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Aliases for TMEM35B Gene

Aliases for TMEM35B Gene

  • Transmembrane Protein 35B 2 3 5
  • ZMYM6 Neighbor Protein 3 4
  • ZMYM6NB 3 4
  • ZMYM6 Neighbor 2

External Ids for TMEM35B Gene

Previous HGNC Symbols for TMEM35B Gene

  • ZMYM6NB

Summaries for TMEM35B Gene

GeneCards Summary for TMEM35B Gene

TMEM35B (Transmembrane Protein 35B) is a Protein Coding gene.

Additional gene information for TMEM35B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM35B Gene

Genomics for TMEM35B Gene

Regulatory Elements for TMEM35B Gene

Enhancers for TMEM35B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H034865 1.5 Ensembl ENCODE dbSUPER 24.6 +118.8 118834 2.7 ATF1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 REST PPARG LOC653160 TMEM35B ZMYM1 ENSG00000230163 ZMYM6 SFPQ RPL5P4 GJB4 TFAP2E SMIM12
GH01H035178 0.9 ENCODE 21.2 -194.4 -194400 2.6 HNRNPUL1 FOXA2 ARID4B RAD21 YY1 TCF12 EGR1 CREM MIXL1 THAP11 LOC653160 TMEM35B ZMYM1 AGO4 SFPQ RPL5P4 ENSG00000230163 COL8A2 ZMYM6 ENSG00000201542
GH01H035189 1.4 Ensembl ENCODE 10.5 -206.4 -206357 5 HNRNPUL1 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SFPQ ZMYM1 LOC653160 ZMYM6 AGO3 ZMYM4 ENSG00000230163 COL8A2 LOC105378647 RPL12P45
GH01H035800 1.2 Ensembl ENCODE dbSUPER 12 -815.2 -815248 1.2 BCOR ZSCAN4 CC2D1A ZNF316 NFE2 SMARCE1 SMARCA5 MCM3 MAFG CEBPB ZMYM1 EVA1B RPL5P4 ENSG00000230163 TMEM35B LOC653160 ZMYM6 THRAP3 SFPQ COL8A2
GH01H035078 1.1 ENCODE 10.9 -94.6 -94557 2.4 ARNT SIN3A DMAP1 YY1 ZNF143 SP3 JUNB REST ZNF592 KAT8 ZMYM6 ZMYM1 LOC653160 ENSG00000230163 SFPQ TMEM35B LOC105378647 LOC105378645 GC01P035069 EFCAB14P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM35B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM35B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004629 53 1401 HDGF ATF1 ZFP64 ARID4B SIN3A DMAP1 YY1 GLIS2 ATF7 RUNX3

Genomic Locations for TMEM35B Gene

Genomic Locations for TMEM35B Gene
chr1:34,981,526-34,985,353
(GRCh38/hg38)
Size:
3,828 bases
Orientation:
Minus strand
chr1:35,447,127-35,450,954
(GRCh37/hg19)

Genomic View for TMEM35B Gene

Genes around TMEM35B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM35B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM35B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM35B Gene

Proteins for TMEM35B Gene

  • Protein details for TMEM35B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCS4-TM35B_HUMAN
    Recommended name:
    Transmembrane protein 35B
    Protein Accession:
    Q8NCS4

    Protein attributes for TMEM35B Gene

    Size:
    154 amino acids
    Molecular mass:
    16885 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM35B Gene

Post-translational modifications for TMEM35B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM35B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM35B Gene

Domains & Families for TMEM35B Gene

Gene Families for TMEM35B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM35B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM35B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NCS4

UniProtKB/Swiss-Prot:

TM35B_HUMAN :
  • Belongs to the DoxX family.
Family:
  • Belongs to the DoxX family.
genes like me logo Genes that share domains with TMEM35B: view

Function for TMEM35B Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM35B Gene

Localization for TMEM35B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM35B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM35B gene
Compartment Confidence
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM35B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM35B: view

Pathways & Interactions for TMEM35B Gene

SuperPathways for TMEM35B Gene

No Data Available

Interacting Proteins for TMEM35B Gene

Selected Interacting proteins: Q8NCS4-TM35B_HUMAN for TMEM35B Gene via IID

Gene Ontology (GO) - Biological Process for TMEM35B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM35B Gene

Drugs & Compounds for TMEM35B Gene

No Compound Related Data Available

Transcripts for TMEM35B Gene

mRNA/cDNA for TMEM35B Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM35B Gene

No ASD Table

Relevant External Links for TMEM35B Gene

GeneLoc Exon Structure for
TMEM35B
ECgene alternative splicing isoforms for
TMEM35B

Expression for TMEM35B Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM35B Gene:

TMEM35B

Evidence on tissue expression from TISSUES for TMEM35B Gene

  • Kidney(4.3)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM35B Gene

Orthologs for TMEM35B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM35B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZMYM6NB 33 34
  • 99.78 (n)
cow
(Bos Taurus)
Mammalia ZMYM6NB 33 34
  • 86.15 (n)
mouse
(Mus musculus)
Mammalia Gm12942 33 34
  • 78.88 (n)
Tmem35b 16
rat
(Rattus norvegicus)
Mammalia Zmym6nb 33
  • 78.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZMYM6NB 34
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZMYM6NB 34
  • 22 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZMYM6NB 33 34
  • 62.6 (n)
lizard
(Anolis carolinensis)
Reptilia ZMYM6NB 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zmym6nb 33
  • 62.47 (n)
Species where no ortholog for TMEM35B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM35B Gene

ENSEMBL:
Gene Tree for TMEM35B (if available)
TreeFam:
Gene Tree for TMEM35B (if available)

Paralogs for TMEM35B Gene

No data available for Paralogs for TMEM35B Gene

Variants for TMEM35B Gene

Sequence variations from dbSNP and Humsavar for TMEM35B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000208212 -- 34,986,780(+) AAGAC(G/T)GAAAT upstream-variant-2KB, utr-variant-3-prime
rs1000276884 -- 34,986,395(+) ATTTA(C/T)AGTTA upstream-variant-2KB, utr-variant-3-prime
rs1001491857 -- 34,983,384(+) CCATC(C/T)TGGCT intron-variant
rs1001754405 -- 34,983,074(+) AGCTT(A/C)CCTGC intron-variant
rs1002101585 -- 34,984,915(+) GGTCC(-/G)GGGGG intron-variant

Variation tolerance for TMEM35B Gene

Gene Damage Index Score: 3.10; 50.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM35B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM35B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM35B Gene

Disorders for TMEM35B Gene

Relevant External Links for TMEM35B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM35B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM35B

No disorders were found for TMEM35B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM35B Gene

Publications for TMEM35B Gene

  1. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 60
  2. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome AS … Carapito C (Proteomics 2015) 4 60
  3. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PMID: 21103663) Schaafhausen A … Müller CR (Thrombosis and haemostasis 2011) 3 60
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for TMEM35B Gene

Sources for TMEM35B Gene

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