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Aliases for TMEM37 Gene

Aliases for TMEM37 Gene

  • Transmembrane Protein 37 2 3 4 5
  • Neuronal Voltage-Gated Calcium Channel Gamma-Like Subunit 3 4
  • PR 3 4
  • Voltage-Dependent Calcium Channel Gamma Subunit-Like Protein 3
  • Voltage-Dependent Calcium Channel Gamma-Like Subunit 3
  • PR1 3

External Ids for TMEM37 Gene

Previous GeneCards Identifiers for TMEM37 Gene

  • GC02P119906
  • GC02P120187
  • GC02P112514

Summaries for TMEM37 Gene

GeneCards Summary for TMEM37 Gene

TMEM37 (Transmembrane Protein 37) is a Protein Coding gene. Diseases associated with TMEM37 include Vulvitis and Poland Syndrome. Among its related pathways are MAPK signaling pathway. GO annotations related to this gene include calcium channel activity and voltage-gated ion channel activity.

UniProtKB/Swiss-Prot for TMEM37 Gene

  • Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM37 Gene

Genomics for TMEM37 Gene

Regulatory Elements for TMEM37 Gene

Enhancers for TMEM37 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G119407 1.3 Ensembl ENCODE dbSUPER 11.9 -21.5 -21494 1.6 ZSCAN5A CTCF PKNOX1 TEAD4 ARID4B DNMT3B ZNF2 RAD21 TEAD3 ZNF316 ENSG00000231013 TMEM37 SCTR DBI PIR46529
GH02G119419 2 FANTOM5 Ensembl ENCODE dbSUPER 7.5 -1.8 -1805 16.7 HDGF PKNOX1 FOXA2 MLX ARID4B ZNF2 ZBTB7B YY1 SLC30A9 ZNF143 SCTR ENSG00000231013 CFAP221 TMEM37 DBI STEAP3 PIR46529
GH02G119387 1.2 Ensembl ENCODE 11.5 -42.1 -42143 1.5 HDAC1 ELF3 RAD21 RARA YY1 ZNF766 EGR1 SCRT2 FOS RELB DBI ENSG00000231013 C2orf76 TMEM37 SCTR STEAP3 PIR46529
GH02G119495 1.1 dbSUPER 11.1 +65.8 65792 1.1 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 YY1 CBX5 FOS ZNF263 SCTR TMEM37 CFAP221 MTND4P26 TMEM177 ENSG00000231013
GH02G119401 1.1 ENCODE dbSUPER 11 -26.9 -26929 2.4 ELF3 RAD21 YY1 THAP11 CEBPB ELF1 NR2F2 KAT8 PPARGC1A ATF4 ENSG00000231013 TMEM37 STEAP3 SCTR DBI PIR46529
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM37 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM37 Gene

Chromosome:
2
Start:
119,429,901 bp from pter
End:
119,438,520 bp from pter
Size:
8,620 bases
Orientation:
Plus strand

Genomic View for TMEM37 Gene

Genes around TMEM37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM37 Gene

Proteins for TMEM37 Gene

  • Protein details for TMEM37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXS4-CCGL_HUMAN
    Recommended name:
    Voltage-dependent calcium channel gamma-like subunit
    Protein Accession:
    Q8WXS4

    Protein attributes for TMEM37 Gene

    Size:
    190 amino acids
    Molecular mass:
    20932 Da
    Quaternary structure:
    • The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.

neXtProt entry for TMEM37 Gene

Post-translational modifications for TMEM37 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM37 Gene

No data available for DME Specific Peptides for TMEM37 Gene

Domains & Families for TMEM37 Gene

Protein Domains for TMEM37 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXS4

UniProtKB/Swiss-Prot:

CCGL_HUMAN :
  • Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
Family:
  • Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
genes like me logo Genes that share domains with TMEM37: view

No data available for Gene Families for TMEM37 Gene

Function for TMEM37 Gene

Molecular function for TMEM37 Gene

UniProtKB/Swiss-Prot Function:
Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity).

