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Aliases for TMEM41A Gene

Aliases for TMEM41A Gene

  • Transmembrane Protein 41A 2 3 5
  • 2900010K02Rik 3

External Ids for TMEM41A Gene

Previous GeneCards Identifiers for TMEM41A Gene

  • GC03M186692
  • GC03M185194
  • GC03M182616

Summaries for TMEM41A Gene

GeneCards Summary for TMEM41A Gene

TMEM41A (Transmembrane Protein 41A) is a Protein Coding gene. An important paralog of this gene is TMEM41B.

Additional gene information for TMEM41A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM41A Gene

Genomics for TMEM41A Gene

Regulatory Elements for TMEM41A Gene

Enhancers for TMEM41A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H185551 1.6 Ensembl ENCODE dbSUPER 11.7 -56.4 -56411 8.4 HDGF PKNOX1 ARNT SIN3A ZNF2 ZNF143 ZNF207 FOS REST ZNF592 SENP2 TMEM41A LIPH VPS8
GH03H185536 1.6 Ensembl ENCODE dbSUPER 11.3 -38.6 -38633 1.9 SIN3A ZNF2 ZNF766 CBX5 FOS DEK SP3 JUNB ZNF592 SMARCA4 SENP2 TMEM41A LIPH LOC105374254
GH03H185539 0.4 dbSUPER 11.3 -40.9 -40949 0.7 ZNF18 TMEM41A LIPH LOC105374254
GH03H185496 1.4 ENCODE dbSUPER 0.7 +1.1 1093 3.7 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 ZNF143 TRA2B MAP3K13 TMEM41A LOC101929018
GH03H185488 1 ENCODE dbSUPER 0.4 +9.3 9289 2.3 SOX13 FOXA2 MAX CEBPG RAD21 YY1 POLR2A SCRT2 HNF4G NR2F6 LOC101929018 TMEM41A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM41A on UCSC Golden Path with GeneCards custom track

Promoters for TMEM41A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000163060 257 1600 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 ZNF143

Genomic Locations for TMEM41A Gene

Genomic Locations for TMEM41A Gene
22,562 bases
Minus strand

Genomic View for TMEM41A Gene

Genes around TMEM41A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM41A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM41A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM41A Gene

Proteins for TMEM41A Gene

  • Protein details for TMEM41A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 41A
    Protein Accession:
    Secondary Accessions:
    • A8K4B3
    • D3DNU2
    • Q6ZMJ0

    Protein attributes for TMEM41A Gene

    264 amino acids
    Molecular mass:
    29665 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD18735.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

neXtProt entry for TMEM41A Gene

Post-translational modifications for TMEM41A Gene

  • Ubiquitination at posLast=138138
  • Glycosylation at posLast=250250
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM41A Gene

No data available for DME Specific Peptides for TMEM41A Gene

Domains & Families for TMEM41A Gene

Gene Families for TMEM41A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM41A Gene


Suggested Antigen Peptide Sequences for TMEM41A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM41 family.
  • Belongs to the TMEM41 family.
genes like me logo Genes that share domains with TMEM41A: view

Function for TMEM41A Gene

Gene Ontology (GO) - Molecular Function for TMEM41A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM41A: view

Phenotypes for TMEM41A Gene

MGI mutant phenotypes for TMEM41A:
inferred from 1 alleles
GenomeRNAi human phenotypes for TMEM41A:
genes like me logo Genes that share phenotypes with TMEM41A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM41A Gene

Localization for TMEM41A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM41A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM41A gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM41A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM41A: view

Pathways & Interactions for TMEM41A Gene

SuperPathways for TMEM41A Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM41A Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM41A Gene

Drugs & Compounds for TMEM41A Gene

No Compound Related Data Available

Transcripts for TMEM41A Gene

Unigene Clusters for TMEM41A Gene

Transmembrane protein 41A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM41A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6
SP1: - -
SP2: - - - - -
SP3: -
SP4: -

Relevant External Links for TMEM41A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM41A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM41A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM41A Gene

This gene is overexpressed in Nasal epithelium (54.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM41A Gene

Protein tissue co-expression partners for TMEM41A Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM41A Gene:


SOURCE GeneReport for Unigene cluster for TMEM41A Gene:


Evidence on tissue expression from TISSUES for TMEM41A Gene

  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with TMEM41A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM41A Gene

Orthologs for TMEM41A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM41A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM41A 33 34
  • 99.49 (n)
(Canis familiaris)
Mammalia TMEM41A 33 34
  • 89.9 (n)
(Bos Taurus)
Mammalia TMEM41A 33 34
  • 87.5 (n)
(Rattus norvegicus)
Mammalia Tmem41a 33
  • 85.23 (n)
(Mus musculus)
Mammalia Tmem41a 33 16 34
  • 84.34 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM41A 34
  • 77 (a)
(Monodelphis domestica)
Mammalia TMEM41A 34
  • 74 (a)
(Gallus gallus)
Aves TMEM41A 33 34
  • 70.8 (n)
(Anolis carolinensis)
Reptilia TMEM41A 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492177 33
  • 66 (n)
(Danio rerio)
Actinopterygii tmem41aa 33 34
  • 61.98 (n)
tmem41ab 34
  • 59 (a)
(Caenorhabditis elegans)
Secernentea bus-19 33 34
  • 52.06 (n)
Y71A12C.2 34
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
Species where no ortholog for TMEM41A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM41A Gene

Gene Tree for TMEM41A (if available)
Gene Tree for TMEM41A (if available)

Paralogs for TMEM41A Gene

Paralogs for TMEM41A Gene

(1) SIMAP similar genes for TMEM41A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TMEM41A: view

Variants for TMEM41A Gene

Sequence variations from dbSNP and Humsavar for TMEM41A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000079100 -- 185,494,642(+) AAGAA(C/G)AACTG nc-transcript-variant, reference, missense
rs1000151136 -- 185,494,148(+) TCAAA(A/C)GGCAG intron-variant
rs1000213414 -- 185,500,516(+) CCAAA(C/T)AGGGA intron-variant, upstream-variant-2KB
rs1000360395 -- 185,487,756(+) CCATC(A/T)ACCAC intron-variant, utr-variant-3-prime
rs1000424686 -- 185,494,464(+) CAGAT(C/T)TGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM41A Gene

Variant ID Type Subtype PubMed ID
nsv829818 CNV loss 17160897

Variation tolerance for TMEM41A Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM41A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM41A Gene

Disorders for TMEM41A Gene

Relevant External Links for TMEM41A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM41A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM41A Gene

Publications for TMEM41A Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 60

Products for TMEM41A Gene

Sources for TMEM41A Gene

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