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Aliases for TMEM39B Gene

Aliases for TMEM39B Gene

  • Transmembrane Protein 39B 2 3 5

External Ids for TMEM39B Gene

Previous GeneCards Identifiers for TMEM39B Gene

  • GC01P032207
  • GC01P032310
  • GC01P032537
  • GC01P030655

Summaries for TMEM39B Gene

GeneCards Summary for TMEM39B Gene

TMEM39B (Transmembrane Protein 39B) is a Protein Coding gene. An important paralog of this gene is TMEM39A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM39B Gene

Genomics for TMEM39B Gene

Regulatory Elements for TMEM39B Gene

Enhancers for TMEM39B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM39B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM39B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM39B on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM39B Gene

Chromosome:
1
Start:
32,072,031 bp from pter
End:
32,102,866 bp from pter
Size:
30,836 bases
Orientation:
Plus strand

Genomic View for TMEM39B Gene

Genes around TMEM39B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM39B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM39B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM39B Gene

Proteins for TMEM39B Gene

  • Protein details for TMEM39B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZU3-TM39B_HUMAN
    Recommended name:
    Transmembrane protein 39B
    Protein Accession:
    Q9GZU3
    Secondary Accessions:
    • B4DKN8
    • B4DQE6
    • B4DTN8
    • D3DPP4
    • Q6IA44

    Protein attributes for TMEM39B Gene

    Size:
    492 amino acids
    Molecular mass:
    56274 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM39B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM39B Gene

Proteomics data for TMEM39B Gene at MOPED

Post-translational modifications for TMEM39B Gene

  • Ubiquitination at Lys 234 and Lys 475
  • Glycosylation at Asn 8
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM39B Gene

No data available for DME Specific Peptides for TMEM39B Gene

Domains & Families for TMEM39B Gene

Protein Domains for TMEM39B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9GZU3

UniProtKB/Swiss-Prot:

TM39B_HUMAN :
  • Belongs to the TMEM39 family.
Family:
  • Belongs to the TMEM39 family.
genes like me logo Genes that share domains with TMEM39B: view

No data available for Gene Families for TMEM39B Gene

Function for TMEM39B Gene

genes like me logo Genes that share phenotypes with TMEM39B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM39B Gene

Localization for TMEM39B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM39B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM39B Gene COMPARTMENTS Subcellular localization image for TMEM39B gene
Compartment Confidence
plasma membrane 3
peroxisome 2

No data available for Gene Ontology (GO) - Cellular Components for TMEM39B Gene

Pathways & Interactions for TMEM39B Gene

SuperPathways for TMEM39B Gene

No Data Available

Interacting Proteins for TMEM39B Gene

Gene Ontology (GO) - Biological Process for TMEM39B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
genes like me logo Genes that share ontologies with TMEM39B: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM39B Gene

Drugs & Compounds for TMEM39B Gene

No Compound Related Data Available

Transcripts for TMEM39B Gene

Unigene Clusters for TMEM39B Gene

Transmembrane protein 39B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM39B Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ·
SP1: - - - - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - -
SP8: - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - -
SP13: - - - -
SP14: - - - -
SP15: -
SP16: -

ExUns: 11c ^ 12a · 12b ^ 13 ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for TMEM39B Gene

GeneLoc Exon Structure for
TMEM39B
ECgene alternative splicing isoforms for
TMEM39B

Expression for TMEM39B Gene

mRNA expression in normal human tissues for TMEM39B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM39B Gene

This gene is overexpressed in Synovial fluid (36.6) and Peripheral blood mononuclear cells (25.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM39B Gene



SOURCE GeneReport for Unigene cluster for TMEM39B Gene Hs.25544

genes like me logo Genes that share expression patterns with TMEM39B: view

Protein tissue co-expression partners for TMEM39B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM39B Gene

Orthologs for TMEM39B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM39B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM39B 35
  • 93.36 (n)
  • 97.56 (a)
TMEM39B 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM39B 35
  • 93.77 (n)
  • 98.58 (a)
TMEM39B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem39b 35
  • 91.87 (n)
  • 96.14 (a)
Tmem39b 16
Tmem39b 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM39B 35
  • 99.93 (n)
  • 100 (a)
TMEM39B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem39b 35
  • 91.12 (n)
  • 95.93 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM39B 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM39B 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM39B 35
  • 77.34 (n)
  • 84.19 (a)
TMEM39B 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM39B 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15850 35
tmem39b 35
  • 70.08 (n)
  • 76.41 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4712 35
zebrafish
(Danio rerio)
Actinopterygii tmem39b 35
  • 67.85 (n)
  • 73.96 (a)
wufi31h12 35
tmem39b 36
  • 74 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6164 35
fruit fly
(Drosophila melanogaster)
Insecta CG13016 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea D1007.5 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for TMEM39B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM39B Gene

ENSEMBL:
Gene Tree for TMEM39B (if available)
TreeFam:
Gene Tree for TMEM39B (if available)

Paralogs for TMEM39B Gene

Paralogs for TMEM39B Gene

(1) SIMAP similar genes for TMEM39B Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TMEM39B: view

Variants for TMEM39B Gene

Sequence variations from dbSNP and Humsavar for TMEM39B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs481679 -- 32,088,928(+) TCTAT(C/G/T)GATCA intron-variant
rs483554 -- 32,089,116(+) agtaa(A/G)tggca intron-variant
rs483584 -- 32,089,132(+) gggaA(A/T)ttttt intron-variant
rs484574 -- 32,070,589(-) aaagt(C/T)tacag upstream-variant-2KB
rs615776 -- 32,081,386(+) cccac(C/T)tcagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM39B Gene

Variant ID Type Subtype PubMed ID
esv25480 CNV Loss 19812545
esv2674125 CNV Deletion 23128226

Variation tolerance for TMEM39B Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM39B Gene

HapMap Linkage Disequilibrium report
TMEM39B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM39B Gene

Disorders for TMEM39B Gene

Relevant External Links for TMEM39B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM39B

No disorders were found for TMEM39B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM39B Gene

Publications for TMEM39B Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Quantitative Lys-I/-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. (PMID: 25147182) Thompson J.W. … Luchansky S.J. (J. Biol. Chem. 2014) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for TMEM39B Gene

Sources for TMEM39B Gene

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