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Aliases for TMEM30B Gene

Aliases for TMEM30B Gene

  • Transmembrane Protein 30B 2 3 4 5
  • P4-ATPase Flippase Complex Beta Subunit TMEM30B 3 4
  • CDC50B 3 4

External Ids for TMEM30B Gene

Previous GeneCards Identifiers for TMEM30B Gene

  • GC14M059735
  • GC14M060814
  • GC14M061744
  • GC14M041907

Summaries for TMEM30B Gene

GeneCards Summary for TMEM30B Gene

TMEM30B (Transmembrane Protein 30B) is a Protein Coding gene. An important paralog of this gene is TMEM30C.

UniProtKB/Swiss-Prot for TMEM30B Gene

  • Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM30B Gene

Genomics for TMEM30B Gene

Regulatory Elements for TMEM30B Gene

Promoters for TMEM30B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM30B on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM30B Gene

Chromosome:
14
Start:
61,277,370 bp from pter
End:
61,281,840 bp from pter
Size:
4,471 bases
Orientation:
Minus strand

Genomic View for TMEM30B Gene

Genes around TMEM30B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM30B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM30B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM30B Gene

Proteins for TMEM30B Gene

  • Protein details for TMEM30B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3MIR4-CC50B_HUMAN
    Recommended name:
    Cell cycle control protein 50B
    Protein Accession:
    Q3MIR4
    Secondary Accessions:
    • B3KR84
    • Q14D00

    Protein attributes for TMEM30B Gene

    Size:
    351 amino acids
    Molecular mass:
    38941 Da
    Quaternary structure:
    • Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit (Probable). Interacts with alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4.

neXtProt entry for TMEM30B Gene

Proteomics data for TMEM30B Gene at MOPED

Post-translational modifications for TMEM30B Gene

  • Glycosylation at Asn 75, Asn 213, and Asn 286
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM30B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TMEM30B Gene

Domains & Families for TMEM30B Gene

Protein Domains for TMEM30B Gene

Suggested Antigen Peptide Sequences for TMEM30B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3MIR4

UniProtKB/Swiss-Prot:

CC50B_HUMAN :
  • Belongs to the CDC50/LEM3 family.
Family:
  • Belongs to the CDC50/LEM3 family.
genes like me logo Genes that share domains with TMEM30B: view

No data available for Gene Families for TMEM30B Gene

Function for TMEM30B Gene

Molecular function for TMEM30B Gene

UniProtKB/Swiss-Prot Function:
Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane.

Phenotypes for TMEM30B Gene

genes like me logo Genes that share phenotypes with TMEM30B: view

Animal Models for TMEM30B Gene

MGI Knock Outs for TMEM30B:

Animal Model Products

CRISPR Products

miRNA for TMEM30B Gene

miRTarBase miRNAs that target TMEM30B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM30B Gene

Localization for TMEM30B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM30B Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM30B Gene COMPARTMENTS Subcellular localization image for TMEM30B gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM30B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM30B: view

Pathways & Interactions for TMEM30B Gene

SuperPathways for TMEM30B Gene

No Data Available

Interacting Proteins for TMEM30B Gene

Selected Interacting proteins: Q3MIR4-CC50B_HUMAN for TMEM30B Gene via I2D

Gene Ontology (GO) - Biological Process for TMEM30B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM30B Gene

Drugs & Compounds for TMEM30B Gene

No Compound Related Data Available

Transcripts for TMEM30B Gene

mRNA/cDNA for TMEM30B Gene

Unigene Clusters for TMEM30B Gene

Transmembrane protein 30B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM30B Gene

No ASD Table

Relevant External Links for TMEM30B Gene

GeneLoc Exon Structure for
TMEM30B
ECgene alternative splicing isoforms for
TMEM30B

Expression for TMEM30B Gene

mRNA expression in normal human tissues for TMEM30B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM30B Gene

This gene is overexpressed in Prostate (28.0), Rectum (20.4), and Pancreas (17.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TMEM30B Gene



SOURCE GeneReport for Unigene cluster for TMEM30B Gene Hs.146180

genes like me logo Genes that share expression patterns with TMEM30B: view

Protein tissue co-expression partners for TMEM30B Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM30B Gene

Orthologs for TMEM30B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMEM30B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM30B 35
  • 99.43 (n)
  • 99.71 (a)
cow
(Bos Taurus)
Mammalia TMEM30B 35
  • 93.83 (n)
  • 95.09 (a)
TMEM30B 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM30B 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem30b 16
Tmem30b 35
  • 91.03 (n)
  • 90.64 (a)
Tmem30b 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM30B 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 27 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tmem30b 35
  • 90.74 (n)
  • 90.06 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM30B 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem30b 35
  • 55.45 (n)
  • 61.11 (a)
zebrafish
(Danio rerio)
Actinopterygii TMEM30B 36
  • 56 (a)
OneToOne
zgc:91908 35
  • 56.75 (n)
  • 57.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9947 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea chat-1 36
  • 41 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 28 (a)
ManyToMany
CDC50 36
  • 30 (a)
ManyToMany
LEM3 36
  • 22 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for TMEM30B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM30B Gene

ENSEMBL:
Gene Tree for TMEM30B (if available)
TreeFam:
Gene Tree for TMEM30B (if available)

Paralogs for TMEM30B Gene

Paralogs for TMEM30B Gene

(1) SIMAP similar genes for TMEM30B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM30B: view

Variants for TMEM30B Gene

Sequence variations from dbSNP and Humsavar for TMEM30B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2000075 -- 61,282,701(+) TCACA(C/T)TAAAA upstream-variant-2KB
rs3196765 -- 61,280,926(+) CAGTT(A/G)CCGGT reference, synonymous-codon
rs11538992 -- 61,280,990(-) GGGCC(A/T)CTACT reference, missense
rs12890078 -- 61,278,926(+) AAAAA(A/C/T)TTTTT utr-variant-3-prime
rs35762036 -- 61,280,872(+) ACGAG(-/T)CAGGG reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM30B Gene

Variant ID Type Subtype PubMed ID
nsv902005 CNV Gain 21882294

Variation tolerance for TMEM30B Gene

Gene Damage Index Score: 3.92; 59.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM30B Gene

HapMap Linkage Disequilibrium report
TMEM30B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM30B Gene

Disorders for TMEM30B Gene

Relevant External Links for TMEM30B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM30B

No disorders were found for TMEM30B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM30B Gene

Publications for TMEM30B Gene

  1. Identification and characterization of CDC50A, CDC50B and CDC50C genes in silico. (PMID: 15375526) Katoh Y. … Katoh M. (Oncol. Rep. 2004) 2 3 4 23 67
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  3. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. (PMID: 21914794) Takatsu H. … Shin H.W. (J. Biol. Chem. 2011) 3
  4. Differential expression profiling analyses identifies downregulation of 1p, 6q, and 14q genes and overexpression of 6p histone cluster 1 genes as markers of recurrence in meningiomas. (PMID: 20685720) PAcrez-MagA!n E. … MelAcndez B. (Neuro-oncology 2010) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for TMEM30B Gene

Sources for TMEM30B Gene

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