TMEM35 Gene
protein-coding GIFtS : 43
GCID: GC0X P100333
transmembrane protein 35
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Aliasesfor TMEM35 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Transmembrane Protein 35 1 2 FLJ140841
Export aliases for TMEM35 gene to outside databases Previous GC identifers: GC0XP100140 GC0XP100220 GC0XP090152
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Summariesfor TMEM35 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: TMM35_HUMAN, Q53FP2 Function : A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth (By similarity)
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Genomic Viewsfor TMEM35 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000023.10 NC_018934.1 NT_011651.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TMEM35 gene promoter: HOXA9B HOXA9 RFX1 p53 Brachyury POU6F1 (c2) LCR-F1 MZF-1 Meis-1a Meis-1 Other transcription factors Search SABiosciences Chromatin IP Primers for TMEM35 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM35
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xq22.1 Ensembl cytogenetic band: Xq22.1 HGNC cytogenetic band: Xq22 TMEM35 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XP100333: view genomic region
(about GC identifiers )
Start:
100,333,709 bp from pter
End:
100,351,356 bp from pter
Size:
17,648 bases
Orientation:
plus strand
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Proteinsfor TMEM35 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TMM35_HUMAN, Q53FP2 (See
protein sequence )Recommended Name: Transmembrane protein 35 Size : 167 amino acids; 18440 Da
Subunit : May interact with NGFR (By similarity)
Subcellular location : Peroxisome membrane; Multi-pass membrane protein (By similarity). Cytoplasmic vesicle (Bysimilarity). Note=Shedding may lead to a soluble peptide (By similarity)
Secondary accessions : Q9H7Y3Explore the universe of human proteins at neXtProt for TMEM35: NX_Q53FP2 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q53FP2 TMEM35 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_067650.1 ENSEMBL proteins: ENSP00000362021 Human Recombinant Protein Products for TMEM35: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
TMEM35 for ontologies About GeneDecksing TMEM35 Antibody Products: Assay Products for TMEM35:
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Protein
Domains / Familiesfor TMEM35 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q53FP2
UniProtKB/Swiss-Prot: TMM35_HUMAN, Q53FP2 Similarity : Belongs to the TMEM35 family
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Functionfor TMEM35 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: TMM35_HUMAN, Q53FP2 Function : A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth (By similarity)
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003674 molecular_function
ND --
TMEM35 for ontologies About GeneDecksing Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM35 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM35OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TMEM35 (NM_021637 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM35 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM35
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM35
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Pathways & Interactionsfor TMEM35 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM35 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)4 Interacting proteins for TMEM35 (Q53FP2 3 ENSP00000362021 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0008150 biological_process
ND --
TMEM35 for ontologies About GeneDecksing
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Drugs & Compoundsfor TMEM35 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TMEM35 Search CenterWatch for drugs/clinical trials and news about TMEM35 / TMM35
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Transcriptsfor TMEM35 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TMEM35 gene: NM_021637.2 Unigene Clusters for TMEM35:
Transmembrane protein 35 Hs.45140 [show with all ESTs ] , Hs.714277 Unigene Representative Sequences: NM_021637 , AK297745 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000372930 (uc004egw.3 ) ENST00000478351 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM35 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM35OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TMEM35 (NM_021637 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM35 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM35
Additional cDNA sequence: AK297745.1
4 DOTS entries : DT.205866 DT.121323501
DT.100705202 DT.121323514 24/64 AceView cDNA sequences (see all 64 ):
AW779198 BP362901 AI633786 BQ639085 AI198124 BX107287 BM704234 AW236460 AI201659 AU121235 BI914882 BQ722513 BI546807 BI603267 AI808603 BG699203 AW014707 NM_021637 BM699255 AW665541 T08400 AI198175 AA912278 BM669472 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM35 About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c SP1 :     -           SP2 :     -   -         SP3 :       -        
ECgene alternative splicing isoforms for TMEM35
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Expression for TMEM35 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TMEM35 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CAGTCAAATTAbout this image TMEM35 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See TMEM35 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TMEM35 SOURCE GeneReport for Unigene clusters: Hs.45140 Hs.714277 SABiosciences Custom PCR Arrays for TMEM35 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TMEM35Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TMEM35 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TMEM35 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TMEM35 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM35
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Orthologsfor TMEM35 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for TMEM35 gene from 5/15 species (see all 15 ) About this table
ENSEMBL Gene Tree for TMEM35 (if available)TreeFam Gene Tree for TMEM35 (if available)
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Paralogsfor TMEM35 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor TMEM35 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr X pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TMEM35 (100333709 - 100351356 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for TMEM35 1 Indel : 13238
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TMEM35
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Disorders
/ Diseasesfor TMEM35 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Publicationsfor TMEM35 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TMEM35 gene integrated from 9 sources : (articles sorted by number of sources associating them with TMEM35) Utopia : connect your pdf to the dynamic world of online information
The DNA sequence of the human X chromosome. (PubMed id 15772651) 1 , 2 Ross M.T.... Bentley D.R. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548) 1 Bonaldo M.F.... Soares M.B. (1996) Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298) 1 Maruyama K. and Sugano S. (1994)
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External Searches for TMEM35 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TMEM35 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TMEM35 gene
(According to HUGE )
About This Section --
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Specialized Databases showing TMEM35 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TMEM35 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TMEM35 gene: Search GeneIP for patents involving TMEM35 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TMEM35 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TMEM35 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TMEM35 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TMEM35 OriGene Protein Over-expression Lysate for TMEM35 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TMEM35 OriGene 3'-UTR Clone for TMEM35 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM35 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM35 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for TMEM35 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TMEM35 OriGene Custom Protein Services for TMEM35 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM35 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TMEM35 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM35 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TMEM35 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TMEM35 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TMEM35
Search Tocris compounds for TMEM35
TMEM35 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM35
ThermoFisher Antibodies for TMEM35
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM35
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Expression for TMEM35
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Genomic Views for TMEM35
Intellectual Property for TMEM35
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Paralogs for TMEM35
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