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Aliases for TMEM39B Gene

Aliases for TMEM39B Gene

  • Transmembrane Protein 39B 2 3

External Ids for TMEM39B Gene

Previous GeneCards Identifiers for TMEM39B Gene

  • GC01P032207
  • GC01P032310
  • GC01P032537
  • GC01P030655

Summaries for TMEM39B Gene

GeneCards Summary for TMEM39B Gene

TMEM39B (Transmembrane Protein 39B) is a Protein Coding gene. An important paralog of this gene is TMEM39A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM39B Gene

Genomics for TMEM39B Gene

Regulatory Elements for TMEM39B Gene

Genomic Location for TMEM39B Gene

Start:
32,072,031 bp from pter
End:
32,102,866 bp from pter
Size:
30,836 bases
Orientation:
Plus strand

Genomic View for TMEM39B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM39B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM39B Gene

Proteins for TMEM39B Gene

  • Protein details for TMEM39B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZU3-TM39B_HUMAN
    Recommended name:
    Transmembrane protein 39B
    Protein Accession:
    Q9GZU3
    Secondary Accessions:
    • B4DKN8
    • B4DQE6
    • B4DTN8
    • D3DPP4
    • Q6IA44

    Protein attributes for TMEM39B Gene

    Size:
    492 amino acids
    Molecular mass:
    56274 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM39B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM39B Gene

Proteomics data for TMEM39B Gene at MOPED

Post-translational modifications for TMEM39B Gene

  • Ubiquitination at Lys234 and Lys475
  • Glycosylation at Asn8
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM39B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM39B Gene

Domains for TMEM39B Gene

Protein Domains for TMEM39B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9GZU3

UniProtKB/Swiss-Prot:

TM39B_HUMAN :
  • Q9GZU3
Family:
  • Belongs to the TMEM39 family.
genes like me logo Genes that share domains with TMEM39B: view

No data available for Gene Families for TMEM39B Gene

Function for TMEM39B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM39B Gene

Localization for TMEM39B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM39B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM39B Gene COMPARTMENTS Subcellular localization image for TMEM39B gene
Compartment Confidence
plasma membrane 3
peroxisome 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TMEM39B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM39B: view

Pathways for TMEM39B Gene

SuperPathways for TMEM39B Gene

No Data Available

Interacting Proteins for TMEM39B Gene

Gene Ontology (GO) - Biological Process for TMEM39B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
genes like me logo Genes that share ontologies with TMEM39B: view

No data available for Pathways by source for TMEM39B Gene

Transcripts for TMEM39B Gene

Unigene Clusters for TMEM39B Gene

Transmembrane protein 39B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM39B Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ·
SP1: - - - - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - -
SP8: - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - -
SP13: - - - -
SP14: - - - -
SP15: -
SP16: -

ExUns: 11c ^ 12a · 12b ^ 13 ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for TMEM39B Gene

GeneLoc Exon Structure for
TMEM39B
ECgene alternative splicing isoforms for
TMEM39B

Expression for TMEM39B Gene

mRNA expression in normal human tissues for TMEM39B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMEM39B Gene

SOURCE GeneReport for Unigene cluster for TMEM39B Gene Hs.25544

genes like me logo Genes that share expressions with TMEM39B: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM39B Gene

Orthologs for TMEM39B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM39B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM39B 35
  • 99.93 (n)
  • 100 (a)
TMEM39B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM39B 35
  • 93.36 (n)
  • 97.56 (a)
TMEM39B 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM39B 35
  • 93.77 (n)
  • 98.58 (a)
TMEM39B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem39b 35
  • 91.87 (n)
  • 96.14 (a)
Tmem39b 16
Tmem39b 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM39B 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM39B 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem39b 35
  • 91.12 (n)
  • 95.93 (a)
chicken
(Gallus gallus)
Aves TMEM39B 35
  • 77.34 (n)
  • 84.19 (a)
TMEM39B 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM39B 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4712 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15850 35
tmem39b 35
  • 70.08 (n)
  • 76.41 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6164 35
zebrafish
(Danio rerio)
Actinopterygii tmem39b 35
  • 67.85 (n)
  • 73.96 (a)
tmem39b 36
  • 74 (a)
OneToOne
wufi31h12 35
fruit fly
(Drosophila melanogaster)
Insecta CG13016 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea D1007.5 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for TMEM39B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM39B Gene

ENSEMBL:
Gene Tree for TMEM39B (if available)
TreeFam:
Gene Tree for TMEM39B (if available)

Paralogs for TMEM39B Gene

Paralogs for TMEM39B Gene

Selected SIMAP similar genes for TMEM39B Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TMEM39B: view

Variants for TMEM39B Gene

Sequence variations from dbSNP and Humsavar for TMEM39B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs481679 -- 32,088,928(+) TCTAT(C/G/T)GATCA intron-variant
rs483554 -- 32,089,116(+) agtaa(A/G)tggca intron-variant
rs483584 -- 32,089,132(+) gggaA(A/T)ttttt intron-variant
rs615776 -- 32,081,386(+) cccac(C/T)tcagc intron-variant
rs628836 -- 32,088,867(+) CATTT(A/T)AGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM39B Gene

Variant ID Type Subtype PubMed ID
esv25480 CNV Loss 19812545
esv2674125 CNV Deletion 23128226

Relevant External Links for TMEM39B Gene

HapMap Linkage Disequilibrium report
TMEM39B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM39B Gene

Disorders for TMEM39B Gene

No disorders were found for TMEM39B Gene.

No data available for UniProtKB/Swiss-Prot for TMEM39B Gene

Publications for TMEM39B Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for TMEM39B Gene

Sources for TMEM39B Gene

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