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Aliases for TMEM40 Gene

Aliases for TMEM40 Gene

  • Transmembrane Protein 40 2 3

External Ids for TMEM40 Gene

Summaries for TMEM40 Gene

GeneCards Summary for TMEM40 Gene

TMEM40 (Transmembrane Protein 40) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM40 Gene

Genomics for TMEM40 Gene

Genomic Location for TMEM40 Gene

Start:
12,733,525 bp from pter
End:
12,769,457 bp from pter
Size:
35,933 bases
Orientation:
Minus strand

Genomic View for TMEM40 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM40 Gene

Regulatory Elements for TMEM40 Gene

Proteins for TMEM40 Gene

  • Protein details for TMEM40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWA1-TMM40_HUMAN
    Recommended name:
    Transmembrane protein 40
    Protein Accession:
    Q8WWA1
    Secondary Accessions:
    • C9JID5
    • Q8NAL4
    • Q9NUZ4

    Protein attributes for TMEM40 Gene

    Size:
    233 amino acids
    Molecular mass:
    25495 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM40 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM40 Gene

Proteomics data for TMEM40 Gene at MOPED

Post-translational modifications for TMEM40 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM40 Gene

No data available for DME Specific Peptides for TMEM40 Gene

Domains for TMEM40 Gene

Protein Domains for TMEM40 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with TMEM40: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM40 Gene

Function for TMEM40 Gene

Phenotypes for TMEM40 Gene

GenomeRNAi human phenotypes for TMEM40:
genes like me logo Genes that share phenotypes with TMEM40: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM40 Gene

Localization for TMEM40 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM40 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM40 Gene COMPARTMENTS Subcellular localization image for TMEM40 gene
Compartment Confidence
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM40: view

Pathways for TMEM40 Gene

SuperPathways for TMEM40 Gene

No Data Available

Interacting Proteins for TMEM40 Gene

Gene Ontology (GO) - Biological Process for TMEM40 Gene

None

No data available for Pathways by source for TMEM40 Gene

Transcripts for TMEM40 Gene

Unigene Clusters for TMEM40 Gene

Transmembrane protein 40:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM40 Gene

No ASD Table

Relevant External Links for TMEM40 Gene

GeneLoc Exon Structure for
TMEM40
ECgene alternative splicing isoforms for
TMEM40

Expression for TMEM40 Gene

mRNA expression in normal human tissues for TMEM40 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM40 Gene

This gene is overexpressed in Esophagus - Mucosa (20.5), Skin - Sun Exposed (Lower leg) (6.5), Vagina (6.5), Skin - Not Sun Exposed (Suprapubic) (6.1), and Cervix - Ectocervix (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TMEM40 Gene

SOURCE GeneReport for Unigene cluster for TMEM40 Gene Hs.475502

genes like me logo Genes that share expressions with TMEM40: view

Orthologs for TMEM40 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM40 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM40 36
  • 91.67 (n)
  • 90 (a)
TMEM40 37
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM40 36
  • 85.65 (n)
  • 81.74 (a)
TMEM40 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM40 36
  • 86.4 (n)
  • 86.07 (a)
TMEM40 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem40 36
  • 80.42 (n)
  • 78.92 (a)
Tmem40 16
Tmem40 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM40 37
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem40 36
  • 75.58 (n)
  • 71.78 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM40 37
  • 43 (a)
OneToOne
Species with no ortholog for TMEM40:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM40 Gene

ENSEMBL:
Gene Tree for TMEM40 (if available)
TreeFam:
Gene Tree for TMEM40 (if available)

Paralogs for TMEM40 Gene

No data available for Paralogs for TMEM40 Gene

Variants for TMEM40 Gene

Sequence variations from dbSNP and Humsavar for TMEM40 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs937915 -- 12,749,673(-) GCTCA(A/G)CTCAC intron-variant
rs1003080 -- 12,770,129(+) TAACA(C/T)GCCTT upstream-variant-2KB
rs1467025 -- 12,747,439(-) TCTCA(C/T)AGCAA intron-variant
rs2055740 -- 12,749,510(-) TTGGG(C/T)TGGCA intron-variant
rs2271209 -- 12,737,910(-) GACAG(C/T)ACCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM40 Gene

Variant ID Type Subtype PubMed ID
dgv810e201 CNV Deletion 23290073
dgv850e199 CNV Deletion 23128226
nsv7351 OTHER Inversion 18451855
esv2751977 CNV Gain 17911159
dgv597n27 CNV Gain 19166990
nsv470394 CNV Gain 18288195
nsv460434 CNV Loss 19166990
nsv821993 CNV Loss 20364138
nsv821994 CNV Gain 20364138
nsv818127 CNV Gain 17921354

Relevant External Links for TMEM40 Gene

HapMap Linkage Disequilibrium report
TMEM40

Disorders for TMEM40 Gene

No disorders were found for TMEM40 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM40 Gene

Publications for TMEM40 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PMID: 17192395) Macaulay I.C. … Ouwehand W.H. (Blood 2007) 3

Products for TMEM40 Gene

Sources for TMEM40 Gene

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