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Aliases for TMEM267 Gene

Aliases for TMEM267 Gene

  • Transmembrane Protein 267 2 3 5
  • C5orf28 3 4
  • Chromosome 5 Open Reading Frame 28 2
  • Transmembrane Protein C5orf28 3

External Ids for TMEM267 Gene

Previous HGNC Symbols for TMEM267 Gene

  • C5orf28

Summaries for TMEM267 Gene

GeneCards Summary for TMEM267 Gene

TMEM267 (Transmembrane Protein 267) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM267 Gene

Genomics for TMEM267 Gene

Regulatory Elements for TMEM267 Gene

Enhancers for TMEM267 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G043396 1 ENCODE dbSUPER 11.4 +88.1 88144 1.4 GTF2F1 TAF1 SIN3A BMI1 RBBP5 RAD21 CHAMP1 YY1 E2F1 POLR2A ENSG00000249492 TMEM267 HMGCS1 CCL28 ENSG00000188850
GH05G043403 0.8 Ensembl 10.8 +82.1 82078 0.2 HDGF SAP130 CREB3L1 NFRKB ARID4B DMAP1 ZNF644 RARA POLR2A FOXK2 TMEM267 ENSG00000249492 CCL28 ENSG00000188850
GH05G043401 0.7 ENCODE 10.8 +83.2 83165 0.2 ELF3 CTCF SAP130 MAX ARID4B ZSCAN9 ZNF644 RAD21 RFX5 TEAD3 TMEM267 ENSG00000249492 CCL28 ENSG00000188850
GH05G043409 1 ENCODE dbSUPER 5.8 +75.1 75122 1.4 FEZF1 ZNF366 ZSCAN5C RCOR1 PRDM10 TCF7L2 SCRT1 MAZ ZNF10 OVOL3 TMEM267 NNT CCL28 ENSG00000188850
GH05G043619 0.7 dbSUPER 6 -135.1 -135084 2.3 ZNF10 HLF CEBPB MAX CEBPG NR2F2 YY1 FOXA1 GABPA ZNF316 NNT NNT-AS1 TMEM267 GC05M043668
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM267 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM267 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000180207 1478 1801 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 SP3 ZNF610 ZNF585B GLIS1

Genomic Location for TMEM267 Gene

Chromosome:
5
Start:
43,444,252 bp from pter
End:
43,485,178 bp from pter
Size:
40,927 bases
Orientation:
Minus strand

Genomic View for TMEM267 Gene

Genes around TMEM267 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM267 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM267 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM267 Gene

Proteins for TMEM267 Gene

  • Protein details for TMEM267 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VDI3-TM267_HUMAN
    Recommended name:
    Transmembrane protein 267
    Protein Accession:
    Q0VDI3
    Secondary Accessions:
    • B2RDA6
    • Q9H6Z2

    Protein attributes for TMEM267 Gene

    Size:
    215 amino acids
    Molecular mass:
    24217 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM267 Gene

Post-translational modifications for TMEM267 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM267 Gene

Domains & Families for TMEM267 Gene

Protein Domains for TMEM267 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM267 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM267: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM267 Gene

Function for TMEM267 Gene

Phenotypes for TMEM267 Gene

genes like me logo Genes that share phenotypes with TMEM267: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM267 Gene

Localization for TMEM267 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM267 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM267 gene
Compartment Confidence
peroxisome 2
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM267 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM267: view

Pathways & Interactions for TMEM267 Gene

SuperPathways for TMEM267 Gene

No Data Available

Interacting Proteins for TMEM267 Gene

Selected Interacting proteins: Q0VDI3-TM267_HUMAN for TMEM267 Gene via IID

Symbol External ID(s) Details
APP

Gene Ontology (GO) - Biological Process for TMEM267 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM267 Gene

Transcripts for TMEM267 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM267 Gene

No ASD Table

Relevant External Links for TMEM267 Gene

GeneLoc Exon Structure for
TMEM267
ECgene alternative splicing isoforms for
TMEM267

Expression for TMEM267 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM267 Gene:

TMEM267

Evidence on tissue expression from TISSUES for TMEM267 Gene

  • Nervous system(4.5)
  • Intestine(4.2)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM267 Gene

Orthologs for TMEM267 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM267 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C5orf28 35
  • 100 (a)
OneToOne
C5H5orf28 34
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia C4H5orf28 34
  • 91.63 (n)
C5orf28 35
  • 79 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C20H5orf28 34
  • 90.08 (n)
C5orf28 35
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C5orf28 35
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm7120 34 35
  • 80.93 (n)
Gm21967 35
  • 71 (a)
OneToMany
Tmem267 16
rat
(Rattus norvegicus)
Mammalia RGD1562550 34
  • 80.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C5orf28 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves CZH5ORF28 34
  • 78.91 (n)
C5orf28 35
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C5orf28 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490930 34
  • 68.06 (n)
zebrafish
(Danio rerio)
Actinopterygii si:busm1-79m10.4 34
  • 64.81 (n)
C10H5orf28 35
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10866 34 35
  • 48.68 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005379 34
  • 43.08 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToOne
Species where no ortholog for TMEM267 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM267 Gene

ENSEMBL:
Gene Tree for TMEM267 (if available)
TreeFam:
Gene Tree for TMEM267 (if available)

Paralogs for TMEM267 Gene

No data available for Paralogs for TMEM267 Gene

Variants for TMEM267 Gene

Sequence variations from dbSNP and Humsavar for TMEM267 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000004093 -- 43,447,999(+) AGTAG(G/T)AAAAG intron-variant
rs1000066304 -- 43,486,038(+) GTGAG(C/G)TCATT intron-variant, upstream-variant-2KB
rs1000131860 -- 43,444,850(+) CAAAA(C/T)ATAAT utr-variant-3-prime
rs1000159651 -- 43,454,359(+) TATCC(A/G)TTGGG intron-variant
rs1000201060 -- 43,456,755(+) ATGTT(G/T)ACAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM267 Gene

Variant ID Type Subtype PubMed ID
esv2597772 CNV deletion 19546169
esv2665243 CNV deletion 23128226
esv3565866 CNV deletion 23714750
esv3604903 CNV loss 21293372
nsv478024 CNV novel sequence insertion 20440878
nsv830275 CNV gain 17160897

Variation tolerance for TMEM267 Gene

Residual Variation Intolerance Score: 33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM267 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM267

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM267 Gene

Disorders for TMEM267 Gene

Relevant External Links for TMEM267

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM267
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM267

No disorders were found for TMEM267 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM267 Gene

Publications for TMEM267 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for TMEM267 Gene

Sources for TMEM267 Gene

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