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Aliases for TMEM38A Gene

Aliases for TMEM38A Gene

  • Transmembrane Protein 38A 2 3 4 5
  • TRIC-A 3 4
  • TRICA 3 4
  • Trimeric Intracellular Cation Channel Type A 3

External Ids for TMEM38A Gene

Previous GeneCards Identifiers for TMEM38A Gene

  • GC19P016633
  • GC19P016771
  • GC19P016340

Summaries for TMEM38A Gene

GeneCards Summary for TMEM38A Gene

TMEM38A (Transmembrane Protein 38A) is a Protein Coding gene. GO annotations related to this gene include potassium channel activity and cation channel activity. An important paralog of this gene is TMEM38B.

UniProtKB/Swiss-Prot for TMEM38A Gene

  • Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

Additional gene information for TMEM38A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM38A Gene

Genomics for TMEM38A Gene

Regulatory Elements for TMEM38A Gene

Enhancers for TMEM38A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H016568 1.4 ENCODE dbSUPER 22.5 -88.9 -88936 7 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 C19orf44 CHERP TMEM38A SIN3B ENSG00000268743 LOC100507551 RN7SL146P ENSG00000141979 ENSG00000269578 SMIM7
GH19H016658 1.1 ENCODE 24.6 -0.5 -517 3 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 CHERP ENSG00000268743 ENSG00000269578 C19orf44 MED26 HAUS8 TMEM38A SMIM7 COLGALT1 ENSG00000268087
GH19H016607 1.4 Ensembl ENCODE dbSUPER 12 -52.8 -52773 1 PKNOX1 ARNT INSM2 FEZF1 ZNF2 RAD21 ZNF366 ZSCAN5C RUNX3 ZNF362 C19orf44 EPS15L1 MED26 CALR3 SLC35E1 TMEM38A SMIM7 CHERP RN7SL146P CPAMD8
GH19H016626 1.4 ENCODE dbSUPER 11.1 -32.6 -32611 4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207 SMIM7 C19orf44 LINC00905 LINC01855 OR1AB1P OR10H5 OR10H2 SLC35E1 TMEM38A ENSG00000269044
GH19H016676 0.6 Ensembl 24.2 +15.4 15374 0 IRF2 FOXA2 SAP130 CEBPA CEBPB CEBPG NR2F6 YY1 TMEM38A CPAMD8 GC19P019917 GC19P019880
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM38A on UCSC Golden Path with GeneCards custom track

Promoters for TMEM38A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107790 -427 2601 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for TMEM38A Gene

Chromosome:
19
Start:
16,661,127 bp from pter
End:
16,690,029 bp from pter
Size:
28,903 bases
Orientation:
Plus strand

Genomic View for TMEM38A Gene

Genes around TMEM38A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM38A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM38A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM38A Gene

Proteins for TMEM38A Gene

  • Protein details for TMEM38A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6F2-TM38A_HUMAN
    Recommended name:
    Trimeric intracellular cation channel type A
    Protein Accession:
    Q9H6F2
    Secondary Accessions:
    • A8K9P9

    Protein attributes for TMEM38A Gene

    Size:
    299 amino acids
    Molecular mass:
    33260 Da
    Quaternary structure:
    • Homotrimer; trimerization probably requires binding to phosphatidylinositol 4,5-bisphosphate (PIP2).

neXtProt entry for TMEM38A Gene

Post-translational modifications for TMEM38A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM38A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for TMEM38A
  • Santa Cruz Biotechnology (SCBT) Antibodies for TMEM38A

No data available for DME Specific Peptides for TMEM38A Gene

Domains & Families for TMEM38A Gene

Gene Families for TMEM38A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM38A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM38A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6F2

UniProtKB/Swiss-Prot:

TM38A_HUMAN :
  • Belongs to the TMEM38 family.
Family:
  • Belongs to the TMEM38 family.
genes like me logo Genes that share domains with TMEM38A: view

Function for TMEM38A Gene

Molecular function for TMEM38A Gene

UniProtKB/Swiss-Prot Function:
Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

Phenotypes From GWAS Catalog for TMEM38A Gene

Gene Ontology (GO) - Molecular Function for TMEM38A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005267 potassium channel activity TAS 19095005
GO:0015269 calcium-activated potassium channel activity IBA --
genes like me logo Genes that share ontologies with TMEM38A: view

Phenotypes for TMEM38A Gene

genes like me logo Genes that share phenotypes with TMEM38A: view

Animal Models for TMEM38A Gene

MGI Knock Outs for TMEM38A:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM38A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM38A Gene

Localization for TMEM38A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM38A Gene

Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM38A gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
nucleus 4
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM38A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016529 sarcoplasmic reticulum IEA --
GO:0031965 nuclear membrane NAS 19095005
genes like me logo Genes that share ontologies with TMEM38A: view

Pathways & Interactions for TMEM38A Gene

SuperPathways for TMEM38A Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM38A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA --
GO:0015672 monovalent inorganic cation transport IEA --
GO:0071805 potassium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with TMEM38A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM38A Gene

Drugs & Compounds for TMEM38A Gene

(1) Drugs for TMEM38A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with TMEM38A: view

Transcripts for TMEM38A Gene

mRNA/cDNA for TMEM38A Gene

Unigene Clusters for TMEM38A Gene

Transmembrane protein 38A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM38A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM38A Gene

No ASD Table

Relevant External Links for TMEM38A Gene

GeneLoc Exon Structure for
TMEM38A
ECgene alternative splicing isoforms for
TMEM38A

Expression for TMEM38A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM38A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM38A Gene

This gene is overexpressed in Muscle - Skeletal (x21.6).

Protein differential expression in normal tissues from HIPED for TMEM38A Gene

This gene is overexpressed in Heart (25.1), Breast (18.9), Esophagus (10.3), and Frontal cortex (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM38A Gene



Protein tissue co-expression partners for TMEM38A Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM38A Gene:

TMEM38A

SOURCE GeneReport for Unigene cluster for TMEM38A Gene:

Hs.436068

Evidence on tissue expression from TISSUES for TMEM38A Gene

  • Eye(4.1)
  • Muscle(3)
genes like me logo Genes that share expression patterns with TMEM38A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM38A Gene

Orthologs for TMEM38A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM38A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM38A 33 34
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia TMEM38A 33 34
  • 91.42 (n)
cow
(Bos Taurus)
Mammalia TMEM38A 33 34
  • 91.19 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM38A 34
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem38a 33 16 34
  • 85.57 (n)
rat
(Rattus norvegicus)
Mammalia Tmem38a 33
  • 84.51 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM38A 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM38A 33 34
  • 73.31 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem38a 33
  • 70.8 (n)
MGC75707 33
African clawed frog
(Xenopus laevis)
Amphibia MGC53433 33
zebrafish
(Danio rerio)
Actinopterygii tmem38a 33 34
  • 69.04 (n)
zgc77831 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.371 33
fruit fly
(Drosophila melanogaster)
Insecta CG4239 34
  • 35 (a)
ManyToMany
CG33061 34
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y57A10A.10 34
  • 29 (a)
ManyToMany
Y57A10A.28 34
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8498 34
  • 28 (a)
OneToMany
Species where no ortholog for TMEM38A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM38A Gene

ENSEMBL:
Gene Tree for TMEM38A (if available)
TreeFam:
Gene Tree for TMEM38A (if available)

Paralogs for TMEM38A Gene

Paralogs for TMEM38A Gene

(1) SIMAP similar genes for TMEM38A Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TMEM38A Gene

genes like me logo Genes that share paralogs with TMEM38A: view

Variants for TMEM38A Gene

Sequence variations from dbSNP and Humsavar for TMEM38A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000013406 -- 16,685,032(+) TGATA(G/T)AGAGA intron-variant
rs1000135279 -- 16,662,033(+) GGGTA(C/T)AGCCT intron-variant, upstream-variant-2KB
rs1000402060 -- 16,661,759(+) CGCCA(A/G)CGGAG intron-variant, upstream-variant-2KB
rs1000445827 -- 16,663,855(+) AAACC(C/T)CCTAT intron-variant
rs1000820926 -- 16,684,969(+) ACTTG(A/T)GCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM38A Gene

Variant ID Type Subtype PubMed ID
esv2669434 CNV deletion 23128226
esv3556105 CNV deletion 23714750
nsv1118360 CNV deletion 24896259
nsv1135850 CNV deletion 24896259

Variation tolerance for TMEM38A Gene

Residual Variation Intolerance Score: 39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM38A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM38A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM38A Gene

Disorders for TMEM38A Gene

Relevant External Links for TMEM38A

Genetic Association Database (GAD)
TMEM38A
Human Genome Epidemiology (HuGE) Navigator
TMEM38A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM38A

No disorders were found for TMEM38A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM38A Gene

Publications for TMEM38A Gene

  1. TRIC channels are essential for Ca2+ handling in intracellular stores. (PMID: 17611541) Yazawa M … Takeshima H (Nature 2007) 2 3 4 60
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for TMEM38A Gene

Sources for TMEM38A Gene

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