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TMEM33 Gene

protein-coding   GIFtS: 51
GCID: GC04P041937

Transmembrane Protein 33

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 331 2
1600019D15Rik2
SHINC32
DB833
Protein DB833

External Ids:    HGNC: 255411   Entrez Gene: 551612   Ensembl: ENSG000001091337   UniProtKB: P570883   

Export aliases for TMEM33 gene to outside databases

Previous GC identifers: GC04P041778 GC04P041631 GC04P041259


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM33 Gene:
TMEM33 (transmembrane protein 33) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006238.12  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM33 gene promoter:
         Nkx3-1   STAT1   Nkx3-1 v4   STAT1beta   MyoD   Nkx3-1 v1   STAT1alpha   Evi-1   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM33 promoter sequence
   Search Chromatin IP Primers for TMEM33

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM33


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p13   Ensembl cytogenetic band:  4p13   HGNC cytogenetic band: 4p14

TMEM33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM33 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P041937:  view genomic region     (about GC identifiers)

Start:
41,937,137 bp from pter      End:
41,962,824 bp from pter
Size:
25,688 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TMM33_HUMAN, P57088 (See protein sequence)
Recommended Name: Transmembrane protein 33  
Size: 247 amino acids; 27978 Da
Secondary accessions: B3KSS8 Q9H953

Explore the universe of human proteins at neXtProt for TMEM33: NX_P57088

Explore proteomics data for TMEM33 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys148
  • Modification sites at PhosphoSitePlus

  • See TMEM33 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060596.2  
    ENSEMBL proteins: 
     ENSP00000422473   ENSP00000422810   ENSP00000427006   ENSP00000264452   ENSP00000422517  
     ENSP00000421546   ENSP00000441455  

    TMEM33 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TMEM33

     
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    Abcam antibodies for TMEM33
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    ThermoFisher Antibodies for TMEM33
    LSBio Antibodies in human, mouse, rat for TMEM33

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    Search eBioscience for ELISAs for TMEM33 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005344 UPF0121

    Graphical View of Domain Structure for InterPro Entry P57088

    ProtoNet protein and cluster: P57088

    1 Blocks protein domain: IPB005344 Protein of unknown function UPF0121

    UniProtKB/Swiss-Prot: TMM33_HUMAN, P57088
    Similarity: Belongs to the PER33/POM33 family


    Find genes that share domains with TMEM33           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TMEM33           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TMEM33:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM33
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMEM33

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM33
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM33

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMEM33:
    hsa-mir-328-3p (MIRT043766), hsa-mir-193b-3p (MIRT016601), hsa-mir-615-3p (MIRT040248), hsa-mir-155-5p (MIRT021042), hsa-let-7b-5p (MIRT032486), hsa-mir-191-5p (MIRT045784)

    Block miRNA regulation of human, mouse, rat TMEM33 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMEM33 (see all 134):
    hsa-miR-640 hsa-miR-199a-3p hsa-miR-146a hsa-miR-3921 hsa-miR-298 hsa-miR-376a* hsa-miR-200b hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidTMEM33 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TMEM33
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM33

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TMEM33 (NM_018126)
    Sino Biological Human cDNA Clone for TMEM33
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM33
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM33

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM33 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM33


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMM33_HUMAN, P57088: Membrane; Multi-pass membrane protein (Potential). Melanosome. Note=Identified by mass
    spectrometry in melanosome fractions from stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--
    GO:0042470melanosome IDA17081065

    Find genes that share ontologies with TMEM33           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM33
    Interactions:

        Search GeneGlobe Interaction Network for TMEM33

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TMEM33 (P570882, 3 ENSP000002644524) via UniProtKB, MINT, STRING, and/or I2D (see all 139)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDNQ996083, ENSP000003326434I2D: score=2 STRING: ENSP00000332643
    USP19O949663, ENSP000003818634I2D: score=2 STRING: ENSP00000381863
    C20orf24Q9BUV83, ENSP000003412134I2D: score=1 STRING: ENSP00000341213
    PSMD6Q150083, ENSP000002959014I2D: score=1 STRING: ENSP00000295901
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with TMEM33           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM33 (TMM33)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMEM33 gene: 
    NM_018126.2  

    Unigene Cluster for TMEM33:

    Transmembrane protein 33
    Hs.31082  [show with all ESTs]
    Unigene Representative Sequence: NM_018126
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504986(uc003gwi.2 uc010ifw.2) ENST00000508448 ENST00000513702
    ENST00000264452 ENST00000510383 ENST00000506794 ENST00000513558 ENST00000325094

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMEM33 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMEM33 (see all 134):
    hsa-miR-640 hsa-miR-199a-3p hsa-miR-146a hsa-miR-3921 hsa-miR-298 hsa-miR-376a* hsa-miR-200b hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidTMEM33 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMEM33
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM33
    Clone
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    OriGene clones in human, mouse for TMEM33 (see all 8)
    OriGene ORF clones in mouse, rat for TMEM33
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMEM33 (NM_018126)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM33
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM33
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMEM33
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM33
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM33
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM33
      QuantiFast Probe-based Assays in human, mouse, rat TMEM33

