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Aliases for TMEM266 Gene

Aliases for TMEM266 Gene

  • Transmembrane Protein 266 2 3 5
  • C15orf27 3 4
  • Chromosome 15 Open Reading Frame 27 2
  • Transmembrane Protein C15orf27 3
  • Hv1 Related Protein 1 3
  • HVRP1 3

External Ids for TMEM266 Gene

Previous HGNC Symbols for TMEM266 Gene

  • C15orf27

Summaries for TMEM266 Gene

GeneCards Summary for TMEM266 Gene

TMEM266 (Transmembrane Protein 266) is a Protein Coding gene. An important paralog of this gene is HVCN1.

Additional gene information for TMEM266 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM266 Gene

Genomics for TMEM266 Gene

GeneHancer (GH) Regulatory Elements for TMEM266 Gene

Promoters and enhancers for TMEM266 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I076059 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.1 88 1.4 PKNOX1 KLF17 ZNF76 SIN3A FEZF1 ZNF335 GLIS2 SCRT2 ZNF391 ETV6 NRG4 TMEM266 LOC441728 DNM1P35 LOC101929439
GH15I076058 Enhancer 0.7 ENCODE 550.8 -0.8 -792 0.1 CTCF PKNOX1 SUZ12 MAX SIN3A RAD21 ZNF335 ZNF600 RUNX3 ZBTB20 NRG4 TMEM266 LOC441728 DNM1P35 GC15M075978
GH15I076113 Promoter 0.6 EPDnew 550.2 +53.9 53908 0.1 CTCF TMEM266 LOC101929439
GH15I076195 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.2 +137.8 137761 4.3 PKNOX1 ARID4B DMAP1 SLC30A9 GLIS2 FOS DEK SP5 MXD4 PPARG SCAPER TMEM266 NRG4 ISL2 ETFA TSPAN3 LOC101929439 ENSG00000196274
GH15I076190 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.2 +131.2 131175 1.2 RB1 SIN3A DMAP1 IRF4 ZNF48 RAD21 RFX5 SCRT2 ZNF207 ZNF143 SCAPER NRG4 TMEM266 MIR631 LOC101929439 ENSG00000196274
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM266 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM266 Gene

Genomic Locations for TMEM266 Gene
chr15:76,059,837-76,229,121
(GRCh38/hg38)
Size:
169,285 bases
Orientation:
Plus strand
chr15:76,352,178-76,521,462
(GRCh37/hg19)

Genomic View for TMEM266 Gene

Genes around TMEM266 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM266 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM266 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM266 Gene

Proteins for TMEM266 Gene

  • Protein details for TMEM266 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M3C6-TM266_HUMAN
    Recommended name:
    Transmembrane protein 266
    Protein Accession:
    Q2M3C6
    Secondary Accessions:
    • Q8N993
    • Q96LL5

    Protein attributes for TMEM266 Gene

    Size:
    531 amino acids
    Molecular mass:
    58444 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI04954.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI04956.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71676.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04562.1; Type=Frameshift; Positions=13, 93; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM266 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM266 Gene

Post-translational modifications for TMEM266 Gene

No Post-translational modifications

Other Protein References for TMEM266 Gene

No data available for DME Specific Peptides for TMEM266 Gene

Domains & Families for TMEM266 Gene

Gene Families for TMEM266 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM266 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM266 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM266: view

No data available for UniProtKB/Swiss-Prot for TMEM266 Gene

Function for TMEM266 Gene

Phenotypes for TMEM266 Gene

genes like me logo Genes that share phenotypes with TMEM266: view

miRNA for TMEM266 Gene

miRTarBase miRNAs that target TMEM266

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM266 Gene

Localization for TMEM266 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM266 Gene

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM266 gene
Compartment Confidence
plasma membrane 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM266 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM266: view

Pathways & Interactions for TMEM266 Gene

SuperPathways for TMEM266 Gene

No Data Available

Interacting Proteins for TMEM266 Gene

Gene Ontology (GO) - Biological Process for TMEM266 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM266 Gene

Drugs & Compounds for TMEM266 Gene

No Compound Related Data Available

Transcripts for TMEM266 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM266 Gene

No ASD Table

Relevant External Links for TMEM266 Gene

GeneLoc Exon Structure for
TMEM266
ECgene alternative splicing isoforms for
TMEM266

Expression for TMEM266 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of TMEM266 Gene:

TMEM266

Evidence on tissue expression from TISSUES for TMEM266 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with TMEM266: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM266 Gene

Orthologs for TMEM266 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM266 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C15H15orf27 33
  • 99.31 (n)
C15orf27 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C21H15orf27 33
  • 88.76 (n)
C15orf27 34
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1562084 33
  • 88.23 (n)
mouse
(Mus musculus)
Mammalia AI118078 33 34
  • 87.36 (n)
Tmem266 16
dog
(Canis familiaris)
Mammalia LOC487670 33
  • 86.27 (n)
C15orf27 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C15orf27 34
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C15orf27 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves C15ORF27 33
  • 74.61 (n)
C15orf27 34
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C15orf27 34
  • 35 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:158624 33
  • 68.05 (n)
C25H15orf27 34
  • 60 (a)
OneToOne
Dr.14493 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
OneToOne
Species where no ortholog for TMEM266 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM266 Gene

ENSEMBL:
Gene Tree for TMEM266 (if available)
TreeFam:
Gene Tree for TMEM266 (if available)

Paralogs for TMEM266 Gene

Paralogs for TMEM266 Gene

genes like me logo Genes that share paralogs with TMEM266: view

Variants for TMEM266 Gene

Sequence variations from dbSNP and Humsavar for TMEM266 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000026071 -- 76,067,632(+) C/A intron_variant
rs1000026396 -- 76,174,636(+) A/G intron_variant
rs1000058104 -- 76,167,738(+) C/T intron_variant
rs1000072277 -- 76,069,422(+) A/G intron_variant
rs1000098177 -- 76,133,247(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM266 Gene

Variant ID Type Subtype PubMed ID
dgv2623n100 CNV gain 25217958
dgv2624n100 CNV gain 25217958
dgv2625n100 CNV gain 25217958
dgv2626n100 CNV gain 25217958
esv2660944 CNV deletion 23128226
esv2665159 CNV deletion 23128226
esv2669418 CNV deletion 23128226
esv274972 CNV loss 21479260
esv2749895 CNV deletion 23290073
esv2749898 CNV deletion 23290073
esv3350114 CNV insertion 20981092
esv3552697 CNV deletion 23714750
esv3636935 CNV loss 21293372
esv3636937 CNV loss 21293372
esv3636938 CNV loss 21293372
nsv1048760 CNV gain 25217958
nsv1054713 CNV gain 25217958
nsv1108967 CNV deletion 24896259
nsv1116463 OTHER inversion 24896259
nsv1142180 CNV tandem duplication 24896259
nsv1617 CNV deletion 18451855
nsv569998 CNV gain 21841781
nsv833057 CNV loss 17160897

Variation tolerance for TMEM266 Gene

Residual Variation Intolerance Score: 49.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.33; 95.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM266 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM266

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM266 Gene

Disorders for TMEM266 Gene

No disorders were found for TMEM266 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM266 Gene

Publications for TMEM266 Gene

  1. Aspartate 112 is the selectivity filter of the human voltage-gated proton channel. (PMID: 22020278) Musset B … Decoursey TE (Nature 2011) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 58
  3. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TMEM266 Gene

Sources for TMEM266 Gene

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