions for TMEM41B Gene

SuperPathways for TMEM41B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM41B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with TMEM41B: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM41B Gene

Transcripts for TMEM41B Gene

Unigene Clusters for TMEM41B Gene

Transmembrane protein 41B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM41B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6
SP1: -
SP2:

Relevant External Links for TMEM41B Gene

GeneLoc Exon Structure for
TMEM41B
ECgene alternative splicing isoforms for
TMEM41B

Expression for TMEM41B Gene

mRNA expression in normal human tissues for TMEM41B Gene

Protein differential expression in normal tissues from HIPED for TMEM41B Gene

This gene is overexpressed in Bone (16.8) and Fetal testis (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM41B Gene



Protein tissue co-expression partners for TMEM41B Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM41B Gene:

TMEM41B

SOURCE GeneReport for Unigene cluster for TMEM41B Gene:

Hs.594563
genes like me logo Genes that share expression patterns with TMEM41B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM41B Gene

Orthologs for TMEM41B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM41B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM41B 34 35
  • 99.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM41B 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM41B 34 35
  • 93.59 (n)
cow
(Bos Taurus)
Mammalia TMEM41B 34 35
  • 92.44 (n)
rat
(Rattus norvegicus)
Mammalia Tmem41b 34
  • 88.43 (n)
mouse
(Mus musculus)
Mammalia Tmem41b 34 16 35
  • 87.63 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM41B 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM41B 34 35
  • 82.38 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM41B 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem41b 34
  • 70.16 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem41b 34 35
  • 67.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8408 34 35
  • 54.74 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000769 34
  • 53.95 (n)
worm
(Caenorhabditis elegans)
Secernentea tag-175 34 35
  • 55.94 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G17790 34
  • 51.1 (n)
rice
(Oryza sativa)
Liliopsida Os02g0693500 34
  • 48.44 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3420 35
  • 56 (a)
OneToOne
Species where no ortholog for TMEM41B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM41B Gene

ENSEMBL:
Gene Tree for TMEM41B (if available)
TreeFam:
Gene Tree for TMEM41B (if available)

Paralogs for TMEM41B Gene

Paralogs for TMEM41B Gene

(1) SIMAP similar genes for TMEM41B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMEM41B: view

Variants for TMEM41B Gene

Sequence variations from dbSNP and Humsavar for TMEM41B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10559215 -- 9,312,955(+) TAATG(-/ATAAA)ATAAG intron-variant
rs10559878 -- 9,315,604(+) GTCCC(-/A)AAAAA upstream-variant-2KB
rs1063312 -- 9,310,870(-) AGTGG(A/C)AAATA intron-variant
rs1063313 -- 9,310,804(-) GAGTC(C/T)GTTTG intron-variant
rs10638432 -- 9,284,787(+) AGAAA(-/GAAA)CGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM41B Gene

Variant ID Type Subtype PubMed ID
dgv1641n54 CNV gain 21841781
dgv1642n54 CNV gain+loss 21841781
dgv583n106 CNV deletion 24896259
esv1001197 CNV deletion 20482838
esv24655 CNV loss 19812545
esv2567694 CNV deletion 19546169
esv2744092 CNV deletion 23290073
esv32901 CNV loss 17666407
esv33264 CNV loss 17666407
esv3370049 CNV insertion 20981092
esv3547296 CNV deletion 23714750
esv3578238 CNV gain 25503493
esv3579356 CNV loss 25503493
esv3579357 CNV loss 25503493
esv3579358 CNV loss 25503493
esv3625328 CNV loss 21293372
nsv1055078 CNV gain 25217958
nsv1075413 CNV deletion 25765185
nsv499766 OTHER inversion 21111241
nsv508617 CNV deletion 20534489
nsv512208 CNV loss 21212237
nsv515891 CNV gain 19592680
nsv521969 CNV loss 19592680
nsv553456 CNV gain 21841781
nsv553460 CNV gain 21841781
nsv553461 CNV loss 21841781
nsv553463 CNV gain 21841781
nsv553464 CNV gain 21841781
nsv553466 CNV loss 21841781
nsv7215 OTHER inversion 18451855
nsv7669 CNV deletion 18451855
nsv957172 CNV deletion 24416366
nsv971985 CNV duplication 23825009

Variation tolerance for TMEM41B Gene

Residual Variation Intolerance Score: 60.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.01; 60.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM41B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM41B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM41B Gene

Disorders for TMEM41B Gene

Relevant External Links for TMEM41B

Genetic Association Database (GAD)
TMEM41B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM41B

No disorders were found for TMEM41B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM41B Gene

Publications for TMEM41B Gene

  1. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PMID: 7584026) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). (PMID: 7584028) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64

Products for TMEM41B Gene

Sources for TMEM41B Gene

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