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Aliases for TMEM37 Gene

Aliases for TMEM37 Gene

  • Transmembrane Protein 37 2 3 4
  • Neuronal Voltage-Gated Calcium Channel Gamma-Like Subunit 3 4
  • PR 3 4
  • Voltage-Dependent Calcium Channel Gamma Subunit-Like Protein 3
  • Voltage-Dependent Calcium Channel Gamma-Like Subunit 3
  • PR1 3

External Ids for TMEM37 Gene

Previous GeneCards Identifiers for TMEM37 Gene

  • GC02P119906
  • GC02P120187
  • GC02P112514

Summaries for TMEM37 Gene

GeneCards Summary for TMEM37 Gene

TMEM37 (Transmembrane Protein 37) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway. GO annotations related to this gene include calcium channel activity and voltage-gated ion channel activity.

UniProtKB/Swiss-Prot for TMEM37 Gene

  • Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM37 Gene

Genomics for TMEM37 Gene

Regulatory Elements for TMEM37 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM37 Gene

Start:
119,429,901 bp from pter
End:
119,438,520 bp from pter
Size:
8,620 bases
Orientation:
Plus strand

Genomic View for TMEM37 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM37 Gene

Proteins for TMEM37 Gene

  • Protein details for TMEM37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXS4-CCGL_HUMAN
    Recommended name:
    Voltage-dependent calcium channel gamma-like subunit
    Protein Accession:
    Q8WXS4
    Secondary Accessions:

    Protein attributes for TMEM37 Gene

    Size:
    190 amino acids
    Molecular mass:
    20932 Da
    Quaternary structure:
    • The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.

neXtProt entry for TMEM37 Gene

Proteomics data for TMEM37 Gene at MOPED

Post-translational modifications for TMEM37 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM37 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for TMEM37

No data available for DME Specific Peptides for TMEM37 Gene

Domains for TMEM37 Gene

Protein Domains for TMEM37 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXS4

UniProtKB/Swiss-Prot:

CCGL_HUMAN :
  • Q8WXS4
Family:
  • Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
genes like me logo Genes that share domains with TMEM37: view

No data available for Gene Families for TMEM37 Gene

Function for TMEM37 Gene

Molecular function for TMEM37 Gene

UniProtKB/Swiss-Prot Function:
Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity).

Gene Ontology (GO) - Molecular Function for TMEM37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005262 calcium channel activity IEA --
genes like me logo Genes that share ontologies with TMEM37: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM37

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM37 Gene

Localization for TMEM37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM37 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM37 Gene COMPARTMENTS Subcellular localization image for TMEM37 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM37: view

Pathways for TMEM37 Gene

SuperPathways for TMEM37 Gene

Superpath Contained pathways
1 MAPK signaling pathway
genes like me logo Genes that share pathways with TMEM37: view

Pathways by source for TMEM37 Gene

1 BioSystems pathway for TMEM37 Gene

Interacting Proteins for TMEM37 Gene

Gene Ontology (GO) - Biological Process for TMEM37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0070588 calcium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with TMEM37: view

Compounds for TMEM37 Gene

(1) HMDB Compounds for TMEM37 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(3) Novoseek inferred chemical compound relationships for TMEM37 Gene

Compound -log(P) Hits PubMed IDs
tga 2 92.9 3
salicylic acid 70.6 13
jasmonic acid 64.3 1
genes like me logo Genes that share compounds with TMEM37: view

Transcripts for TMEM37 Gene

Unigene Clusters for TMEM37 Gene

Transmembrane protein 37:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM37

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM37 Gene

No ASD Table

Relevant External Links for TMEM37 Gene

GeneLoc Exon Structure for
TMEM37
ECgene alternative splicing isoforms for
TMEM37

Expression for TMEM37 Gene

mRNA expression in normal human tissues for TMEM37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM37 Gene

This gene is overexpressed in Kidney - Cortex (7.8), Liver (7.6), and Colon - Transverse (4.3).

SOURCE GeneReport for Unigene cluster for TMEM37 Gene Hs.26216

genes like me logo Genes that share expressions with TMEM37: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for TMEM37 Gene

Orthologs for TMEM37 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM37 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM37 35
  • 79.54 (n)
  • 71.96 (a)
TMEM37 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM37 35
  • 85.89 (n)
  • 83.07 (a)
TMEM37 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem37 35
  • 79.65 (n)
  • 74.74 (a)
Tmem37 16
Tmem37 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM37 35
  • 99.09 (n)
  • 98.91 (a)
TMEM37 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem37 35
  • 80.39 (n)
  • 75.4 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM37 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM37 35
  • 70.39 (n)
  • 62.77 (a)
TMEM37 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM37 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487438 35
  • 60.8 (n)
  • 53.98 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4287 35
zebrafish
(Danio rerio)
Actinopterygii tmem37 35
  • 55.44 (n)
  • 47.06 (a)
tmem37 36
  • 41 (a)
OneToOne
Species with no ortholog for TMEM37:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM37 Gene

ENSEMBL:
Gene Tree for TMEM37 (if available)
TreeFam:
Gene Tree for TMEM37 (if available)

Paralogs for TMEM37 Gene

No data available for Paralogs for TMEM37 Gene

Variants for TMEM37 Gene

Sequence variations from dbSNP and Humsavar for TMEM37 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2043867 -- 119,431,724(-) CCCTC(C/T)GCGGC upstream-variant-2KB, intron-variant
rs2278565 -- 119,437,606(-) CCCCC(C/G)GGCCA utr-variant-3-prime
rs2579631 -- 119,433,884(+) GAAGA(C/T)TCTAT intron-variant
rs2579632 -- 119,436,241(+) CAGGA(A/G)CAGAC intron-variant
rs2579633 -- 119,436,442(+) AGAAC(C/T)GTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM37 Gene

Variant ID Type Subtype PubMed ID
nsv459119 CNV Gain 19166990
nsv874961 CNV Gain 21882294

Relevant External Links for TMEM37 Gene

HapMap Linkage Disequilibrium report
TMEM37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM37 Gene

Disorders for TMEM37 Gene

No disorders were found for TMEM37 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TMEM37 Gene

Publications for TMEM37 Gene

  1. Calcium channel gamma subunits provide insights into the evolution of this gene family. (PMID: 11738816) Chu P.-J. … Best P.M. (Gene 2001) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  4. The global gene-expression profiles of U-937 human macrophages treated with Tat peptide and Tat-FITC conjugate. (PMID: 22632162) Lin C.W. … Jan M.S. (J Drug Target 2012) 3
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4

Products for TMEM37 Gene

Sources for TMEM37 Gene

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