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Aliases for TMEM33 Gene

Aliases for TMEM33 Gene

  • Transmembrane Protein 33 2 3
  • 1600019D15Rik 3
  • Protein DB83 4
  • SHINC3 3
  • DB83 4

External Ids for TMEM33 Gene

Previous GeneCards Identifiers for TMEM33 Gene

  • GC04P041778
  • GC04P041631
  • GC04P041259

Summaries for TMEM33 Gene

GeneCards Summary for TMEM33 Gene

TMEM33 (Transmembrane Protein 33) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM33 Gene

Genomics for TMEM33 Gene

Regulatory Elements for TMEM33 Gene

Genomic Location for TMEM33 Gene

Start:
41,935,120 bp from pter
End:
41,960,807 bp from pter
Size:
25,688 bases
Orientation:
Plus strand

Genomic View for TMEM33 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM33 Gene

Proteins for TMEM33 Gene

  • Protein details for TMEM33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57088-TMM33_HUMAN
    Recommended name:
    Transmembrane protein 33
    Protein Accession:
    P57088
    Secondary Accessions:
    • B3KSS8
    • Q9H953

    Protein attributes for TMEM33 Gene

    Size:
    247 amino acids
    Molecular mass:
    27978 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM33 Gene

Proteomics data for TMEM33 Gene at MOPED

Post-translational modifications for TMEM33 Gene

  • Ubiquitination at Lys148
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM33 Gene

No data available for DME Specific Peptides for TMEM33 Gene

Domains for TMEM33 Gene

Protein Domains for TMEM33 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P57088

UniProtKB/Swiss-Prot:

TMM33_HUMAN :
  • P57088
Family:
  • Belongs to the PER33/POM33 family.
genes like me logo Genes that share domains with TMEM33: view

No data available for Gene Families for TMEM33 Gene

Function for TMEM33 Gene

Gene Ontology (GO) - Molecular Function for TMEM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0017056 structural constituent of nuclear pore IBA --
genes like me logo Genes that share ontologies with TMEM33: view

Phenotypes for TMEM33 Gene

GenomeRNAi human phenotypes for TMEM33:
genes like me logo Genes that share phenotypes with TMEM33: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM33 Gene

Localization for TMEM33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM33 Gene

Membrane; Multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM33 Gene COMPARTMENTS Subcellular localization image for TMEM33 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005643 nuclear pore IBA --
GO:0005783 endoplasmic reticulum IBA --
GO:0016021 integral component of membrane --
GO:0042470 melanosome IDA 17081065
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TMEM33: view

Pathways for TMEM33 Gene

SuperPathways for TMEM33 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0034613 cellular protein localization IBA --
GO:0051292 nuclear pore complex assembly IBA --
GO:0071786 endoplasmic reticulum tubular network organization IBA --
genes like me logo Genes that share ontologies with TMEM33: view

No data available for Pathways by source for TMEM33 Gene

Transcripts for TMEM33 Gene

Unigene Clusters for TMEM33 Gene

Transmembrane protein 33:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM33 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - -
SP2: - - -
SP3: - -
SP4: -
SP5: - - -
SP6: - - -

Relevant External Links for TMEM33 Gene

GeneLoc Exon Structure for
TMEM33
ECgene alternative splicing isoforms for
TMEM33

Expression for TMEM33 Gene

mRNA expression in normal human tissues for TMEM33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM33 Gene

SOURCE GeneReport for Unigene cluster for TMEM33 Gene Hs.31082

genes like me logo Genes that share expressions with TMEM33: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM33 Gene

Orthologs for TMEM33 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM33 35
  • 99.46 (n)
  • 100 (a)
TMEM33 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM33 35
  • 93.5 (n)
  • 96.75 (a)
TMEM33 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM33 35
  • 93.22 (n)
  • 97.97 (a)
TMEM33 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem33 35
  • 91.06 (n)
  • 97.97 (a)
Tmem33 16
Tmem33 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM33 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM33 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem33 35
  • 90.65 (n)
  • 98.37 (a)
chicken
(Gallus gallus)
Aves TMEM33 35
  • 81.09 (n)
  • 92.65 (a)
TMEM33 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM33 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem33 35
  • 77.1 (n)
  • 87.8 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem33 35
  • 68.84 (n)
  • 82.04 (a)
tmem33 36
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010214 35
  • 50.58 (n)
  • 47.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta Kr-h2 35
  • 47.89 (n)
  • 44.98 (a)
Kr-h2 36
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y37D8A.17 35
  • 46.5 (n)
  • 40.74 (a)
Y37D8A.17 36
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1815 36
  • 38 (a)
OneToOne
Species with no ortholog for TMEM33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM33 Gene

ENSEMBL:
Gene Tree for TMEM33 (if available)
TreeFam:
Gene Tree for TMEM33 (if available)

Paralogs for TMEM33 Gene

Selected SIMAP similar genes for TMEM33 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMEM33: view

No data available for Paralogs for TMEM33 Gene

Variants for TMEM33 Gene

Sequence variations from dbSNP and Humsavar for TMEM33 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs724633 -- 41,956,355(+) TTTTA(C/T)ATAAC utr-variant-3-prime
rs1043343 -- 41,960,474(+) AAATT(A/C)AATTG utr-variant-3-prime
rs1043347 -- 41,960,751(+) GTGAT(C/T)TAAGG utr-variant-3-prime
rs1054382 -- 41,955,758(+) AATGG(G/T)TTTAG utr-variant-3-prime
rs1507086 -- 41,954,396(-) ACAGC(A/G)CAGTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM33 Gene

Variant ID Type Subtype PubMed ID
dgv5529n71 CNV Loss 21882294
nsv517276 CNV Loss 19592680
esv33587 CNV Loss 17666407
nsv878960 CNV Loss 21882294
esv2662681 CNV Deletion 23128226

Relevant External Links for TMEM33 Gene

HapMap Linkage Disequilibrium report
TMEM33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM33 Gene

Disorders for TMEM33 Gene

No disorders were found for TMEM33 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM33 Gene

Publications for TMEM33 Gene

  1. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PMID: 17081065) Chi A. … Hunt D.F. (J. Proteome Res. 2006) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Identification and characterization of TMEM33 as a reticulon-binding protein. (PMID: 25612671) Urade T. … Sakisaka T. (Kobe J Med Sci 2014) 2 3
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4

Products for TMEM33 Gene

Sources for TMEM33 Gene

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