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Aliases for TMEM41B Gene

Aliases for TMEM41B Gene

  • Transmembrane Protein 41B 2 3
  • KIAA0033 4

External Ids for TMEM41B Gene

Previous GeneCards Identifiers for TMEM41B Gene

  • GC11M009259
  • GC11M008974

Summaries for TMEM41B Gene

GeneCards Summary for TMEM41B Gene

TMEM41B (Transmembrane Protein 41B) is a Protein Coding gene. An important paralog of this gene is TMEM41A.

UniProtKB/Swiss-Prot for TMEM41B Gene

  • Required for normal motor neuron development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM41B Gene

Genomics for TMEM41B Gene

Regulatory Elements for TMEM41B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM41B Gene

Start:
9,280,654 bp from pter
End:
9,314,780 bp from pter
Size:
34,127 bases
Orientation:
Minus strand

Genomic View for TMEM41B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM41B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM41B Gene

Proteins for TMEM41B Gene

  • Protein details for TMEM41B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5BJD5-TM41B_HUMAN
    Recommended name:
    Transmembrane protein 41B
    Protein Accession:
    Q5BJD5
    Secondary Accessions:
    • D3DQU9
    • E9PP29
    • Q15055
    • Q4G0P0

    Protein attributes for TMEM41B Gene

    Size:
    291 amino acids
    Molecular mass:
    32513 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA05062.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM41B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM41B Gene

Proteomics data for TMEM41B Gene at MOPED

Post-translational modifications for TMEM41B Gene

  • Ubiquitination at Lys100 and Lys185
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM41B Gene

No data available for DME Specific Peptides for TMEM41B Gene

Domains for TMEM41B Gene

Protein Domains for TMEM41B Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM41B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5BJD5

UniProtKB/Swiss-Prot:

TM41B_HUMAN :
  • Q5BJD5
Family:
  • Belongs to the TMEM41 family.
genes like me logo Genes that share domains with TMEM41B: view

No data available for Gene Families for TMEM41B Gene

Function for TMEM41B Gene

Molecular function for TMEM41B Gene

UniProtKB/Swiss-Prot Function:
Required for normal motor neuron development.

Phenotypes for TMEM41B Gene

GenomeRNAi human phenotypes for TMEM41B:
genes like me logo Genes that share phenotypes with TMEM41B: view

Animal Model Products

CRISPR Products

miRNA for TMEM41B Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM41B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM41B Gene

Localization for TMEM41B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM41B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM41B Gene COMPARTMENTS Subcellular localization image for TMEM41B gene
Compartment Confidence
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM41B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM41B: view

Pathways for TMEM41B Gene

SuperPathways for TMEM41B Gene

No Data Available

Interacting Proteins for TMEM41B Gene

Gene Ontology (GO) - Biological Process for TMEM41B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with TMEM41B: view

No data available for Pathways by source for TMEM41B Gene

Transcripts for TMEM41B Gene

Unigene Clusters for TMEM41B Gene

Transmembrane protein 41B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM41B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM41B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6
SP1: -
SP2:

Relevant External Links for TMEM41B Gene

GeneLoc Exon Structure for
TMEM41B
ECgene alternative splicing isoforms for
TMEM41B

Expression for TMEM41B Gene

mRNA expression in normal human tissues for TMEM41B Gene

Protein differential expression in normal tissues for TMEM41B Gene

This gene is overexpressed in Bone (16.8) and Fetal testis (10.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM41B Gene

SOURCE GeneReport for Unigene cluster for TMEM41B Gene Hs.594563

genes like me logo Genes that share expressions with TMEM41B: view

Expression partners for TMEM41B Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM41B Gene

Orthologs for TMEM41B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM41B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM41B 35
  • 92.44 (n)
  • 92.44 (a)
TMEM41B 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM41B 35
  • 93.59 (n)
  • 93.81 (a)
TMEM41B 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem41b 35
  • 87.63 (n)
  • 90.38 (a)
Tmem41b 16
Tmem41b 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM41B 35
  • 99.77 (n)
  • 99.66 (a)
TMEM41B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem41b 35
  • 88.43 (n)
  • 93.13 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM41B 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM41B 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM41B 35
  • 82.38 (n)
  • 90.42 (a)
TMEM41B 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM41B 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem41b 35
  • 70.16 (n)
  • 85.2 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem41b 35
  • 67.75 (n)
  • 76.17 (a)
tmem41b 36
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000769 35
  • 53.95 (n)
  • 54.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8408 35
  • 54.74 (n)
  • 52.85 (a)
CG8408 36
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tag-175 35
  • 55.94 (n)
  • 53.48 (a)
tag-175 36
  • 50 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G17790 35
  • 51.1 (n)
  • 41.04 (a)
rice
(Oryza sativa)
Liliopsida Os02g0693500 35
  • 48.44 (n)
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3420 36
  • 56 (a)
OneToOne
Species with no ortholog for TMEM41B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM41B Gene

ENSEMBL:
Gene Tree for TMEM41B (if available)
TreeFam:
Gene Tree for TMEM41B (if available)

Paralogs for TMEM41B Gene

Paralogs for TMEM41B Gene

Selected SIMAP similar genes for TMEM41B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TMEM41B: view

Variants for TMEM41B Gene

Sequence variations from dbSNP and Humsavar for TMEM41B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs9215 -- 9,280,714(+) GTGTC(A/G)TGGAA utr-variant-3-prime, nc-transcript-variant
rs15248 -- 9,280,830(+) ACCAC(A/T)GATGC utr-variant-3-prime, nc-transcript-variant
rs1063313 -- 9,310,804(-) GAGTC(C/T)GTTTG intron-variant
rs1136330 -- 9,283,392(-) CTGTC(A/G)TCACC utr-variant-3-prime, nc-transcript-variant
rs1140288 -- 9,310,803(-) AGTCT(A/G)TTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM41B Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241
esv33264 CNV Loss 17666407
nsv515891 CNV Gain 19592680
nsv7669 CNV Loss 18451855
esv32901 CNV Loss 17666407
nsv508617 CNV Loss 20534489
esv1001197 CNV Deletion 20482838
esv2567694 CNV Deletion 19546169
nsv512208 CNV Loss 21212237
esv2744092 CNV Deletion 23290073
esv24655 CNV Loss 19812545
esv271231 CNV Insertion 20981092
nsv521969 CNV Loss 19592680

Relevant External Links for TMEM41B Gene

HapMap Linkage Disequilibrium report
TMEM41B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM41B Gene

Disorders for TMEM41B Gene

Relevant External Links for TMEM41B

Genetic Association Database (GAD)
TMEM41B

No disorders were found for TMEM41B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TMEM41B Gene

Publications for TMEM41B Gene

  1. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PMID: 7584026) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). (PMID: 7584028) Nomura N. … Tabata S. (DNA Res. 1994) 2 3
  3. Generation and analysis of 280,000 human expressed sequence tags. (PMID: 8889549) Hillier L.D. … Marra M. (Genome Res. 1996) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for TMEM41B Gene

Sources for TMEM41B Gene

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