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Aliases for TMEM35A Gene

Aliases for TMEM35A Gene

  • Transmembrane Protein 35A 2 3 5
  • Transmembrane Protein 35 2 3
  • TMEM35 3 4

External Ids for TMEM35A Gene

Previous HGNC Symbols for TMEM35A Gene

  • TMEM35

Summaries for TMEM35A Gene

GeneCards Summary for TMEM35A Gene

TMEM35A (Transmembrane Protein 35A) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM35A Gene

  • A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth.

Additional gene information for TMEM35A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM35A Gene

Genomics for TMEM35A Gene

Regulatory Elements for TMEM35A Gene

Enhancers for TMEM35A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH101056 1 Ensembl ENCODE 14.1 -21.4 -21435 0.6 PKNOX1 TAL1 JUN CEBPG BATF FOSL1 TCF12 CTBP1 NCOR1 ETV6 TMEM35A TRMT2B
GH0XH101243 0.3 FANTOM5 3.3 +164.8 164849 0.3 DRP2 TMEM35A ARMCX3 GC0XP101262
GH0XH101078 0.5 ENCODE 0.7 +0.1 80 0.4 MXI1 POLR2A ZNF143 TMEM35A TRMT2B-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM35A on UCSC Golden Path with GeneCards custom track

Promoters for TMEM35A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247604 481 1199 POLR2A ZNF143

Genomic Locations for TMEM35A Gene

Genomic Locations for TMEM35A Gene
chrX:101,078,720-101,096,367
(GRCh38/hg38)
Size:
17,648 bases
Orientation:
Plus strand
chrX:100,333,709-100,351,356
(GRCh37/hg19)

Genomic View for TMEM35A Gene

Genes around TMEM35A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM35A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM35A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM35A Gene

Proteins for TMEM35A Gene

  • Protein details for TMEM35A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53FP2-TM35A_HUMAN
    Recommended name:
    Transmembrane protein 35A
    Protein Accession:
    Q53FP2
    Secondary Accessions:
    • Q9H7Y3

    Protein attributes for TMEM35A Gene

    Size:
    167 amino acids
    Molecular mass:
    18440 Da
    Quaternary structure:
    • May interact with NGFR.

neXtProt entry for TMEM35A Gene

Post-translational modifications for TMEM35A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM35A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM35A Gene

Domains & Families for TMEM35A Gene

Gene Families for TMEM35A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM35A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM35A Gene

Graphical View of Domain Structure for InterPro Entry

Q53FP2

UniProtKB/Swiss-Prot:

TM35A_HUMAN :
  • Belongs to the DoxX family.
Family:
  • Belongs to the DoxX family.
genes like me logo Genes that share domains with TMEM35A: view

Function for TMEM35A Gene

Molecular function for TMEM35A Gene

UniProtKB/Swiss-Prot Function:
A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth.

Gene Ontology (GO) - Molecular Function for TMEM35A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM35A: view
genes like me logo Genes that share phenotypes with TMEM35A: view

Animal Model Products

miRNA for TMEM35A Gene

miRTarBase miRNAs that target TMEM35A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM35A Gene

Localization for TMEM35A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM35A Gene

Peroxisome membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Shedding may lead to a soluble peptide. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM35A gene
Compartment Confidence
peroxisome 3
extracellular 2
plasma membrane 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM35A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005777 peroxisome IEA --
GO:0005778 peroxisomal membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM35A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM35A Gene

Pathways & Interactions for TMEM35A Gene

SuperPathways for TMEM35A Gene

No Data Available

Interacting Proteins for TMEM35A Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000362021%0d%0a9606.ENSP00000287482%0d%0a9606.ENSP00000371308%0d%0a9606.ENSP00000362465%0d%0a9606.ENSP00000349689%0d%0a
Selected Interacting proteins: ENSP00000362021 Q53FP2-TM35A_HUMAN for TMEM35A Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM35A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM35A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM35A Gene

Drugs & Compounds for TMEM35A Gene

No Compound Related Data Available

Transcripts for TMEM35A Gene

mRNA/cDNA for TMEM35A Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM35A Gene

No ASD Table

Relevant External Links for TMEM35A Gene

GeneLoc Exon Structure for
TMEM35A
ECgene alternative splicing isoforms for
TMEM35A

Expression for TMEM35A Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM35A Gene:

TMEM35A

Evidence on tissue expression from TISSUES for TMEM35A Gene

  • Nervous system(4.9)
  • Stomach(4)
genes like me logo Genes that share expression patterns with TMEM35A: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM35A Gene

Orthologs for TMEM35A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM35A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM35 33 34
  • 99.2 (n)
dog
(Canis familiaris)
Mammalia TMEM35 33 34
  • 93.81 (n)
rat
(Rattus norvegicus)
Mammalia Tmem35 33
  • 93.01 (n)
cow
(Bos Taurus)
Mammalia TMEM35 33 34
  • 92.81 (n)
mouse
(Mus musculus)
Mammalia Tmem35 33 34
  • 92.42 (n)
Tmem35a 16
oppossum
(Monodelphis domestica)
Mammalia TMEM35 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM35 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 87 (a)
OneToMany
-- 34
  • 87 (a)
OneToMany
TMEM35 33
  • 80.04 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM35 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem35 33
  • 71.85 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem35 33 34
  • 71.67 (n)
flj14084 33
fruit fly
(Drosophila melanogaster)
Insecta CG13920 33 34
  • 53.78 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007501 33
  • 49.63 (n)
Species where no ortholog for TMEM35A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM35A Gene

ENSEMBL:
Gene Tree for TMEM35A (if available)
TreeFam:
Gene Tree for TMEM35A (if available)

Paralogs for TMEM35A Gene

No data available for Paralogs for TMEM35A Gene

Variants for TMEM35A Gene

Sequence variations from dbSNP and Humsavar for TMEM35A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000155550 -- 101,084,827(+) ACTAC(C/T)GCACT intron-variant
rs1000166460 -- 101,092,722(+) AAATC(-/A)AGCCA intron-variant
rs1000173609 -- 101,093,915(+) CTGAG(G/T)CCTCT intron-variant
rs1000209796 -- 101,085,339(+) CTCAC(C/G)CCTGT intron-variant
rs1000382303 -- 101,085,700(+) GAGGC(A/G)GGCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM35A Gene

Variant ID Type Subtype PubMed ID
nsv425546 CNV deletion 16902084
esv2673239 CNV deletion 23128226

Variation tolerance for TMEM35A Gene

Residual Variation Intolerance Score: 36.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM35A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM35A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM35A Gene

Disorders for TMEM35A Gene

Relevant External Links for TMEM35A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM35A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM35A

No disorders were found for TMEM35A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM35A Gene

Publications for TMEM35A Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for TMEM35A Gene

Sources for TMEM35A Gene

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