Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM38A Gene

Aliases for TMEM38A Gene

  • Transmembrane Protein 38A 2 3 4
  • TRIC-A 3 4
  • TRICA 3 4
  • Trimeric Intracellular Cation Channel Type A 3

External Ids for TMEM38A Gene

Previous GeneCards Identifiers for TMEM38A Gene

  • GC19P016633
  • GC19P016771
  • GC19P016340

Summaries for TMEM38A Gene

GeneCards Summary for TMEM38A Gene

TMEM38A (Transmembrane Protein 38A) is a Protein Coding gene. GO annotations related to this gene include potassium channel activity. An important paralog of this gene is TMEM38B.

UniProtKB/Swiss-Prot for TMEM38A Gene

  • Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM38A Gene

Genomics for TMEM38A Gene

Regulatory Elements for TMEM38A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM38A Gene

Start:
16,661,127 bp from pter
End:
16,690,029 bp from pter
Size:
28,903 bases
Orientation:
Plus strand

Genomic View for TMEM38A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM38A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM38A Gene

Proteins for TMEM38A Gene

  • Protein details for TMEM38A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6F2-TM38A_HUMAN
    Recommended name:
    Trimeric intracellular cation channel type A
    Protein Accession:
    Q9H6F2
    Secondary Accessions:
    • A8K9P9

    Protein attributes for TMEM38A Gene

    Size:
    299 amino acids
    Molecular mass:
    33260 Da
    Quaternary structure:
    • Homotrimer.

neXtProt entry for TMEM38A Gene

Proteomics data for TMEM38A Gene at MOPED

Post-translational modifications for TMEM38A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM38A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TMEM38A Gene

Domains for TMEM38A Gene

Protein Domains for TMEM38A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM38A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6F2

UniProtKB/Swiss-Prot:

TM38A_HUMAN :
  • Q9H6F2
Domain:
  • The second transmembrane domain has been proposed to cross only half of the lipid bilayer and to loop back into the cytosol, so that the domains on each side of this domain are both found on the cytosolic face of the membrane. The cytosolic loop may form an ion-conducting pore
Family:
  • Belongs to the TMEM38 family.
genes like me logo Genes that share domains with TMEM38A: view

No data available for Gene Families for TMEM38A Gene

Function for TMEM38A Gene

Molecular function for TMEM38A Gene

UniProtKB/Swiss-Prot Function: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity).

Gene Ontology (GO) - Molecular Function for TMEM38A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005261 cation channel activity --
GO:0005267 potassium channel activity TAS 19095005
genes like me logo Genes that share ontologies with TMEM38A: view

Phenotypes for TMEM38A Gene

genes like me logo Genes that share phenotypes with TMEM38A: view

Animal Models for TMEM38A Gene

MGI Knock Outs for TMEM38A:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM38A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM38A Gene

Localization for TMEM38A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM38A Gene

Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM38A Gene COMPARTMENTS Subcellular localization image for TMEM38A gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 4
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TMEM38A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane NAS 19095005
GO:0033017 sarcoplasmic reticulum membrane NAS 19095005
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TMEM38A: view

Pathways for TMEM38A Gene

SuperPathways for TMEM38A Gene

No Data Available

Interacting Proteins for TMEM38A Gene

Gene Ontology (GO) - Biological Process for TMEM38A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015672 monovalent inorganic cation transport --
GO:0071805 potassium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with TMEM38A: view

No data available for Pathways by source for TMEM38A Gene

Compounds for TMEM38A Gene

(1) HMDB Compounds for TMEM38A Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with TMEM38A: view

Transcripts for TMEM38A Gene

mRNA/cDNA for TMEM38A Gene

(80) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM38A Gene

Transmembrane protein 38A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM38A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM38A Gene

No ASD Table

Relevant External Links for TMEM38A Gene

GeneLoc Exon Structure for
TMEM38A
ECgene alternative splicing isoforms for
TMEM38A

Expression for TMEM38A Gene

mRNA expression in normal human tissues for TMEM38A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM38A Gene

This gene is overexpressed in Muscle - Skeletal (21.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMEM38A Gene

SOURCE GeneReport for Unigene cluster for TMEM38A Gene Hs.436068

genes like me logo Genes that share expressions with TMEM38A: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM38A Gene

Orthologs for TMEM38A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM38A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM38A 35
  • 99.44 (n)
  • 99.33 (a)
TMEM38A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM38A 35
  • 91.19 (n)
  • 93.65 (a)
TMEM38A 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM38A 35
  • 91.42 (n)
  • 95.65 (a)
TMEM38A 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem38a 35
  • 85.57 (n)
  • 90.6 (a)
Tmem38a 16
Tmem38a 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM38A 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM38A 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem38a 35
  • 84.51 (n)
  • 89.23 (a)
chicken
(Gallus gallus)
Aves TMEM38A 35
  • 73.31 (n)
  • 75.34 (a)
TMEM38A 36
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53433 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75707 35
tmem38a 35
  • 70.8 (n)
  • 74.83 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.371 35
zebrafish
(Danio rerio)
Actinopterygii tmem38a 35
  • 69.04 (n)
  • 71.53 (a)
tmem38a 36
  • 72 (a)
OneToOne
zgc77831 35
fruit fly
(Drosophila melanogaster)
Insecta CG33061 36
  • 23 (a)
ManyToMany
CG4239 36
  • 35 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y57A10A.10 36
  • 29 (a)
ManyToMany
Y57A10A.28 36
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8498 36
  • 28 (a)
OneToMany
Species with no ortholog for TMEM38A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM38A Gene

ENSEMBL:
Gene Tree for TMEM38A (if available)
TreeFam:
Gene Tree for TMEM38A (if available)

Paralogs for TMEM38A Gene

Paralogs for TMEM38A Gene

Selected SIMAP similar genes for TMEM38A Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TMEM38A Gene

genes like me logo Genes that share paralogs with TMEM38A: view

Variants for TMEM38A Gene

Sequence variations from dbSNP and Humsavar for TMEM38A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs730120 -- 16,680,048(-) CTCCC(A/G)AAGCA reference, synonymous-codon
rs901792 -- 16,680,632(+) TTGGT(C/T)CAGTG intron-variant
rs1987411 -- 16,669,427(+) GTCTT(A/G)AACTC intron-variant
rs2249827 -- 16,686,429(+) GCAGC(A/G)TTCTT intron-variant
rs2249839 -- 16,686,712(+) AGGTA(C/G)CCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM38A Gene

Variant ID Type Subtype PubMed ID
esv2669434 CNV Deletion 23128226

Relevant External Links for TMEM38A Gene

HapMap Linkage Disequilibrium report
TMEM38A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM38A Gene

Disorders for TMEM38A Gene

Relevant External Links for TMEM38A

Genetic Association Database (GAD)
TMEM38A
Human Genome Epidemiology (HuGE) Navigator
TMEM38A
genes like me logo Genes that share disorders with TMEM38A: view

No data available for UniProtKB/Swiss-Prot for TMEM38A Gene

Publications for TMEM38A Gene

  1. TRIC channels are essential for Ca2+ handling in intracellular stores. (PMID: 17611541) Yazawa M. … Takeshima H. (Nature 2007) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM38A Gene

Sources for TMEM38A Gene

Back to Top

Content