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Aliases for TMEM38A Gene

Aliases for TMEM38A Gene

  • Transmembrane Protein 38A 2 3 4 5
  • TRIC-A 3 4
  • TRICA 3 4

External Ids for TMEM38A Gene

Previous GeneCards Identifiers for TMEM38A Gene

  • GC19P016633
  • GC19P016771
  • GC19P016340

Summaries for TMEM38A Gene

GeneCards Summary for TMEM38A Gene

TMEM38A (Transmembrane Protein 38A) is a Protein Coding gene. GO annotations related to this gene include potassium channel activity and cation channel activity. An important paralog of this gene is TMEM38B.

UniProtKB/Swiss-Prot for TMEM38A Gene

  • Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM38A Gene

Genomics for TMEM38A Gene

Regulatory Elements for TMEM38A Gene

Enhancers for TMEM38A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM38A on UCSC Golden Path with GeneCards custom track

Promoters for TMEM38A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM38A on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM38A Gene

Chromosome:
19
Start:
16,661,127 bp from pter
End:
16,690,029 bp from pter
Size:
28,903 bases
Orientation:
Plus strand

Genomic View for TMEM38A Gene

Genes around TMEM38A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM38A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM38A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM38A Gene

Proteins for TMEM38A Gene

  • Protein details for TMEM38A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6F2-TM38A_HUMAN
    Recommended name:
    Trimeric intracellular cation channel type A
    Protein Accession:
    Q9H6F2
    Secondary Accessions:
    • A8K9P9

    Protein attributes for TMEM38A Gene

    Size:
    299 amino acids
    Molecular mass:
    33260 Da
    Quaternary structure:
    • Homotrimer.

neXtProt entry for TMEM38A Gene

Proteomics data for TMEM38A Gene at MOPED

Post-translational modifications for TMEM38A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM38A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TMEM38A Gene

Domains & Families for TMEM38A Gene

Protein Domains for TMEM38A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM38A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6F2

UniProtKB/Swiss-Prot:

TM38A_HUMAN :
  • The second transmembrane domain has been proposed to cross only half of the lipid bilayer and to loop back into the cytosol, so that the domains on each side of this domain are both found on the cytosolic face of the membrane. The cytosolic loop may form an ion-conducting pore.
  • Belongs to the TMEM38 family.
Domain:
  • The second transmembrane domain has been proposed to cross only half of the lipid bilayer and to loop back into the cytosol, so that the domains on each side of this domain are both found on the cytosolic face of the membrane. The cytosolic loop may form an ion-conducting pore.
Family:
  • Belongs to the TMEM38 family.
genes like me logo Genes that share domains with TMEM38A: view

No data available for Gene Families for TMEM38A Gene

Function for TMEM38A Gene

Molecular function for TMEM38A Gene

UniProtKB/Swiss-Prot Function:
Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity).

Phenotypes for TMEM38A Gene

genes like me logo Genes that share phenotypes with TMEM38A: view

Animal Models for TMEM38A Gene

MGI Knock Outs for TMEM38A:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM38A Gene

Localization for TMEM38A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM38A Gene

Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM38A Gene COMPARTMENTS Subcellular localization image for TMEM38A gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
nucleus 4
plasma membrane 3
cytosol 1

Gene Ontology (GO) - Cellular Components for TMEM38A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TMEM38A: view

Pathways & Interactions for TMEM38A Gene

SuperPathways for TMEM38A Gene

No Data Available

Interacting Proteins for TMEM38A Gene

Gene Ontology (GO) - Biological Process for TMEM38A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with TMEM38A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM38A Gene

Drugs & Compounds for TMEM38A Gene

(1) Drugs for TMEM38A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with TMEM38A: view

Transcripts for TMEM38A Gene

mRNA/cDNA for TMEM38A Gene

Unigene Clusters for TMEM38A Gene

Transmembrane protein 38A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM38A Gene

No ASD Table

Relevant External Links for TMEM38A Gene

GeneLoc Exon Structure for
TMEM38A
ECgene alternative splicing isoforms for
TMEM38A

Expression for TMEM38A Gene

mRNA expression in normal human tissues for TMEM38A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM38A Gene

This gene is overexpressed in Muscle - Skeletal (x21.6).

Protein differential expression in normal tissues from HIPED for TMEM38A Gene

This gene is overexpressed in Heart (25.1), Breast (18.9), Esophagus (10.3), and Frontal cortex (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM38A Gene



SOURCE GeneReport for Unigene cluster for TMEM38A Gene Hs.436068

genes like me logo Genes that share expression patterns with TMEM38A: view

Protein tissue co-expression partners for TMEM38A Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM38A Gene

Orthologs for TMEM38A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM38A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM38A 35
  • 91.19 (n)
  • 93.65 (a)
TMEM38A 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM38A 35
  • 91.42 (n)
  • 95.65 (a)
TMEM38A 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem38a 35
  • 85.57 (n)
  • 90.6 (a)
Tmem38a 16
Tmem38a 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM38A 35
  • 99.44 (n)
  • 99.33 (a)
TMEM38A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem38a 35
  • 84.51 (n)
  • 89.23 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM38A 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM38A 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM38A 35
  • 73.31 (n)
  • 75.34 (a)
TMEM38A 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75707 35
tmem38a 35
  • 70.8 (n)
  • 74.83 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53433 35
zebrafish
(Danio rerio)
Actinopterygii tmem38a 35
  • 69.04 (n)
  • 71.53 (a)
zgc77831 35
tmem38a 36
  • 72 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.371 35
fruit fly
(Drosophila melanogaster)
Insecta CG33061 36
  • 23 (a)
ManyToMany
CG4239 36
  • 35 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y57A10A.10 36
  • 29 (a)
ManyToMany
Y57A10A.28 36
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8498 36
  • 28 (a)
OneToMany
Species with no ortholog for TMEM38A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM38A Gene

ENSEMBL:
Gene Tree for TMEM38A (if available)
TreeFam:
Gene Tree for TMEM38A (if available)

Paralogs for TMEM38A Gene

Paralogs for TMEM38A Gene

(1) SIMAP similar genes for TMEM38A Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TMEM38A Gene

genes like me logo Genes that share paralogs with TMEM38A: view

Variants for TMEM38A Gene

Sequence variations from dbSNP and Humsavar for TMEM38A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7257953 -- 16,682,744(+) AGGGT(G/T)AGCAG intron-variant
rs7259112 -- 16,667,216(+) gtgag(C/T)cgaga intron-variant
rs7259569 -- 16,682,891(+) GGAGC(A/G)TATCT intron-variant
rs7260025 -- 16,669,813(+) TCTAG(C/T)ACCAC intron-variant
rs7359919 -- 16,662,869(+) TTACT(G/T)TGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM38A Gene

Variant ID Type Subtype PubMed ID
esv2669434 CNV Deletion 23128226

Variation tolerance for TMEM38A Gene

Residual Variation Intolerance Score: 39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.60% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM38A Gene

Disorders for TMEM38A Gene

Relevant External Links for TMEM38A

Genetic Association Database (GAD)
TMEM38A
Human Genome Epidemiology (HuGE) Navigator
TMEM38A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM38A

No disorders were found for TMEM38A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM38A Gene

Publications for TMEM38A Gene

  1. TRIC channels are essential for Ca2+ handling in intracellular stores. (PMID: 17611541) Yazawa M. … Takeshima H. (Nature 2007) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  5. New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes. (PMID: 19095005) Yamazaki D. … Takeshima H. (Pharmacol. Ther. 2009) 3

Products for TMEM38A Gene

Sources for TMEM38A Gene

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