Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM27 Gene

protein-coding   GIFtS: 51
GCID: GC0XM015555

transmembrane protein 27

 Explore 8 diseases affiliated with
TMEM27 via our new
 Human Malady Compendium 
Biological research products
for TMEM27
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Transmembrane Protein 271 2 3
NX171 2 5
0610008J07Rik2
NX-172
Collectrin1
Kidney-Specific Membrane Protein2

External Ids:    HGNC: 294371   Entrez Gene: 573932   Ensembl: ENSG000001470037   OMIM: 3006315   UniProtKB: Q9HBJ83   

Export aliases for TMEM27 gene to outside databases

Previous GC identifers: GC0XM015007 GC0XM015405 GC0XM013399


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TMEM27:
This gene encodes a transmembrane protein that is important for trafficking amino acid transporters to the apical brush
border of proximal tubules. It also plays a role in controlling insulin exocytosis by regulating formation of the
SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells.
(provided by RefSeq, Nov 2009)

UniProtKB/Swiss-Prot: TMM27_HUMAN, Q9HBJ8
Function: Regulator of SNARE complex function. Stimulator of beta cell replication




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167197.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM27 gene promoter:
         c-Fos   AP-1   CUTL1   Nkx5-1   Evi-1   GATA-1   RORalpha2   FOXO4   HFH-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM27 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM27

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22

TMEM27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM27 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM015555:  view genomic region     (about GC identifiers)

Start:
15,645,441 bp from pter      End:
15,683,154 bp from pter
Size:
37,714 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TMM27_HUMAN, Q9HBJ8 (See protein sequence)
Recommended Name: Collectrin precursor  
Size: 222 amino acids; 25235 Da
Subunit: Homodimer (By similarity). Associates with SLC6A18 (By similarity). Interacts with SNAPIN
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=AAQ89419.1; Type=Frameshift; Positions=207;
Secondary accessions: B2R9M1 Q6UW07

Explore the universe of human proteins at neXtProt for TMEM27: NX_Q9HBJ8

Post-translational modifications:

  • Glycosylated (By similarity)1
  • The extracellular domain is cleaved and released from the cell membrane of pancreatic beta cells (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HBJ8

  • TMEM27 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065716.1  
    ENSEMBL proteins: 
     ENSP00000369699  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for TMEM27 (Collectrin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: TMEM27
    OriGene Protein Over-expression Lysate: TMEM27
    OriGene Custom Protein Services for TMEM27 
    GenScript Custom Purified and Recombinant Proteins Services for TMEM27
    Novus Biologicals TMEM27 Protein
    Novus Biologicals TMEM27 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TMEM27

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    TMEM27 for ontologies           About GeneDecksing



    TMEM27 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for TMEM27 (Collectrin)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TMEM27 
    GenScript Custom Superior Antibodies Services for TMEM27
    Novus Biologicals TMEM27 Antibodies
    Search for Antibodies for TMEM27 at Abcam  
    Uscn Antibodies for TMEM27
    Search ThermoFisher Antibodies for TMEM27

    Assay Products for TMEM27: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TMEM27
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TMEM27


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TMEM27 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001548 Peptidase_M2

    Graphical View of Domain Structure for InterPro Entry Q9HBJ8

    ProtoNet protein and cluster: Q9HBJ8

    UniProtKB/Swiss-Prot: TMM27_HUMAN, Q9HBJ8
    Similarity: Belongs to the TMEM27 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TMM27_HUMAN, Q9HBJ8
    Function: Regulator of SNARE complex function. Stimulator of beta cell replication

    miRNA
    Products:
        
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM27
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TMEM27
    SwitchGear 3'UTR luciferase reporter plasmidTMEM27 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM27 (see all 7)
    OriGene shRNA RFP: TMEM27
    OriGene siRNA: TMEM27
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM27

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TMEM27

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM27 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM27
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TMEM27 (NM_020665)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM27
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM27 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TMEM27
    Search LifeMap BioReagents cell lines for TMEM27

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM27

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008237metallopeptidase activity IEA--
    GO:0008241peptidyl-dipeptidase activity IEA--


    TMEM27 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TMEM27:
     Increased HPV18 LCR reporter a 

