Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM39A Gene

Aliases for TMEM39A Gene

  • Transmembrane Protein 39A 2 3 5

External Ids for TMEM39A Gene

Previous GeneCards Identifiers for TMEM39A Gene

  • GC03M120632
  • GC03M119148
  • GC03M116525

Summaries for TMEM39A Gene

GeneCards Summary for TMEM39A Gene

TMEM39A (Transmembrane Protein 39A) is a Protein Coding gene. An important paralog of this gene is TMEM39B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM39A Gene

Genomics for TMEM39A Gene

Regulatory Elements for TMEM39A Gene

Promoters for TMEM39A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM39A on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM39A Gene

Chromosome:
3
Start:
119,428,960 bp from pter
End:
119,468,830 bp from pter
Size:
39,871 bases
Orientation:
Minus strand

Genomic View for TMEM39A Gene

Genes around TMEM39A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM39A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM39A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM39A Gene

Proteins for TMEM39A Gene

  • Protein details for TMEM39A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NV64-TM39A_HUMAN
    Recommended name:
    Transmembrane protein 39A
    Protein Accession:
    Q9NV64
    Secondary Accessions:
    • D3DN80
    • Q53FN4
    • Q53GI1
    • Q6PKB5

    Protein attributes for TMEM39A Gene

    Size:
    488 amino acids
    Molecular mass:
    55667 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM39A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM39A Gene

Proteomics data for TMEM39A Gene at MOPED

Post-translational modifications for TMEM39A Gene

  • Ubiquitination at Lys 358
  • Glycosylation at Asn 31 and Asn 39
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM39A Gene

Domains & Families for TMEM39A Gene

Protein Domains for TMEM39A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM39A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NV64

UniProtKB/Swiss-Prot:

TM39A_HUMAN :
  • Belongs to the TMEM39 family.
Family:
  • Belongs to the TMEM39 family.
genes like me logo Genes that share domains with TMEM39A: view

No data available for Gene Families for TMEM39A Gene

Function for TMEM39A Gene

genes like me logo Genes that share phenotypes with TMEM39A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM39A

CRISPR Products

miRNA for TMEM39A Gene

miRTarBase miRNAs that target TMEM39A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM39A Gene

Localization for TMEM39A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM39A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM39A Gene COMPARTMENTS Subcellular localization image for TMEM39A gene
Compartment Confidence
nucleus 3
plasma membrane 3
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM39A Gene

Pathways & Interactions for TMEM39A Gene

SuperPathways for TMEM39A Gene

No Data Available

Interacting Proteins for TMEM39A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000326063%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q9NV64-TM39A_HUMAN ENSP00000326063 for TMEM39A Gene via I2D STRING

Gene Ontology (GO) - Biological Process for TMEM39A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
genes like me logo Genes that share ontologies with TMEM39A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM39A Gene

Drugs & Compounds for TMEM39A Gene

No Compound Related Data Available

Transcripts for TMEM39A Gene

Unigene Clusters for TMEM39A Gene

Transmembrane protein 39A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM39A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: -
SP2: - -
SP3: -
SP4: - - - -
SP5: - -
SP6: -
SP7: -
SP8: - - - - - - -
SP9: - -
SP10:

Relevant External Links for TMEM39A Gene

GeneLoc Exon Structure for
TMEM39A
ECgene alternative splicing isoforms for
TMEM39A

Expression for TMEM39A Gene

mRNA expression in normal human tissues for TMEM39A Gene

Protein differential expression in normal tissues from HIPED for TMEM39A Gene

This gene is overexpressed in Lung (48.9) and Placenta (20.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TMEM39A Gene



SOURCE GeneReport for Unigene cluster for TMEM39A Gene Hs.594171

genes like me logo Genes that share expression patterns with TMEM39A: view

Protein tissue co-expression partners for TMEM39A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM39A Gene

Orthologs for TMEM39A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM39A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM39A 36
  • 100 (a)
OneToOne
TMEM39A 35
  • 99.8 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia TMEM39A 35
  • 93.78 (n)
  • 98.57 (a)
TMEM39A 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM39A 36
  • 99 (a)
OneToOne
TMEM39A 35
  • 94.81 (n)
  • 99.39 (a)
mouse
(Mus musculus)
Mammalia Tmem39a 36
  • 95 (a)
OneToOne
Tmem39a 16
Tmem39a 35
  • 90.12 (n)
  • 95.47 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM39A 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem39a 35
  • 89.24 (n)
  • 94.13 (a)
chicken
(Gallus gallus)
Aves TMEM39A 35
  • 80.85 (n)
  • 91.12 (a)
TMEM39A 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM39A 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11343 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10539 35
tmem39a 35
  • 76.2 (n)
  • 86.01 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem39a 36
  • 72 (a)
OneToOne
tmem39a 35
  • 66.53 (n)
  • 72.63 (a)
wufb92e03 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011817 35
  • 44.16 (n)
  • 33.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13016 36
  • 28 (a)
OneToMany
CG13016 35
  • 44 (n)
  • 32.53 (a)
worm
(Caenorhabditis elegans)
Secernentea D1007.5 35
  • 43.71 (n)
  • 33.33 (a)
D1007.5 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for TMEM39A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM39A Gene

ENSEMBL:
Gene Tree for TMEM39A (if available)
TreeFam:
Gene Tree for TMEM39A (if available)

Paralogs for TMEM39A Gene

Paralogs for TMEM39A Gene

(1) SIMAP similar genes for TMEM39A Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TMEM39A: view

Variants for TMEM39A Gene

Sequence variations from dbSNP and Humsavar for TMEM39A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1132200 - 119,431,989(-) TCAAG(A/G)CAAAC nc-transcript-variant, reference, missense, utr-variant-3-prime
VAR_036095 A breast cancer sample
rs9688 -- 119,430,859(+) GCACA(G/T)AAAAC nc-transcript-variant, utr-variant-3-prime
rs1919586 -- 119,452,433(-) TCATT(C/G)ACTAT intron-variant
rs1919590 -- 119,441,576(+) agttc(A/G)tgagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM39A Gene

Variant ID Type Subtype PubMed ID
nsv829694 CNV Gain 17160897
esv2725823 CNV Deletion 23290073
nsv829695 CNV Loss 17160897

Variation tolerance for TMEM39A Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.52; 71.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM39A Gene

HapMap Linkage Disequilibrium report
TMEM39A
Human Gene Mutation Database (HGMD)
TMEM39A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM39A Gene

Disorders for TMEM39A Gene

Relevant External Links for TMEM39A

Genetic Association Database (GAD)
TMEM39A
Human Genome Epidemiology (HuGE) Navigator
TMEM39A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM39A

No disorders were found for TMEM39A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM39A Gene

Publications for TMEM39A Gene

  1. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. (PMID: 24823311) Guan W. … Steffen L.M. (Circ Cardiovasc Genet 2014) 3
  5. Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study. (PMID: 22464253) Lessard C.J. … . (Am. J. Hum. Genet. 2012) 3

Products for TMEM39A Gene

Sources for TMEM39A Gene

Back to Top

Content