    Additional mRNA sequence: 

    AF403224.1 AK001387.1 AK023062.1 AK024587.1 AK056974.1 AK094190.1 AK308501.1 AY659966.1 
    BC000948.2 BC014384.1 CR457260.1 

    12 DOTS entries:

    DT.444510  DT.453560  DT.95281541  DT.40131642  DT.100822691  DT.95372634  DT.100810545  DT.99940776 
    DT.121245301  DT.92035674  DT.95369629  DT.99973358 

    Selected AceView cDNA sequences (see all 207):

    AI702169 BM847480 AI339806 BM452373 AI291712 BX117504 CA454965 CR592529 
    CA495394 AL598045 CB128750 BU626484 BQ574641 AA262633 BU681718 CB161861 
    CA488997 AA827260 AA243617 AI337735 BM465799 CD368991 AW301721 CA842185 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMEM33 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:                                                                          -                       -         
    SP2:              -     -                                                     -                                 
    SP3:                    -                                                     -                                 
    SP4:                                                                          -                                 
    SP5:                                      -     -     -                                                         


    ECgene alternative splicing isoforms for TMEM33

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM33 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGTACCTG
    TMEM33 Expression
    About this image


    TMEM33 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Brain (Nervous System)
             Hypothalamus
     
     Spinal Cord (Nervous System)
    TMEM33 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM33 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.31082
        Custom PCR Arrays for TMEM33
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM33

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMEM33 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem331 , 5 transmembrane protein 331, 5 91.06(n)1
    97.97(a)1
      5 (36.00 cM)5
    678781  NM_001285452.11  NP_001272381.11 
     672605655 
    chicken
    (Gallus gallus)
    Aves TMEM331 transmembrane protein 33 81.09(n)
    92.65(a)
      422779  XM_420732.4  XP_420732.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM336
    transmembrane protein 33
    91(a)
    1 ↔ 1
    5(101084986-101098384)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD362524.12   -- 78.07(n)    CD362524.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC044544.12   -- 73.64(n)    BC044544.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Kr-h21 Kruppel homolog 2 47.89(n)
    44.98(a)
      33859  NM_001169423.1  NP_001162894.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y37D8A.171 Y37D8A.17 46.5(n)
    40.74(a)
      189617  NM_067283.1  NP_499684.1 


    ENSEMBL Gene Tree for TMEM33 (if available)
    TreeFam Gene Tree for TMEM33 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEM33 gene
    1 SIMAP similar gene for TMEM33 using alignment to 5 protein entries:     TMM33_HUMAN (see all proteins):
    SHINC3

    Find genes that share paralogs with TMEM33           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM33 (see all 510)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1825568961,2
    --41935191(+) CTTATC/GTGGAG 1 -- us2k10--------
    rs1460924881,2
    C--41935229(+) AATCAA/TAGCTG 1 -- us2k10--------
    rs797978861,2
    F--41935254(+) ATAGCA/GGGGGT 1 -- us2k11Minor allele frequency- G:0.03NA 120
    rs738104381,2
    C,F--41935345(+) GAGGGA/GAAAAA 1 -- us2k13Minor allele frequency- G:0.15WA NA 240
    rs738104391,2
    C,F--41935346(+) AGGGAG/AAAAAA 1 -- us2k11Minor allele frequency- A:0.00WA 2
    rs1401146541,2
    --41935394(+) GTAGGG/TGGTGC 1 -- us2k10--------
    rs1421589331,2
    C--41935659(+) CTGGGG/TTCCCC 1 -- us2k10--------
    rs351332601,2
    C,F--41935684(+) GATCTA/GTCCAG 1 -- us2k112Minor allele frequency- G:0.45NA WA CSA EA 374
    rs1463891061,2
    --41935799(+) CCACCC/TTGTTG 1 -- us2k10--------
    rs744815111,2
    --41935906(+) AGTACG/ACCCCT 1 -- us2k11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for TMEM33 (41937137 - 41962824 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TMEM33:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662681CNV Deletion23128226
    nsv878960CNV Loss21882294
    esv33587CNV Loss17666407
    nsv517276CNV Loss19592680
    dgv5529n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM33
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM33

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM33 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with TMEM33)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    6. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PubMed id 23464991)1 Scifo E....Lalowski M. (J. Proteome Res. 2013)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. (PubMed id 23798571)1 Roy S.J....Parent J.L. (Mol. Endocrinol. 2013)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (J Proteomics 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55161 HGNC: 25541 AceView: TMEM33 Ensembl:ENSG00000109133 euGenes: HUgn55161
    ECgene: TMEM33 H-InvDB: TMEM33

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TMEM33 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM33 gene:
    Search GeneIP for patents involving TMEM33

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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