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Aliases for TMEM37 Gene

Aliases for TMEM37 Gene

  • Transmembrane Protein 37 2 3 4 5
  • Neuronal Voltage-Gated Calcium Channel Gamma-Like Subunit 3 4
  • PR 3 4
  • Voltage-Dependent Calcium Channel Gamma Subunit-Like Protein 3
  • PR1 3

External Ids for TMEM37 Gene

Previous GeneCards Identifiers for TMEM37 Gene

  • GC02P119906
  • GC02P120187
  • GC02P112514

Summaries for TMEM37 Gene

GeneCards Summary for TMEM37 Gene

TMEM37 (Transmembrane Protein 37) is a Protein Coding gene. Diseases associated with TMEM37 include Vulvitis and Generalized Atherosclerosis. Among its related pathways are MAPK signaling pathway. GO annotations related to this gene include calcium channel activity and voltage-gated ion channel activity.

UniProtKB/Swiss-Prot for TMEM37 Gene

  • Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM37 Gene

Genomics for TMEM37 Gene

Regulatory Elements for TMEM37 Gene

Enhancers for TMEM37 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM37 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM37 Gene

119,429,901 bp from pter
119,438,520 bp from pter
8,620 bases
Plus strand

Genomic View for TMEM37 Gene

Genes around TMEM37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM37 Gene

Proteins for TMEM37 Gene

  • Protein details for TMEM37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Voltage-dependent calcium channel gamma-like subunit
    Protein Accession:

    Protein attributes for TMEM37 Gene

    190 amino acids
    Molecular mass:
    20932 Da
    Quaternary structure:
    • The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.

neXtProt entry for TMEM37 Gene

Proteomics data for TMEM37 Gene at MOPED

Post-translational modifications for TMEM37 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM37 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM37 Gene

Domains & Families for TMEM37 Gene

Protein Domains for TMEM37 Gene


Suggested Antigen Peptide Sequences for TMEM37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
  • Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
genes like me logo Genes that share domains with TMEM37: view

No data available for Gene Families for TMEM37 Gene

Function for TMEM37 Gene

Molecular function for TMEM37 Gene

UniProtKB/Swiss-Prot Function:
Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity).
genes like me logo Genes that share phenotypes with TMEM37: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM37 Gene

Localization for TMEM37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM37 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM37 Gene COMPARTMENTS Subcellular localization image for TMEM37 gene
Compartment Confidence
plasma membrane 4
cytosol 3
nucleus 3
extracellular 2
chloroplast 1
golgi apparatus 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM37 Gene

Pathways & Interactions for TMEM37 Gene

SuperPathways for TMEM37 Gene

Superpath Contained pathways
1 MAPK signaling pathway
genes like me logo Genes that share pathways with TMEM37: view

Pathways by source for TMEM37 Gene

1 BioSystems pathway for TMEM37 Gene

Interacting Proteins for TMEM37 Gene

Gene Ontology (GO) - Biological Process for TMEM37 Gene


No data available for SIGNOR curated interactions for TMEM37 Gene

Drugs & Compounds for TMEM37 Gene

(2) Drugs for TMEM37 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(2) Additional Compounds for TMEM37 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TMEM37: view

Transcripts for TMEM37 Gene

Unigene Clusters for TMEM37 Gene

Transmembrane protein 37:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM37 Gene

No ASD Table

Relevant External Links for TMEM37 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM37 Gene

mRNA expression in normal human tissues for TMEM37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM37 Gene

This gene is overexpressed in Kidney - Cortex (x7.8), Liver (x7.6), and Colon - Transverse (x4.3).

SOURCE GeneReport for Unigene cluster for TMEM37 Gene Hs.26216

genes like me logo Genes that share expression patterns with TMEM37: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM37 Gene

Orthologs for TMEM37 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM37 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM37 35
  • 79.54 (n)
  • 71.96 (a)
TMEM37 36
  • 67 (a)
(Canis familiaris)
Mammalia TMEM37 35
  • 85.89 (n)
  • 83.07 (a)
TMEM37 36
  • 79 (a)
(Mus musculus)
Mammalia Tmem37 35
  • 79.65 (n)
  • 74.74 (a)
Tmem37 16
Tmem37 36
  • 67 (a)
(Pan troglodytes)
Mammalia TMEM37 35
  • 99.09 (n)
  • 98.91 (a)
TMEM37 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Tmem37 35
  • 80.39 (n)
  • 75.4 (a)
(Monodelphis domestica)
Mammalia TMEM37 36
  • 70 (a)
(Gallus gallus)
Aves TMEM37 35
  • 70.39 (n)
  • 62.77 (a)
TMEM37 36
  • 60 (a)
(Anolis carolinensis)
Reptilia TMEM37 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487438 35
  • 60.8 (n)
  • 53.98 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4287 35
(Danio rerio)
Actinopterygii tmem37 35
  • 55.44 (n)
  • 47.06 (a)
tmem37 36
  • 41 (a)
Species with no ortholog for TMEM37:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM37 Gene

Gene Tree for TMEM37 (if available)
Gene Tree for TMEM37 (if available)

Paralogs for TMEM37 Gene

No data available for Paralogs for TMEM37 Gene

Variants for TMEM37 Gene

Sequence variations from dbSNP and Humsavar for TMEM37 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2043867 -- 119,431,724(-) CCCTC(C/T)GCGGC intron-variant, upstream-variant-2KB
rs3217464 -- 119,437,075(-) GATCG(-/CACAC/GCACAC/GCAGGCACAC)TCTGG cds-indel, utr-variant-5-prime
rs2278565 -- 119,437,606(-) CCCCC(C/G)GGCCA utr-variant-3-prime
rs4340531 -- 119,431,828(+) GGAGA(A/G)GTCCC intron-variant, upstream-variant-2KB
rs4344946 -- 119,432,144(+) TCCCG(A/G)GGCGC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM37 Gene

Variant ID Type Subtype PubMed ID
nsv459119 CNV Gain 19166990
nsv874961 CNV Gain 21882294

Variation tolerance for TMEM37 Gene

Residual Variation Intolerance Score: 73.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM37 Gene

Disorders for TMEM37 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TMEM37 Gene - From: DISEASES

Disorder Aliases PubMed IDs
generalized atherosclerosis
  • generalised atherosclerosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM37

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMEM37: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM37 Gene

Publications for TMEM37 Gene

  1. Calcium channel gamma subunits provide insights into the evolution of this gene family. (PMID: 11738816) Chu P.-J. … Best P.M. (Gene 2001) 3 4 67
  2. The global gene-expression profiles of U-937 human macrophages treated with Tat peptide and Tat-FITC conjugate. (PMID: 22632162) Lin C.W. … Jan M.S. (J Drug Target 2012) 3
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  4. Cold activation of a plasma membrane-tethered NAC transcription factor induces a pathogen resistance response in Arabidopsis. (PMID: 19947982) Seo P.J. … Park C.M. (Plant J. 2010) 23
  5. Binding of GAPR-1 to negatively charged phospholipid membranes: unusual binding characteristics to phosphatidylinositol. (PMID: 20095951) Van Galen J. … Helms J.B. (Mol. Membr. Biol. 2010) 23

Products for TMEM37 Gene

Sources for TMEM37 Gene