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Aliases for TMEM268 Gene

Aliases for TMEM268 Gene

  • Transmembrane Protein 268 2 3 5
  • C9orf91 3 4
  • Chromosome 9 Open Reading Frame 91 2
  • Transmembrane Protein C9orf91 3

External Ids for TMEM268 Gene

Previous HGNC Symbols for TMEM268 Gene

  • C9orf91

Summaries for TMEM268 Gene

GeneCards Summary for TMEM268 Gene

TMEM268 (Transmembrane Protein 268) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM268 Gene

Genomics for TMEM268 Gene

Regulatory Elements for TMEM268 Gene

Enhancers for TMEM268 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G114360 2 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -227.8 -227807 30.6 HDGF PKNOX1 FOXA2 ZFP64 WRNIP1 SIN3A YBX1 ZNF143 ZNF207 FOS WHRN AKNA TMEM268 ENSG00000201749 ORM1 ORM2 ATP6V1G1 ENSG00000235119
GH09G114348 1.5 Ensembl ENCODE dbSUPER 10 -254.6 -254628 2.5 HDGF PKNOX1 CREB3L1 WRNIP1 SIN3A FEZF1 GLIS2 ZNF143 FOS SP3 WHRN COL27A1 TMEM268 ENSG00000201749 AKNA ORM2 ENSG00000235119
GH09G114487 1.3 Ensembl ENCODE dbSUPER 11.1 -116.3 -116295 0.9 HDGF WRNIP1 ARID4B RAD21 ZNF143 RELB IKZF2 ZNF263 ZNF654 GATAD2B WHRN ENSG00000201749 TMEM268 LOC100131877 AKNA
GH09G114413 1.2 FANTOM5 Ensembl ENCODE dbSUPER 11 -189.4 -189446 2.1 NR2F2 TNFSF15 WHRN TMEM268 ENSG00000201749 AKNA ATP6V1G1 LOC100131877
GH09G114493 1.1 ENCODE dbSUPER 10.9 -110.0 -110046 1.0 HDGF ARNT E2F7 CHAMP1 TCF12 ZNF766 ZBTB2 NCOA1 GATAD2B ZEB2 TMEM268 ENSG00000201749 LOC105376228 WHRN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM268 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM268 Gene

Chromosome:
9
Start:
114,603,942 bp from pter
End:
114,646,423 bp from pter
Size:
42,482 bases
Orientation:
Plus strand

Genomic View for TMEM268 Gene

Genes around TMEM268 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM268 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM268 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM268 Gene

Proteins for TMEM268 Gene

  • Protein details for TMEM268 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZI3-TM268_HUMAN
    Recommended name:
    Transmembrane protein 268
    Protein Accession:
    Q5VZI3
    Secondary Accessions:
    • A0PJA3
    • Q3KNS4
    • Q5VZI2
    • Q6P5Z7
    • Q8N1P3
    • Q8ND43

    Protein attributes for TMEM268 Gene

    Size:
    342 amino acids
    Molecular mass:
    37569 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04537.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM268 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM268 Gene

Post-translational modifications for TMEM268 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM268 Gene

Domains & Families for TMEM268 Gene

Protein Domains for TMEM268 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM268 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM268: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM268 Gene

Function for TMEM268 Gene

Gene Ontology (GO) - Molecular Function for TMEM268 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM268: view
genes like me logo Genes that share phenotypes with TMEM268: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM268 Gene

Localization for TMEM268 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM268 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM268 gene
Compartment Confidence
plasma membrane 3
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM268 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM268: view

Pathways & Interactions for TMEM268 Gene

SuperPathways for TMEM268 Gene

No Data Available

Interacting Proteins for TMEM268 Gene

Selected Interacting proteins: Q5VZI3-TM268_HUMAN for TMEM268 Gene via IID

Symbol External ID(s) Details
ELAVL1
REL

Gene Ontology (GO) - Biological Process for TMEM268 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM268: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM268 Gene

Transcripts for TMEM268 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM268 Gene

No ASD Table

Relevant External Links for TMEM268 Gene

GeneLoc Exon Structure for
TMEM268
ECgene alternative splicing isoforms for
TMEM268

Expression for TMEM268 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM268 Gene:

TMEM268

Evidence on tissue expression from TISSUES for TMEM268 Gene

  • Nervous system(4.4)
  • Lung(4.2)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM268 Gene

Orthologs for TMEM268 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM268 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf91 34
  • 99.22 (n)
C9ORF91 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C9orf91 35
  • 90 (a)
OneToOne
C11H9orf91 34
  • 87.82 (n)
cow
(Bos Taurus)
Mammalia C9orf91 35
  • 88 (a)
OneToOne
C8H9orf91 34
  • 87.33 (n)
mouse
(Mus musculus)
Mammalia 6330416G13Rik 34 35
  • 85.92 (n)
Tmem268 16
rat
(Rattus norvegicus)
Mammalia RGD1304595 34
  • 85.04 (n)
oppossum
(Monodelphis domestica)
Mammalia C9orf91 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf91 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves C17H9ORF91 34
  • 61.37 (n)
C9orf91 35
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485830 34
  • 52.26 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC559789 34
  • 46.21 (n)
C19H9orf91 35
  • 28 (a)
OneToOne
Species where no ortholog for TMEM268 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM268 Gene

ENSEMBL:
Gene Tree for TMEM268 (if available)
TreeFam:
Gene Tree for TMEM268 (if available)

Paralogs for TMEM268 Gene

No data available for Paralogs for TMEM268 Gene

Variants for TMEM268 Gene

Sequence variations from dbSNP and Humsavar for TMEM268 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000047619 -- 114,627,561(+) TATGT(A/G)TAAAT intron-variant
rs1000082685 -- 114,632,140(+) GTAAA(C/T)TGGAG intron-variant
rs1000260239 -- 114,643,567(+) AAGCT(A/G)CTCTC intron-variant, utr-variant-3-prime
rs1000291332 -- 114,643,191(+) TAGTG(A/G)CCTCC nc-transcript-variant, reference, missense
rs1000358830 -- 114,614,250(+) CAGGG(C/T)AGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM268 Gene

Variant ID Type Subtype PubMed ID
dgv12859n54 CNV gain 21841781
dgv7706n100 CNV gain 25217958
dgv948n27 CNV gain 19166990
esv1008480 CNV deletion 20482838
nsv520757 CNV gain 19592680
nsv615249 CNV loss 21841781
nsv6679 CNV insertion 18451855
nsv7433 OTHER inversion 18451855
nsv831694 CNV gain 17160897

Variation tolerance for TMEM268 Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 32.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM268 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM268

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM268 Gene

Disorders for TMEM268 Gene

Relevant External Links for TMEM268

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM268
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM268

No disorders were found for TMEM268 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM268 Gene

Publications for TMEM268 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 64
  2. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for TMEM268 Gene

Sources for TMEM268 Gene

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