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Aliases for TMEM33 Gene

Aliases for TMEM33 Gene

  • Transmembrane Protein 33 2 3 5
  • SHINC-3 3 4
  • 1600019D15Rik 3
  • Protein DB83 4
  • SHINC3 3
  • DB83 4

External Ids for TMEM33 Gene

Previous GeneCards Identifiers for TMEM33 Gene

  • GC04P041778
  • GC04P041631
  • GC04P041259

Summaries for TMEM33 Gene

GeneCards Summary for TMEM33 Gene

TMEM33 (Transmembrane Protein 33) is a Protein Coding gene. Diseases associated with TMEM33 include Ichthyosis, Congenital, Autosomal Recessive 11 and Autosomal Recessive Congenital Ichthyosis. GO annotations related to this gene include structural constituent of nuclear pore.

UniProtKB/Swiss-Prot for TMEM33 Gene

  • Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules (PubMed:25612671). Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed:26268696).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM33 Gene

Genomics for TMEM33 Gene

Regulatory Elements for TMEM33 Gene

Enhancers for TMEM33 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G041933 1.4 FANTOM5 ENCODE 3.8 +0.1 98 3.1 PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 TMEM33 GC04P041959
GH04G041938 0.8 ENCODE 0.7 +4.1 4126 1.4 MAX CEBPG RAD21 IRF9 ZNF316 SCRT2 TRIM24 MAFK GATAD2A HLF DCAF4L1 TMEM33 GC04P041959
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM33 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000167925 180 1801 PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766

Genomic Location for TMEM33 Gene

Chromosome:
4
Start:
41,935,120 bp from pter
End:
41,960,807 bp from pter
Size:
25,688 bases
Orientation:
Plus strand

Genomic View for TMEM33 Gene

Genes around TMEM33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM33 Gene

Proteins for TMEM33 Gene

  • Protein details for TMEM33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57088-TMM33_HUMAN
    Recommended name:
    Transmembrane protein 33
    Protein Accession:
    P57088
    Secondary Accessions:
    • B3KSS8
    • Q9H953

    Protein attributes for TMEM33 Gene

    Size:
    247 amino acids
    Molecular mass:
    27978 Da
    Quaternary structure:
    • Interacts with EIF2AK3 (PubMed:26268696). Interacts with ARL6IP1, isoform RTN1-A of RTN1, isoform RTN2-B of RTN2, isoform 3 of RTN3 and isoform 3 of RTN4 (PubMed:25612671).

neXtProt entry for TMEM33 Gene

Post-translational modifications for TMEM33 Gene

  • Ubiquitination at posLast=148148
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM33 Gene

Domains & Families for TMEM33 Gene

Protein Domains for TMEM33 Gene

Suggested Antigen Peptide Sequences for TMEM33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P57088

UniProtKB/Swiss-Prot:

TMM33_HUMAN :
  • Belongs to the PER33/POM33 family.
Family:
  • Belongs to the PER33/POM33 family.
genes like me logo Genes that share domains with TMEM33: view

No data available for Gene Families for TMEM33 Gene

Function for TMEM33 Gene

Molecular function for TMEM33 Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules (PubMed:25612671). Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed:26268696).
UniProtKB/Swiss-Prot Induction:
By endoplasmic reticulum (ER) stress.

Gene Ontology (GO) - Molecular Function for TMEM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25612671
GO:0017056 structural constituent of nuclear pore IBA --
genes like me logo Genes that share ontologies with TMEM33: view
genes like me logo Genes that share phenotypes with TMEM33: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM33 Gene

Localization for TMEM33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM33 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Melanosome. Nucleus envelope. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Co-localizes with RTN4 at the ER sheets. {ECO:0000269 PubMed:17081065, ECO:0000269 PubMed:25612671}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM33 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
nucleus 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IDA 25612671
GO:0005643 nuclear pore IBA --
GO:0005783 endoplasmic reticulum IDA 25612671
GO:0005789 endoplasmic reticulum membrane IEA,IDA 25612671
genes like me logo Genes that share ontologies with TMEM33: view

Pathways & Interactions for TMEM33 Gene

SuperPathways for TMEM33 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0034613 cellular protein localization IBA --
GO:0034976 response to endoplasmic reticulum stress IDA 26268696
GO:0051292 nuclear pore complex assembly IBA --
GO:1903371 regulation of endoplasmic reticulum tubular network organization IDA 25612671
genes like me logo Genes that share ontologies with TMEM33: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM33 Gene