    Animal Models:
         Mouse knock-outs for TMEM27: Tmem27tm1.1Pngr Tmem27tm1Thu
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tmem27):
     adipose tissue  behavior/neurological  cellular  growth/size  homeostasis/metabolism 
     muscle  renal/urinary system 

    TMEM27 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM27

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TMEM27 (ENSP000003696994) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBM18ENSP000004093154STRING: ENSP00000409315
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--


    TMEM27 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM27
    Search CenterWatch for drugs/clinical trials and news about TMEM27 / TMM27 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM27 gene: 
    NM_020665.4  

    Unigene Cluster for TMEM27:

    Transmembrane protein 27
    Hs.129614  [show with all ESTs]
    Unigene Representative Sequence: BC014317
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000380342(uc004cxc.2)

    miRNA
    Products:
         
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM27
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TMEM27
    SwitchGear 3'UTR luciferase reporter plasmidTMEM27 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM27 (see all 7)
    OriGene shRNA RFP: TMEM27
    OriGene siRNA: TMEM27
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM27
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM27 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM27
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TMEM27 (NM_020665)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM27
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM27 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM27
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM27
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM27
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM27

    Additional cDNA sequence: 

    AF229179.1 AK313835.1 AY359060.1 BC014317.1 BC015099.1 BC050606.1 

    7 DOTS entries:

    DT.202718  DT.121314624  DT.91766823  DT.102823265  DT.121314632  DT.121314666  DT.91655565 

    24/101 AceView cDNA sequences (see all 101):

    CB137859 CB139958 AI373739 AI253234 AA999850 CB137251 AI650909 CB133561 
    CB134037 CB163923 BC015099 AY359060 BG564304 CB139945 AF229179 BC050606 
    AI985237 CB139939 BG429174 CB125058 AI793025 BG430790 AA345162 BF431418 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGTATTTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    TMEM27 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyProximal TubuleProximal Tubule CellsKidney
    KidneyS-shaped BodyKidney
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TMEM27 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM27

    SOURCE GeneReport for Unigene cluster: Hs.129614

    UniProtKB/Swiss-Prot: TMM27_HUMAN, Q9HBJ8
    Tissue specificity: Kidney; collecting ducts. Pancreas; beta cells of islets

        SABiosciences Custom PCR Arrays for TMEM27
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM27
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM27
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM27
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM27
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM27

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM27 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem271 , 5 transmembrane protein 271, 5 86.64(n)1
    84.68(a)1
      X (76.12 cM)5
    573941  NM_020626.21  NP_065651.11 
     1640888305 
    chicken
    (Gallus gallus)
    Aves TMEM271 transmembrane protein 27 67.99(n)
    62.87(a)
      418622  XM_416821.3  XP_416821.3 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM276
    --
    64(a)
    1 ↔ 1
    3(121549204-121579457)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686342 hypothetical protein MGC68634 73.72(n)    BC058203.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-194e6.11 si:dkey-194e6.1 53(n)
    41.94(a)
      402976  NM_001139458.1  NP_001132930.1 


    ENSEMBL Gene Tree for TMEM27 (if available)
    TreeFam Gene Tree for TMEM27 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMEM27 gene
    ACE2  ENSG000002648132  ACE22  
    1 SIMAP similar gene for TMEM27 using alignment to 1 protein entry:     TMM27_HUMAN:
    ACE2

    TMEM27 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/471 NCBI SNPs in TMEM27 are shown (see all 471    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1926015991,2
    --15645049(+) CCTCAC/TTTCTT 1 -- ds50010--------
    rs1844627701,2
    --15645124(+) TTGTAC/TGCAAG 1 -- ds50010--------
    rs1891240961,2
    --15645313(+) AAGGTA/GTCTTC 1 -- ds50010--------
    rs1811715881,2
    --15645438(+) ATCAGA/TCACAC 1 -- ds50010--------
    rs66539791,2
    C,F,A,H,--15645545(+) GCTGAT/CATTCA 1 -- ut31 ese313Minor allele frequency- C:0.09NS EA NA 1332
    rs611703541,2
    C,--15645576(+) TGGTGA/TGATAA 1 -- ut310--------
    rs1848894741,2
    --15645585(+) AACAGG/TATAAA 1 -- ut310--------
    rs1164195801,2
    C,--15645609(+) TATGAA/GTAATT 1 -- ut310--------
    rs1890210031,2
    --15645625(+) TTTATA/CCATCC 1 -- ut310--------
    rs1424234711,2
    --15645674(+) ATATAC/TAGAGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TMEM27 (15645441 - 15683154 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TMEM27
         1 CNV: 3262
    Locus Specific Mutation Databases (LSDB): TMEM27

