TMEM39A Gene
protein-coding GIFtS: 46
GCID: GC03M119148
|
|
transmembrane protein 39A
| |
Aliases
for TMEM39A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 39A1 2 | | FLJ109021 |
Export aliases for TMEM39A gene to outside databasesPrevious GC identifers: GC03M120632 GC03M116525 |
Summaries
for TMEM39A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM39A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM39A gene promoter:
AML1a HTF STAT1beta AP-4 YY1 AREB6 S8 POU2F1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM39A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM39A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q13.33 Ensembl cytogenetic band: 3q13.33 HGNC cytogenetic band: 3q13.33TMEM39A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M119148: view genomic region
(about GC identifiers)
Start:
|
119,148,347 bp from pter |
End:
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119,187,677 bp from pter |
Size:
|
39,331 bases |
Orientation:
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minus strand |
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Proteins
for TMEM39A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM39A_HUMAN, Q9NV64 (See
protein sequence)Recommended Name: Transmembrane protein 39A Size: 488 amino acids; 55667 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: D3DN80 Q53FN4 Q53GI1 Q6PKB5Alternative splicing: 2 isoforms: Q9NV64-1 Q9NV64-2 Explore the universe of human proteins at neXtProt for TMEM39A: NX_Q9NV64
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NV64
TMEM39A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060736.1
ENSEMBL proteins: ENSP00000420432 ENSP00000402149 ENSP00000326063 ENSP00000419641 ENSP00000418796 ENSP00000417233 ENSP00000419405 ENSP00000419068
Human Recombinant Protein Products for TMEM39A:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM39A for ontologies About GeneDecksing
TMEM39A Antibody Products:
Assay Products for TMEM39A: |
Protein
Domains /
Families
for TMEM39A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM39A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NV64ProtoNet protein and cluster: Q9NV64 UniProtKB/Swiss-Prot: TM39A_HUMAN, Q9NV64Similarity: Belongs to the TMEM39 family |
Function
for TMEM39A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 GenomeRNAi human phenotype for TMEM39A:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM39A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM39A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM39A (NM_018266) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM39A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM39A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM39A |
|
Pathways & Interactions
for TMEM39A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM39A
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for TMEM39A (Q9NV643 ENSP000003260634) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TMEM39A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM39A
Search CenterWatch for drugs/clinical trials and news about TMEM39A / TM39A
|
Transcripts
for TMEM39A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM39A gene: NM_018266.2 Unigene Cluster for TMEM39A: Transmembrane protein 39A Hs.594171 [show with all ESTs]Unigene Representative Sequence: NR_07350612 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000473684 ENST00000438581(uc003ecl.1) ENST00000319172(uc003eck.1)
ENST00000468545 ENST00000491685 ENST00000486159 ENST00000486235 ENST00000468676
ENST00000490099 ENST00000497993 ENST00000482162 ENST00000461654
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM39A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM39A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM39A (NM_018266) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM39A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM39A |
Additional cDNA sequence: AK001764.1 AK092064.1 AK222950.1 AK223248.1 BC003192.1 BC010070.2 BC021277.2 NR_073506.1 10 DOTS entries: DT.214439 DT.99987617 DT.102831309 DT.100641272 DT.120849913 DT.214441 DT.214443 DT.120849905 DT.422133 DT.100777787 24/164 AceView cDNA sequences (see all 164): BM932280 AI378909 AI129100 BQ053549 BP372073 AA709227 BC010070 AI804471 BX119597 CA414932 AI431734 NM_018266 AL561639 AW769185 BP341984 AI753393 BC021277 AI206500 BQ574359 AI634728 AA554709 BX100266 H01940 BI819547
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM39A (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | |
ECgene alternative splicing isoforms for TMEM39A
|
Expression
for TMEM39A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM39A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTAGTATA
About this image
See TMEM39A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM39A
SOURCE GeneReport for Unigene cluster: Hs.594171
SABiosciences Custom PCR Arrays for TMEM39A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM39A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM39A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM39A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM39A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM39A |
Orthologs
for TMEM39A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM39A gene from 7/20 species (see all 20) About this table
ENSEMBL Gene Tree for TMEM39A (if available)
TreeFam Gene Tree for TMEM39A (if available) |
Paralogs
for TMEM39A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM39A gene
- TMEM39B2
1 SIMAP similar gene for TMEM39A using alignment to 7 protein entries: TM39A_HUMAN (see all proteins):TMEM39B
TMEM39A for paralogs About GeneDecksing
|
Genomic Variants
for TMEM39A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM39A (119148347 - 119187677 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM39A: --
Human Gene Mutation Database (HGMD): TMEM39A
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM39A |
|
Disorders
/ Diseases
for TMEM39A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM39A for disorders About GeneDecksing
1  disease for TMEM39A: About MalaCardsmultiple sclerosis
Human Genome Epidemiology (HuGE) Navigator: TMEM39A (3 documents)
Export disorders for TMEM39A gene to outside databases
|
Publications
for TMEM39A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM39A gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with TMEM39A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as su sceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study. (PubMed id 22464253)1 Lessard C.J.... . (2012)
- Replication study of 10 genes showing evidence for ass ociation with multiple sclerosis: validation of TMEM39A, IL12B and CBLB [correct ion of CLBL] genes. (PubMed id 22194214)1 Varade J....Urcelay E. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)1 ....Compston A. (2011)
- Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1 Oguri M....Yamada Y. (2010)
- Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1 Yoshida T....Yamada Y. (2010)
- Comprehensive follow-up of the first genome-wide asso ciation study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibi lity loci. (PubMed id 20007504)1 (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
|
External Searches for TMEM39A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM39A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM39A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM39A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM39A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM39A gene:
Search GeneIP for patents involving TMEM39A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM39A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM39A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM39A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM39A | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM39A | | OriGene 3'-UTR Clone for TMEM39A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM39A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM39A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM39A | | OriGene Custom Protein Services for TMEM39A | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM39A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM39A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM39A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM39A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM39A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM39A |
| |
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| | | | Search Tocris compounds for TMEM39A |
| |  |  |  |  | | | | |
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 | | | TMEM39A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM39A |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TMEM39A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM39A |
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