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Aliases for TMEM35 Gene

Aliases for TMEM35 Gene

  • Transmembrane Protein 35 2 3

External Ids for TMEM35 Gene

Summaries for TMEM35 Gene

GeneCards Summary for TMEM35 Gene

TMEM35 (Transmembrane Protein 35) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM35 Gene

  • A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM35 Gene

Genomics for TMEM35 Gene

Genomic Location for TMEM35 Gene

101,078,720 bp from pter
101,096,367 bp from pter
17,648 bases
Plus strand

Genomic View for TMEM35 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM35 Gene

Regulatory Elements for TMEM35 Gene

Proteins for TMEM35 Gene

  • Protein details for TMEM35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 35
    Protein Accession:
    Secondary Accessions:
    • Q9H7Y3

    Protein attributes for TMEM35 Gene

    167 amino acids
    Molecular mass:
    18440 Da
    Quaternary structure:
    • May interact with NGFR.

neXtProt entry for TMEM35 Gene

Proteomics data for TMEM35 Gene at MOPED

Post-translational modifications for TMEM35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM35 Gene

Domains for TMEM35 Gene

Protein Domains for TMEM35 Gene


Suggested Antigen Peptide Sequences for TMEM35 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM35 family.:
    • Q53FP2
genes like me logo Genes that share domains with TMEM35: view

No data available for Gene Families for TMEM35 Gene

Function for TMEM35 Gene

Molecular function for TMEM35 Gene

UniProtKB/Swiss-Prot Function: A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth.

Gene Ontology (GO) - Molecular Function for TMEM35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM35: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM35 Gene

Localization for TMEM35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM35 Gene

Peroxisome membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Shedding may lead to a soluble peptide. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for TMEM35 Gene COMPARTMENTS Subcellular localization image for TMEM35 gene
Compartment Confidence
peroxisome 5
extracellular 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TMEM35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005777 peroxisome --
GO:0005778 peroxisomal membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
genes like me logo Genes that share ontologies with TMEM35: view

Pathways for TMEM35 Gene

SuperPathways for TMEM35 Gene

No Data Available

Interacting Proteins for TMEM35 Gene

Gene Ontology (GO) - Biological Process for TMEM35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM35: view

No data available for Pathways by source for TMEM35 Gene

Transcripts for TMEM35 Gene

mRNA/cDNA for TMEM35 Gene

Unigene Clusters for TMEM35 Gene

Transmembrane protein 35:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM35 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3: -

Relevant External Links for TMEM35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM35 Gene

mRNA expression in normal human tissues for TMEM35 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM35 Gene

This gene is overexpressed in Brain - Hypothalamus (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMEM35 Gene

SOURCE GeneReport for Unigene cluster for TMEM35 Gene Hs.45140

genes like me logo Genes that share expressions with TMEM35: view

No data available for mRNA Expression by UniProt/SwissProt for TMEM35 Gene

Orthologs for TMEM35 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM35 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM35 35
  • 99.2 (n)
  • 100 (a)
TMEM35 36
  • 100 (a)
(Bos Taurus)
Mammalia TMEM35 35
  • 92.81 (n)
  • 95.81 (a)
TMEM35 36
  • 91 (a)
(Canis familiaris)
Mammalia TMEM35 35
  • 93.81 (n)
  • 97.01 (a)
TMEM35 36
  • 94 (a)
(Mus musculus)
Mammalia Tmem35 35
  • 92.42 (n)
  • 97.01 (a)
Tmem35 16
Tmem35 36
  • 97 (a)
(Monodelphis domestica)
Mammalia TMEM35 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM35 36
  • 78 (a)
(Rattus norvegicus)
Mammalia Tmem35 35
  • 93.01 (n)
  • 97.6 (a)
(Gallus gallus)
Aves -- 36
  • 87 (a)
-- 36
  • 87 (a)
TMEM35 35
  • 80.04 (n)
  • 87.43 (a)
(Anolis carolinensis)
Reptilia TMEM35 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem35 35
  • 71.85 (n)
  • 84.46 (a)
(Danio rerio)
Actinopterygii flj14084 35
tmem35 35
  • 71.67 (n)
  • 81.87 (a)
tmem35 36
  • 70 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007501 35
  • 49.63 (n)
  • 39.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13920 35
  • 53.78 (n)
  • 38 (a)
CG13920 36
  • 36 (a)
Species with no ortholog for TMEM35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM35 Gene

Gene Tree for TMEM35 (if available)
Gene Tree for TMEM35 (if available)

Paralogs for TMEM35 Gene

No data available for Paralogs for TMEM35 Gene

Variants for TMEM35 Gene

Sequence variations from dbSNP and Humsavar for TMEM35 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs743090 -- 101,095,511(-) AAGTT(G/T)TTAGT utr-variant-3-prime
rs761844 -- 101,095,201(+) GTATA(C/T)GGCTA utr-variant-3-prime
rs910753 -- 101,095,445(+) CCTAT(A/G)AAGAG utr-variant-3-prime
rs2014595 -- 101,087,276(+) ATGTC(A/G)CTATT intron-variant
rs2359999 -- 101,086,382(+) tccca(A/C)agtgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM35 Gene

Variant ID Type Subtype PubMed ID
esv2673239 CNV Deletion 23128226
nsv425546 CNV Loss 16902084

Relevant External Links for TMEM35 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM35 Gene

Disorders for TMEM35 Gene

No disorders were found for TMEM35 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM35 Gene

Publications for TMEM35 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3

Products for TMEM35 Gene

  • antibodies-online peptides for TMEM35
  • antibodies-online antibodies for TMEM35
  • antibodies-online kits for TMEM35

Sources for TMEM35 Gene

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