TMEM30C Gene
protein-coding GIFtS: 28
GCID: GC03P099904
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transmembrane protein 30C
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Aliases
for TMEM30C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Transmembrane Protein 30C1 2 3 | | CDC50C1 2 3 5 |
| External Ids: | HGNC: 304431 | Entrez Gene: 6444442 | Ensembl: ENSG000002351567 | OMIM: 6110305 | UniProtKB: A0ZSE63 |
|---|
| | ORGUL members: | |
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| NONCODE:n408211 | |
Export aliases for TMEM30C gene to outside databasesPrevious GC identifers: GC03U900581 GC03P101389 GC03P097272
Summaries
for TMEM30C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM30C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM30C gene promoter:
HFH-3 Pbx1a Brachyury CUTL1 FOXI1 MEF-2A POU2F1 POU2F1a aMEF-2 TGIF
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM30C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM30C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q12.1 Ensembl cytogenetic band: 3q12.1 HGNC cytogenetic band: 3q12.1TMEM30C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P099904: view genomic region
(about GC identifiers)
Start:
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99,904,531 bp from pter |
End:
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99,913,035 bp from pter |
Size:
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8,505 bases |
Orientation:
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plus strand |
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Proteins
for TMEM30C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CC50C_HUMAN, A0ZSE6 (See
protein sequence)Recommended Name: Cell cycle control protein 50C Size: 113 amino acids; 13039 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Caution: According to PubMed:17258408, the major transcript has no stop-codon and is probably non protein-coding. Aminor transcript is also expressed and encodes the displayed protein which misses C-terminal part compared to othermammalian orthologsExplore the universe of human proteins at neXtProt for TMEM30C: NX_A0ZSE6
TMEM30C Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000419663 ENSP00000402698
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM30C for ontologies About GeneDecksing
TMEM30C Antibody Products:
Assay Products for TMEM30C: |
Protein
Domains /
Families
for TMEM30C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM30C for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A0ZSE6ProtoNet protein and cluster: A0ZSE6 UniProtKB/Swiss-Prot: CC50C_HUMAN, A0ZSE6Similarity: Belongs to the CDC50/LEM3 family |
Function
for TMEM30C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
|
Pathways & Interactions
for TMEM30C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM30C
|
Drugs & Compounds
for TMEM30C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM30C
Search CenterWatch for drugs/clinical trials and news about TMEM30C / CC50C 
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Transcripts
for TMEM30C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
Unigene Cluster for TMEM30C: Transmembrane protein 30C Hs.652353 Unigene Representative Sequence: AB2496663 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000476804 ENST00000489487(uc003dtr.2) ENST00000429523
Additional cDNA sequence: AB249666.1 AB250297.1 NR_028357.1 NR_028358.1
GeneLoc Exon Structure
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Expression
for TMEM30C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM30C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATGCTTTC
About this image
See TMEM30C Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.652353
UniProtKB/Swiss-Prot: CC50C_HUMAN, A0ZSE6Tissue specificity: Specifically expressed in testis
SABiosciences Custom PCR Arrays for TMEM30C
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TMEM30C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM30C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM30C |
Orthologs
for TMEM30C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of human and mouse.
Orthologs for TMEM30C gene from 1 species (see representative species ) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Tmem30c5 |
transmembrane protein 30C |
-- |
|
16 (34.22 cM) 57266139 |
ENSEMBL Gene Tree for TMEM30C (if available)
TreeFam Gene Tree for TMEM30C (if available) |
Paralogs
for TMEM30C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM30C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM30C (99904531 - 99913035 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM30C: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM30C |
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Disorders
/ Diseases
for TMEM30C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TMEM30C for disorders About MalaCards
TMEM30C for disorders About GeneDecksing
OMIM gene information: 611030
OMIM disorders: --
Export disorders for TMEM30C gene to outside databases
|
Publications
for TMEM30C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for TMEM30C gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM30C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of CDC50A, CDC50B and CDC50C genes in silico. (PubMed id 15375526)1, 2, 3 Katoh Y. and Katoh M. (2004)
- Aberrant termination of reproduction-related TMEM30C transcripts in the hominoids. (PubMed id 17258408)1, 2 Osada N.... Kusuda J. (2007)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
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External Searches for TMEM30C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TMEM30C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing TMEM30C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM30C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM30C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM30C gene:
Search GeneIP for patents involving TMEM30C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM30C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM30C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM30C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM30C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM30C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM30C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM30C |
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 |  |  |  | |
| | | | Search Tocris compounds for TMEM30C |
| |  |  |  |  | | | | |
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 | | | TMEM30C Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for TMEM30C |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM30C |
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GeneCards Homepage -
Last full update: 18 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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