Gene Ontology (GO) - Molecular Function for TMEM37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005262 calcium channel activity IEA --
genes like me logo Genes that share ontologies with TMEM37: view
genes like me logo Genes that share phenotypes with TMEM37: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM37 Gene

Localization for TMEM37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM37 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM37 gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytosol 3
extracellular 2

Gene Ontology (GO) - Cellular Components for TMEM37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM37: view

Pathways & Interactions for TMEM37 Gene

SuperPathways for TMEM37 Gene

SuperPathway Contained pathways
1 MAPK signaling pathway
genes like me logo Genes that share pathways with TMEM37: view

Pathways by source for TMEM37 Gene

1 BioSystems pathway for TMEM37 Gene

Interacting Proteins for TMEM37 Gene

Selected Interacting proteins: Q8WXS4-CCGL_HUMAN for TMEM37 Gene via IID

Gene Ontology (GO) - Biological Process for TMEM37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006816 calcium ion transport IEA --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0070588 calcium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with TMEM37: view

No data available for SIGNOR curated interactions for TMEM37 Gene

Drugs & Compounds for TMEM37 Gene

(2) Drugs for TMEM37 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(2) Additional Compounds for TMEM37 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TMEM37: view

Transcripts for TMEM37 Gene

Unigene Clusters for TMEM37 Gene

Transmembrane protein 37:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM37 Gene

No ASD Table

Relevant External Links for TMEM37 Gene

GeneLoc Exon Structure for
TMEM37
ECgene alternative splicing isoforms for
TMEM37

Expression for TMEM37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM37 Gene

This gene is overexpressed in Kidney - Cortex (x7.8), Liver (x7.6), and Colon - Transverse (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of TMEM37 Gene:

TMEM37

SOURCE GeneReport for Unigene cluster for TMEM37 Gene:

Hs.26216
genes like me logo Genes that share expression patterns with TMEM37: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM37 Gene

Orthologs for TMEM37 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM37 34 35
  • 99.09 (n)
dog
(Canis familiaris)
Mammalia TMEM37 34 35
  • 85.89 (n)
rat
(Rattus norvegicus)
Mammalia Tmem37 34
  • 80.39 (n)
mouse
(Mus musculus)
Mammalia Tmem37 34 16 35
  • 79.65 (n)
cow
(Bos Taurus)
Mammalia TMEM37 34 35
  • 79.54 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM37 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM37 34 35
  • 70.39 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM37 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487438 34
  • 60.8 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4287 34
zebrafish
(Danio rerio)
Actinopterygii tmem37 34 35
  • 55.44 (n)
Species where no ortholog for TMEM37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM37 Gene

ENSEMBL:
Gene Tree for TMEM37 (if available)
TreeFam:
Gene Tree for TMEM37 (if available)

Paralogs for TMEM37 Gene

No data available for Paralogs for TMEM37 Gene

Variants for TMEM37 Gene

Sequence variations from dbSNP and Humsavar for TMEM37 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000027808 -- 119,430,483(+) TCTCC(A/G)TTTGT intron-variant, upstream-variant-2KB
rs1000441352 -- 119,430,830(+) TAGGT(A/G)CTGCC intron-variant, upstream-variant-2KB
rs1001035386 -- 119,428,363(+) ACATG(C/T)CTGGC upstream-variant-2KB
rs1001279859 -- 119,435,814(+) GTGGG(C/G)AGGAA intron-variant
rs1001291277 -- 119,436,089(+) CAGTG(C/T)CCGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM37 Gene

Variant ID Type Subtype PubMed ID
esv3592167 CNV gain 21293372
nsv459119 CNV gain 19166990
nsv582784 CNV gain 21841781

Variation tolerance for TMEM37 Gene

Residual Variation Intolerance Score: 73.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM37 Gene

Disorders for TMEM37 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TMEM37 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
vulvitis
poland syndrome
  • poland sequence
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM37

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM37
genes like me logo Genes that share disorders with TMEM37: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM37 Gene

Publications for TMEM37 Gene

  1. Calcium channel gamma subunits provide insights into the evolution of this gene family. (PMID: 11738816) Chu P.-J. … Best P.M. (Gene 2001) 3 4 64
  2. The global gene-expression profiles of U-937 human macrophages treated with Tat peptide and Tat-FITC conjugate. (PMID: 22632162) Lin C.W. … Jan M.S. (J Drug Target 2012) 3 64
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64
  4. Binding of GAPR-1 to negatively charged phospholipid membranes: unusual binding characteristics to phosphatidylinositol. (PMID: 20095951) Van Galen J. … Helms J.B. (Mol. Membr. Biol. 2010) 22 64
  5. Cold activation of a plasma membrane-tethered NAC transcription factor induces a pathogen resistance response in Arabidopsis. (PMID: 19947982) Seo P.J. … Park C.M. (Plant J. 2010) 22 64

Products for TMEM37 Gene

Sources for TMEM37 Gene

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