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Aliases for TMEM35 Gene

Aliases for TMEM35 Gene

  • Transmembrane Protein 35 2 3 5

External Ids for TMEM35 Gene

Previous GeneCards Identifiers for TMEM35 Gene

  • GC0XP100140
  • GC0XP100220
  • GC0XP100333
  • GC0XP090152

Summaries for TMEM35 Gene

GeneCards Summary for TMEM35 Gene

TMEM35 (Transmembrane Protein 35) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM35 Gene

  • A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM35 Gene

Genomics for TMEM35 Gene

Regulatory Elements for TMEM35 Gene

Enhancers for TMEM35 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM35 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM35 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM35 Gene

Chromosome:
X
Start:
101,078,720 bp from pter
End:
101,096,367 bp from pter
Size:
17,648 bases
Orientation:
Plus strand

Genomic View for TMEM35 Gene

Genes around TMEM35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM35 Gene

Proteins for TMEM35 Gene

  • Protein details for TMEM35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53FP2-TMM35_HUMAN
    Recommended name:
    Transmembrane protein 35
    Protein Accession:
    Q53FP2
    Secondary Accessions:
    • Q9H7Y3

    Protein attributes for TMEM35 Gene

    Size:
    167 amino acids
    Molecular mass:
    18440 Da
    Quaternary structure:
    • May interact with NGFR.

neXtProt entry for TMEM35 Gene

Proteomics data for TMEM35 Gene at MOPED

Post-translational modifications for TMEM35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM35 Gene

Domains & Families for TMEM35 Gene

Protein Domains for TMEM35 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM35 Gene

Graphical View of Domain Structure for InterPro Entry

Q53FP2

UniProtKB/Swiss-Prot:

TMM35_HUMAN :
  • Belongs to the TMEM35 family.
Family:
  • Belongs to the TMEM35 family.
genes like me logo Genes that share domains with TMEM35: view

No data available for Gene Families for TMEM35 Gene

Function for TMEM35 Gene

Molecular function for TMEM35 Gene

UniProtKB/Swiss-Prot Function:
A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth.

Phenotypes for TMEM35 Gene

genes like me logo Genes that share phenotypes with TMEM35: view

Animal Model Products

miRNA for TMEM35 Gene

miRTarBase miRNAs that target TMEM35

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM35 Gene

Localization for TMEM35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM35 Gene

Peroxisome membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Shedding may lead to a soluble peptide. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM35 Gene COMPARTMENTS Subcellular localization image for TMEM35 gene
Compartment Confidence
peroxisome 3
extracellular 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMEM35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0016023 cytoplasmic, membrane-bounded vesicle IEA --
genes like me logo Genes that share ontologies with TMEM35: view

Pathways & Interactions for TMEM35 Gene

SuperPathways for TMEM35 Gene

No Data Available

Interacting Proteins for TMEM35 Gene

Gene Ontology (GO) - Biological Process for TMEM35 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM35 Gene

Drugs & Compounds for TMEM35 Gene

No Compound Related Data Available

Transcripts for TMEM35 Gene

mRNA/cDNA for TMEM35 Gene

Unigene Clusters for TMEM35 Gene

Transmembrane protein 35:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM35 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3: -

Relevant External Links for TMEM35 Gene

GeneLoc Exon Structure for
TMEM35
ECgene alternative splicing isoforms for
TMEM35

Expression for TMEM35 Gene

mRNA expression in normal human tissues for TMEM35 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM35 Gene

This gene is overexpressed in Brain - Hypothalamus (x5.9).

Protein differential expression in normal tissues from HIPED for TMEM35 Gene

This gene is overexpressed in Fetal Brain (28.3) and Seminal vesicle (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM35 Gene



SOURCE GeneReport for Unigene cluster for TMEM35 Gene Hs.45140

genes like me logo Genes that share expression patterns with TMEM35: view

Protein tissue co-expression partners for TMEM35 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM35 Gene

Orthologs for TMEM35 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM35 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM35 35
  • 92.81 (n)
  • 95.81 (a)
TMEM35 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM35 35
  • 93.81 (n)
  • 97.01 (a)
TMEM35 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem35 35
  • 92.42 (n)
  • 97.01 (a)
Tmem35 16
Tmem35 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM35 35
  • 99.2 (n)
  • 100 (a)
TMEM35 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem35 35
  • 93.01 (n)
  • 97.6 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM35 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM35 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM35 35
  • 80.04 (n)
  • 87.43 (a)
-- 36
  • 87 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia TMEM35 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem35 35
  • 71.85 (n)
  • 84.46 (a)
zebrafish
(Danio rerio)
Actinopterygii flj14084 35
tmem35 35
  • 71.67 (n)
  • 81.87 (a)
tmem35 36
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007501 35
  • 49.63 (n)
  • 39.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13920 35
  • 53.78 (n)
  • 38 (a)
CG13920 36
  • 36 (a)
OneToOne
Species with no ortholog for TMEM35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM35 Gene

ENSEMBL:
Gene Tree for TMEM35 (if available)
TreeFam:
Gene Tree for TMEM35 (if available)

Paralogs for TMEM35 Gene

No data available for Paralogs for TMEM35 Gene

Variants for TMEM35 Gene

Sequence variations from dbSNP and Humsavar for TMEM35 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747860400 -- 101,095,536(+) AGGAG(-/A)AAAAA utr-variant-3-prime
rs747907340 -- 101,095,991(+) AAACA(C/G)ATTCA utr-variant-3-prime
rs748081804 -- 101,080,659(+) ACAGG(G/T)TGGAG intron-variant
rs748118417 -- 101,090,056(+) CTCTT(C/T)TTAAA intron-variant
rs748132794 -- 101,079,363(+) TACCC(C/G)CCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM35 Gene

Variant ID Type Subtype PubMed ID
esv2673239 CNV Deletion 23128226
nsv425546 CNV Loss 16902084

Variation tolerance for TMEM35 Gene

Residual Variation Intolerance Score: 36.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.83% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM35 Gene

Disorders for TMEM35 Gene

Relevant External Links for TMEM35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM35

No disorders were found for TMEM35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM35 Gene

Publications for TMEM35 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 67
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM35 Gene

Sources for TMEM35 Gene

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