Aliases for TMEM27 Gene
External Ids for TMEM27 Gene
Previous GeneCards Identifiers for TMEM27 Gene
This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. [provided by RefSeq, Jun 2013]
GeneCards Summary for TMEM27 Gene
TMEM27 (Transmembrane Protein 27) is a Protein Coding gene. Diseases associated with TMEM27 include Aminoaciduria and Polycystic Kidney Disease 4, With Or Without Hepatic Disease. Among its related pathways are Peptide hormone metabolism and Metabolism of proteins. GO annotations related to this gene include metallopeptidase activity and peptidyl-dipeptidase activity. An important paralog of this gene is ACE2.
UniProtKB/Swiss-Prot for TMEM27 Gene
Regulator of SNARE complex function. Stimulator of beta cell replication.