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Aliases for TMEM33 Gene

Aliases for TMEM33 Gene

  • Transmembrane Protein 33 2 3 5
  • 1600019D15Rik 3
  • Protein DB83 4
  • SHINC3 3
  • DB83 4

External Ids for TMEM33 Gene

Previous GeneCards Identifiers for TMEM33 Gene

  • GC04P041778
  • GC04P041631
  • GC04P041259

Summaries for TMEM33 Gene

GeneCards Summary for TMEM33 Gene

TMEM33 (Transmembrane Protein 33) is a Protein Coding gene. GO annotations related to this gene include structural constituent of nuclear pore.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM33 Gene

Genomics for TMEM33 Gene

Regulatory Elements for TMEM33 Gene

Promoters for TMEM33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM33 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM33 Gene

Chromosome:
4
Start:
41,935,120 bp from pter
End:
41,960,807 bp from pter
Size:
25,688 bases
Orientation:
Plus strand

Genomic View for TMEM33 Gene

Genes around TMEM33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM33 Gene

Proteins for TMEM33 Gene

  • Protein details for TMEM33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57088-TMM33_HUMAN
    Recommended name:
    Transmembrane protein 33
    Protein Accession:
    P57088
    Secondary Accessions:
    • B3KSS8
    • Q9H953

    Protein attributes for TMEM33 Gene

    Size:
    247 amino acids
    Molecular mass:
    27978 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM33 Gene

Proteomics data for TMEM33 Gene at MOPED

Post-translational modifications for TMEM33 Gene

  • Ubiquitination at Lys 148
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM33 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for TMEM33

No data available for DME Specific Peptides for TMEM33 Gene

Domains & Families for TMEM33 Gene

Protein Domains for TMEM33 Gene

Suggested Antigen Peptide Sequences for TMEM33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P57088

UniProtKB/Swiss-Prot:

TMM33_HUMAN :
  • Belongs to the PER33/POM33 family.
Family:
  • Belongs to the PER33/POM33 family.
genes like me logo Genes that share domains with TMEM33: view

No data available for Gene Families for TMEM33 Gene

Function for TMEM33 Gene

Gene Ontology (GO) - Molecular Function for TMEM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25612671
genes like me logo Genes that share ontologies with TMEM33: view
genes like me logo Genes that share phenotypes with TMEM33: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM33 Gene

Localization for TMEM33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM33 Gene

Membrane; Multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM33 Gene COMPARTMENTS Subcellular localization image for TMEM33 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
nucleus 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005643 nuclear pore IBA --
GO:0005789 endoplasmic reticulum membrane IDA 25612671
GO:0016021 integral component of membrane IEA --
GO:0030176 integral component of endoplasmic reticulum membrane IDA 26268696
GO:0042470 melanosome IDA 17081065
genes like me logo Genes that share ontologies with TMEM33: view

Pathways & Interactions for TMEM33 Gene

SuperPathways for TMEM33 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0034613 cellular protein localization IBA --
GO:0034976 response to endoplasmic reticulum stress IDA 26268696
GO:0051292 nuclear pore complex assembly IBA --
GO:1903371 regulation of endoplasmic reticulum tubular network organization IDA 25612671
genes like me logo Genes that share ontologies with TMEM33: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM33 Gene

Drugs & Compounds for TMEM33 Gene

No Compound Related Data Available

Transcripts for TMEM33 Gene

Unigene Clusters for TMEM33 Gene

Transmembrane protein 33:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM33 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - -
SP2: - - -
SP3: - -
SP4: -
SP5: - - -
SP6: - - -

Relevant External Links for TMEM33 Gene

GeneLoc Exon Structure for
TMEM33
ECgene alternative splicing isoforms for
TMEM33

Expression for TMEM33 Gene

mRNA expression in normal human tissues for TMEM33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM33 Gene

This gene is overexpressed in Nasal epithelium (30.3) and Bone (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM33 Gene



SOURCE GeneReport for Unigene cluster for TMEM33 Gene Hs.31082

genes like me logo Genes that share expression patterns with TMEM33: view

Protein tissue co-expression partners for TMEM33 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM33 Gene

Orthologs for TMEM33 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM33 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM33 35
  • 93.5 (n)
  • 96.75 (a)
TMEM33 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM33 35
  • 93.22 (n)
  • 97.97 (a)
TMEM33 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem33 35
  • 91.06 (n)
  • 97.97 (a)
Tmem33 16
Tmem33 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM33 35
  • 99.46 (n)
  • 100 (a)
TMEM33 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem33 35
  • 90.65 (n)
  • 98.37 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM33 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM33 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM33 35
  • 81.09 (n)
  • 92.65 (a)
TMEM33 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM33 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem33 35
  • 77.1 (n)
  • 87.8 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem33 35
  • 68.84 (n)
  • 82.04 (a)
tmem33 36
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010214 35
  • 50.58 (n)
  • 47.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta Kr-h2 35
  • 47.89 (n)
  • 44.98 (a)
Kr-h2 36
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y37D8A.17 35
  • 46.5 (n)
  • 40.74 (a)
Y37D8A.17 36
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1815 36
  • 38 (a)
OneToOne
Species with no ortholog for TMEM33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM33 Gene

ENSEMBL:
Gene Tree for TMEM33 (if available)
TreeFam:
Gene Tree for TMEM33 (if available)

Paralogs for TMEM33 Gene

(1) SIMAP similar genes for TMEM33 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMEM33: view

No data available for Paralogs for TMEM33 Gene

Variants for TMEM33 Gene

Sequence variations from dbSNP and Humsavar for TMEM33 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs724633 -- 41,956,355(+) TTTTA(C/T)ATAAC utr-variant-3-prime
rs1043343 -- 41,960,474(+) AAATT(A/C)AATTG utr-variant-3-prime
rs1043347 -- 41,960,751(+) GTGAT(C/T)TAAGG utr-variant-3-prime
rs1054382 -- 41,955,758(+) AATGG(G/T)TTTAG utr-variant-3-prime
rs1532939 -- 41,961,265(-) TATTT(C/T)ATAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TMEM33 Gene

Variant ID Type Subtype PubMed ID
dgv5529n71 CNV Loss 21882294
nsv517276 CNV Loss 19592680
esv33587 CNV Loss 17666407
nsv878960 CNV Loss 21882294
esv2662681 CNV Deletion 23128226

Variation tolerance for TMEM33 Gene

Residual Variation Intolerance Score: 32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM33 Gene

HapMap Linkage Disequilibrium report
TMEM33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM33 Gene

Disorders for TMEM33 Gene

Relevant External Links for TMEM33

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM33

No disorders were found for TMEM33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM33 Gene

Publications for TMEM33 Gene

  1. Identification and characterization of TMEM33 as a reticulon-binding protein. (PMID: 25612671) Urade T. … Sakisaka T. (Kobe J Med Sci 2014) 2 3 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for TMEM33 Gene

Sources for TMEM33 Gene

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