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Aliases for TMEM266 Gene

Aliases for TMEM266 Gene

  • Transmembrane Protein 266 2 3 5
  • C15orf27 3 4
  • Chromosome 15 Open Reading Frame 27 2
  • Transmembrane Protein C15orf27 3
  • Hv1 Related Protein 1 3
  • HVRP1 3

External Ids for TMEM266 Gene

Previous HGNC Symbols for TMEM266 Gene

  • C15orf27

Summaries for TMEM266 Gene

GeneCards Summary for TMEM266 Gene

TMEM266 (Transmembrane Protein 266) is a Protein Coding gene. An important paralog of this gene is HVCN1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM266 Gene

Genomics for TMEM266 Gene

Regulatory Elements for TMEM266 Gene

Promoters for TMEM266 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM266 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM266 Gene

Chromosome:
15
Start:
76,059,837 bp from pter
End:
76,229,121 bp from pter
Size:
169,285 bases
Orientation:
Plus strand

Genomic View for TMEM266 Gene

Genes around TMEM266 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM266 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM266 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM266 Gene

Proteins for TMEM266 Gene

  • Protein details for TMEM266 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M3C6-TM266_HUMAN
    Recommended name:
    Transmembrane protein 266
    Protein Accession:
    Q2M3C6
    Secondary Accessions:
    • Q8N993
    • Q96LL5

    Protein attributes for TMEM266 Gene

    Size:
    531 amino acids
    Molecular mass:
    58444 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI04954.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI04956.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71676.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04562.1; Type=Frameshift; Positions=13, 93; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM266 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM266 Gene

Proteomics data for TMEM266 Gene at MOPED

Post-translational modifications for TMEM266 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM266 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM266 Gene

Domains & Families for TMEM266 Gene

Protein Domains for TMEM266 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM266 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM266: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM266 Gene

Function for TMEM266 Gene

Phenotypes for TMEM266 Gene

genes like me logo Genes that share phenotypes with TMEM266: view

Animal Model Products

miRNA for TMEM266 Gene

miRTarBase miRNAs that target TMEM266

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM266 Gene

Localization for TMEM266 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM266 Gene

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM266 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with TMEM266: view

No data available for Subcellular locations from COMPARTMENTS for TMEM266 Gene

Pathways & Interactions for TMEM266 Gene

SuperPathways for TMEM266 Gene

No Data Available

Interacting Proteins for TMEM266 Gene

Gene Ontology (GO) - Biological Process for TMEM266 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM266 Gene

Drugs & Compounds for TMEM266 Gene

No Compound Related Data Available

Transcripts for TMEM266 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM266 Gene

No ASD Table

Relevant External Links for TMEM266 Gene

GeneLoc Exon Structure for
TMEM266
ECgene alternative splicing isoforms for
TMEM266

Expression for TMEM266 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expression patterns with TMEM266: view

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM266 Gene

Orthologs for TMEM266 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM266 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C21H15orf27 35
  • 88.76 (n)
  • 87.9 (a)
C15orf27 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC487670 35
  • 86.27 (n)
  • 84.71 (a)
C15orf27 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia AI118078 35
  • 87.36 (n)
  • 88.11 (a)
Tmem266 16
AI118078 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C15H15orf27 35
  • 99.31 (n)
  • 99.44 (a)
C15orf27 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1562084 35
  • 88.23 (n)
  • 88.29 (a)
oppossum
(Monodelphis domestica)
Mammalia C15orf27 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C15orf27 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves C15ORF27 35
  • 74.61 (n)
  • 76.55 (a)
C15orf27 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C15orf27 36
  • 35 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.14493 35
zgc:158624 35
  • 68.05 (n)
  • 64.16 (a)
C25H15orf27 36
  • 60 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToOne
Species with no ortholog for TMEM266:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM266 Gene

ENSEMBL:
Gene Tree for TMEM266 (if available)
TreeFam:
Gene Tree for TMEM266 (if available)

Paralogs for TMEM266 Gene

Paralogs for TMEM266 Gene

genes like me logo Genes that share paralogs with TMEM266: view

Variants for TMEM266 Gene

Sequence variations from dbSNP and Humsavar for TMEM266 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs937732 - 76,203,891(+) CTCCC(A/G)CAGCT reference, missense
rs937733 - 76,203,999(+) TCCCC(C/G/T)GCCGC reference, missense
rs1018099 -- 76,155,467(-) GAGGT(C/G)AGGCC intron-variant
rs1018100 -- 76,155,412(-) GTCAC(A/G)GAATC intron-variant
rs904278 -- 76,158,002(-) ATTTA(C/T)TTACT intron-variant

Variation tolerance for TMEM266 Gene

Residual Variation Intolerance Score: 49.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.33; 95.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM266 Gene

HapMap Linkage Disequilibrium report
TMEM266

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM266 Gene

Disorders for TMEM266 Gene

Relevant External Links for TMEM266

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM266
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM266

No disorders were found for TMEM266 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM266 Gene

Publications for TMEM266 Gene

  1. Aspartatea88112 is the selectivity filter of the human voltage-gated proton channel. (PMID: 22020278) Musset B. … Decoursey T.E. (Nature 2011) 2 3 4 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3
  3. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 3

Products for TMEM266 Gene

Sources for TMEM266 Gene

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