TMEM41B Gene
protein-coding GIFtS : 50
GCID: GC11 M009302
transmembrane protein 41B
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Aliasesfor TMEM41B gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section This gene clusters with an RNA geneSubcategory (RNA class): lncRNAQuality score for the ORGUL clustered with this gene is 3 Aliases Transmembrane Protein 41B 1 2 KIAA00331 3
External Ids: HGNC: 28948 1 Entrez Gene: 440026 2 Ensembl: ENSG00000166471 7 UniProtKB: Q5BJD5 3 ORGUL members: NONCODE:n408284
Export aliases for TMEM41B gene to outside databases Previous GC identifers: GC11M009259 GC11M008974
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Summariesfor TMEM41B gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor TMEM41B gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_009237.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TMEM41B gene promoter: RFX1 Pax-5 p53 Tal-1 AML1a GATA-1 Egr-4 E47 E2F-1 NRF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for TMEM41B Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TMEM41B
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.3 TMEM41B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11M009302: view genomic region
(about GC identifiers )
Start:
9,302,201 bp from pter
End:
9,336,327 bp from pter
Size:
34,127 bases
Orientation:
minus strand
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Proteinsfor TMEM41B gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TM41B_HUMAN, Q5BJD5 (See
protein sequence )Recommended Name: Transmembrane protein 41B Size : 291 amino acids; 32513 Da
Subcellular location : Membrane; Multi-pass membrane protein (Potential)
Sequence caution : Sequence=BAA05062.1; Type=Erroneous initiation;
Secondary accessions : D3DQU9 E9PP29 Q15055 Q4G0P0Alternative splicing : 3 isoforms : Q5BJD5-1 Q5BJD5-2 Q5BJD5-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TMEM41B: NX_Q5BJD5 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q5BJD5 TMEM41B Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001158502.1 NP_055827.1 ENSEMBL proteins: ENSP00000299596 ENSP00000431934 ENSP00000433126 ENSP00000435685 ENSP00000436480 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
TMEM41B for ontologies About GeneDecksing TMEM41B Antibody Products: Assay Products for TMEM41B:
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Protein
Domains / Familiesfor TMEM41B gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TMEM41B for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q5BJD5 ProtoNet protein and cluster: Q5BJD5
UniProtKB/Swiss-Prot: TM41B_HUMAN, Q5BJD5 Similarity : Belongs to the TMEM41 family
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Functionfor TMEM41B gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM41B (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM41B (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): TMEM41B (NM_015012 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM41B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM41B
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM41B
2 GenomeRNAi human phenotypes for TMEM41B :
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Pathways & Interactionsfor TMEM41B gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM41B STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)5/6 Interacting proteins for TMEM41B (Q5BJD5 3 ENSP00000299596 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 6 )About this table
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Drugs & Compoundsfor TMEM41B gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TMEM41B Search CenterWatch for drugs/clinical trials and news about TMEM41B / TM41B
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Transcriptsfor TMEM41B gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TMEM41B gene (2 alternative transcripts): NM_001165030.2 NM_015012.3 Unigene Cluster for TMEM41B:
Transmembrane protein 41B Hs.594563 [show with all ESTs ] Unigene Representative Sequence: NM_015012 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000299596 ENST00000524543 ENST00000528080 (uc001mhm.3 uc001mhn.2 )ENST00000533867 ENST00000527813 ENST00000533723 (uc021qdm.1 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM41B (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM41B (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): TMEM41B (NM_015012 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM41B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM41B
Additional cDNA sequence: AK303339.1 BC064366.1 BC091524.1 D26067.1 NR_028491.2
8 DOTS entries : DT.91832516 DT.218523
DT.100023639 DT.75132026 DT.100827619 DT.102832550 DT.100653356 DT.100735084 24/228 AceView cDNA sequences (see all 228 ):
CR625188 BX485830 CA487558 BU145525 BM554990 AA677093 BX956807 N54391 AA768142 BX092235 BF197888 BM789626 CR602952 AA371629 AA297604 N79382 N53603 CR612310 AA421070 BQ017431 D26067 AA319158 AW474531 AI287600 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM41B About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 SP1 :         -           SP2 :                  
ECgene alternative splicing isoforms for TMEM41B
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Expression for TMEM41B gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TMEM41B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TAAATTCAAG
About this image TMEM41B expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Definitive endoderm-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See TMEM41B Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TMEM41B SOURCE GeneReport for Unigene cluster: Hs.594563 SABiosciences Custom PCR Arrays for TMEM41B Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TMEM41BBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TMEM41B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TMEM41B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TMEM41B In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM41B
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Orthologsfor TMEM41B gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for TMEM41B gene from 7/25 species (see all 25 ) About this table
ENSEMBL Gene Tree for TMEM41B (if available)TreeFam Gene Tree for TMEM41B (if available)
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Paralogsfor TMEM41B gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TMEM41B gene TMEM41A 2 1 SIMAP similar gene for TMEM41B using alignment to 2 protein entries: TM41B_HUMAN (see all proteins ):TMEM41A
TMEM41B for paralogs About GeneDecksing
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Genomic Variantsfor TMEM41B gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TMEM41B (9302201 - 9336327 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 4 variations for TMEM41B 3 CNVs : 6956 101128 6953 1 Indel : 65862
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TMEM41B
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Disorders
/ Diseasesfor TMEM41B gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TMEM41B for disorders About GeneDecksing 2 diseases for TMEM41B : About MalaCards malaria neuronitis Export disorders for TMEM41B gene to outside databases
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Publicationsfor TMEM41B gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TMEM41B gene, integrated from 9 sources (see all 15 ): (articles sorted by number of sources associating them with TMEM41B) Utopia : connect your pdf to the dynamic world of online information
Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026) 1 , 2 , 3 Nomura N.... Tabata S. (1994) Prediction of the coding sequences of unidentified hu man genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell li ne KG-1 (supplement). (PubMed id 7584028) 1 , 3 Nomura N....Tabata S. (1994) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231) 2 Olsen J.V....Mann M. (2010) Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201) 1 Abdelmohsen K....Gorospe M. (2009) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976) 2 Daub H.... Mann M. (2008) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006)
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External Searches for TMEM41B gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TMEM41B gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TMEM41B gene
(According to HUGE )
About This Section
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Specialized Databases showing TMEM41B gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TMEM41B Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TMEM41B gene: Search GeneIP for patents involving TMEM41B GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TMEM41B gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TMEM41B OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TMEM41B OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TMEM41B OriGene Protein Over-expression Lysate for TMEM41B Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TMEM41B OriGene 3'-UTR Clone for TMEM41B OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM41B OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM41B Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for TMEM41B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TMEM41B OriGene Custom Protein Services for TMEM41B OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM41B QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TMEM41B QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TMEM41B QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TMEM41B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TMEM41B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TMEM41B
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM41B
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