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM27
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM27

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TMEM27 for disorders           About GeneDecksing

    OMIM gene information: 300631    OMIM disorders: --

    8 diseases for TMEM27:    About MalaCards
    maturity-onset diabetes of the young    pancreatitis    hartnup disease    dent disease
    polycystic kidney disease    aminoaciduria    turner syndrome    kidney disease

    2 diseases from the University of Copenhagen DISEASES database for TMEM27:
    Hartnup disease     maturity-onset diabetes of the young
    Human Genome Epidemiology (HuGE) Navigator: TMEM27 (1 document)

    Export disorders for TMEM27 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM27 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with TMEM27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys. (PubMed id 11278314)1, 2, 3, 9 Zhang H.... Makino H. (2001)
    2. The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation. (PubMed id 16330323)1, 2 Fukui K.... Yamagata K. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Locus heterogeneity of Dent's disease: OCRL1 and TMEM 27 genes in patients with no CLCN5 mutations. (PubMed id 19582483)1, 9 Tosetto E....Anglani F. (2009)
    6. The role of transmembrane protein 27 (TMEM27) in isle t physiology and its potential use as a beta cell mass biomarker. (PubMed id 20386877)1, 9 Altirriba J....Gomis R. (2010)
    7. Collectrin and the kidney. (PubMed id 17693757)1, 9 Mount D.B. (2007)
    8. Not just angiotensinases: new roles for the angiotens in-converting enzymes. (PubMed id 19763395)1, 9 Lambert D.W....Turner A.J. (2010)
    9. Tmem27 dimerization, deglycosylation, plasma membrane depletion, and the extracellular Phe-Phe motif are negative regulators of cleava ge by Bace2. (PubMed id 22628310)1 Esterhazy D....Stoffel M. (2012)
    10. Collectrin and ACE2 in renal and intestinal amino aci d transport. (PubMed id 21814048)1 Singer D. and Camargo S.M. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57393 HGNC: 29437 AceView: TMEM27 Ensembl:ENSG00000147003 euGenes: HUgn57393
    ECgene: TMEM27 H-InvDB: TMEM27

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM27 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM27 gene:
    Search GeneIP for patents involving TMEM27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for TMEM27 (Collectrin)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for TMEM27 (Collectrin)  
     Browse OriGene Antibodies   OriGene shRNA RFP for TMEM27  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM27   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM27  
     OriGene Protein Over-expression Lysate for TMEM27   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TMEM27   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM27   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM27  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for TMEM27   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TMEM27   OriGene Custom Protein Services for TMEM27  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM27
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM27
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM27
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM27
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM27
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM27
     GenScript Custom Purified and Recombinant Proteins Services for TMEM27 GenScript cDNA clones with any tag delivered in your preferred vector for TMEM27
     GenScript Custom Assay Services for TMEM27 GenScript Custom Superior Antibodies Services for TMEM27
     GenScript Custom overexpressing Cell Line Services for TMEM27 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TMEM27 promoter
     Search Chromatin IP Primers for TMEM27
     RT2 qPCR Primer Assay in human, mouse, rat TMEM27
     Search GNC Networks for TMEM27
     SABiosciences Custom PCR Arrays for TMEM27
     Search Tocris compounds for TMEM27
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TMEM27 antibodies
     TMEM27 proteins
     TMEM27 lysates
     Search for Antibodies for TMEM27 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TMEM27
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TMEM27 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TMEM27
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM27
     SwitchGear 3'UTR luciferase reporter plasmids for TMEM27
     SwitchGear Promoter luciferase reporter plasmids for TMEM27
     Search ThermoFisher Antibodies for TMEM27
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM27
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TMEM27 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4