Transcripts for TMEM33 Gene

Unigene Clusters for TMEM33 Gene

Transmembrane protein 33:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM33 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - -
SP2: - - -
SP3: - -
SP4: -
SP5: - - -
SP6: - - -

Relevant External Links for TMEM33 Gene

GeneLoc Exon Structure for
TMEM33
ECgene alternative splicing isoforms for
TMEM33

Expression for TMEM33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM33 Gene

This gene is overexpressed in Nasal epithelium (30.3) and Bone (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM33 Gene



Protein tissue co-expression partners for TMEM33 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM33 Gene:

TMEM33

SOURCE GeneReport for Unigene cluster for TMEM33 Gene:

Hs.31082

mRNA Expression by UniProt/SwissProt for TMEM33 Gene:

P57088-TMM33_HUMAN
Tissue specificity: Prostate cancer and several cancer cell lines (at protein level). Widely expressed. Expressed at higher levels in endocrine-resistant breast cancer cells as compared to endocrine-sensitive breast cancer cells. Expressed at higher levels in early recurrence breast cancer tissues as compared to non-recurrent breast tumors.

Evidence on tissue expression from TISSUES for TMEM33 Gene

  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with TMEM33: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM33 Gene

Orthologs for TMEM33 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM33 34 35
  • 99.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM33 35
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM33 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM33 34 35
  • 93.5 (n)
dog
(Canis familiaris)
Mammalia TMEM33 34 35
  • 93.22 (n)
mouse
(Mus musculus)
Mammalia Tmem33 34 16 35
  • 91.06 (n)
rat
(Rattus norvegicus)
Mammalia Tmem33 34
  • 90.65 (n)
chicken
(Gallus gallus)
Aves TMEM33 34 35
  • 81.09 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM33 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem33 34
  • 77.1 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem33 34 35
  • 68.84 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010214 34
  • 50.58 (n)
fruit fly
(Drosophila melanogaster)
Insecta Kr-h2 34 35
  • 47.89 (n)
worm
(Caenorhabditis elegans)
Secernentea Y37D8A.17 34 35
  • 46.5 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1815 35
  • 38 (a)
OneToOne
Species where no ortholog for TMEM33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM33 Gene

ENSEMBL:
Gene Tree for TMEM33 (if available)
TreeFam:
Gene Tree for TMEM33 (if available)

Paralogs for TMEM33 Gene

(1) SIMAP similar genes for TMEM33 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMEM33: view

No data available for Paralogs for TMEM33 Gene

Variants for TMEM33 Gene

Sequence variations from dbSNP and Humsavar for TMEM33 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000045598 -- 41,956,890(+) CTACA(A/C)CCGGC downstream-variant-500B, utr-variant-3-prime
rs1000112069 -- 41,949,069(+) GTAAT(A/G)CAGAT intron-variant
rs1000135817 -- 41,944,557(+) AAGCA(A/G)CTAAG intron-variant
rs1000177840 -- 41,935,776(+) TGGAA(A/G)TTGGG intron-variant, upstream-variant-2KB
rs1000225819 -- 41,942,284(+) CATAT(A/G)TGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM33 Gene

Variant ID Type Subtype PubMed ID
esv2662681 CNV deletion 23128226
esv3600342 CNV loss 21293372
nsv517276 CNV loss 19592680

Variation tolerance for TMEM33 Gene

Residual Variation Intolerance Score: 32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM33 Gene

Disorders for TMEM33 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TMEM33 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ichthyosis, congenital, autosomal recessive 11
  • autosomal recessive congenital ichthyosis 11
autosomal recessive congenital ichthyosis
  • arci
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM33

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM33
genes like me logo Genes that share disorders with TMEM33: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM33 Gene

Publications for TMEM33 Gene

  1. Identification and characterization of TMEM33 as a reticulon-binding protein. (PMID: 25612671) Urade T. … Sakisaka T. (Kobe J Med Sci 2014) 2 3 4 64
  2. TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling. (PMID: 26268696) Sakabe I. … Kasid U.N. (Breast Cancer Res. Treat. 2015) 3 4 64
  3. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PMID: 17081065) Chi A. … Hunt D.F. (J. Proteome Res. 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for TMEM33 Gene

Sources for TMEM33 Gene

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